{"id":"https://openalex.org/W2171069693","doi":"https://doi.org/10.1093/nar/gku583","title":"HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway","display_name":"HIV-1 Nef and KSHV oncogene K1 synergistically promote angiogenesis by inducing cellular miR-718 to regulate the PTEN/AKT/mTOR signaling pathway","publication_year":2014,"publication_date":"2014-08-07","ids":{"openalex":"https://openalex.org/W2171069693","doi":"https://doi.org/10.1093/nar/gku583","mag":"2171069693","pmid":"https://pubmed.ncbi.nlm.nih.gov/25104021"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gku583","doi":"https://doi.org/10.1093/nar/gku583","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku583","pdf_url":"https://academic.oup.com/nar/article-pdf/42/15/9862/28910487/gku583.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/42/15/9862/28910487/gku583.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Min Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4391767661","display_name":"State Key Laboratory of Reproductive Medicine","ror":"https://ror.org/00cagf561","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Xue","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","Department of Physiology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, P.R. China","Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, P.R. China","State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Physiology, Xuzhou Medical College, Xuzhou, Jiangsu 221004, P.R. China","institution_ids":["https://openalex.org/I177388780"]},{"raw_affiliation_string":"Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, P.R. China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China","institution_ids":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102936376","display_name":"Shuihong Yao","orcid":"https://orcid.org/0000-0001-6657-2755","observed_orcids":["https://orcid.org/0000-0001-6657-2755"]},"institutions":[{"id":"https://openalex.org/I4210096600","display_name":"Quzhou College of Technology","ror":"https://ror.org/00q0v3357","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210096600"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuihong Yao","raw_affiliation_strings":["Medical School, Quzhou College of Technology, Quzhou 324000, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School, Quzhou College of Technology, Quzhou 324000, P.R. China","institution_ids":["https://openalex.org/I4210096600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102198257","display_name":"Minmin Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minmin Hu","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320147","display_name":"Li Wan","orcid":"https://orcid.org/0009-0002-1858-9522","observed_orcids":["https://orcid.org/0009-0002-1858-9522"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wan Li","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tingting Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingting Hao","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080625732","display_name":"Feng Zhou","orcid":"https://orcid.org/0000-0001-8469-5548","observed_orcids":["https://orcid.org/0000-0001-8469-5548"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Zhou","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040987305","display_name":"Xiaofei Zhu","orcid":"https://orcid.org/0000-0001-6360-140X","observed_orcids":["https://orcid.org/0000-0001-6360-140X","https://orcid.org/0000-0002-8745-3488"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofei Zhu","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hongmei Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongmei Lu","raw_affiliation_strings":["Department of Obstetrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741042","display_name":"Di Qin","orcid":"https://orcid.org/0000-0002-9730-4072","observed_orcids":["https://orcid.org/0000-0002-9730-4072"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Qin","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023282229","display_name":"Qin Yan","orcid":"https://orcid.org/0000-0002-3974-0298","observed_orcids":["https://orcid.org/0000-0002-3974-0298"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qin Yan","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055690600","display_name":"Jianzhong Zhu","orcid":"https://orcid.org/0000-0002-7082-1993","observed_orcids":["https://orcid.org/0000-0002-7082-1993"]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianzhong Zhu","raw_affiliation_strings":["Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010896860","display_name":"Shou\u2010Jiang Gao","orcid":"https://orcid.org/0000-0001-6194-1742","observed_orcids":["https://orcid.org/0000-0001-6194-1742"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shou-Jiang Gao","raw_affiliation_strings":["Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047958805","display_name":"Chun Lu","orcid":"https://orcid.org/0000-0002-6078-9352","observed_orcids":["https://orcid.org/0000-0002-6078-9352"]},"institutions":[{"id":"https://openalex.org/I4391767661","display_name":"State Key Laboratory of Reproductive Medicine","ror":"https://ror.org/00cagf561","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chun Lu","raw_affiliation_strings":["Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, P.R. China","State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Nanjing Medical University, Nanjing 210029, P.R. China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing Medical