{"id":"https://openalex.org/W2171620158","doi":"https://doi.org/10.1093/nass/1.1.71","title":"Chromatin structure of yeast minichromosomes containing triplet repeat sequences associated with human hereditary neurological diseases","display_name":"Chromatin structure of yeast minichromosomes containing triplet repeat sequences associated with human hereditary neurological diseases","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2171620158","doi":"https://doi.org/10.1093/nass/1.1.71","mag":"2171620158","pmid":"https://pubmed.ncbi.nlm.nih.gov/12836269"},"language":"en","primary_location":{"id":"doi:10.1093/nass/1.1.71","doi":"https://doi.org/10.1093/nass/1.1.71","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nass/1.1.71","pdf_url":null,"source":{"id":"https://openalex.org/S193378857","display_name":"Nucleic Acids Symposium Series","issn_l":"0261-3166","issn":["0261-3166","1746-8272"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Symposium Series","raw_type":"journal-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032267670","display_name":"Mitsuhiro Shimizu","orcid":"https://orcid.org/0000-0002-6939-2546","observed_orcids":["https://orcid.org/0000-0002-6939-2546"]},"institutions":[{"id":"https://openalex.org/I63030401","display_name":"Meisei University","ror":"https://ror.org/022yhjq53","country_code":"JP","type":"education","lineage":["https://openalex.org/I63030401"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Shimizu","raw_affiliation_strings":["Department of Chemistry, Meisei University, Hino, Tokyo 191-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Meisei University, Hino, Tokyo 191-8506, Japan","institution_ids":["https://openalex.org/I63030401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003389108","display_name":"Risa Fujita","orcid":"https://orcid.org/0009-0004-2307-7470","observed_orcids":["https://orcid.org/0009-0004-2307-7470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Fujita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"N. Tomita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Tomita","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H. Shindo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Shindo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040500435","display_name":"Robert D. Wells","orcid":"https://orcid.org/0000-0002-7240-8473","observed_orcids":["https://orcid.org/0000-0002-7240-8473"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. D. Wells","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.09872611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"1","first_page":"71","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.5942000150680542,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.5942000150680542,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.2874000072479248,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cgg-repeat","display_name":"CGG repeat","score":0.7250000238418579},{"id":"https://openalex.org/keywords/ctg-repeat","display_name":"CTG repeat","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nucleosome-positioning","display_name":"nucleosome positioning","score":0.718999981880188},{"id":"https://openalex.org/keywords/nucleosome-formation","display_name":"nucleosome formation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/trinucleotide-repeat-expansion","display_name":"trinucleotide repeat expansion","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hereditary-neurological-disorders","display_name":"hereditary neurological disorders","score":0.8690000176429749},{"id":"https://openalex.org/keywords/trinucleotide-repeat-disorders","display_name":"trinucleotide repeat disorders","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7354520559310913},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.6478906869888306},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6199418902397156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4704990088939667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20553404092788696}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D015825","descriptor_name":"Chromosomes, Fungal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019680","descriptor_name":"Trinucleotide Repeat Expansion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020271","descriptor_name":"Heredodegenerative Disorders, Nervous System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/nass/1.1.71","doi":"https://doi.org/10.1093/nass/1.1.71","is_oa":false,"landing_page_url":"https://doi.org/10.1093/nass/1.1.71","pdf_url":null,"source":{"id":"https://openalex.org/S193378857","display_name":"Nucleic Acids Symposium Series","issn_l":"0261-3166","issn":["0261-3166","1746-8272"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Symposium Series","raw_type":"journal-article"},{"id":"pmid:12836269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12836269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research. Supplement (2001)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":2,"referenced_works":["https://openalex.org/W1532858692","https://openalex.org/W2133306685"],"related_works":["https://openalex.org/W2109462298","https://openalex.org/W1999327905","https://openalex.org/W2169366310","https://openalex.org/W2067092315","https://openalex.org/W1984800943","https://openalex.org/W2057602838","https://openalex.org/W2012245463","https://openalex.org/W2060694389","https://openalex.org/W2061773171","https://openalex.org/W3157019717"],"abstract_inverted_index":{"Expansion":[0],"of":[1,21,33,45,68,101],"triplet":[2,34,46,78,93,105],"repeat":[3,35,47,79,94,106],"sequences":[4,48,80],"such":[5],"as":[6],"(CTG)n,":[7],"(CGG)n,":[8],"and":[9],"(GAA)n":[10],"causes":[11],"human":[12],"genetic":[13],"diseases.":[14,36,107],"Since":[15],"DNA":[16],"is":[17],"packaged":[18],"into":[19],"arrays":[20],"nucleosomes":[22],"in":[23,30,53,86,98],"eukaryotic":[24],"cells,":[25],"chromatin":[26,51,84],"may":[27,89],"be":[28],"involved":[29],"the":[31,50,74,83,92,99],"mechanism":[32],"To":[37],"elucidate":[38],"this":[39],"issue,":[40],"we":[41],"have":[42],"examined":[43],"effects":[44],"on":[49],"organization":[52,85],"vivo":[54],"using":[55],"well":[56],"defined":[57],"yeast":[58],"minichromosomes.":[59],"We":[60],"show":[61],"here":[62],"that":[63],"(CGG)12":[64],"disrupts":[65],"an":[66],"array":[67],"positioned":[69],"nucleosomes,":[70],"whereas":[71],"(CTG)12":[72],"promotes":[73],"nucleosome":[75],"formation.":[76],"Thus,":[77],"can":[81],"affect":[82],"vivo,":[87],"which":[88],"contribute":[90],"to":[91],"expansion":[95],"or":[96],"alterations":[97],"expression":[100],"genes":[102],"associated":[103],"with":[104]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}