{"id":"https://openalex.org/W2171241069","doi":"https://doi.org/10.1124/mol.112.080689","title":"A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion","display_name":"A Novel EPAC-Specific Inhibitor Suppresses Pancreatic Cancer Cell Migration and Invasion","publication_year":2012,"publication_date":"2012-10-11","ids":{"openalex":"https://openalex.org/W2171241069","doi":"https://doi.org/10.1124/mol.112.080689","mag":"2171241069","pmid":"https://pubmed.ncbi.nlm.nih.gov/23066090","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3533471"},"language":"en","primary_location":{"id":"doi:10.1124/mol.112.080689","doi":"https://doi.org/10.1124/mol.112.080689","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.112.080689","pdf_url":"https://molpharm.aspetjournals.org/content/molpharm/83/1/122.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://molpharm.aspetjournals.org/content/molpharm/83/1/122.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037359600","display_name":"Muayad F. Almahariq","orcid":"https://orcid.org/0000-0001-8138-3389","observed_orcids":["https://orcid.org/0000-0001-8138-3389"]},"institutions":[{"id":"https://openalex.org/I4210100236","display_name":"Biolog Life Science Institute","ror":"https://ror.org/010e6tc72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100236"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Muayad Almahariq","raw_affiliation_strings":["Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0615, USA. xcheng@utmb.edu","BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0615, USA. xcheng@utmb.edu","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062125545","display_name":"Tamara N. Tsalkova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100236","display_name":"Biolog Life Science Institute","ror":"https://ror.org/010e6tc72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100236"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Tamara Tsalkova","raw_affiliation_strings":["Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236","https://openalex.org/I55302922"]},{"raw_affiliation_string":"BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064997314","display_name":"Fang C. Mei","orcid":"https://orcid.org/0000-0002-2589-1036","observed_orcids":["https://orcid.org/0000-0002-2589-1036"]},"institutions":[{"id":"https://openalex.org/I4210100236","display_name":"Biolog Life Science Institute","ror":"https://ror.org/010e6tc72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100236"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Fang C. Mei","raw_affiliation_strings":["Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236","https://openalex.org/I55302922"]},{"raw_affiliation_string":"BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657690","display_name":"Haijun Chen","orcid":"https://orcid.org/0000-0002-8061-1949","observed_orcids":["https://orcid.org/0000-0002-8061-1949"]},"institutions":[{"id":"https://openalex.org/I4210100236","display_name":"Biolog Life Science Institute","ror":"https://ror.org/010e6tc72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100236"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Haijun Chen","raw_affiliation_strings":["Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236","https://openalex.org/I55302922"]},{"raw_affiliation_string":"BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023901418","display_name":"Jia Zhou","orcid":"https://orcid.org/0000-0002-2811-1090","observed_orcids":["https://orcid.org/0000-0002-2811-1090"]},"institutions":[{"id":"https://openalex.org/I4210100236","display_name":"Biolog Life Science Institute","ror":"https://ror.org/010e6tc72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100236"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jia Zhou","raw_affiliation_strings":["Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236","https://openalex.org/I55302922"]},{"raw_affiliation_string":"BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111882091","display_name":"Sarita K. Sastry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100236","display_name":"Biolog Life Science Institute","ror":"https://ror.org/010e6tc72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100236"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Sarita K. Sastry","raw_affiliation_strings":["Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236","https://openalex.org/I55302922"]},{"raw_affiliation_string":"BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049654018","display_name":"Frank Schwede","orcid":"https://orcid.org/0000-0002-8185-3392","observed_orcids":["https://orcid.org/0000-0002-8185-3392"]},"institutions":[{"id":"https://openalex.org/I4210100236","display_name":"Biolog Life Science Institute","ror":"https://ror.org/010e6tc72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100236"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Frank Schwede","raw_affiliation_strings":["Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236","https://openalex.org/I55302922"]},{"raw_affiliation_string":"BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080619609","display_name":"Xiaodong Cheng","orcid":"https://orcid.org/0000-0002-3479-1694","observed_orcids":["https://orcid.org/0000-0002-3479-1694"]},"institutions":[{"id":"https://openalex.org/I4210100236","display_name":"Biolog Life Science Institute","ror":"https://ror.org/010e6tc72","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210100236"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Xiaodong Cheng","raw_affiliation_strings":["Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas; and BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236","https://openalex.org/I55302922"]},{"raw_affiliation_string":"BIOLOG Life Science Institute, Forschungslabor und