{"id":"https://openalex.org/W2171571981","doi":"https://doi.org/10.1128/jb.01683-06","title":"Genes Required for Glycolipid Synthesis and Lipoteichoic Acid Anchoring in Staphylococcus aureus","display_name":"Genes Required for Glycolipid Synthesis and Lipoteichoic Acid Anchoring in Staphylococcus aureus","publication_year":2007,"publication_date":"2007-01-06","ids":{"openalex":"https://openalex.org/W2171571981","doi":"https://doi.org/10.1128/jb.01683-06","mag":"2171571981","pmid":"https://pubmed.ncbi.nlm.nih.gov/17209021","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1899383"},"language":"en","primary_location":{"id":"doi:10.1128/jb.01683-06","doi":"https://doi.org/10.1128/jb.01683-06","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.01683-06","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2171571981"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1899383/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081883664","display_name":"Angelika Gr\u00fcndling","orcid":"https://orcid.org/0000-0002-6235-8687","observed_orcids":["https://orcid.org/0000-0002-6235-8687"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelika Gru\u0308ndling","raw_affiliation_strings":["Department of Microbiology, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083683183","display_name":"Olaf Schneewind","orcid":"https://orcid.org/0000-0001-9652-3823","observed_orcids":["https://orcid.org/0000-0001-9652-3823"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Olaf Schneewind","raw_affiliation_strings":["Department of Microbiology, University of Chicago, Chicago, Illinois 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Chicago, Chicago, Illinois 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5083683183"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":6.3539,"has_fulltext":false,"cited_by_count":203,"citation_normalized_percentile":{"value":0.96861522,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"189","issue":"6","first_page":"2521","last_page":"2530"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.20340000092983246,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.06019999831914902,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9710000157356262},{"id":"https://openalex.org/keywords/lipoteichoic-acid","display_name":"lipoteichoic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/glycolipid-biosynthesis","display_name":"glycolipid synthesis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/bacterial-pathogenesis","display_name":"bacterial pathogenesis","score":0.6690000295639038},{"id":"https://openalex.org/keywords/membrane-lipid-transport","display_name":"membrane lipid transport","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C6977687","wikidata":"https://www.wikidata.org/wiki/Q781350","display_name":"Lipoteichoic acid","level":4,"score":0.9630993604660034},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.8919979929924011},{"id":"https://openalex.org/C22222904","wikidata":"https://www.wikidata.org/wiki/Q422882","display_name":"Glycolipid","level":2,"score":0.8591465950012207},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7807171940803528},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6154650449752808},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.5968391299247742},{"id":"https://openalex.org/C2778253522","wikidata":"https://www.wikidata.org/wiki/Q899834","display_name":"Teichoic acid","level":4,"score":0.5726149678230286},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.4601363241672516},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.4483798146247864},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4274982511997223},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2722529470920563},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.24622949957847595},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2298130989074707},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19104143977165222},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.14189651608467102},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005694","descriptor_name":"UTP-Hexose-1-Phosphate Uridylyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005694","descriptor_name":"UTP-Hexose-1-Phosphate Uridylyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006017","descriptor_name":"Glycolipids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010733","descriptor_name":"Phosphoglucomutase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010733","descriptor_name":"Phosphoglucomutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D013682","descriptor_name":"Teichoic