{"id":"https://openalex.org/W2170997374","doi":"https://doi.org/10.1210/jc.2003-031822","title":"The Relationship of Fasting Serum Radioimmune Insulin Levels to Incident Coronary Heart Disease in an Insulin-Treated Diabetic Cohort","display_name":"The Relationship of Fasting Serum Radioimmune Insulin Levels to Incident Coronary Heart Disease in an Insulin-Treated Diabetic Cohort","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2170997374","doi":"https://doi.org/10.1210/jc.2003-031822","mag":"2170997374","pmid":"https://pubmed.ncbi.nlm.nih.gov/15181068"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2003-031822","doi":"https://doi.org/10.1210/jc.2003-031822","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-031822","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035106740","display_name":"Richard A. Kronmal","orcid":"https://orcid.org/0000-0002-9897-7076","observed_orcids":["https://orcid.org/0000-0002-9897-7076"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Kronmal","raw_affiliation_strings":["Department of Biostatistics, University of Washington (R.A.K.), Seattle, Washington 98115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington (R.A.K.), Seattle, Washington 98115","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006293947","display_name":"Joshua I. Barzilay","orcid":"https://orcid.org/0000-0001-7044-4166","observed_orcids":["https://orcid.org/0000-0001-7044-4166"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua I. Barzilay","raw_affiliation_strings":["Kaiser Permanente of Georgia and Division of Endocrinology, Emory University (J.I.B.), Atlanta, Georgia 30082"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kaiser Permanente of Georgia and Division of Endocrinology, Emory University (J.I.B.), Atlanta, Georgia 30082","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048908501","display_name":"Russell P. Tracy","orcid":"https://orcid.org/0000-0002-0080-2420","observed_orcids":["https://orcid.org/0000-0002-0080-2420"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell P. Tracy","raw_affiliation_strings":["Department of Pathology and Biochemistry, University of Vermont College of Medicine (R.P.T.), Colchester, Vermont 05446"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Biochemistry, University of Vermont College of Medicine (R.P.T.), Colchester, Vermont 05446","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041967659","display_name":"Peter J. Savage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J. Savage","raw_affiliation_strings":["Division of Epidemiology and Clinical Applications, National Heart, Lung, Blood Institute, National Institutes of Health (P.J.S.), Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Epidemiology and Clinical Applications, National Heart, Lung, Blood Institute, National Institutes of Health (P.J.S.), Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005102981","display_name":"Trevor John Orchard","orcid":"https://orcid.org/0000-0001-9552-3215","observed_orcids":["https://orcid.org/0000-0001-9552-3215"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor J. Orchard","raw_affiliation_strings":["Department of Epidemiology, Graduate School of Public Health (T.J.O.), University of Pittsburgh, Pittsburgh, Pennsylvania 15251"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Graduate School of Public Health (T.J.O.), University of Pittsburgh, Pittsburgh, Pennsylvania 15251","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036551563","display_name":"Gregory L. Burke","orcid":"https://orcid.org/0000-0002-9347-7873","observed_orcids":["https://orcid.org/0000-0002-9347-7873","https://orcid.org/0000-0002-6771-4943"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory L. Burke","raw_affiliation_strings":["Department of Public Health Sciences, Wake Forest University School of Medicine (G.L.B.), Winston-Salem, North Carolina 27157"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health Sciences, Wake Forest University School of Medicine (G.L.B.), Winston-Salem, North Carolina 27157","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.0318,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.80071483,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"89","issue":"6","first_page":"2852","last_page":"2858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.826200008392334,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.09809999912977219,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.04410000145435333,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.44699999690055847},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.8650000095367432},{"id":"https://openalex.org/keywords/insulin-treated-diabetes","display_name":"insulin-treated diabetes","score":0.625},{"id":"https://openalex.org/keywords/fasting-insulin","display_name":"fasting insulin","score":0.5569999814033508},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5070000290870667},{"id":"https://openalex.org/keywords/proinsulin","display_name":"proinsulin","score":0.7749999761581421},{"id":"https://openalex.org/keywords/insulin-antibodies","display_name":"insulin antibodies","score":0.9760000109672546},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.8169999718666077},{"id":"https://openalex.org/keywords/insulin-therapy","display_name":"insulin