{"id":"https://openalex.org/W2171582091","doi":"https://doi.org/10.1136/bjo.71.4.250","title":"Levobunolol and metipranolol: comparative ocular hypotensive efficacy, safety, and comfort.","display_name":"Levobunolol and metipranolol: comparative ocular hypotensive efficacy, safety, and comfort.","publication_year":1987,"publication_date":"1987-04-01","ids":{"openalex":"https://openalex.org/W2171582091","doi":"https://doi.org/10.1136/bjo.71.4.250","mag":"2171582091","pmid":"https://pubmed.ncbi.nlm.nih.gov/2883990","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1041137"},"language":"en","primary_location":{"id":"doi:10.1136/bjo.71.4.250","doi":"https://doi.org/10.1136/bjo.71.4.250","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.71.4.250","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/71/4/250.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://bjo.bmj.com/content/bjophthalmol/71/4/250.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110135183","display_name":"Guenter K. Krieglstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"G K Krieglstein","raw_affiliation_strings":["2University of California, Irvine, USA,","3Allergan Pharmaceuticals, Irvine, California, USA, and 4Ophthalmologists, FR","Department of Ophthalmology, University of Wurzburg, F R G,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of California, Irvine, USA,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"3Allergan Pharmaceuticals, Irvine, California, USA, and 4Ophthalmologists, FR","institution_ids":[]},{"raw_affiliation_string":"Department of Ophthalmology, University of Wurzburg, F R G,","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086953802","display_name":"Gary D. Novack","orcid":"https://orcid.org/0000-0002-9699-8543","observed_orcids":["https://orcid.org/0000-0002-9699-8543"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"G D Novack","raw_affiliation_strings":["Allergan Pharma- ccuticals , 2525 Dupont Drive , Irvine , CA 92715 , USA","2University of California, Irvine, USA,","3Allergan Pharmaceuticals, Irvine, California, USA, and 4Ophthalmologists, FR","Department of Ophthalmology, University of Wurzburg, F R G,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergan Pharma- ccuticals , 2525 Dupont Drive , Irvine , CA 92715 , USA","institution_ids":[]},{"raw_affiliation_string":"2University of California, Irvine, USA,","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"3Allergan Pharmaceuticals, Irvine, California, USA, and 4Ophthalmologists, FR","institution_ids":[]},{"raw_affiliation_string":"Department of Ophthalmology, University of Wurzburg, F R G,","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043264050","display_name":"E Voepel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Voepel","raw_affiliation_strings":["3Allergan Pharmaceuticals , Irvine , California , USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Allergan Pharmaceuticals , Irvine , California , USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055016920","display_name":"G Schwarzbach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Schwarzbach","raw_affiliation_strings":["and 4Ophthalmologists , FR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and 4Ophthalmologists , FR","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090715212","display_name":"Uwe Lange","orcid":"https://orcid.org/0000-0001-7904-0619","observed_orcids":["https://orcid.org/0000-0001-7904-0619"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U Lange","raw_affiliation_strings":["3Allergan Pharmaceuticals , Irvine , California , USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Allergan Pharmaceuticals , Irvine , California , USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009379122","display_name":"K P Schunck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K P Schunck","raw_affiliation_strings":["3Allergan Pharmaceuticals , Irvine , California , USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Allergan Pharmaceuticals , Irvine , California , USA,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111408286","display_name":"John C. Lue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Lue","raw_affiliation_strings":["3Allergan Pharmaceuticals , Irvine , California , USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Allergan Pharmaceuticals , Irvine , California , USA,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026834939","display_name":"E P Glavinos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E P Glavinos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4879,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.89202658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"71","issue":"4","first_page":"250","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levobunolol","display_name":"levobunolol","score":1.0},{"id":"https://openalex.org/keywords/metipranolol","display_name":"metipranolol","score":1.0},{"id":"https://openalex.org/keywords/beta-blocker-eye-drops","display_name":"beta-blocker eye drops","score":0.609000027179718},{"id":"https://openalex.org/keywords/ocular-hypotensive-agents","display_name":"ocular hypotensive agents","score":0.9070000052452087},{"id":"https://openalex.org/keywords/open-angle-glaucoma","display_name":"open-angle