{"id":"https://openalex.org/W2171027490","doi":"https://doi.org/10.1259/0007-1285-65-772-309","title":"The role of 99Tcm-HMPAO white cell imaging in suspected orthopaedic infection","display_name":"The role of 99Tcm-HMPAO white cell imaging in suspected orthopaedic infection","publication_year":1992,"publication_date":"1992-04-01","ids":{"openalex":"https://openalex.org/W2171027490","doi":"https://doi.org/10.1259/0007-1285-65-772-309","mag":"2171027490","pmid":"https://pubmed.ncbi.nlm.nih.gov/1581787"},"language":"en","primary_location":{"id":"doi:10.1259/0007-1285-65-772-309","doi":"https://doi.org/10.1259/0007-1285-65-772-309","is_oa":false,"landing_page_url":"https://doi.org/10.1259/0007-1285-65-772-309","pdf_url":null,"source":{"id":"https://openalex.org/S142542876","display_name":"British Journal of Radiology","issn_l":"0007-1285","issn":["0007-1285","1748-880X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British Journal of Radiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024889937","display_name":"C. Copping","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800160768","display_name":"Lincoln County Hospital","ror":"https://ror.org/03p30f964","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800160768","https://openalex.org/I2803040662"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. Copping","raw_affiliation_strings":["Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK","institution_ids":["https://openalex.org/I2800160768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085955316","display_name":"S. M. Dalgliesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800160768","display_name":"Lincoln County Hospital","ror":"https://ror.org/03p30f964","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800160768","https://openalex.org/I2803040662"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S. M. Dalgliesh","raw_affiliation_strings":["Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK","institution_ids":["https://openalex.org/I2800160768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009404655","display_name":"Nicholas John Dudley","orcid":"https://orcid.org/0000-0002-0057-3760","observed_orcids":["https://orcid.org/0000-0002-0057-3760"]},"institutions":[{"id":"https://openalex.org/I2800160768","display_name":"Lincoln County Hospital","ror":"https://ror.org/03p30f964","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800160768","https://openalex.org/I2803040662"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. J. Dudley","raw_affiliation_strings":["Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK","institution_ids":["https://openalex.org/I2800160768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009542291","display_name":"Peter A. Griffiths","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800160768","display_name":"Lincoln County Hospital","ror":"https://ror.org/03p30f964","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800160768","https://openalex.org/I2803040662"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. A. Griffiths","raw_affiliation_strings":["Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK","institution_ids":["https://openalex.org/I2800160768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046193581","display_name":"Michael G. Harrington","orcid":"https://orcid.org/0000-0002-7923-8032","observed_orcids":["https://orcid.org/0000-0002-7923-8032"]},"institutions":[{"id":"https://openalex.org/I2800160768","display_name":"Lincoln County Hospital","ror":"https://ror.org/03p30f964","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800160768","https://openalex.org/I2803040662"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Harrington","raw_affiliation_strings":["Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK","institution_ids":["https://openalex.org/I2800160768"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R. Potter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800160768","display_name":"Lincoln County Hospital","ror":"https://ror.org/03p30f964","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800160768","https://openalex.org/I2803040662"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Potter","raw_affiliation_strings":["Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Physics & Computing, County Hospital , Lincoln LN2 5QY, UK","institution_ids":["https://openalex.org/I2800160768"]}]},{"author_position":"last","author":{"id":null,"display_name":"B. D. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800160768","display_name":"Lincoln County Hospital","ror":"https://ror.org/03p30f964","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800160768","https://openalex.org/I2803040662"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"B. D. Smith","raw_affiliation_strings":["Department of Orthopaedic Surgery, County Hospital , Lincoln LN2 5QY, UK","Department of Orthopaedic Surgery, County Hospital, Lincoln LN2 5QY, UKDepartment of Medical Physics & Computing, County Hospital, Lincoln LN2 5QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, County Hospital , Lincoln LN2 5QY, UK","institution_ids":["https://openalex.org/I2800160768"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, County Hospital, Lincoln LN2 5QY, UKDepartment of Medical Physics & Computing, County Hospital, Lincoln LN2 5QY, UK","institution_ids":["https://openalex.org/I2800160768"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800160768"],"apc_list":{"value":2279,"currency":"GBP","value_usd":3005},"apc_paid":null,"fwci":3.1008,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.89888587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"65","issue":"772","first_page":"309","last_page":"312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11293","display_name":"Orthopedic