{"id":"https://openalex.org/W2171058658","doi":"https://doi.org/10.1186/1471-2180-8-213","title":"Uptake and intra-inclusion accumulation of exogenous immunoglobulin by Chlamydia-infected cells","display_name":"Uptake and intra-inclusion accumulation of exogenous immunoglobulin by Chlamydia-infected cells","publication_year":2008,"publication_date":"2008-12-01","ids":{"openalex":"https://openalex.org/W2171058658","doi":"https://doi.org/10.1186/1471-2180-8-213","mag":"2171058658","pmid":"https://pubmed.ncbi.nlm.nih.gov/19061499","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2621372"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2180-8-213","doi":"https://doi.org/10.1186/1471-2180-8-213","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-8-213","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-8-213","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-8-213","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002906810","display_name":"David V Pollack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David V Pollack","raw_affiliation_strings":["Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01002, USA. dpollack@microbio.umass.edu","Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, 01002, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01002, USA. dpollack@microbio.umass.edu","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, 01002, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046045509","display_name":"Nancy L Croteau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy L Croteau","raw_affiliation_strings":["University of Massachusetts Medical School, Worcester Massachusetts, 01655, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts Medical School, Worcester Massachusetts, 01655, USA","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071079232","display_name":"Elizabeth S. Stuart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth S Stuart","raw_affiliation_strings":["Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, 01002, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Massachusetts, Amherst, Massachusetts, 01002, USA","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071079232"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.6009,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72253172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"213","last_page":"213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.02800000086426735,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chlamydia","display_name":"chlamydia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.625},{"id":"https://openalex.org/keywords/chlamydial-inclusions","display_name":"chlamydial inclusions","score":0.953000009059906},{"id":"https://openalex.org/keywords/host-cell-manipulation","display_name":"host cell manipulation","score":0.5419999957084656},{"id":"https://openalex.org/keywords/obligate-intracellular-pathogens","display_name":"obligate intracellular pathogens","score":0.8100000023841858},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.6639999747276306},{"id":"https://openalex.org/keywords/leukocytes","display_name":"leukocytes","score":0.625}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8712615370750427},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5330387949943542},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.5154967904090881},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4608878791332245},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.4341524839401245},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4266703426837921},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4003046751022339},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3151949644088745},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21646347641944885},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002689","descriptor_name":"Chlamydia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002690","descriptor_name":"Chlamydia Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2180-8-213","doi":"https://doi.org/10.1186/1471-2180-8-213","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-8-213","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-8-213","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2621372","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2621372","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiol","raw_type":"Text"},{"id":"pmid:19061499","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19061499","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.umassmed.edu:oapubs-3282","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/oapubs/2283","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications by UMass Chan Authors","raw_type":"text"},{"id":"pmh:oai:scholarworks.umass.edu:micro_faculty_pubs-1235","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.umass.edu/micro_faculty_pubs/236","pdf_url":null,"source":{"id":"https://openalex.org/S4306402240","display_name":"ScholarWorks@UMassAmherst (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiology Department Faculty Publication Series","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:7b1affee34d64bad87d007c1d5bc6913","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/7b1affee34d64bad87d007c1d5bc6913","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Microbiology, Vol 8, Iss 1, p 213 (2008)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2180-8-213","doi":"https://doi.org/10.1186/1471-2180-8-213","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2180-8-213","pdf_url":"https://bmcmicrobiol.biomedcentral.com/counter/pdf/10.1186/1471-2180-8-213","source":{"id":"https://openalex.org/S128543880","display_name":"BMC Microbiology","issn_l":"1471-2180","issn":["1471-2180"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2171058658.pdf","grobid_xml":"https://content.openalex.org/works/W2171058658.