{"id":"https://openalex.org/W2171968158","doi":"https://doi.org/10.1371/journal.pbio.0040351","title":"Ammonium Toxicity and Potassium Limitation in Yeast","display_name":"Ammonium Toxicity and Potassium Limitation in Yeast","publication_year":2006,"publication_date":"2006-10-13","ids":{"openalex":"https://openalex.org/W2171968158","doi":"https://doi.org/10.1371/journal.pbio.0040351","mag":"2171968158","pmid":"https://pubmed.ncbi.nlm.nih.gov/17048990","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1609136"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pbio.0040351","doi":"https://doi.org/10.1371/journal.pbio.0040351","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.0040351","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0040351&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0040351&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023562848","display_name":"David C. Hess","orcid":"https://orcid.org/0000-0003-2821-1021","observed_orcids":["https://orcid.org/0000-0003-2821-1021"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David C Hess","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA. dhess@princeton.edu","Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA. dhess@princeton.edu","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003316821","display_name":"Wenyun Lu","orcid":"https://orcid.org/0000-0003-1787-2617","observed_orcids":["https://orcid.org/0000-0003-1787-2617"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenyun Lu","raw_affiliation_strings":["","Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053467552","display_name":"Joshua D. Rabinowitz","orcid":"https://orcid.org/0000-0002-1247-4727","observed_orcids":["https://orcid.org/0000-0002-1247-4727"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D Rabinowitz","raw_affiliation_strings":["","Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077542898","display_name":"David Botstein","orcid":"https://orcid.org/0000-0001-9499-4883","observed_orcids":["https://orcid.org/0000-0001-9499-4883"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Botstein","raw_affiliation_strings":["","Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023562848"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":2.8967,"has_fulltext":true,"cited_by_count":153,"citation_normalized_percentile":{"value":0.91388269,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"4","issue":"11","first_page":"e351","last_page":"e351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ammonium-toxicity","display_name":"ammonium toxicity","score":1.0},{"id":"https://openalex.org/keywords/potassium-limitation","display_name":"potassium limitation","score":0.996999979019165},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ammonium-transporters","display_name":"ammonium transporters","score":0.7409999966621399},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.9419999718666077},{"id":"https://openalex.org/keywords/ammonium-detoxification","display_name":"ammonium detoxification","score":0.7400000095367432},{"id":"https://openalex.org/keywords/amino-acid-excretion","display_name":"amino acid excretion","score":0.984000027179718},{"id":"https://openalex.org/keywords/nitrogen-source","display_name":"nitrogen source","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6869999766349792},{"id":"https://openalex.org/keywords/chemostat-culture","display_name":"chemostat culture","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2779870022","wikidata":"https://www.wikidata.org/wiki/Q190901","display_name":"Ammonium","level":2,"score":0.8810237646102905},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.691388726234436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6860219240188599},{"id":"https://openalex.org/C125111812","wikidata":"https://www.wikidata.org/wiki/Q902311","display_name":"Chemostat","level":3,"score":0.6143343448638916},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5976315140724182},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5724744200706482},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5008015632629395},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.44532835483551025},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.43298307061195374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23289573192596436},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0633230209350586},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.056655436754226685},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.04976862668991089}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000641","descriptor_name":"Ammonia","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017920","descriptor_name":"Antiporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pbio.0040351","doi":"https://doi.org/10.1371/journal.pbio.0040351","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.0040351","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0040351&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1814553","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC1609136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:17048990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17048990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.322.4674","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.322.4674","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.princeton.edu/genomics/rabinowitz/publications/30.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.420.4613","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.420.4613","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.princeton.edu/genomics/botstein/publications/2006_Hess_Ammonium.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.814.1704","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.814.1704","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/21/73/pbio.0040351.PMC1609136.