{"id":"https://openalex.org/W2171336799","doi":"https://doi.org/10.1371/journal.pone.0048164","title":"Increased Expression of Intranuclear Matrix Metalloproteinase 9 in Atrophic Renal Tubules Is Associated with Renal Fibrosis","display_name":"Increased Expression of Intranuclear Matrix Metalloproteinase 9 in Atrophic Renal Tubules Is Associated with Renal Fibrosis","publication_year":2012,"publication_date":"2012-10-24","ids":{"openalex":"https://openalex.org/W2171336799","doi":"https://doi.org/10.1371/journal.pone.0048164","mag":"2171336799","pmid":"https://pubmed.ncbi.nlm.nih.gov/23110201","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3480489"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0048164","doi":"https://doi.org/10.1371/journal.pone.0048164","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048164","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048164&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048164&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063808289","display_name":"Jen\u2010Pi Tsai","orcid":"https://orcid.org/0000-0001-9405-8649","observed_orcids":["https://orcid.org/0000-0001-9405-8649"]},"institutions":[{"id":"https://openalex.org/I4405279312","display_name":"Dalin Tzu Chi Hospital","ror":"https://ror.org/019t5b256","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4405279312"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jen-Pi Tsai","raw_affiliation_strings":["Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan","Department of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]},{"raw_affiliation_string":"Department of Nephrology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan","institution_ids":["https://openalex.org/I4405279312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029237495","display_name":"Jia\u2010Hung Liou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159511","display_name":"Changhua Christian Hospital","ror":"https://ror.org/05d9dtr71","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210159511"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jia-Hung Liou","raw_affiliation_strings":["Department of Medical Technology, Jen-The Junior College of Medicine, Nursing and Management, Miaoli, Taiwan","Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan","Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Technology, Jen-The Junior College of Medicine, Nursing and Management, Miaoli, Taiwan","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan","institution_ids":["https://openalex.org/I4210159511"]},{"raw_affiliation_string":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017325385","display_name":"Wei-Tse Kao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Tse Kao","raw_affiliation_strings":["Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shao-Chung Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104362","display_name":"Chung Shan Medical University Hospital","ror":"https://ror.org/01abtsn51","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210104362"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shao-Chung Wang","raw_affiliation_strings":["Department of Urology, Chung Shan Medical University Hospital, Taichung, Taiwan","Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Chung Shan Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362"]},{"raw_affiliation_string":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111627736","display_name":"Jong\u2010Da Lian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104362","display_name":"Chung Shan Medical University Hospital","ror":"https://ror.org/01abtsn51","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210104362"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jong-Da Lian","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021435490","display_name":"Horng\u2010Rong Chang","orcid":"https://orcid.org/0000-0002-6097-4056","observed_orcids":["https://orcid.org/0000-0002-6097-4056"]},"institutions":[{"id":"https://openalex.org/I4210104362","display_name":"Chung Shan Medical University Hospital","ror":"https://ror.org/01abtsn51","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210104362"]},{"id":"https://openalex.org/I91279580","display_name":"Chung Shan Medical University","ror":"https://ror.org/059ryjv25","country_code":"TW","type":"education","lineage":["https://openalex.org/I91279580"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Horng-Rong Chang","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan","Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan","institution_ids":["https://openalex.org/I4210104362"]},{"raw_affiliation_string":"Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan","institution_ids":["https://openalex.org/I91279580"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021435490"],"corresponding_institution_ids":["https://openalex.org/I4210104362","https://openalex.org/I91279580"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.9567,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.85239362,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"10","first_page":"e48164","last_page":"e48164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.7523999810218811,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.1607999950647354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9549999833106995},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.875},{"id":"https://openalex.org/keywords/glomerular-fibrosis","display_name":"glomerular fibrosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.7580000162124634},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.8989999890327454},{"id":"https://openalex.org/keywords/extracellular-matrix-turnover","display_name":"extracellular matrix