{"id":"https://openalex.org/W2171451622","doi":"https://doi.org/10.1186/1471-2172-14-53","title":"Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice","display_name":"Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2171451622","doi":"https://doi.org/10.1186/1471-2172-14-53","mag":"2171451622","pmid":"https://pubmed.ncbi.nlm.nih.gov/24313934","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924189"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2172-14-53","doi":"https://doi.org/10.1186/1471-2172-14-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-14-53","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-14-53","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-14-53","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100424026","display_name":"Jinhee Lee","orcid":"https://orcid.org/0000-0003-4255-1831","observed_orcids":["https://orcid.org/0000-0003-4255-1831"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jinhee Lee","raw_affiliation_strings":["Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. jinhee.lee@umassmed.edu","Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. jinhee.lee@umassmed.edu","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023032912","display_name":"Michael A. Brehm","orcid":"https://orcid.org/0000-0001-6813-3262","observed_orcids":["https://orcid.org/0000-0001-6813-3262"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A Brehm","raw_affiliation_strings":["Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022634163","display_name":"Dale L. Greiner","orcid":"https://orcid.org/0000-0002-5923-339X","observed_orcids":["https://orcid.org/0000-0002-5923-339X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale Greiner","raw_affiliation_strings":["Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394378","display_name":"Leonard D. Shultz","orcid":"https://orcid.org/0000-0002-4868-1031","observed_orcids":["https://orcid.org/0000-0002-4868-1031"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard D Shultz","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, USA","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030705731","display_name":"Hardy Kornfeld","orcid":"https://orcid.org/0000-0002-8970-7306","observed_orcids":["https://orcid.org/0000-0002-8970-7306"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hardy Kornfeld","raw_affiliation_strings":["Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100424026"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":2.4983,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.89309137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"53","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mycobacterium-bovis-bcg","display_name":"Mycobacterium bovis BCG","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/hla-a2","display_name":"HLA-A2","score":0.7170000076293945},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7559999823570251},{"id":"https://openalex.org/keywords/t-cell-response","display_name":"T cell response","score":0.75},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.6349999904632568},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/lung-granulomas","display_name":"lung granulomas","score":0.6209999918937683},{"id":"https://openalex.org/keywords/human-macrophages","display_name":"human macrophages","score":0.6439999938011169},{"id":"https://openalex.org/keywords/mouse-model-of-tuberculosis","display_name":"mouse model of tuberculosis","score":0.43700000643730164},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7355043888092041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6570574045181274},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.648302435874939},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.605857789516449},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4895413815975189},{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.4689074754714966},{"id":"https://openalex.org/C55851684","wikidata":"https://www.wikidata.org/wiki/Q518390","display_name":"Nod","level":3,"score":0.42285022139549255},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3535740077495575},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.11005717515945435},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009163","descriptor_name":"Mycobacterium bovis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009163","descriptor_name":"Mycobacterium bovis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014376","descriptor_name":"Tuberculosis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053631","descriptor_name":"Interleukin Receptor Common gamma Subunit","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D053631","descriptor_name":"Interleukin Receptor Common gamma Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2172-14-53","doi":"https://doi.org/10.1186/1471-2172-14-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-14-53","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-14-53","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2908189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924189","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3924189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3924189","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunol","raw_type":"Text"},{"id":"pmid:24313934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24313934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC immunology","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:stfb2013-1197","doi":null,"is_oa":true,"landing_page_url":"http://dx.doi.org/10.1186/1471-2172-14-53","pdf_url":"https://link.springer.com/content/pdf/10.1186/1471-2172-14-53.pdf","source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2013","raw_type":"text"},{"id":"pmh:oai:escholarship.umassmed.edu:faculty_pubs-1322","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/faculty_pubs/323","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Massachusetts Medical School Faculty Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1186/1471-2172-14-53","doi":"https://doi.org/10.1186/1471-2172-14-53","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2172-14-53","pdf_url":"https://bmcimmunol.biomedcentral.com/counter/pdf/10.1186/1471-2172-14-53","source":{"id":"https://openalex.org/S127311448","display_name":"BMC Immunology","issn_l":"1471-2172","issn":["1471-2172"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6543545613","display_name":"Viral Infection Influence on Transplantation Tolerance","funder_award_id":"P01AI046629","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6913914756","display_name":"Impact of Diabetes and Hyperlipidemia on Host Defense","funder_award_id":"R01HL081149","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171451622.pdf","grobid_xml":"https://content.openalex.org/works/W2171451622.