{"id":"https://openalex.org/W2171378243","doi":"https://doi.org/10.1542/peds.2013-1021d","title":"Home Visiting and the Biology of Toxic Stress: Opportunities to Address Early Childhood Adversity","display_name":"Home Visiting and the Biology of Toxic Stress: Opportunities to Address Early Childhood Adversity","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2171378243","doi":"https://doi.org/10.1542/peds.2013-1021d","mag":"2171378243","pmid":"https://pubmed.ncbi.nlm.nih.gov/24187125"},"language":"en","primary_location":{"id":"doi:10.1542/peds.2013-1021d","doi":"https://doi.org/10.1542/peds.2013-1021d","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2013-1021d","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112038353","display_name":"Andrew S. Garner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew S. Garner","raw_affiliation_strings":["University Hospitals Medical Practices, and Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospitals Medical Practices, and Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112038353"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":1.3148,"has_fulltext":false,"cited_by_count":164,"citation_normalized_percentile":{"value":0.76012146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"132","issue":"Supplement_2","first_page":"S65","last_page":"S73"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10182","display_name":"Child and Adolescent Psychosocial and Emotional Development","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/home-visiting","display_name":"home visiting","score":0.9480000138282776},{"id":"https://openalex.org/keywords/toxic-stress","display_name":"toxic stress","score":0.9850000143051147},{"id":"https://openalex.org/keywords/early-childhood-adversity","display_name":"early childhood adversity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.8399999737739563},{"id":"https://openalex.org/keywords/stress-physiology","display_name":"stress physiology","score":0.699999988079071},{"id":"https://openalex.org/keywords/developmental-origins-of-health-and-disease","display_name":"developmental origins of health and disease","score":0.7319999933242798},{"id":"https://openalex.org/keywords/non-communicable-diseases","display_name":"non-communicable diseases","score":0.7549999952316284},{"id":"https://openalex.org/keywords/caregiver-capacity","display_name":"caregiver capacity","score":0.5139999985694885},{"id":"https://openalex.org/keywords/social-emotional-development","display_name":"social-emotional development","score":0.8029999732971191},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.7820000052452087},{"id":"https://openalex.org/keywords/public-health-partnerships","display_name":"public health partnerships","score":0.7229999899864197},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.3880000114440918}],"concepts":[{"id":"https://openalex.org/C157541749","wikidata":"https://www.wikidata.org/wiki/Q3612637","display_name":"Allostasis","level":2,"score":0.7474049925804138},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5811870098114014},{"id":"https://openalex.org/C187150481","wikidata":"https://www.wikidata.org/wiki/Q4733156","display_name":"Allostatic load","level":2,"score":0.5460420250892639},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.5145887136459351},{"id":"https://openalex.org/C2777082460","wikidata":"https://www.wikidata.org/wiki/Q3377398","display_name":"Early childhood","level":2,"score":0.4858217239379883},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.4536641240119934},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.44570624828338623},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.33098268508911133},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3264291286468506},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2725028395652771},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000223","descriptor_name":"Adaptation, Psychological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002657","descriptor_name":"Child Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002669","descriptor_name":"Child Welfare","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006792","descriptor_name":"House Calls","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1542/peds.2013-1021d","doi":"https://doi.org/10.1542/peds.2013-1021d","is_oa":false,"landing_page_url":"https://doi.org/10.1542/peds.2013-1021d","pdf_url":null,"source":{"id":"https://openalex.org/S77494981","display_name":"PEDIATRICS","issn_l":"0031-4005","issn":["0031-4005","1098-4275"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315734","host_organization_name":"American Academy of Pediatrics","host_organization_lineage":["https://openalex.org/P4310315734"],"host_organization_lineage_names":["American Academy of