glaucoma","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ocular-hypertension","display_name":"ocular hypertension","score":1.0},{"id":"https://openalex.org/keywords/intraocular-pressure-reduction","display_name":"intraocular pressure reduction","score":0.9570000171661377},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7099999785423279},{"id":"https://openalex.org/keywords/eye-irritation","display_name":"eye irritation","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9239407777786255},{"id":"https://openalex.org/C2781092963","wikidata":"https://www.wikidata.org/wiki/Q650050","display_name":"Intraocular pressure","level":2,"score":0.6496493816375732},{"id":"https://openalex.org/C2776521421","wikidata":"https://www.wikidata.org/wiki/Q9294051","display_name":"Ocular hypertension","level":3,"score":0.6486458778381348},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.530460000038147},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5201480984687805},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.447763055562973},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.4030326008796692},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20310398936271667}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002040","descriptor_name":"Levobunolol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002040","descriptor_name":"Levobunolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005902","descriptor_name":"Glaucoma, Open-Angle","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014290","descriptor_name":"Metipranolol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014290","descriptor_name":"Metipranolol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014290","descriptor_name":"Metipranolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/bjo.71.4.250","doi":"https://doi.org/10.1136/bjo.71.4.250","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.71.4.250","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/71/4/250.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1041137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1041137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Ophthalmol","raw_type":"Text"},{"id":"pmid:2883990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2883990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of ophthalmology","raw_type":"Clinical Trial"},{"id":"pmh:oai:open-archive.highwire.org:bjophthalmol:71/4/250","doi":null,"is_oa":false,"landing_page_url":"http://bjo.bmj.com/cgi/content/short/71/4/250","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/bjo.71.4.250","doi":"https://doi.org/10.1136/bjo.71.4.250","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bjo.71.4.250","pdf_url":"https://bjo.bmj.com/content/bjophthalmol/71/4/250.full.pdf","source":{"id":"https://openalex.org/S79587146","display_name":"British Journal of Ophthalmology","issn_l":"0007-1161","issn":["0007-1161","1468-2079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Ophthalmology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171582091.pdf","grobid_xml":"https://content.openalex.org/works/W2171582091.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1969180256","https://openalex.org/W1981276290","https://openalex.org/W1984425972","https://openalex.org/W1989314580","https://openalex.org/W2015103799","https://openalex.org/W2018340607","https://openalex.org/W2092846420","https://openalex.org/W2114645049","https://openalex.org/W2138443190","https://openalex.org/W2216360067","https://openalex.org/W2466593639"],"related_works":["https://openalex.org/W2407495786","https://openalex.org/W2078547092","https://openalex.org/W2060296451","https://openalex.org/W23599833","https://openalex.org/W1969180256","https://openalex.org/W2089512061","https://openalex.org/W1981276290","https://openalex.org/W2401930467","https://openalex.org/W2016106689","https://openalex.org/W2038544972"],"abstract_inverted_index":{"Topical":[0],"levobunolol":[1,104,111],"0.5%":[2,112],"was":[3,26,59],"compared":[4],"with":[5,17],"topical":[6],"metipranolol":[7,99,114],"0.6%":[8,115],"for":[9],"efficacy,":[10],"safety,":[11],"and":[12,32,86,93,113],"comfort":[13],"in":[14,48,55,63,71,83,97,102],"46":[15],"patients":[16,70],"open":[18],"angle":[19],"glaucoma":[20],"or":[21],"ocular":[22,120],"hypertension.":[23],"The":[24,51],"study":[25,42,109],"of":[27,33,69,91],"parallel":[28],"design,":[29],"randomised,":[30],"double-masked,":[31],"three":[34],"months'":[35],"duration.":[36],"After":[37],"a":[38],"washout":[39],"interval":[40],"the":[41,76,98,103],"medications":[43],"were":[44,95],"instilled":[45],"twice":[46],"daily":[47],"both":[49,64,72],"eyes.":[50],"overall":[52],"mean":[53],"decrease":[54],"intraocular":[56],"pressure":[57],"(IOP)":[58],"approximately":[60],"7":[61],"mmHg":[62],"groups.":[65],"More":[66,89],"than":[67,101],"90%":[68],"groups":[73],"successfully":[74],"completed":[75],"study.":[77],"Both":[78],"agents":[79],"caused":[80],"slight":[81],"decreases":[82],"heart":[84],"rate":[85],"blood":[87],"pressure.":[88],"complaints":[90],"burning":[92],"stinging":[94],"reported":[96],"group":[100],"group.":[105],"This":[106],"three-month,":[107],"46-patient":[108],"showed":[110],"to":[116],"be":[117],"similarly":[118],"effective":[119],"hypotensive":[121],"agents.":[122]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
