{"id":"https://openalex.org/W2171757585","doi":"https://doi.org/10.1128/jb.02340-14","title":"Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile","display_name":"Cyclic Di-GMP Riboswitch-Regulated Type IV Pili Contribute to Aggregation of Clostridium difficile","publication_year":2014,"publication_date":"2014-12-16","ids":{"openalex":"https://openalex.org/W2171757585","doi":"https://doi.org/10.1128/jb.02340-14","mag":"2171757585","pmid":"https://pubmed.ncbi.nlm.nih.gov/25512308","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4325102"},"language":"en","primary_location":{"id":"doi:10.1128/jb.02340-14","doi":"https://doi.org/10.1128/jb.02340-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.02340-14","pdf_url":"https://jb.asm.org/content/jb/197/5/819.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jb.asm.org/content/jb/197/5/819.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001593620","display_name":"\u00c9ric Bordeleau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eric Bordeleau","raw_affiliation_strings":["D\u00e9partement de Biologie, Facult\u00e9 des Sciences, Universit\u00e9 de Sherbrooke, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biologie, Facult\u00e9 des Sciences, Universit\u00e9 de Sherbrooke, QC, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065968534","display_name":"Erin B. Purcell","orcid":"https://orcid.org/0000-0002-8736-0433","observed_orcids":["https://orcid.org/0000-0002-8736-0433"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin B. Purcell","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014915537","display_name":"Daniel A. Lafontaine","orcid":"https://orcid.org/0000-0001-7891-5700","observed_orcids":["https://orcid.org/0000-0001-7891-5700"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Daniel A. Lafontaine","raw_affiliation_strings":["D\u00e9partement de Biologie, Facult\u00e9 des Sciences, Universit\u00e9 de Sherbrooke, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biologie, Facult\u00e9 des Sciences, Universit\u00e9 de Sherbrooke, QC, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056715158","display_name":"Louis\u2010Charles Fortier","orcid":"https://orcid.org/0000-0003-1950-763X","observed_orcids":["https://orcid.org/0000-0003-1950-763X"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Louis-Charles Fortier","raw_affiliation_strings":["D\u00e9partement de Microbiologie et d'Infectiologie, Facult\u00e9 de M\u00e9decine et Sciences de la Sant\u00e9, Universit\u00e9 de Sherbrooke, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Microbiologie et d'Infectiologie, Facult\u00e9 de M\u00e9decine et Sciences de la Sant\u00e9, Universit\u00e9 de Sherbrooke, QC, Canada","institution_ids":["https://openalex.org/I135117807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084941155","display_name":"Rita Tamayo","orcid":"https://orcid.org/0000-0002-3745-3316","observed_orcids":["https://orcid.org/0000-0002-3745-3316"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Tamayo","raw_affiliation_strings":["Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014704768","display_name":"Vincent Burrus","orcid":"https://orcid.org/0000-0001-6318-6904","observed_orcids":["https://orcid.org/0000-0001-6318-6904"]},"institutions":[{"id":"https://openalex.org/I135117807","display_name":"Universit\u00e9 de Sherbrooke","ror":"https://ror.org/00kybxq39","country_code":"CA","type":"education","lineage":["https://openalex.org/I135117807"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vincent Burrus","raw_affiliation_strings":["D\u00e9partement de Biologie, Facult\u00e9 des Sciences, Universit\u00e9 de Sherbrooke, QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de Biologie, Facult\u00e9 des Sciences, Universit\u00e9 de Sherbrooke, QC, Canada","institution_ids":["https://openalex.org/I135117807"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7376,"has_fulltext":true,"cited_by_count":144,"citation_normalized_percentile":{"value":0.97346326,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"197","issue":"5","first_page":"819","last_page":"832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.41530001163482666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.41530001163482666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.1995999962091446,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.18320000171661377,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridioides-difficile","display_name":"Clostridium difficile","score":1.0},{"id":"https://openalex.org/keywords/c-di-gmp","display_name":"c-di-GMP","score":0.8299999833106995},{"id":"https://openalex.org/keywords/riboswitches","display_name":"riboswitches","score":0.902999997138977},{"id":"https://openalex.org/keywords/type-iv-pili","display_name":"type IV pili","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cell-aggregation","display_name":"cell aggregation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.734000027179718},{"id":"https://openalex.org/keywords/second-messenger-signaling","display_name":"second messenger signaling","score":0.6840000152587891},{"id":"https://openalex.org/keywords/multicellular-behavior","display_name":"multicellular