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7a6bfade9ca64be78716c2902864de18","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7a6bfade9ca64be78716c2902864de18","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Biology, Vol 4, Iss 11, p e351 (2006)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/152976","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Ammonium_Toxicity_and_Potassium_Limitation_in_Yeast_/152976","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pbio.0040351","doi":"https://doi.org/10.1371/journal.pbio.0040351","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pbio.0040351","pdf_url":"https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0040351&type=printable","source":{"id":"https://openalex.org/S154343897","display_name":"PLoS Biology","issn_l":"1544-9173","issn":["1544-9173","1545-7885"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5037410752","display_name":"Genetics of Functional Interactions in Yeast","funder_award_id":"R01GM046406","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6567509300","display_name":null,"funder_award_id":"P50 GM071508","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6777823385","display_name":"DDDAS-SMRP: Development of a closed-loop identification machine for bionetworks (CLIMB) and its application to nucleotide metabolism","funder_award_id":"0540181","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7483086961","display_name":"Center for Quantitative Biology","funder_award_id":"P50GM071508","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306253","display_name":"Arnold and Mabel Beckman Foundation","ror":"https://ror.org/05avmtm72"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171968158.pdf","grobid_xml":"https://content.openalex.org/works/W2171968158.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1521448744","https://openalex.org/W1534435141","https://openalex.org/W1551766707","https://openalex.org/W1631944702","https://openalex.org/W1848248203","https://openalex.org/W1903635354","https://openalex.org/W1965901809","https://openalex.org/W1966072209","https://openalex.org/W1982862502","https://openalex.org/W1984017442","https://openalex.org/W1984354326","https://openalex.org/W1985342306","https://openalex.org/W1987364769","https://openalex.org/W1988681504","https://openalex.org/W1993239625","https://openalex.org/W1998115661","https://openalex.org/W2005028417","https://openalex.org/W2009721042","https://openalex.org/W2015507790","https://openalex.org/W2017811519","https://openalex.org/W2026174841","https://openalex.org/W2028400128","https://openalex.org/W2034162523","https://openalex.org/W2037898994","https://openalex.org/W2048384173","https://openalex.org/W2054624670","https://openalex.org/W2061028193","https://openalex.org/W2074704582","https://openalex.org/W2078380250","https://openalex.org/W2085680124","https://openalex.org/W2098667036","https://openalex.org/W2106450047","https://openalex.org/W2106894636","https://openalex.org/W2118056423","https://openalex.org/W2122436542","https://openalex.org/W2123723625","https://openalex.org/W2127270784","https://openalex.org/W2131755635","https://openalex.org/W2136254499","https://openalex.org/W2136947295","https://openalex.org/W2137683543","https://openalex.org/W2150910409","https://openalex.org/W2153152988","https://openalex.org/W2156071016","https://openalex.org/W2159108936","https://openalex.org/W2159368155","https://openalex.org/W2165885746","https://openalex.org/W3173114588","https://openalex.org/W3175283501","https://openalex.org/W4231391803","https://openalex.org/W4243741585"],"related_works":["https://openalex.org/W6901979187","https://openalex.org/W6958162996","https://openalex.org/W6920470122","https://openalex.org/W6901906345","https://openalex.org/W6977088998","https://openalex.org/W6901948408","https://openalex.org/W1968360560","https://openalex.org/W4285492267","https://openalex.org/W2127479096","https://openalex.org/W47667500"],"abstract_inverted_index":{"DNA":[0],"microarray":[1],"analysis":[2],"of":[3,51,63,92,121,130,140],"gene":[4],"expression":[5],"in":[6,72,108,135],"steady-state":[7],"chemostat":[8],"cultures":[9,94],"limited":[10],"for":[11,39,79,95,117,154],"potassium":[12,18,21,32,54],"revealed":[13],"a":[14,118],"surprising":[15],"connection":[16],"between":[17],"and":[19],"ammonium:":[20],"limits":[22],"growth":[23,141],"only":[24],"when":[25],"ammonium":[26,34,43,52,64,67,86,104,155],"is":[27,56,69,150],"the":[28,83,90,103,138],"nitrogen":[29],"source.":[30],"Under":[31],"limitation,":[33],"appears":[35,46],"to":[36,47,85,101,115,137],"be":[37],"toxic":[38],"Saccharomyces":[40],"cerevisiae.":[41],"This":[42],"toxicity,":[44,87],"which":[45],"occur":[48],"by":[49,61,143,152],"leakage":[50],"through":[53],"channels,":[55],"recapitulated":[57],"under":[58],"high-potassium":[59],"conditions":[60],"over-expression":[62],"transporters.":[65],"Although":[66],"toxicity":[68],"well":[70],"established":[71],"metazoans,":[73],"it":[74],"has":[75],"never":[76],"been":[77],"reported":[78],"yeast.":[80],"To":[81],"characterize":[82],"response":[84],"we":[88,123],"examined":[89],"filtrates":[91],"these":[93],"compounds":[96],"whose":[97],"excretion":[98,149],"might":[99],"serve":[100],"detoxify":[102],"(such":[105],"as":[106],"urea":[107],"mammals).":[109],"Using":[110],"liquid":[111],"chromatography-tandem":[112],"mass":[113],"spectrometry":[114],"assay":[116],"wide":[119],"array":[120],"metabolites,":[122],"detected":[124],"excreted":[125,133],"amino":[126,131,147],"acids.":[127],"The":[128],"amounts":[129],"acids":[132],"increased":[134],"relation":[136],"severity":[139],"impairment":[142],"ammonium,":[144],"suggesting":[145],"that":[146],"acid":[148],"used":[151],"yeast":[153],"detoxification.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}