therapy","score":0.7260000109672546}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.8537622094154358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8137698173522949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7668089866638184},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7091540694236755},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.59713214635849},{"id":"https://openalex.org/C90061646","wikidata":"https://www.wikidata.org/wiki/Q426173","display_name":"Proinsulin","level":3,"score":0.551332414150238},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5266504287719727},{"id":"https://openalex.org/C176674119","wikidata":"https://www.wikidata.org/wiki/Q11582","display_name":"Liter","level":2,"score":0.5238621234893799},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.4490448236465454},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4398535490036011},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4351623058319092},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.42882055044174194},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.4273108243942261},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4147312641143799},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2533458173274994}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.2003-031822","doi":"https://doi.org/10.1210/jc.2003-031822","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-031822","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:15181068","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15181068","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmid:15531557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15531557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G161289361","display_name":"CORONARY HEART DISEASE AND STROKE","funder_award_id":"n01hc085079-024","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1659331632","display_name":"MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY","funder_award_id":"n01hc015103-009","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1909643007","display_name":null,"funder_award_id":"N01HC15103","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7651489270","display_name":"CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY","funder_award_id":"n01hc035129-010","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G905887895","display_name":null,"funder_award_id":"N01-HC85079","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G960597250","display_name":null,"funder_award_id":"N01HC35129","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W95932901","https://openalex.org/W1873738835","https://openalex.org/W1969894862","https://openalex.org/W1978027514","https://openalex.org/W1979952662","https://openalex.org/W1984553087","https://openalex.org/W1987505479","https://openalex.org/W1999775886","https://openalex.org/W2049124610","https://openalex.org/W2049637077","https://openalex.org/W2054092776","https://openalex.org/W2063131612","https://openalex.org/W2068596738","https://openalex.org/W2069824034","https://openalex.org/W2094595851","https://openalex.org/W2102906564","https://openalex.org/W2104055366","https://openalex.org/W2113510279","https://openalex.org/W2116977853","https://openalex.org/W2117196705","https://openalex.org/W2133691474","https://openalex.org/W2150939399","https://openalex.org/W2151169124","https://openalex.org/W2161197885","https://openalex.org/W2164846176","https://openalex.org/W2168280281","https://openalex.org/W2265061734","https://openalex.org/W2318236356","https://openalex.org/W2410080958","https://openalex.org/W2421065843","https://openalex.org/W2465067193","https://openalex.org/W4234853462","https://openalex.org/W4302415630","https://openalex.org/W4321429522"],"related_works":["https://openalex.org/W2009373999","https://openalex.org/W2152414855","https://openalex.org/W2126267442","https://openalex.org/W2103077445","https://openalex.org/W3146193974","https://openalex.org/W7098178740","https://openalex.org/W2066613154","https://openalex.org/W1976471579","https://openalex.org/W124856878","https://openalex.org/W2011955055"],"abstract_inverted_index":{"It":[0],"is":[1],"not":[2],"known":[3],"whether":[4],"insulin":[5,11,62,80,145,148,158,165,195],"levels,":[6],"in":[7,87,110,119,174],"the":[8,68,88,111,120,140],"setting":[9],"of":[10,27,44,139,177],"treatment,":[12],"are":[13],"an":[14,96,128,168],"independent":[15,169],"risk":[16,101,132,170],"factor":[17,171],"for":[18,38,71,172,194],"coronary":[19],"heart":[20],"disease":[21],"(CHD).":[22],"We":[23],"studied":[24],"a":[25,65],"cohort":[26,141],"116":[28],"insulin-treated":[29,178],"individuals,":[30],"65":[31],"yr":[32],"or":[33],"older,":[34],"who":[35],"were":[36,42,49,82,150,167],"followed":[37],"5.6-9":[39],"yr.":[40],"All":[41],"free":[43],"CHD":[45,52,72,173],"at":[46],"baseline.":[47],"There":[48],"47":[50],"incident":[51],"events.":[53],"In":[54],"Cox":[55],"proportional":[56],"hazards":[57],"modeling,":[58],"with":[59,108,153],"fasting":[60,163],"immune-reactive":[61,164],"levels":[63,81,149,166],"as":[64],"continuous":[66],"variable,":[67],"hazard":[69],"ratio":[70],"was":[73],"statistically":[74],"significant":[75],"(P":[76],"<":[77,135],"0.0001).":[78,136],"When":[79],"divided":[83],"into":[84],"intervals,":[85],"those":[86,109],"third":[89],"interval":[90,113,122],"[43-150":[91],"microU/ml":[92,115,124],"(258-900":[93],"pmol/liter)]":[94,126],"had":[95,127,142],"adjusted":[97,129],"30%":[98],"increased":[99,131],"relative":[100],"(95%":[102],"confidence":[103],"interval,":[104],"0.57,":[105],"2.98)":[106],"compared":[107],"first":[112],"[<20":[114],"(<120":[116],"pmol/liter)].":[117],"Those":[118],"fourth":[121],"[151-400":[123],"(906-2400":[125],"5.6-fold":[130],"(2.3-13.1;":[133],"P":[134],"Approximately":[137],"15%":[138],"such":[143],"elevated":[144,162],"levels.":[146,160],"Immune-reactive":[147],"strongly":[151],"correlated":[152],"specific":[154],"insulin,":[155],"proinsulin,":[156],"and":[157],"antibody":[159],"Markedly":[161],"this":[175],"study":[176],"older":[179],"adults.":[180],"These":[181],"observational":[182],"findings":[183],"should":[184],"be":[185],"confirmed":[186],"through":[187],"larger":[188],"prospective":[189],"studies,":[190],"given":[191],"their":[192],"implications":[193],"therapy.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}