behavior","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C174832134","wikidata":"https://www.wikidata.org/wiki/Q934786","display_name":"Pilus","level":4,"score":0.8464223146438599},{"id":"https://openalex.org/C148625055","wikidata":"https://www.wikidata.org/wiki/Q418840","display_name":"Riboswitch","level":5,"score":0.7763684988021851},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.772458553314209},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6022005081176758},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5632193684577942},{"id":"https://openalex.org/C178046730","wikidata":"https://www.wikidata.org/wiki/Q331824","display_name":"Terminator (solar)","level":3,"score":0.466336727142334},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4535948634147644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40644848346710205},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.36888471245765686},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.3441930413246155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32245495915412903},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30345940589904785},{"id":"https://openalex.org/C116403925","wikidata":"https://www.wikidata.org/wiki/Q162219","display_name":"Ionosphere","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C194993378","wikidata":"https://www.wikidata.org/wiki/Q427087","display_name":"Non-coding RNA","level":4,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010861","descriptor_name":"Fimbriae, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012329","descriptor_name":"RNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016360","descriptor_name":"Clostridioides difficile","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D058928","descriptor_name":"Riboswitch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1128/jb.02340-14","doi":"https://doi.org/10.1128/jb.02340-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.02340-14","pdf_url":"https://jb.asm.org/content/jb/197/5/819.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4325102","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4325102","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:25512308","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25512308","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:f1881t57q","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/p39q-ar75","pdf_url":"https://cdr.lib.unc.edu/downloads/jw827k46s","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Bacteriology, 197(5)","raw_type":"Article"},{"id":"pmh:oai:usherbrooke.scholaris.ca:11143/8058","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11143/8058","pdf_url":"https://usherbrooke.scholaris.ca/bitstreams/bd1d6e28-684d-4a02-a93e-e5e633a30071/download","source":{"id":"https://openalex.org/S4306401321","display_name":"Knowledge UdeS (Institutional Deposit of the University of Sherbrooke)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I135117807","host_organization_name":"Universit\u00e9 de Sherbrooke","host_organization_lineage":["https://openalex.org/I135117807"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17615/p39q-ar75","doi":"https://doi.org/10.17615/p39q-ar75","is_oa":true,"landing_page_url":"https://doi.org/10.17615/p39q-ar75","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1128/jb.02340-14","doi":"https://doi.org/10.1128/jb.02340-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jb.02340-14","pdf_url":"https://jb.asm.org/content/jb/197/5/819.full.pdf","source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6028708039","display_name":"Phase variation of virulence factors in Clostridium difficile","funder_award_id":"R01AI107029","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7840417775","display_name":"Southeast Regional Centers of Excellence for Biodefense & Emerging Infectious Di","funder_award_id":"U54AI057157","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000162070","display_name":null,"funder_award_id":"AI057157","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000176455","display_name":null,"funder_award_id":"AI107029","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000876864","display_name":"Gastroenterology Research Training","funder_award_id":"T32DK007737","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000917021","display_name":"Phase variation of virulence factors in Clostridioides difficile","funder_award_id":"R37AI107029","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320334841","display_name":"Fonds de recherche du Qu\u00e9bec \u2013 Nature et technologies","ror":"https://ror.org/00b9f9778"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171757585.pdf","grobid_xml":"https://content.openalex.org/works/W2171757585.