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1661544713","https://openalex.org/W1973225312","https://openalex.org/W1974847449","https://openalex.org/W1976165637","https://openalex.org/W1984295407","https://openalex.org/W1985585926","https://openalex.org/W1986226400","https://openalex.org/W1992384164","https://openalex.org/W1999253174","https://openalex.org/W2004694654","https://openalex.org/W2012451546","https://openalex.org/W2013659792","https://openalex.org/W2021586066","https://openalex.org/W2022159086","https://openalex.org/W2027657858","https://openalex.org/W2030697288","https://openalex.org/W2031603575","https://openalex.org/W2032410318","https://openalex.org/W2035256770","https://openalex.org/W2038535814","https://openalex.org/W2041515126","https://openalex.org/W2043816723","https://openalex.org/W2044502594","https://openalex.org/W2054957138","https://openalex.org/W2058042162","https://openalex.org/W2086757300","https://openalex.org/W2091188952","https://openalex.org/W2100531445","https://openalex.org/W2101392460","https://openalex.org/W2104941073","https://openalex.org/W2107168469","https://openalex.org/W2108811173","https://openalex.org/W2109484445","https://openalex.org/W2116654815","https://openalex.org/W2118841838","https://openalex.org/W2124580054","https://openalex.org/W2130191021","https://openalex.org/W2137633461","https://openalex.org/W2145254159","https://openalex.org/W2146051699","https://openalex.org/W2146193668","https://openalex.org/W2153612828","https://openalex.org/W2156729761","https://openalex.org/W2162660367","https://openalex.org/W2165536326","https://openalex.org/W2172093416","https://openalex.org/W2343429234"],"related_works":["https://openalex.org/W3099650195","https://openalex.org/W2091188952","https://openalex.org/W2612874011","https://openalex.org/W7115905506","https://openalex.org/W1564179573","https://openalex.org/W1575709646","https://openalex.org/W4391315239","https://openalex.org/W2153612828","https://openalex.org/W3127333155","https://openalex.org/W7160097792"],"abstract_inverted_index":{"BACKGROUND:":[0],"Currently":[1],"used":[2],"mouse":[3,248],"models":[4],"fail":[5],"to":[6,11,46,50,67,77,84,155,223,243,257,274],"fully":[7],"reflect":[8],"human":[9,29,48,62,74,93,109,180,184,198,202,254],"immunity":[10,49],"tuberculosis":[12,259],"(TB),":[13],"which":[14],"hampers":[15],"progress":[16],"in":[17,37,205,218,260],"research":[18],"and":[19,33,71,103,182,213,236,265],"vaccine":[20],"development.":[21],"Bone":[22],"marrow-liver-thymus":[23],"(BLT)":[24],"mice,":[25,42],"generated":[26],"by":[27,126,142,148,160],"engrafting":[28],"fetal":[30,55],"liver,":[31],"thymus,":[32],"hematopoietic":[34],"stem":[35],"cells":[36,111,123,204,241],"severely":[38],"immunodeficient":[39],"NOD/SCID/IL-2R\u03b3(-/-)":[40],"(NSG)":[41],"have":[43],"shown":[44],"potential":[45],"model":[47,90,280],"infection.":[51,225],"We":[52],"engrafted":[53,108],"HLA-A2-positive":[54],"tissues":[56],"into":[57],"NSG":[58],"mice":[59,70,97,152,173,207],"transgenically":[60],"expressing":[61],"leukocyte":[63],"antigen":[64],"(HLA)-A2.1":[65],"(NSG-A2)":[66],"generate":[68],"NSG-A2-BLT":[69,96,133,151,172,206,247],"characterized":[72],"their":[73],"immune":[75,105,110,203,215,255],"response":[76,106,256,270],"Mycobacterium":[78],"bovis":[79],"bacillus":[80],"Calmette-Guerin":[81],"(BCG)":[82],"infection":[83,157],"assess":[85],"the":[86,104,136,166,244,276],"utility":[87,277],"of":[88,107,119,138,179,197,211,228,239,251,278],"this":[89,279],"for":[91,281],"investigating":[92],"TB.":[94,199],"RESULTS:":[95],"were":[98,124,144,153],"infected":[99],"intravenously":[100],"with":[101,232],"BCG":[102,156],"was":[112,230],"characterized.":[113],"After":[114],"ex":[115],"vivo":[116,261],"antigenic":[117,149],"stimulation":[118],"splenocytes,":[120],"interferon":[121],"(IFN)-\u03b3-producing":[122],"detected":[125],"ELISPOT":[127],"from":[128],"infected,":[129],"but":[130,262],"not":[131,145,193],"uninfected":[132],"mice.":[134,170],"However,":[135],"levels":[137,235],"secreted":[139],"IFN-\u03b3,":[140],"determined":[141,159],"ELISA,":[143],"significantly":[146],"elevated":[147],"stimulation.":[150],"susceptible":[154],"as":[158],"higher":[161],"lung":[162,175],"bacillary":[163],"load":[164],"than":[165],"non-engrafted":[167],"control":[168],"NSG-A2":[169],"BCG-infected":[171],"developed":[174],"lesions":[176,191],"composed":[177],"mostly":[178],"macrophages":[181],"few":[183],"CD4+":[185],"or":[186],"CD8+":[187],"T":[188,220,240],"cells.":[189],"The":[190,226,246],"did":[192],"resemble":[194],"granulomas":[195],"typical":[196],"CONCLUSIONS:":[200],"Engrafted":[201],"showed":[208],"partial":[209],"function":[210],"innate":[212],"adaptive":[214],"systems":[216],"culminating":[217],"antigen-specific":[219],"cell":[221],"responses":[222],"mycobacterial":[224],"lack":[227],"protection":[229],"associated":[231],"low":[233],"IFN-\u03b3":[234],"limited":[237],"numbers":[238],"recruited":[242],"lesions.":[245],"is":[249],"capable":[250],"mounting":[252],"a":[253,263],"M.":[258],"quantitatively":[264],"possibly":[266],"qualitatively":[267],"enhanced":[268],"effector":[269],"will":[271],"be":[272],"needed":[273],"improve":[275],"TB":[282],"research.":[283]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}