Pediatrics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"journal-article"},{"id":"pmid:24187125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24187125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatrics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1602251555","https://openalex.org/W1686749590","https://openalex.org/W1731306270","https://openalex.org/W1890675559","https://openalex.org/W1965107178","https://openalex.org/W1965999423","https://openalex.org/W1968718808","https://openalex.org/W1969308307","https://openalex.org/W1969412681","https://openalex.org/W1970780234","https://openalex.org/W1975678969","https://openalex.org/W1982041899","https://openalex.org/W1986444542","https://openalex.org/W1988047357","https://openalex.org/W1996624610","https://openalex.org/W1996838710","https://openalex.org/W2003627321","https://openalex.org/W2004648920","https://openalex.org/W2006505737","https://openalex.org/W2011000693","https://openalex.org/W2018570780","https://openalex.org/W2018647656","https://openalex.org/W2023393179","https://openalex.org/W2024994042","https://openalex.org/W2033929686","https://openalex.org/W2045448404","https://openalex.org/W2046265580","https://openalex.org/W2046314278","https://openalex.org/W2050896885","https://openalex.org/W2056105279","https://openalex.org/W2067455620","https://openalex.org/W2070684401","https://openalex.org/W2071580102","https://openalex.org/W2072248889","https://openalex.org/W2073537354","https://openalex.org/W2075745469","https://openalex.org/W2077878361","https://openalex.org/W2089418395","https://openalex.org/W2091143533","https://openalex.org/W2093712290","https://openalex.org/W2096799018","https://openalex.org/W2104818125","https://openalex.org/W2106884640","https://openalex.org/W2116769635","https://openalex.org/W2116839388","https://openalex.org/W2120295167","https://openalex.org/W2123697255","https://openalex.org/W2124451138","https://openalex.org/W2126492264","https://openalex.org/W2128782957","https://openalex.org/W2135943618","https://openalex.org/W2136687084","https://openalex.org/W2138884119","https://openalex.org/W2139564895","https://openalex.org/W2140199620","https://openalex.org/W2148337554","https://openalex.org/W2151041365","https://openalex.org/W2158352058","https://openalex.org/W2159223986","https://openalex.org/W2160108952","https://openalex.org/W2162783540","https://openalex.org/W2163188298","https://openalex.org/W2165546874","https://openalex.org/W2166152454","https://openalex.org/W2166372248","https://openalex.org/W2168924585","https://openalex.org/W2310561001","https://openalex.org/W3023024409","https://openalex.org/W3023070006","https://openalex.org/W4254613362"],"related_works":["https://openalex.org/W2023393179","https://openalex.org/W2104818125","https://openalex.org/W2031964472","https://openalex.org/W2138884119","https://openalex.org/W6999323359","https://openalex.org/W2507183583","https://openalex.org/W2990789327","https://openalex.org/W4414642878","https://openalex.org/W1975731627","https://openalex.org/W3208173536"],"abstract_inverted_index":{"Home":[0],"visiting":[1,244],"is":[2],"an":[3],"important":[4],"mechanism":[5],"for":[6,159],"minimizing":[7],"the":[8,23,36,42,91,120,128,141,150,168,177,186,198,235],"lifelong":[9,154],"effects":[10,169],"of":[11,25,38,59,75,86,131,137,143,153,170,179,230],"early":[12,26,49,160,238,240],"childhood":[13,50,171],"adversity.":[14],"To":[15],"do":[16],"so,":[17],"it":[18],"must":[19],"be":[20],"informed":[21],"by":[22],"biology":[24,136],"brain":[27],"and":[28,35,52,67,69,106,117,123,133,140,156,162,181,189,196,204,218,232,242],"child":[29],"development.":[30],"Advances":[31],"in":[32,119],"neuroscience,":[33],"epigenetics,":[34],"physiology":[37],"stress":[39,61,92,110,139],"are":[40,127],"revealing":[41],"biological":[43],"mechanisms":[44],"underlying":[45],"well-established":[46],"associations":[47],"between":[48,234],"adversity":[51,172],"suboptimal":[53],"life-course":[54],"trajectories.":[55],"Left":[56],"unchecked,":[57],"mediators":[58],"physiologic":[60],"become":[62,115],"toxic,":[63],"alter":[64],"both":[65],"genome":[66],"brain,":[68],"lead":[70],"to":[71,89,166,183,208],"a":[72,83,94,223],"vicious":[73],"cycle":[74],"chronic":[76],"stress.":[77],"This":[78],"so-called":[79],"\"toxic":[80],"stress\"":[81],"results":[82],"wide":[84],"array":[85],"behavioral":[87,144],"attempts":[88],"blunt":[90],"response,":[93],"process":[95],"known":[96],"as":[97],"\"behavioral":[98],"allostasis.\"":[99],"Although":[100],"behaviors":[101],"like":[102],"smoking,":[103],"overeating,":[104],"promiscuity,":[105],"substance":[107],"abuse":[108],"decrease":[109],"transiently,":[111],"over":[112],"time":[113],"they":[114],"maladaptive":[116],"result":[118],"unhealthy":[121],"lifestyles":[122],"noncommunicable":[124],"diseases":[125],"that":[126,192],"leading":[129],"causes":[130],"morbidity":[132],"mortality.":[134],"The":[135],"toxic":[138,194],"concept":[142],"allostasis":[145],"shed":[146],"new":[147],"light":[148],"on":[149,175],"developmental":[151],"origins":[152],"disease":[155],"highlight":[157],"opportunities":[158],"intervention":[161],"prevention.":[163],"Future":[164],"efforts":[165],"minimize":[167],"should":[173],"focus":[174],"expanding":[176],"capacity":[178],"caregivers":[180],"communities":[182],"promote":[184],"(1)":[185],"safe,":[187],"stable,":[188],"nurturing":[190],"relationships":[191],"buffer":[193],"stress,":[195],"(2)":[197],"rudimentary":[199],"but":[200],"foundational":[201],"social-emotional,":[202],"language,":[203],"cognitive":[205],"skills":[206],"needed":[207],"develop":[209],"healthy,":[210],"adaptive":[211],"coping":[212],"skills.":[213],"Building":[214],"these":[215],"critical":[216],"caregiver":[217],"community":[219],"capacities":[220],"will":[221],"require":[222],"public":[224],"health":[225],"approach":[226],"with":[227],"unprecedented":[228],"levels":[229],"collaboration":[231],"coordination":[233],"healthcare,":[236],"childcare,":[237],"education,":[239],"intervention,":[241],"home":[243],"sectors.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":50},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