turnover","score":0.8489999771118164},{"id":"https://openalex.org/keywords/nephrectomy","display_name":"nephrectomy","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6941208839416504},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5823017954826355},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.54246586561203},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5358266830444336},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5075010657310486},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4915340840816498},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.47559604048728943},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37895703315734863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3428518772125244}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007674","descriptor_name":"Kidney Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007684","descriptor_name":"Kidney Tubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0048164","doi":"https://doi.org/10.1371/journal.pone.0048164","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048164","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048164&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2475048","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3480489","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23110201","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23110201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3480489","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3480489/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.3119","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.3119","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/af/0b/pone.0048164.PMC3480489.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:bec90a585b3d48b2b22bf7ddd6a4a7b4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bec90a585b3d48b2b22bf7ddd6a4a7b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 10, p e48164 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0048164","doi":"https://doi.org/10.1371/journal.pone.0048164","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0048164","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0048164&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9907000064849854}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171336799.pdf","grobid_xml":"https://content.openalex.org/works/W2171336799.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1655785542","https://openalex.org/W1943317391","https://openalex.org/W1969745650","https://openalex.org/W1982976290","https://openalex.org/W1989750432","https://openalex.org/W2014439086","https://openalex.org/W2033002781","https://openalex.org/W2034172614","https://openalex.org/W2037670681","https://openalex.org/W2073647089","https://openalex.org/W2082137823","https://openalex.org/W2088037339","https://openalex.org/W2098615761","https://openalex.org/W2107302657","https://openalex.org/W2119218375","https://openalex.org/W2135188993","https://openalex.org/W2138620116","https://openalex.org/W2144244630","https://openalex.org/W2147104008","https://openalex.org/W2152850030","https://openalex.org/W2157877775","https://openalex.org/W2165107740","https://openalex.org/W2165176988","https://openalex.org/W2170783508","https://openalex.org/W2318993770","https://openalex.org/W2487377689","https://openalex.org/W2607031541"],"related_works":["https://openalex.org/W2393546994","https://openalex.org/W2152850030","https://openalex.org/W128745504","https://openalex.org/W2154603554","https://openalex.org/W2019535584","https://openalex.org/W2060380664","https://openalex.org/W2279073859","https://openalex.org/W4388495080","https://openalex.org/W2001176233","https://openalex.org/W2371606800"],"abstract_inverted_index":{"BACKGROUND:":[0],"Reduced":[1],"turnover":[2],"of":[3,25,48,60,64,72,80,83,199,217,242,248,255,260],"extracellular":[4],"matrix":[5],"has":[6],"a":[7,36,240],"role":[8],"in":[9,74,92,185,205,226,245,257],"renal":[10,29,81,86,94,235,263],"fibrosis.":[11],"Matrix":[12],"metalloproteinases":[13],"(MMPs)":[14],"is":[15,31,35,237],"associated":[16,158,238],"with":[17,58,113,159,172,223,239],"many":[18],"glomerular":[19,120,131],"diseases,":[20],"but":[21],"the":[22,46,78,227,246,258],"histological":[23],"association":[24,79],"MMPs":[26],"and":[27,54,77,85,96,108,119,135,145,154,161,167,201,252],"human":[28],"fibrosis":[30,87,97,116,121,221,236],"unclear.":[32],"METHODS:":[33],"This":[34],"retrospective":[37],"study.":[38],"Institutional":[39],"Review":[40],"Board":[41],"approval":[42],"was":[43,88,98,169,195,213],"obtained":[44],"for":[45],"review":[47],"patients'":[49],"medical":[50],"records,":[51],"data":[52],"analysis":[53,150],"pathological":[55],"specimens":[56],"staining":[57,107],"waiver":[59],"informed":[61],"consents.":[62],"Specimens":[63],"forty-six":[65],"patients":[66],"were":[67,136,156],"examined":[68],"by":[69],"immunohistochemical":[70],"stain":[71],"MMP-9":[73,84,90,106,165,176,183,203,224,243,256],"nephrectomized":[75],"kidneys,":[76],"expression":[82,91,166,184,204,225,244,254],"determined.":[89],"individual":[93],"components":[95],"graded":[99],"as":[100],"high":[101,114],"or":[102],"low":[103],"based":[104],"on":[105],"fibrotic":[109],"scores.":[110],"RESULTS:":[111],"Patients":[112],"interstitial":[115],"scores":[117,122],"(IFS)":[118],"(GFS)":[123],"had":[124],"significantly":[125],"higher":[126],"serum":[127],"creatinine,":[128],"lower":[129],"estimated":[130],"filtration":[132],"rate":[133],"(eGFR),":[134],"more":[137],"likely":[138],"to":[139],"have":[140],"chronic":[141],"kidney":[142],"disease":[143],"(CKD)":[144],"urothelial":[146],"cell":[147],"carcinoma.":[148],"Univariate":[149],"showed":[151],"that":[152,182,202,234],"IFS":[153,168],"GFS":[155],"negatively":[157],"normal":[160,206,249],"atrophic":[162,173,186,228,262],"tubular":[163,174,187,207,229,250,261],"cytoplasmic":[164],"positively":[170],"correlated":[171,222],"nuclear":[175],"expression.":[177],"Multivariate":[178],"stepwise":[179],"regression":[180],"indicated":[181],"nuclei":[188,259],"(r":[189,209],"=":[190,193,210],"0.4,":[191],"p":[192],"0.002)":[194],"an":[196,214],"independent":[197,215],"predictor":[198,216],"IFS,":[200],"cytoplasm":[208,247],"-0.465,":[211],"p<0.001)":[212],"GFS.":[218],"CONCLUSIONS:":[219],"Interstitial":[220],"nuclei.":[230],"Our":[231],"results":[232],"indicate":[233],"decline":[241],"cells":[251],"increased":[253],"tubules.":[264]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}