Infections and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukocyte-scintigraphy","display_name":"leukocyte scintigraphy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/bone-infection","display_name":"bone infection","score":0.8550000190734863},{"id":"https://openalex.org/keywords/osteomyelitis","display_name":"osteomyelitis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/bone-and-joint-infections","display_name":"bone and joint infections","score":0.9150000214576721},{"id":"https://openalex.org/keywords/three-phase-bone-scintigraphy","display_name":"three-phase bone scintigraphy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/methylene-diphosphonate","display_name":"methylene diphosphonate","score":0.8830000162124634},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.7170000076293945},{"id":"https://openalex.org/keywords/infection-diagnosis","display_name":"infection diagnosis","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8123789429664612},{"id":"https://openalex.org/C2910515535","wikidata":"https://www.wikidata.org/wiki/Q938983","display_name":"Bone Infection","level":3,"score":0.7570720911026001},{"id":"https://openalex.org/C2909260394","wikidata":"https://www.wikidata.org/wiki/Q1928938","display_name":"Bone imaging","level":2,"score":0.6644482612609863},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.503091037273407},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4432007670402527},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3414574861526489},{"id":"https://openalex.org/C2780551157","wikidata":"https://www.wikidata.org/wiki/Q938983","display_name":"Osteomyelitis","level":2,"score":0.21708908677101135},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16182470321655273}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001847","descriptor_name":"Bone Diseases","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006622","descriptor_name":"Hip Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007239","descriptor_name":"Infections","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010091","descriptor_name":"Oximes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019690","descriptor_name":"Technetium Tc 99m Exametazime","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1259/0007-1285-65-772-309","doi":"https://doi.org/10.1259/0007-1285-65-772-309","is_oa":false,"landing_page_url":"https://doi.org/10.1259/0007-1285-65-772-309","pdf_url":null,"source":{"id":"https://openalex.org/S142542876","display_name":"British Journal of Radiology","issn_l":"0007-1285","issn":["0007-1285","1748-880X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British Journal of Radiology","raw_type":"journal-article"},{"id":"pmid:1581787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1581787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of radiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1968305512","https://openalex.org/W1968773337","https://openalex.org/W1974595599","https://openalex.org/W2018044433","https://openalex.org/W2026491158","https://openalex.org/W2060860171","https://openalex.org/W2165365751","https://openalex.org/W4246860734"],"related_works":["https://openalex.org/W2314077464","https://openalex.org/W2044248252","https://openalex.org/W2329184461","https://openalex.org/W1546970115","https://openalex.org/W2007237009","https://openalex.org/W7211352928","https://openalex.org/W2085938091","https://openalex.org/W2090106970","https://openalex.org/W2330813584","https://openalex.org/W6987843696"],"abstract_inverted_index":{"Accurate":[0],"diagnosis":[1,159],"is":[2,22,179],"essential":[3],"for":[4,32,46,116,157],"the":[5,35,54,85,158,177],"effective":[6],"management":[7],"of":[8,56,67,118,160],"suspected":[9,94],"bone":[10,89,95,102,112,161,174],"infection.":[11],"Current":[12],"imaging":[13,79,103,107,148],"techniques":[14,28],"have":[15,29,38,50],"had":[16],"limited":[17],"success":[18],"and":[19,44,76,82,104,124,138],"further":[20],"work":[21],"required.":[23],"Although":[24],"white":[25,135,146],"cell":[26,136,147],"labelling":[27,63],"been":[30,51,150],"available":[31],"many":[33],"years":[34],"radiopharmaceuticals":[36],"employed":[37],"disadvantages,":[39],"particularly":[40],"in":[41,60,78],"their":[42],"availability":[43],"suitability":[45],"imaging.":[47,90],"These":[48],"problems":[49],"overcome":[52],"by":[53],"use":[55],"99Tcm-HMPAO":[57,145],"as":[58],"an":[59,154],"vitro":[61],"leukocyte":[62,106],"agent.":[64],"The":[65],"aims":[66],"this":[68],"study":[69],"were":[70,114,121,126,131],"to":[71,83,152],"assess":[72],"retrospectively":[73],"its":[74],"role":[75],"accuracy":[77],"orthopaedic":[80],"infection":[81,96,141,162],"compare":[84],"results":[86],"with":[87,93],"three-phase":[88,98,173],"30":[91],"patients":[92],"underwent":[97],"methylene":[99],"diphosphonate":[100],"(MDP)":[101],"labelled":[105],"on":[108,172],"separate":[109],"occasions.":[110],"16":[111],"scans":[113],"positive":[115,134,170],"infection,":[117],"which":[119],"14":[120],"subsequently":[122],"confirmed,":[123],"there":[125],"no":[127,132],"false":[128,133],"negatives.":[129],"There":[130],"studies":[137],"only":[139,167],"one":[140],"was":[142],"not":[143],"identified.":[144],"has":[149],"shown":[151],"be":[153,165],"accurate":[155],"technique":[156],"but":[163,182],"should":[164],"performed":[166],"following":[168],"a":[169,188],"finding":[171],"scanning,":[175],"since":[176],"latter":[178],"highly":[180],"sensitive":[181],"significantly":[183],"less":[184],"expensive,":[185],"making":[186],"it":[187],"more":[189],"appropriate":[190],"screening":[191],"procedure.":[192]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}