{"id":"https://openalex.org/W2171828296","doi":"https://doi.org/10.1124/mol.61.1.160","title":"Allosteric Site on Muscarinic Acetylcholine Receptors: A Single Amino Acid in Transmembrane Region 7 Is Critical to the Subtype Selectivities of Caracurine V Derivatives and Alkane-Bisammonium Ligands","display_name":"Allosteric Site on Muscarinic Acetylcholine Receptors: A Single Amino Acid in Transmembrane Region 7 Is Critical to the Subtype Selectivities of Caracurine V Derivatives and Alkane-Bisammonium Ligands","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2171828296","doi":"https://doi.org/10.1124/mol.61.1.160","mag":"2171828296","pmid":"https://pubmed.ncbi.nlm.nih.gov/11752217"},"language":"en","primary_location":{"id":"doi:10.1124/mol.61.1.160","doi":"https://doi.org/10.1124/mol.61.1.160","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.61.1.160","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076296966","display_name":"Stefan Buller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Stefan Buller","raw_affiliation_strings":["Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania, USA","3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.)","Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]},{"raw_affiliation_string":"3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.)","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.)","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008709840","display_name":"Darius Paul Zlotos","orcid":"https://orcid.org/0000-0002-1193-3119","observed_orcids":["https://orcid.org/0000-0002-1193-3119"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Darius Paul Zlotos","raw_affiliation_strings":["Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.); Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.); and \n3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.)","Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.); Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.); and \n3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I135140700","https://openalex.org/I25974101","https://openalex.org/I82783531"]},{"raw_affiliation_string":"3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.)","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.)","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108426397","display_name":"Klaus Mohr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Klaus Mohr","raw_affiliation_strings":["Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.); Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.); and \n3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.)","Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.); Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.); and \n3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I135140700","https://openalex.org/I25974101","https://openalex.org/I82783531"]},{"raw_affiliation_string":"3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.)","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.)","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":null,"display_name":"John Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"John Ellis","raw_affiliation_strings":["Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.); Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.); and \n3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.)","Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.); Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.); and \n3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I135140700","https://openalex.org/I25974101","https://openalex.org/I82783531"]},{"raw_affiliation_string":"3Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of W\u00fcrzburg, W\u00fcrzburg, Germany (D.P.Z.)","institution_ids":["https://openalex.org/I25974101"]},{"raw_affiliation_string":"Departments of\n2Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (S.B., K.M.)","institution_ids":["https://openalex.org/I135140700"]},{"raw_affiliation_string":"Departments of 1Psychiatry and Pharmacology, Penn State College of Medicine, Hershey Pennsylvania (S.B., J.E.)","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":2.7117,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.90867155,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"61","issue":"1","first_page":"160","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/allosteric-ligands","display_name":"allosteric ligands","score":0.8899999856948853},{"id":"https://openalex.org/keywords/alcuronium","display_name":"alcuronium","score":0.8669999837875366},{"id":"https://openalex.org/keywords/m4-receptor","display_name":"M4 receptor","score":0.5630000233650208},{"id":"https://openalex.org/keywords/receptor-chimeras","display_name":"receptor chimeras","score":0.7250000238418579},{"id":"https://openalex.org/keywords/site-directed-mutagenesis","display_name":"site-directed mutagenesis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/stereospecificity","display_name":"stereospecificity","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8861350417137146},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7857245206832886},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6683804988861084},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.5911955237388611},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4962204098701477},{"id":"https://openalex.org/C47488739","wikidata":"https://www.wikidata.org/wiki/Q17861931","display_name":"Muscarinic acetylcholine receptor M2","level":4,"score":0.49580201506614685},{"id":"https://openalex.org/C109129352","wikidata":"https://www.wikidata.org/wiki/Q7426583","display_name":"Saturated mutagenesis","level":4,"score":0.4565051198005676},{"id":"https://openalex.org/C2775880066","wikidata":"https://www.wikidata.org/wiki/Q186521","display_name":"Threonine","level":4,"score":0.45344313979148865},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44931477308273315},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.41415935754776},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.3732105493545532},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3236099183559418},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.122307687997818},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08298173546791077},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016296","descriptor_name":"Mutagenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1124/mol.61.1.160","doi":"https://doi.org/10.1124/mol.61.1.160","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.61.1.160","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:11752217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11752217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6388404642","display_name":"Responses of subpopulation of muscarinic receptors","funder_award_id":"R01AG005214","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1504598914","https://openalex.org/W1506106609","https://openalex.org/W1903317486","https://openalex.org/W1924799369","https://openalex.org/W1928384246","https://openalex.org/W1967970867","https://openalex.org/W1982772302","https://openalex.org/W1986155885","https://openalex.org/W2023708421","https://openalex.org/W2031476108","https://openalex.org/W2078353587","https://openalex.org/W2081364550","https://openalex.org/W2082421347","https://openalex.org/W2084958803","https://openalex.org/W2090434636","https://openalex.org/W2098273077","https://openalex.org/W2113630547","https://openalex.org/W2119772884","https://openalex.org/W2148786572","https://openalex.org/W2153929247","https://openalex.org/W2161685942","https://openalex.org/W2170038549","https://openalex.org/W2384135000","https://openalex.org/W2399010992","https://openalex.org/W2408967267","https://openalex.org/W2415423152","https://openalex.org/W2418775721","https://openalex.org/W2419620389","https://openalex.org/W2470477664"],"related_works":["https://openalex.org/W2009445406","https://openalex.org/W2106630611","https://openalex.org/W2098273077","https://openalex.org/W6982805347","https://openalex.org/W2082421347","https://openalex.org/W2411209332","https://openalex.org/W2012108326","https://openalex.org/W1991512318","https://openalex.org/W7098702003","https://openalex.org/W1936577905"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}