{"id":"https://openalex.org/W2171591972","doi":"https://doi.org/10.1093/genetics/164.3.1015","title":"A New Genetic Locus Controlling Growth and Proliferation in Drosophila melanogaster","display_name":"A New Genetic Locus Controlling Growth and Proliferation in Drosophila melanogaster","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2171591972","doi":"https://doi.org/10.1093/genetics/164.3.1015","mag":"2171591972","pmid":"https://pubmed.ncbi.nlm.nih.gov/12871911","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1462610"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/164.3.1015","doi":"https://doi.org/10.1093/genetics/164.3.1015","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/164.3.1015","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1462610/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044317772","display_name":"Sophie Raisin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Raisin","raw_affiliation_strings":["Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006515296","display_name":"Sophie Pantalacci","orcid":"https://orcid.org/0000-0002-0771-8985","observed_orcids":["https://orcid.org/0000-0002-0771-8985"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Pantalacci","raw_affiliation_strings":["Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110105344","display_name":"Jean\u2010Philippe Breittmayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118460","display_name":"H\u00f4pital l'Archet","ror":"https://ror.org/02fsxgh46","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018988418","https://openalex.org/I4210118460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Philippe Breittmayer","raw_affiliation_strings":["INSERM U343, H\u00f4pital de l\u2019Archet, BP79, 06202 Nice Cedex 3, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U343, H\u00f4pital de l\u2019Archet, BP79, 06202 Nice Cedex 3, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210118460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040300771","display_name":"Pierre L\u00e9opold","orcid":"https://orcid.org/0000-0002-2365-2103","observed_orcids":["https://orcid.org/0000-0002-2365-2103"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pierre L\u00e9opold","raw_affiliation_strings":["Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS, Parc Valrose, 06108 Nice Cedex 2, France","institution_ids":["https://openalex.org/I1294671590"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040300771"],"corresponding_institution_ids":["https://openalex.org/I1294671590"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":0.7542,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.63123896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"164","issue":"3","first_page":"1015","last_page":"1025"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.04610000178217888,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.8930000066757202},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8339999914169312},{"id":"https://openalex.org/keywords/clonal-analysis","display_name":"clonal analysis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/polyadenylated-transcripts","display_name":"polyadenylated transcripts","score":0.8640000224113464},{"id":"https://openalex.org/keywords/transcription-units","display_name":"transcription units","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.963029146194458},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6128634810447693},{"id":"https://openalex.org/C91986751","wikidata":"https://www.wikidata.org/wiki/Q996011","display_name":"Imaginal disc","level":4,"score":0.6003419160842896},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5550134181976318},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5467033982276917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5401725769042969},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5130623579025269},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5044771432876587},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5037147402763367},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.45486730337142944},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.43499821424484253},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.38950231671333313},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32962435483932495},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001837","descriptor_name":"Body Weights and Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D014921","descriptor_name":"Wings, Animal","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/genetics/164.3.1015","doi":"https://doi.org/10.1093/genetics/164.3.1015","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/164.3.1015","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmid:12871911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12871911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1462610","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1462610/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-00322347v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00322347","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Genetics, 2003, 164 (3), pp.1015-25","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1462610","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1462610/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1926929858","https://openalex.org/W1935419873","https://openalex.org/W1968883815","https://openalex.org/W1970139226","https://openalex.org/W1974037176","https://openalex.org/W1977545091","https://openalex.org/W1989461823","https://openalex.org/W1994528729","https://openalex.org/W2010379212","https://openalex.org/W2025693577","https://openalex.org/W2047151879","https://openalex.org/W2050771413","https://openalex.org/W2071344712","https://openalex.org/W2083850113","https://openalex.org/W2088355640","https://openalex.org/W2089950231","https://openalex.org/W2110643873","https://openalex.org/W2114990983","https://openalex.org/W2135596918","https://openalex.org/W2158714788"],"related_works":["https://openalex.org/W2146686126","https://openalex.org/W2122342534","https://openalex.org/W2156710834","https://openalex.org/W2080726567","https://openalex.org/W2964675522","https://openalex.org/W2041227849","https://openalex.org/W1990743145","https://openalex.org/W2011199473","https://openalex.org/W2160300536","https://openalex.org/W2169694008"],"abstract_inverted_index":{"Multicellular":[0],"organisms":[1],"grow":[2],"through":[3],"both":[4],"proliferation":[5,72],"and":[6,71],"growth":[7,26,70,102],"of":[8,32,80,96,124,153],"their":[9],"individual":[10],"cells.":[11],"We":[12,104],"have":[13],"conducted":[14],"a":[15,76,97,100,106,112,121,150],"P-element-based":[16],"misexpression":[17,46],"screen":[18],"for":[19],"genes":[20],"whose":[21],"upregulation":[22],"alters":[23],"wing":[24],"disc":[25],"during":[27],"development.":[28],"One":[29],"particular":[30,151],"group":[31],"four":[33],"P":[34,117],"elements,":[35],"all":[36],"inserted":[37],"at":[38,82],"cytological":[39],"location":[40],"61C7-8,":[41],"exhibited":[42],"specific":[43],"overgrowth":[44,143],"upon":[45,55],"in":[47,75,111,132],"proliferating":[48],"imaginal":[49],"tissues.":[50],"Clonal":[51],"analysis":[52],"revealed":[53],"that":[54,68,149,159],"misexpression,":[56,135],"cell":[57,62,69,90],"number":[58],"was":[59,64,137,156],"increased":[60],"but":[61],"size":[63],"not":[65],"affected,":[66],"indicating":[67],"were":[73,130],"induced":[74,131],"coordinate":[77],"manner.":[78],"Loss":[79],"function":[81],"the":[83,94,116],"locus":[84],"produced":[85],"small":[86],"flies":[87],"with":[88,93],"reduced":[89],"number,":[91],"consistent":[92],"presence":[95],"gene":[98],"encoding":[99],"positive":[101],"regulator.":[103],"characterized":[105],"new":[107],"transcription":[108],"unit":[109],"initiating":[110],"region":[113],"adjacent":[114],"to":[115,134,141],"insertions,":[118],"which":[119],"generated":[120],"complex":[122],"series":[123],"polyadenylated":[125],"transcripts.":[126],"Although":[127],"these":[128,154],"RNAs":[129],"response":[133],"none":[136],"sufficient":[138],"by":[139],"itself":[140],"recapitulate":[142],"when":[144],"overexpressed.":[145],"This":[146],"suggested":[147],"either":[148],"combination":[152],"transcripts":[155],"necessary":[157],"or":[158],"other":[160],"sequences":[161],"are":[162],"involved.":[163]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