Biochemica-Vertrieb GmbH, Bremen, Germany (F.S.)","institution_ids":["https://openalex.org/I4210100236"]},{"raw_affiliation_string":"Department of Pharmacology and Toxicology (M.A., T.T., F.C.M., H.C., J.Z., X.C.) and Sealy Center for Structural Biology and Molecular Biophysics (X.C.), Department of Biochemistry and Molecular Biology (S.K.S.), The University of Texas Medical Branch, Galveston, Texas","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":6.9353,"has_fulltext":true,"cited_by_count":207,"citation_normalized_percentile":{"value":0.98117733,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"83","issue":"1","first_page":"122","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.08720000088214874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epac1","display_name":"Epac1","score":0.8240000009536743},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.859000027179718},{"id":"https://openalex.org/keywords/rap1-activation","display_name":"Rap1 activation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6539999842643738},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5978665351867676},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.5338804721832275},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5003402233123779},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49136605858802795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4206107556819916},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4009351134300232},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3783976435661316},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30525726079940796},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19926917552947998},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10321524739265442}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006835","descriptor_name":"Hydrazones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007555","descriptor_name":"Isoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020662","descriptor_name":"Guanine Nucleotide Exchange Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020827","descriptor_name":"rap1 GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1124/mol.112.080689","doi":"https://doi.org/10.1124/mol.112.080689","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.112.080689","pdf_url":"https://molpharm.aspetjournals.org/content/molpharm/83/1/122.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3533471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3533471","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Pharmacol","raw_type":"Text"},{"id":"pmid:23066090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23066090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1124/mol.112.080689","doi":"https://doi.org/10.1124/mol.112.080689","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.112.080689","pdf_url":"https://molpharm.aspetjournals.org/content/molpharm/83/1/122.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G562107762","display_name":"Center for Clinical and Translational Sciences","funder_award_id":"UL1RR024148","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6831578510","display_name":"Epac/cAMP-GEF, A Novel Intracellular cAMP Receptor","funder_award_id":"R01GM066170","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6909879773","display_name":"Training in Pharmacological Sciences","funder_award_id":"T32GM089657","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171241069.pdf","grobid_xml":"https://content.openalex.org/works/W2171241069.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1571595997","https://openalex.org/W1885709862","https://openalex.org/W1964061749","https://openalex.org/W1964171635","https://openalex.org/W1974947279","https://openalex.org/W1977929393","https://openalex.org/W1978696795","https://openalex.org/W1983286754","https://openalex.org/W1983565569","https://openalex.org/W1988098896","https://openalex.org/W1988909797","https://openalex.org/W1991751920","https://openalex.org/W1992718424","https://openalex.org/W1995698227","https://openalex.org/W1996683094","https://openalex.org/W2009061745","https://openalex.org/W2016095963","https://openalex.org/W2018252424","https://openalex.org/W2024235333","https://openalex.org/W2029513101","https://openalex.org/W2032140254","https://openalex.org/W2041028158","https://openalex.org/W2042071773","https://openalex.org/W2043718702","https://openalex.org/W2050731767","https://openalex.org/W2056908604","https://openalex.org/W2070506072","https://openalex.org/W2071644848","https://openalex.org/W2076128131","https://openalex.org/W2076201472","https://openalex.org/W2078037416","https://openalex.org/W2089519239","https://openalex.org/W2104532440","https://openalex.org/W2105100736","https://openalex.org/W2106435662","https://openalex.org/W2126312769","https://openalex.org/W2133553247","https://openalex.org/W2134967712","https://openalex.org/W2137137048","https://openalex.org/W2141261480","https://openalex.org/W2143563119","https://openalex.org/W2144517964","https://openalex.org/W2146603157","https://openalex.org/W2152301430","https://openalex.org/W2155823638","https://openalex.org/W2157035381","https://openalex.org/W2162197907","https://openalex.org/W2163585457","https://openalex.org/W2166287438","https://openalex.org/W2171483278"],"related_works":["https://openalex.org/W2042647961","https://openalex.org/W1244248620","https://openalex.org/W2035870242","https://openalex.org/W2188785471","https://openalex.org/W2038327050","https://openalex.org/W2787338635","https://openalex.org/W2292680100","https://openalex.org/W1945691413","https://openalex.org/W2587976087","https://openalex.org/W2610587060"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":27},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}