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1493274216","https://openalex.org/W1500476463","https://openalex.org/W1526573723","https://openalex.org/W1594971941","https://openalex.org/W1680739067","https://openalex.org/W1895723152","https://openalex.org/W1918492041","https://openalex.org/W1949257097","https://openalex.org/W1988642500","https://openalex.org/W1997388059","https://openalex.org/W2031112158","https://openalex.org/W2043525008","https://openalex.org/W2058180647","https://openalex.org/W2068054150","https://openalex.org/W2100950123","https://openalex.org/W2113200077","https://openalex.org/W2114137438","https://openalex.org/W2114973937","https://openalex.org/W2140582450","https://openalex.org/W2144480059","https://openalex.org/W2145947813","https://openalex.org/W2149910352","https://openalex.org/W2161973037","https://openalex.org/W2166498153","https://openalex.org/W2169039001","https://openalex.org/W2171136826","https://openalex.org/W4233341702","https://openalex.org/W4240390271"],"related_works":["https://openalex.org/W2114489404","https://openalex.org/W1526573723","https://openalex.org/W2160885923","https://openalex.org/W2000437904","https://openalex.org/W2769468726","https://openalex.org/W2024269535","https://openalex.org/W1963704916","https://openalex.org/W1991755116","https://openalex.org/W2979308736","https://openalex.org/W2125452048"],"abstract_inverted_index":{"BACKGROUND:":[0],"Obligate":[1],"intracellular":[2],"pathogens":[3],"belonging":[4],"to":[5,16,106,141,165,195,293],"the":[6,18,27,42,65,77,91,129,145,149,166,183,186,202,233,287],"Chlamydiaceae":[7],"family":[8],"possess":[9],"a":[10,52,198,214,228],"number":[11,54],"of":[12,29,32,44,55,102,126,131,148,168,179,188,204,216,227,246,267],"mechanisms":[13],"by":[14,124,134],"which":[15],"manipulate":[17],"host":[19,229,249],"cell":[20,170],"and":[21,37,41,61,82,88,96,153,175,185,212,286,296],"surrounding":[22],"environment.":[23],"Such":[24],"capabilities":[25],"include":[26],"inhibition":[28],"apoptosis,":[30],"down-regulation":[31],"major":[33],"histocompatability":[34],"complex":[35],"(MHC)":[36],"CD1/d":[38],"gene":[39],"expression,":[40],"acquisition":[43],"host-synthesized":[45],"nutrients.":[46],"It":[47],"is":[48,104,206,238],"also":[49,173],"documented":[50],"that":[51,72,272],"limited":[53],"host-derived":[56],"macromolecules":[57],"such":[58,251],"as":[59,113,115,252],"beta-catenin":[60],"sphingomyelin":[62],"accumulate":[63,196],"within":[64,90,182,232],"inclusion.":[66,93],"RESULTS:":[67],"This":[68],"report":[69],"provides":[70],"evidence":[71],"immunoglobulin,":[73],"inherently":[74],"present":[75,143],"in":[76,80,83,111,118,128,197,260,279],"extracellular":[78,253],"environment":[79],"vivo":[81,112],"vitro,":[84],"enters":[85],"infected":[86,132,169],"cells":[87,116,133],"accumulates":[89],"chlamydial":[92,150,234,263],"Using":[94],"epi-fluorescent":[95],"confocal":[97],"microscopy,":[98],"this":[99,157,268,273],"selective":[100,244],"uptake":[101,274],"Ig":[103],"shown":[105],"occur":[107],"among":[108],"human":[109],"leukocytes":[110],"well":[114],"cultured":[117],"vitro.":[119],"These":[120],"findings":[121],"were":[122],"confirmed":[123],"detection":[125],"IgG":[127,159,210],"lysate":[130],"western":[135],"blot":[136],"hybridization.":[137],"Sequestered":[138],"antibodies":[139],"appear":[140],"be":[142],"during":[144,284],"entire":[146],"course":[147],"developmental":[151],"cycle":[152],"are":[154],"distributed":[155],"throughout":[156],"compartment.":[158],"pre-labeled":[160],"with":[161,262],"fluorescein,":[162],"when":[163],"added":[164],"supernatant":[167],"cultures,":[171],"was":[172],"imported":[174],"readily":[176],"visualized.":[177],"Accumulation":[178],"these":[180],"molecules":[181,211],"inclusion":[184],"failure":[187],"bovine":[189],"serum":[190],"albumin":[191],"or":[192,219,282],"F(ab')2":[193],"fragments":[194],"similar":[199],"manner":[200],"suggests":[201],"process":[203,269],"entry":[205],"specific":[207],"for":[208],"intact":[209],"not":[213,239,256],"result":[215],"pinocytosis,":[217],"diffusion,":[218],"any":[220],"other":[221],"mass":[222],"endocytic":[223],"event.":[224],"CONCLUSION:":[225],"Sequestration":[226],"cell-derived":[230],"protein":[231],"inclusion,":[235],"although":[236],"unexpected,":[237],"an":[240,247,276],"unprecedented":[241],"occurrence.":[242],"However,":[243],"accumulation":[245],"exogenous":[248],"protein,":[250],"IgG,":[254],"has":[255],"been":[257],"previously":[258],"reported":[259],"connection":[261],"infections.":[264],"The":[265],"selectivity":[266],"may":[270,290],"indicate":[271],"plays":[275],"important":[277],"role":[278],"pathogen":[280],"physiology":[281],"virulence":[283],"infection":[285],"phenomenon":[288],"itself":[289],"give":[291],"rise":[292],"novel":[294],"diagnostic":[295],"therapeutic":[297],"approaches.":[298]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