University, Nanjing, P.R. China","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, P.R. China","institution_ids":["https://openalex.org/I4391767661","https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5023282229","https://openalex.org/A5047958805"],"corresponding_institution_ids":["https://openalex.org/I4391767661","https://openalex.org/I83519826"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":3.3023,"has_fulltext":true,"cited_by_count":95,"citation_normalized_percentile":{"value":0.93721945,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"42","issue":"15","first_page":"9862","last_page":"9879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-nef","display_name":"HIV-1 Nef","score":0.972000002861023},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/aids-associated-kaposi-s-sarcoma","display_name":"AIDS-related Kaposi's sarcoma","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9210000038146973},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6589999794960022},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8629999756813049},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8805243968963623},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8547567129135132},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8086507320404053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7670422792434692},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7338130474090576},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6650970578193665},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6518017053604126},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44279980659484863},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.4151993989944458},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4092625379562378},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2715345621109009},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06916278600692749}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054311","descriptor_name":"nef Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gku583","doi":"https://doi.org/10.1093/nar/gku583","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku583","pdf_url":"https://academic.oup.com/nar/article-pdf/42/15/9862/28910487/gku583.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmid:25104021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25104021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4150761","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4150761","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/gku583","doi":"https://doi.org/10.1093/nar/gku583","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gku583","pdf_url":"https://academic.oup.com/nar/article-pdf/42/15/9862/28910487/gku583.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1166027297","display_name":"HIV-1 Nef\u86cb\u767d\u4fc3\u8fdbKSHV K1\u8bf1\u5bfc\u8840\u7ba1\u548c\u80bf\u7624\u5f62\u6210\uff1a\u4fe1\u53f7\u901a\u8def\u4e0emiRNAs\u7684\u4f5c\u7528","funder_award_id":"81371824","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1377658285","display_name":null,"funder_award_id":"R01CA177377","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1927985681","display_name":null,"funder_award_id":"2011CB504803","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G1988149734","display_name":null,"funder_award_id":"81171552","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G312831558","display_name":"HIV-1 Tat\u86cb\u767d\u4fc3\u8fdbKSHV vIL-6\u8bf1\u5bfc\u8840\u7ba1\u751f\u6210\u548c\u80bf\u7624\u5f62\u6210\u53ca\u5176\u5206\u5b50\u673a\u5236","funder_award_id":"31270199","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G574196841","display_name":null,"funder_award_id":"20123234110006","funder_id":"https://openalex.org/F4320321106","funder_display_name":"Ministry of Education of the People's Republic of China"},{"id":"https://openalex.org/G6918348011","display_name":null,"funder_award_id":"P01 CA180779","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8151656049","display_name":null,"funder_award_id":"81361120387","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G9000003995","display_name":null,"funder_award_id":"R01CA177377","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G923287464","display_name":null,"funder_award_id":"R01CA124332","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321106","display_name":"Ministry of Education of the People's Republic of China","ror":"https://ror.org/01mv9t934"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320324291","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171069693.pdf","grobid_xml":"https://content.openalex.org/works/W2171069693.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W1520961493","https://openalex.org/W1576582350","https://openalex.org/W1959848155","https://openalex.org/W1963882002","https://openalex.org/W1968391374","https://openalex.org/W1972989638","https://openalex.org/W1973738171","https://openalex.org/W1975922730","https://openalex.org/W1976247350","https://openalex.org/W1977267072","https://openalex.org/W1979413046","https://openalex.org/W1982209692","https://openalex.org/W1982665299","https://openalex.org/W1985839640","https://openalex.org/W1992845452","https://openalex.org/W1993876923","https://openalex.org/W1998216942","https://openalex.org/W2000093333","https://openalex.org/W2002904708","https://openalex.org/W2006409246","https://openalex.org/W2006484481","https://openalex.org/W2006831423","https://openalex.org/W2008214962","https://openalex.org/W2010258