{"id":"https://openalex.org/W2171604652","doi":null,"title":"The E-cadherin adhesion molecule and colorectal cancer. A global literature approach.","display_name":"The E-cadherin adhesion molecule and colorectal cancer. A global literature approach.","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W2171604652","mag":"2171604652","pmid":"https://pubmed.ncbi.nlm.nih.gov/19189669"},"language":"en","primary_location":{"id":"pmid:19189669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047198969","display_name":"Elena Tsanou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194019607","display_name":"University of Ioannina","ror":"https://ror.org/01qg3j183","country_code":"GR","type":"education","lineage":["https://openalex.org/I194019607"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Elena Tsanou","raw_affiliation_strings":["Department of Pathology-Cytology, Medical School, University of Ioannina, Ioannina, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology-Cytology, Medical School, University of Ioannina, Ioannina, Greece","institution_ids":["https://openalex.org/I194019607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051457159","display_name":"Dimitrios Peschos","orcid":"https://orcid.org/0000-0002-5490-0755","observed_orcids":["https://orcid.org/0000-0002-5490-0755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dimitrios Peschos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048212045","display_name":"Anna K. Batistatou","orcid":"https://orcid.org/0000-0003-4353-9535","observed_orcids":["https://orcid.org/0000-0003-4353-9535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Batistatou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047172680","display_name":"Alexandros Charalabopoulos","orcid":"https://orcid.org/0000-0003-1835-4723","observed_orcids":["https://orcid.org/0000-0003-1835-4723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandros Charalabopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Konstantinos Charalabopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos Charalabopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.24,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.885287,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"28","issue":"6A","first_page":"3815","last_page":"26"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.3752000033855438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.34940001368522644,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.121799997985363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":1.0},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cadherin-catenin-complex","display_name":"cadherin-catenin complex","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cell-cell-adhesion","display_name":"cell-cell adhesion","score":0.890999972820282},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7879999876022339},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.7509999871253967},{"id":"https://openalex.org/keywords/histopathology","display_name":"histopathology","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6480000019073486},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.8940068483352661},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7147049903869629},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.6953178644180298},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.6498203873634338},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5604657530784607},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5254983901977539},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49192261695861816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4611210525035858},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.46034932136535645},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4247579872608185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34514471888542175},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34489086270332336},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27650851011276245},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24262964725494385},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1987430453300476},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.16661196947097778},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.1532885730266571},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12232378125190735},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051177","descriptor_name":"Catenins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19189669","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2171604652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":138,"referenced_works":["https://openalex.org/W24886319","https://openalex.org/W54882976","https://openalex.org/W58216398","https://openalex.org/W172283171","https://openalex.org/W178567571","https://openalex.org/W287045091","https://openalex.org/W1495721247","https://openalex.org/W1516859873","https://openalex.org/W1521591962","https://openalex.org/W1533247917","https://openalex.org/W1542115364","https://openalex.org/W1544044591","https://openalex.org/W1568990669","https://openalex.org/W1579321336","https://openalex.org/W1714545534","https://openalex.org/W1768562956","https://openalex.org/W1772517037","https://openalex.org/W1776783519","https://openalex.org/W1784705092","https://openalex.org/W1809606297","https://openalex.org/W1814857925","https://openalex.org/W1859151740","https://openalex.org/W1886443720","https://openalex.org/W1890238716","https://openalex.org/W1948533188","https://openalex.org/W1967137553","https://openalex.org/W1967243795","https://openalex.org/W1967554899","https://openalex.org/W1969887412","https://openalex.org/W1972202913","https://openalex.org/W1978919869","https://openalex.org/W1979618971","https://openalex.org/W1979909585","https://openalex.org/W1981752846","https://openalex.org