{"id":"https://openalex.org/W2171490360","doi":"https://doi.org/10.1369/jhc.4a6356.2004","title":"Intracellular Hyaluronan in Arterial Smooth Muscle Cells: Association with Microtubules, RHAMM, and the Mitotic Spindle","display_name":"Intracellular Hyaluronan in Arterial Smooth Muscle Cells: Association with Microtubules, RHAMM, and the Mitotic Spindle","publication_year":2004,"publication_date":"2004-11-19","ids":{"openalex":"https://openalex.org/W2171490360","doi":"https://doi.org/10.1369/jhc.4a6356.2004","mag":"2171490360","pmid":"https://pubmed.ncbi.nlm.nih.gov/15557208"},"language":"en","primary_location":{"id":"doi:10.1369/jhc.4a6356.2004","doi":"https://doi.org/10.1369/jhc.4a6356.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1369/jhc.4a6356.2004","pdf_url":null,"source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry &amp; Cytochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088219196","display_name":"Stephen P. Evanko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen P. Evanko","raw_affiliation_strings":["Hope Heart Program-Benaroya Research Institute at Virginia Mason, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hope Heart Program-Benaroya Research Institute at Virginia Mason, Seattle, Washington","institution_ids":["https://openalex.org/I4391012615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103414420","display_name":"William Tony Parks","orcid":"https://orcid.org/0000-0001-7341-3277","observed_orcids":["https://orcid.org/0000-0001-7341-3277"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Tony Parks","raw_affiliation_strings":["Department of Pathology, The University of Washington, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The University of Washington, Seattle, Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035268339","display_name":"Thomas N. Wight","orcid":"https://orcid.org/0000-0002-2794-4197","observed_orcids":["https://orcid.org/0000-0002-2794-4197"]},"institutions":[{"id":"https://openalex.org/I4391012615","display_name":"Benaroya Research Institute","ror":"https://ror.org/04j9rp686","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802797007","https://openalex.org/I4210118434","https://openalex.org/I4391012615"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas N. Wight","raw_affiliation_strings":["Hope Heart Program-Benaroya Research Institute at Virginia Mason, Seattle, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hope Heart Program-Benaroya Research Institute at Virginia Mason, Seattle, Washington","institution_ids":["https://openalex.org/I4391012615"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088219196"],"corresponding_institution_ids":["https://openalex.org/I4391012615"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.8962,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.68258924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"52","issue":"12","first_page":"1525","last_page":"1535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arterial-smooth-muscle-cells","display_name":"arterial smooth muscle cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rhamm","display_name":"RHAMM","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitotic-spindle","display_name":"mitotic spindle","score":0.968999981880188},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.7319999933242798},{"id":"https://openalex.org/keywords/mitosis","display_name":"mitosis","score":0.5630000233650208},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.6340000033378601},{"id":"https://openalex.org/keywords/nucleolus","display_name":"nucleolus","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cleavage-furrow","display_name":"cleavage furrow","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.5419999957084656},{"id":"https://openalex.org/keywords/hyaluronan-metabolism","display_name":"hyaluronan metabolism","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8265478014945984},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.6820964217185974},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5356656312942505},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.535365104675293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5240307450294495},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.45774075388908386},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.42909619212150574},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.427871972322464},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28067415952682495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11782604455947876}],"mesh":[{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1369/jhc.4a6356.2004","doi":"https://doi.org/10.1369/jhc.4a6356.