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1577577364","https://openalex.org/W1584015664","https://openalex.org/W1588731696","https://openalex.org/W1837590098","https://openalex.org/W1934623513","https://openalex.org/W1963147033","https://openalex.org/W1964518979","https://openalex.org/W1967007681","https://openalex.org/W1968953113","https://openalex.org/W1970462201","https://openalex.org/W1975176103","https://openalex.org/W1985543936","https://openalex.org/W1986218977","https://openalex.org/W1994028292","https://openalex.org/W2006544197","https://openalex.org/W2007890464","https://openalex.org/W2009251244","https://openalex.org/W2010466313","https://openalex.org/W2014435852","https://openalex.org/W2016313746","https://openalex.org/W2017555326","https://openalex.org/W2032679787","https://openalex.org/W2036052488","https://openalex.org/W2037413627","https://openalex.org/W2038231155","https://openalex.org/W2039490778","https://openalex.org/W2041053455","https://openalex.org/W2045401515","https://openalex.org/W2048706341","https://openalex.org/W2056230513","https://openalex.org/W2060326192","https://openalex.org/W2060576378","https://openalex.org/W2065786781","https://openalex.org/W2067258168","https://openalex.org/W2067574120","https://openalex.org/W2076243547","https://openalex.org/W2078699438","https://openalex.org/W2086323657","https://openalex.org/W2086341268","https://openalex.org/W2086516780","https://openalex.org/W2095958679","https://openalex.org/W2096602864","https://openalex.org/W2096770879","https://openalex.org/W2097077186","https://openalex.org/W2098108206","https://openalex.org/W2099450499","https://openalex.org/W2100429002","https://openalex.org/W2100673091","https://openalex.org/W2101661346","https://openalex.org/W2103250615","https://openalex.org/W2105618126","https://openalex.org/W2106327168","https://openalex.org/W2106478835","https://openalex.org/W2106923147","https://openalex.org/W2109876698","https://openalex.org/W2110521895","https://openalex.org/W2110567559","https://openalex.org/W2113998048","https://openalex.org/W2115119618","https://openalex.org/W2120077910","https://openalex.org/W2121450083","https://openalex.org/W2121803750","https://openalex.org/W2125181303","https://openalex.org/W2132665880","https://openalex.org/W2132920850","https://openalex.org/W2136285267","https://openalex.org/W2138581811","https://openalex.org/W2140039966","https://openalex.org/W2141474738","https://openalex.org/W2142902947","https://openalex.org/W2143174447","https://openalex.org/W2145792008","https://openalex.org/W2147185759","https://openalex.org/W2148634126","https://openalex.org/W2152845055","https://openalex.org/W2154241726","https://openalex.org/W2155441992","https://openalex.org/W2156062569","https://openalex.org/W2158118590","https://openalex.org/W2158299059","https://openalex.org/W2159410845","https://openalex.org/W2162123770","https://openalex.org/W2162228116","https://openalex.org/W2163275874","https://openalex.org/W2165490685","https://openalex.org/W2166705194","https://openalex.org/W2169054644","https://openalex.org/W2172180816","https://openalex.org/W2466489494","https://openalex.org/W6884605446"],"related_works":["https://openalex.org/W4246959511","https://openalex.org/W4299625276","https://openalex.org/W6887794693","https://openalex.org/W7218846895","https://openalex.org/W2121450083","https://openalex.org/W2788458738","https://openalex.org/W7045786128","https://openalex.org/W7152031714","https://openalex.org/W2023479978","https://openalex.org/W4399851576"],"abstract_inverted_index":{"Clostridium":[0],"difficile":[1,51],"is":[2,24,106,173],"an":[3,184],"anaerobic":[4],"Gram-positive":[5],"bacterium":[6],"that":[7,29,143],"causes":[8],"intestinal":[9],"infections":[10],"with":[11,122],"symptoms":[12],"ranging":[13],"from":[14,34],"mild":[15],"diarrhea":[16],"to":[17,37,55,60,114,156,159,183],"fulminant":[18],"colitis.":[19],"Cyclic":[20],"diguanosine":[21],"monophosphate":[22],"(c-di-GMP)":[23],"a":[25,109,166,178],"bacterial":[26],"second":[27],"messenger":[28],"typically":[30],"regulates":[31],"the":[32,69,72,147,160],"switch":[33],"motile,":[35],"free-living":[36],"sessile":[38],"and":[39,59,90,96,154],"multicellular":[40],"behaviors":[41],"in":[42,49,79,138,168,192],"Gram-negative":[43],"bacteria.":[44],"Increased":[45],"intracellular":[46,126],"c-di-GMP":[47,103,111,119,127,157,176],"concentration":[48,128],"C.":[50,193],"was":[52,151],"recently":[53],"shown":[54],"reduce":[56],"flagellar":[57],"motility":[58],"increase":[61],"cell":[62,81,99,190],"aggregation.":[63,82],"In":[64,135],"this":[65],"work,":[66],"we":[67],"investigated":[68],"role":[70],"of":[71,84,132,146,180],"primary":[73],"type":[74],"IV":[75],"pilus":[76,94],"(T4P)":[77],"locus":[78],"c-di-GMP-dependent":[80],"Inactivation":[83],"two":[85],"T4P":[86,133,170],"genes,":[87],"pilA1":[88,105],"(CD3513)":[89],"pilB1":[91],"(CD3512),":[92],"abolished":[93],"formation":[95],"significantly":[97],"reduced":[98],"aggregation":[100,191],"under":[101],"high":[102,125],"conditions.":[104],"preceded":[107],"by":[108,175],"putative":[110],"riboswitch,":[112,188],"predicted":[113,148],"be":[115],"transcriptionally":[116,186],"active":[117],"upon":[118],"binding.":[120],"Consistent":[121],"our":[123],"prediction,":[124],"increased":[129],"transcript":[130],"levels":[131],"genes.":[134],"addition,":[136],"single-round":[137],"vitro":[139],"transcription":[140,144,149,172],"assays":[141],"confirmed":[142],"downstream":[145],"terminator":[150],"dose":[152],"dependent":[153],"specific":[155],"binding":[158,182],"riboswitch":[161],"aptamer.":[162],"These":[163],"results":[164],"support":[165],"model":[167],"which":[169],"gene":[171],"upregulated":[174],"as":[177],"result":[179],"its":[181],"upstream":[185],"activating":[187],"promoting":[189],"difficile.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}