747","https://openalex.org/W2011726499","https://openalex.org/W2012728850","https://openalex.org/W2015863723","https://openalex.org/W2015878280","https://openalex.org/W2016945496","https://openalex.org/W2023309489","https://openalex.org/W2024185937","https://openalex.org/W2024318541","https://openalex.org/W2026866676","https://openalex.org/W2028286076","https://openalex.org/W2029228478","https://openalex.org/W2031813377","https://openalex.org/W2032201575","https://openalex.org/W2032438721","https://openalex.org/W2034027647","https://openalex.org/W2036279650","https://openalex.org/W2036534625","https://openalex.org/W2043436845","https://openalex.org/W2044387903","https://openalex.org/W2044484966","https://openalex.org/W2048064045","https://openalex.org/W2048158327","https://openalex.org/W2050337099","https://openalex.org/W2050461547","https://openalex.org/W2051764014","https://openalex.org/W2052911190","https://openalex.org/W2054395379","https://openalex.org/W2054699781","https://openalex.org/W2056329949","https://openalex.org/W2057938503","https://openalex.org/W2062715806","https://openalex.org/W2064978615","https://openalex.org/W2070300061","https://openalex.org/W2072047081","https://openalex.org/W2072602437","https://openalex.org/W2080413744","https://openalex.org/W2083560029","https://openalex.org/W2083604122","https://openalex.org/W2084256592","https://openalex.org/W2087685591","https://openalex.org/W2088857928","https://openalex.org/W2092841144","https://openalex.org/W2095220268","https://openalex.org/W2096288748","https://openalex.org/W2097851380","https://openalex.org/W2100301498","https://openalex.org/W2100965959","https://openalex.org/W2101179492","https://openalex.org/W2111316211","https://openalex.org/W2111666869","https://openalex.org/W2117186052","https://openalex.org/W2118448033","https://openalex.org/W2119642469","https://openalex.org/W2121964400","https://openalex.org/W2123509723","https://openalex.org/W2125536613","https://openalex.org/W2132927652","https://openalex.org/W2136010540","https://openalex.org/W2138180461","https://openalex.org/W2139525028","https://openalex.org/W2140716172","https://openalex.org/W2142798790","https://openalex.org/W2143225903","https://openalex.org/W2143795959","https://openalex.org/W2146804066","https://openalex.org/W2147116051","https://openalex.org/W2148919227","https://openalex.org/W2156149964","https://openalex.org/W2160102037","https://openalex.org/W2167715370","https://openalex.org/W2169294034","https://openalex.org/W2388163742","https://openalex.org/W2413178119","https://openalex.org/W2468063039","https://openalex.org/W3149879290","https://openalex.org/W4234715488","https://openalex.org/W6649083605","https://openalex.org/W6664728049","https://openalex.org/W6715489430"],"related_works":["https://openalex.org/W3183179750","https://openalex.org/W2070783513","https://openalex.org/W2024933597","https://openalex.org/W3116479654","https://openalex.org/W4205189596","https://openalex.org/W2916964185","https://openalex.org/W2422815049","https://openalex.org/W2098584395","https://openalex.org/W2019551003","https://openalex.org/W2982360817"],"abstract_inverted_index":{"Kaposi's":[0],"sarcoma":[1],"(KS)":[2],"is":[3],"an":[4,178,190],"AIDS-defining":[5],"cancer":[6],"with":[7,66],"aberrant":[8],"neovascularization":[9],"caused":[10],"by":[11,111,125,161],"KS-associated":[12],"herpesvirus":[13],"(KSHV).":[14],"Although":[15],"the":[16,28,33,132,147],"interaction":[17],"between":[18],"HIV-1":[19,43],"and":[20,57,73,76,94,105,116,145,152,155,167,186],"KSHV":[21,48],"plays":[22],"a":[23,80,128],"pivotal":[24],"role":[25,180],"in":[26,62,79,96,131,184],"promoting":[27],"aggressive":[29],"manifestations":[30],"of":[31,47,60,135,139,150,172,181],"KS,":[32],"pathogenesis":[34],"underlying":[35],"AIDS-KS":[36,185],"remains":[37],"largely":[38],"unknown.":[39],"Here":[40],"we":[41],"examined":[42],"Nef":[44,61,90,104,115],"protein":[45],"promotion":[46],"oncoprotein":[49],"K1-induced":[50,92,153,168],"angiogenesis.":[51],"We":[52],"showed":[53],"that":[54,89,103],"both":[55],"internalized":[56],"ectopic":[58],"expression":[59,124,141],"endothelial":[63],"cells":[64],"synergized":[65],"K1":[67,106,117],"to":[68],"facilitate":[69],"vascular":[70],"tube":[71],"formation":[72],"cell":[74],"proliferation,":[75],"enhance":[77],"angiogenesis":[78,93,154,169],"chicken":[81],"CAM":[82],"model.":[83],"In":[84],"vivo":[85],"experiments":[86],"further":[87],"indicated":[88],"accelerated":[91],"tumorigenesis":[95],"athymic":[97],"nu/nu":[98],"mice.":[99],"Mechanistic":[100],"studies":[101],"revealed":[102],"synergistically":[107],"activated":[108],"PI3K/AKT/mTOR":[109],"signaling":[110],"downregulating":[112],"PTEN.":[113],"Furthermore,":[114],"induced":[118],"cellular":[119],"miR-718,":[120],"which":[121],"inhibited":[122],"PTEN":[123,143],"directly":[126],"targeting":[127,162],"seed":[129],"sequence":[130],"3'":[133],"UTR":[134],"its":[136],"mRNA.":[137],"Inhibition":[138],"miR-718":[140,164],"increased":[142],"synthesis":[144],"suppressed":[146],"synergistic":[148],"effect":[149],"Nef-":[151,166],"tumorigenesis.":[156],"These":[157],"results":[158,176],"indicate":[159],"that,":[160],"PTEN,":[163],"mediates":[165],"via":[170],"activation":[171],"AKT/mTOR":[173],"signaling.":[174],"Our":[175],"demonstrate":[177],"essential":[179],"miR-718/AKT/mTOR":[182],"axis":[183],"thus":[187],"may":[188],"represent":[189],"attractive":[191],"therapeutic":[192],"target.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