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1369/jhc.4a6356.2004","pdf_url":null,"source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry &amp; Cytochemistry","raw_type":"journal-article"},{"id":"pmid:15557208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15557208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7543209011","display_name":"BIOLOGY OF THE ARTERY WALL AND ATHEROSCLEROSIS","funder_award_id":"P01HL018645","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306740","display_name":"Israel Cancer Research Fund","ror":"https://ror.org/02h43gk75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W91710746","https://openalex.org/W1510982074","https://openalex.org/W1567493631","https://openalex.org/W1603789301","https://openalex.org/W1991189072","https://openalex.org/W1998413444","https://openalex.org/W1998531407","https://openalex.org/W2008835126","https://openalex.org/W2013472084","https://openalex.org/W2024910769","https://openalex.org/W2029947874","https://openalex.org/W2036391446","https://openalex.org/W2037012329","https://openalex.org/W2047516844","https://openalex.org/W2049093631","https://openalex.org/W2052888097","https://openalex.org/W2060932633","https://openalex.org/W2062413975","https://openalex.org/W2082006413","https://openalex.org/W2085881800","https://openalex.org/W2090815473","https://openalex.org/W2097940464","https://openalex.org/W2104512411","https://openalex.org/W2118121278","https://openalex.org/W2123283925","https://openalex.org/W2130725713","https://openalex.org/W2134995897","https://openalex.org/W2140526338","https://openalex.org/W2142796088","https://openalex.org/W2154228555","https://openalex.org/W2163344769","https://openalex.org/W2164021363","https://openalex.org/W2207546997","https://openalex.org/W2417808907"],"related_works":["https://openalex.org/W4384493356","https://openalex.org/W2154228555","https://openalex.org/W44745428","https://openalex.org/W2104512411","https://openalex.org/W2953489573","https://openalex.org/W6943983922","https://openalex.org/W2090815473","https://openalex.org/W400776594","https://openalex.org/W2009171728","https://openalex.org/W169830922"],"abstract_inverted_index":{"Although":[0],"considered":[1],"a":[2,72,154],"pericellular":[3],"matrix":[4],"component,":[5],"hyaluronan":[6,22,65,98,145,183,209],"was":[7,23,109,117,130,172,192],"recently":[8],"localized":[9],"in":[10,25,86,91,111,119,210],"the":[11,29,47,78,112,125,134,142,151,176,185,189],"cytoplasm":[12],"and":[13,34,45,55,84,116,124,149,158,165],"nucleus":[14],"of":[15,80,96,182],"proliferating":[16],"cells,":[17,197],"supporting":[18],"earlier":[19],"reports":[20],"that":[21,38,161],"present":[24,118],"locations":[26],"such":[27],"as":[28],"nucleus,":[30],"rough":[31],"endoplasmic":[32],"reticulum,":[33],"caveolae.":[35],"This":[36],"suggests":[37],"it":[39,59],"can":[40],"play":[41],"roles":[42],"both":[43],"inside":[44],"outside":[46],"cell.":[48],"Hyaluronan":[49,108],"metabolism":[50],"is":[51,60],"coupled":[52],"to":[53,133,200],"mitosis":[54],"cell":[56,155],"motility,":[57],"but":[58],"not":[61],"clear":[62],"if":[63],"intracellular":[64,81,97],"associates":[66],"with":[67,138,147,150,163],"cytoskeletal":[68],"elements":[69],"or":[70],"plays":[71],"structural":[73],"role.":[74],"Here":[75],"we":[76],"report":[77],"distribution":[79,95],"hyaluronan,":[82],"microtubules,":[83],"RHAMM":[85],"arterial":[87],"smooth":[88],"muscle":[89],"cells":[90],"vitro.":[92],"The":[93],"general":[94],"more":[99],"closely":[100],"resembled":[101],"microtubule":[102],"staining":[103],"rather":[104],"than":[105],"actin":[106],"filaments.":[107],"abundant":[110],"perinuclear":[113,135],"microtubule-rich":[114],"areas":[115],"lysosomes,":[120],"other":[121],"vesicular":[122],"structures,":[123],"nucleolus.":[126],"Partially":[127],"fragmented":[128],"fluorescein-hyaluronan":[129,171,198],"preferentially":[131],"translocated":[132],"area":[136],"compared":[137],"high-molecular-weight":[139],"hyaluronan.":[140],"In":[141,195],"mitotic":[143],"spindle,":[144],"colocalized":[146],"tubulin":[148],"hyaladherin":[152],"RHAMM,":[153],"surface":[156],"receptor":[157],"microtubule-associated":[159],"protein":[160],"interacts":[162],"dynein":[164],"maintains":[166],"spindle":[167],"pole":[168],"stability.":[169],"Internalized":[170],"also":[173,193],"seen":[174],"at":[175,188],"spindle.":[177],"Following":[178],"telophase,":[179],"an":[180],"abundance":[181],"near":[184],"midbody":[186],"microtubules":[187],"cleavage":[190],"furrow":[191],"noted.":[194],"permeabilized":[196],"bound":[199],"RHAMM-associated":[201],"microtubules.":[202],"These":[203],"findings":[204],"suggest":[205],"novel":[206],"functions":[207],"for":[208],"cellular":[211],"physiology.":[212]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