Acids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jb.01683-06","doi":"https://doi.org/10.1128/jb.01683-06","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.01683-06","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmid:17209021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17209021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1899383","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1899383/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1899383","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1899383/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6014488672","display_name":"Molecular Analyses and Interventions for Biodefense and Emerging Pathogens","funder_award_id":"U54AI057153","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8311035521","display_name":"Surface Proteins of Gram-Positive Bacteria","funder_award_id":"R01AI038897","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000873716","display_name":"Vaccine Assembly from Surface Proteins of Staphylococcus aureus","funder_award_id":"R01AI052474","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W83266996","https://openalex.org/W636776315","https://openalex.org/W1482337168","https://openalex.org/W1497351261","https://openalex.org/W1528735038","https://openalex.org/W1593627202","https://openalex.org/W1642494572","https://openalex.org/W1645044045","https://openalex.org/W1673442010","https://openalex.org/W1776202177","https://openalex.org/W1874562853","https://openalex.org/W1965148084","https://openalex.org/W1977952110","https://openalex.org/W1982642629","https://openalex.org/W1984936173","https://openalex.org/W1986506035","https://openalex.org/W1998504259","https://openalex.org/W2001277616","https://openalex.org/W2004093060","https://openalex.org/W2004675313","https://openalex.org/W2026220836","https://openalex.org/W2039087549","https://openalex.org/W2040226264","https://openalex.org/W2046708334","https://openalex.org/W2053514497","https://openalex.org/W2054315960","https://openalex.org/W2068010121","https://openalex.org/W2079237776","https://openalex.org/W2084351593","https://openalex.org/W2092912158","https://openalex.org/W2096945678","https://openalex.org/W2100673984","https://openalex.org/W2102454428","https://openalex.org/W2119678266","https://openalex.org/W2127690345","https://openalex.org/W2129101133","https://openalex.org/W2130381741","https://openalex.org/W2130534359","https://openalex.org/W2132284354","https://openalex.org/W2136280642","https://openalex.org/W2138369408","https://openalex.org/W2138638997","https://openalex.org/W2141676495","https://openalex.org/W2149878746","https://openalex.org/W2165217923","https://openalex.org/W2165292606","https://openalex.org/W2168452238","https://openalex.org/W2410606726"],"related_works":["https://openalex.org/W2100673984","https://openalex.org/W3199270674","https://openalex.org/W7163063366","https://openalex.org/W2155147216","https://openalex.org/W2005518049","https://openalex.org/W2053514497","https://openalex.org/W2795762451","https://openalex.org/W3130291499","https://openalex.org/W2527869240","https://openalex.org/W2007750617"],"abstract_inverted_index":{"Staphylococcus":[0],"aureus":[1,55,156],"lipoteichoic":[2],"acid":[3,73],"(LTA)":[4],"is":[5,14,26,83,90,97],"composed":[6],"of":[7,69,101,115,126,144,165],"a":[8,21,34,76,107,133],"linear":[9],"1,3-linked":[10],"polyglycerolphosphate":[11],"chain":[12],"and":[13,58],"tethered":[15],"to":[16,40,122,147],"the":[17,29,53,67,113,118,123,127,163],"bacterial":[18,30],"membrane":[19,78],"by":[20,32],"glycolipid":[22],"(diglucosyl-diacylglycerol":[23],"[Glc2-DAG]).":[24],"Glc2-DAG":[25,94,116,131],"synthesized":[27],"in":[28,85,93,109,162],"cytoplasm":[31],"YpfP,":[33],"processive":[35],"enzyme":[36],"that":[37,52],"transfers":[38],"glucose":[39],"diacylglycerol":[41],"(DAG),":[42],"using":[43],"UDP-glucose":[44],"as":[45,132,154],"its":[46],"substrate.":[47],"Here":[48],"we":[49],"present":[50],"evidence":[51],"S.":[54,155],"alpha-phosphoglucomutase":[56],"(PgcA)":[57],"UTP:alpha-glucose":[59],"1-phosphate":[60],"uridyltransferase":[61],"(GtaB)":[62],"homologs":[63],"are":[64],"required":[65,98],"for":[66,99,135],"synthesis":[68,95,100],"Glc2-DAG.":[70],"LtaA":[71,111],"(lipoteichoic":[72],"protein":[74],"A),":[75],"predicted":[77],"permease":[79],"whose":[80],"structural":[81],"gene":[82],"located":[84],"an":[86,149],"operon":[87],"with":[88],"ypfP,":[89],"not":[91],"involved":[92],"but":[96],"glycolipid-anchored":[102,140],"LTA.":[103,141],"Our":[104],"data":[105],"suggest":[106],"model":[108],"which":[110],"facilitates":[112],"transport":[114],"from":[117],"inner":[119],"(cytoplasmic)":[120],"leaflet":[121,125],"outer":[124],"plasma":[128],"membrane,":[129],"delivering":[130],"substrate":[134],"LTA":[136,145],"synthesis,":[137],"thereby":[138],"generating":[139],"Glycolipid":[142],"anchoring":[143],"appears":[146],"play":[148],"important":[150],"role":[151],"during":[152],"infection,":[153],"variants":[157],"lacking":[158],"ltaA":[159],"display":[160],"defects":[161],"pathogenesis":[164],"animal":[166],"infections.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