/W1986679152","https://openalex.org/W1987729382","https://openalex.org/W1993255107","https://openalex.org/W1995003807","https://openalex.org/W1995165918","https://openalex.org/W1995901225","https://openalex.org/W1998597774","https://openalex.org/W2001258296","https://openalex.org/W2001854921","https://openalex.org/W2002038847","https://openalex.org/W2002041258","https://openalex.org/W2007963495","https://openalex.org/W2013480667","https://openalex.org/W2013901453","https://openalex.org/W2015308138","https://openalex.org/W2018348035","https://openalex.org/W2023350337","https://openalex.org/W2023352836","https://openalex.org/W2026198003","https://openalex.org/W2027586189","https://openalex.org/W2029778945","https://openalex.org/W2030462937","https://openalex.org/W2035032903","https://openalex.org/W2035323213","https://openalex.org/W2038126788","https://openalex.org/W2039661491","https://openalex.org/W2041043194","https://openalex.org/W2043797012","https://openalex.org/W2046208473","https://openalex.org/W2048567930","https://openalex.org/W2050276508","https://openalex.org/W2054838338","https://openalex.org/W2055885966","https://openalex.org/W2056612955","https://openalex.org/W2063320748","https://openalex.org/W2063538848","https://openalex.org/W2066109395","https://openalex.org/W2067346711","https://openalex.org/W2067365317","https://openalex.org/W2069505491","https://openalex.org/W2069593816","https://openalex.org/W2070715920","https://openalex.org/W2072274650","https://openalex.org/W2072950423","https://openalex.org/W2073847287","https://openalex.org/W2076583198","https://openalex.org/W2078019820","https://openalex.org/W2081440063","https://openalex.org/W2081758458","https://openalex.org/W2082753119","https://openalex.org/W2083355888","https://openalex.org/W2084064523","https://openalex.org/W2084457841","https://openalex.org/W2089444743","https://openalex.org/W2089594118","https://openalex.org/W2100999743","https://openalex.org/W2102514614","https://openalex.org/W2103033566","https://openalex.org/W2107660783","https://openalex.org/W2107815302","https://openalex.org/W2107976817","https://openalex.org/W2108360007","https://openalex.org/W2112420045","https://openalex.org/W2113921159","https://openalex.org/W2114354954","https://openalex.org/W2116867733","https://openalex.org/W2118625918","https://openalex.org/W2122506460","https://openalex.org/W2122519439","https://openalex.org/W2127121861","https://openalex.org/W2127190652","https://openalex.org/W2127295970","https://openalex.org/W2129898301","https://openalex.org/W2130625675","https://openalex.org/W2134598096","https://openalex.org/W2134801497","https://openalex.org/W2136933812","https://openalex.org/W2141997040","https://openalex.org/W2142393231","https://openalex.org/W2142779171","https://openalex.org/W2146167376","https://openalex.org/W2146509619","https://openalex.org/W2148883613","https://openalex.org/W2149514754","https://openalex.org/W2150692393","https://openalex.org/W2151975451","https://openalex.org/W2152931507","https://openalex.org/W2160376723","https://openalex.org/W2164055070","https://openalex.org/W2168563018","https://openalex.org/W2194781989","https://openalex.org/W2331751054","https://openalex.org/W2394762651","https://openalex.org/W2397228914","https://openalex.org/W2397932901","https://openalex.org/W2408761200","https://openalex.org/W2409351973","https://openalex.org/W2416021253","https://openalex.org/W2417211168","https://openalex.org/W2417332906","https://openalex.org/W2418613570","https://openalex.org/W2465012603","https://openalex.org/W2610386814","https://openalex.org/W3143962991"],"related_works":["https://openalex.org/W2394762651","https://openalex.org/W2129860749","https://openalex.org/W2387486542","https://openalex.org/W1944818102","https://openalex.org/W2025248956","https://openalex.org/W1986281697","https://openalex.org/W7009220924","https://openalex.org/W2516887370","https://openalex.org/W4233301020","https://openalex.org/W2378745150"],"abstract_inverted_index":{"The":[0,63],"E-cadherin-catenin":[1],"complex":[2,51,57,88],"plays":[3],"a":[4,25],"crucial":[5],"role":[6,71,85],"in":[7,13,30,33,40,60,74,89,93,111],"epithelial":[8],"cell":[9,10],"adhesion":[11,56,144],"and":[12,52,82,121,146,149,162],"the":[14,42,45,70,83,87,94,100,135,141,154],"maintenance":[15],"of":[16,20,48,69,72,86,96,156,164],"tissue":[17],"architecture.":[18],"Down-regulation":[19],"E-cadherin":[21,73,112],"expression":[22,113],"correlates":[23],"with":[24,117],"strong":[26],"invasive":[27],"potential,":[28],"resulting":[29],"poor":[31],"prognosis":[32],"human":[34,75],"carcinomas.":[35],"Progress":[36],"has":[37],"been":[38,115],"made":[39],"understanding":[41],"interaction":[43,142],"between":[44,143],"different":[46],"components":[47],"this":[49,54],"protein":[50],"how":[53],"cell-cell":[55],"is":[58,66],"modulated":[59],"cancer":[61],"cells.":[62],"present":[64],"study":[65],"an":[67],"update":[68],"colorectal":[76,108],"cancer.":[77,165],"It":[78],"emphasizes":[79],"new":[80],"features":[81],"possible":[84],"clinical":[90],"practice,":[91],"discussed":[92],"light":[95],"references":[97],"obtained":[98],"from":[99,103],"Medline":[101],"database":[102],"1987":[104],"to":[105,140],"2007.":[106],"In":[107],"carcinomas,":[109],"changes":[110],"have":[114],"correlated":[116],"tumour":[118,147],"size,":[119],"histopathology":[120],"differentiation,":[122],"but":[123],"results":[124],"are":[125],"still":[126],"inconsistent.":[127],"Further":[128],"studies":[129],"may":[130],"yield":[131],"greater":[132],"insight":[133],"into":[134],"early":[136],"molecular":[137],"interactions":[138],"critical":[139],"molecules":[145],"initiation":[148],"progression.":[150],"This":[151],"should":[152],"aid":[153],"development":[155],"novel":[157],"strategies":[158],"for":[159],"both":[160],"prevention":[161],"treatment":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}