{"id":"https://openalex.org/W2170995374","doi":"https://doi.org/10.1093/hmg/11.17.1967","title":"Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor","display_name":"Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor","publication_year":2002,"publication_date":"2002-08-15","ids":{"openalex":"https://openalex.org/W2170995374","doi":"https://doi.org/10.1093/hmg/11.17.1967","mag":"2170995374","pmid":"https://pubmed.ncbi.nlm.nih.gov/12165558"},"language":"en","primary_location":{"id":"doi:10.1093/hmg/11.17.1967","doi":"https://doi.org/10.1093/hmg/11.17.1967","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/11.17.1967","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064188953","display_name":"Andrew P. Lieberman","orcid":"https://orcid.org/0000-0001-9032-580X","observed_orcids":["https://orcid.org/0000-0001-9032-580X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. P. Lieberman","raw_affiliation_strings":["Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. liebermn@umich.edu","Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. liebermn@umich.edu","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064188953"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":3.3424,"has_fulltext":false,"cited_by_count":142,"citation_normalized_percentile":{"value":0.93193304,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"11","issue":"17","first_page":"1967","last_page":"1976"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.8169999718666077},{"id":"https://openalex.org/keywords/polyglutamine-expansion","display_name":"polyglutamine expansion","score":0.9150000214576721},{"id":"https://openalex.org/keywords/spinal-and-bulbar-muscular-atrophy","display_name":"spinal and bulbar muscular atrophy","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cag-repeat-expansion","display_name":"CAG repeat expansion","score":0.8040000200271606},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-degradation","display_name":"ubiquitin-proteasome degradation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/protein-acetylation","display_name":"protein acetylation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.7599999904632568},{"id":"https://openalex.org/keywords/trophic-effects","display_name":"trophic effects","score":0.6570000052452087},{"id":"https://openalex.org/keywords/loss-of-function","display_name":"loss of function","score":0.546999990940094},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8641310930252075},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.7876816987991333},{"id":"https://openalex.org/C2780434838","wikidata":"https://www.wikidata.org/wiki/Q1995327","display_name":"Spinal and bulbar muscular atrophy","level":5,"score":0.767042875289917},{"id":"https://openalex.org/C2777616661","wikidata":"https://www.wikidata.org/wiki/Q7226416","display_name":"Polyglutamine tract","level":5,"score":0.6825326085090637},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.658845067024231},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.599598228931427},{"id":"https://openalex.org/C17971392","wikidata":"https://www.wikidata.org/wiki/Q18027445","display_name":"5-HT5A receptor","level":3,"score":0.5271329879760742},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4819938540458679},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4425915777683258},{"id":"https://openalex.org/C2779926675","wikidata":"https://www.wikidata.org/wiki/Q6943700","display_name":"Mutant protein","level":4,"score":0.42940041422843933},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33599182963371277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2878139615058899},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2510083317756653},{"id":"https://openalex.org/C2781427258","wikidata":"https://www.wikidata.org/wiki/Q2620886","display_name":"Huntingtin","level":4,"score":0.14005139470100403},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009134","descriptor_name":"Muscular Atrophy, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009134","descriptor_name":"Muscular Atrophy, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009134","descriptor_name":"Muscular Atrophy, Spinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009134","descriptor_name":"Muscular Atrophy, Spinal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009134","descriptor_name":"Muscular Atrophy, Spinal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009134","descriptor_name":"Muscular Atrophy, Spinal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019680","descriptor_name":"Trinucleotide Repeat Expansion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019680","descriptor_name":"Trinucleotide Repeat Expansion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019680","descriptor_name":"Trinucleotide Repeat Expansion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045165","descriptor_name":"Testosterone Congeners","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045165","descriptor_name":"Testosterone Congeners","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045165","descriptor_name":"Testosterone Congeners","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/hmg/11.17.1967","doi":"https://doi.org/10.1093/hmg/11.17.1967","is_oa":false,"landing_page_url":"https://doi.org/10.1093/hmg/11.17.1967","pdf_url":null,"source":{"id":"https://openalex.org/S166515463","display_name":"Human Molecular Genetics","issn_l":"0964-6906","issn":["0964-6906","1460-2083"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:12165558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12165558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human molecular genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.4399999976158142,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306725","display_name":"Hereditary Disease Foundation","ror":"https://ror.org/02a3w7r50"},{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1484666375","https://openalex.org/W1526142701","https://openalex.org/W1527609591","https://openalex.org/W1529494566","https://openalex.org/W1532930401","https://openalex.org/W1541950149","https://openalex.org/W1569018103","https://openalex.org/W1588279803","https://openalex.org/W1617816798","https://openalex.org/W1643390591","https://openalex.org/W1820767944","https://openalex.org/W1950891478","https://openalex.org/W1975658312","https://openalex.org/W1977383752","https://openalex.org/W1978580506","https://openalex.org/W1988797567","https://openalex.org/W1989429141","https://openalex.org/W1996920204","https://openalex.org/W1997555550","https://openalex.org/W1998476721","https://openalex.org/W2000731870","https://openalex.org/W2003511983","https://openalex.org/W2013029120","https://openalex.org/W2015441541","https://openalex.org/W2016756042","https://openalex.org/W2021549542","https://openalex.org/W2032255653","https://openalex.org/W2033325995","https://openalex.org/W2034493211","https://openalex.org/W2040762618","https://openalex.org/W2042437056","https://openalex.org/W2042716629","https://openalex.org/W2043888873","https://openalex.org/W2043899474","https://openalex.org/W2050310623","https://openalex.org/W2056545208","https://openalex.org/W2057810961","https://openalex.org/W2058731494","https://openalex.org/W2067953302","https://openalex.org/W2075782851","https://openalex.org/W2079250951","https://openalex.org/W2083229159","https://openalex.org/W2086762476","https://openalex.org/W2093045406","https://openalex.org/W2094478098","https://openalex.org/W2095265125","https://openalex.org/W2099685145","https://openalex.org/W2099997349","https://openalex.org/W2101065984","https://openalex.org/W2102513168","https://openalex.org/W2103636084","https://openalex.org/W2104340629","https://openalex.org/W2106786078","https://openalex.org/W2113333419","https://openalex.org/W2113998330","https://openalex.org/W2117138295","https://openalex.org/W2122440289","https://openalex.org/W2122631256","https://openalex.org/W2130538948","https://openalex.org/W2132082381","https://openalex.org/W2132513906","https://openalex.org/W2136364567","https://openalex.org/W2140594382","https://openalex.org/W2141153456","https://openalex.org/W2145669564","https://openalex.org/W2146027649","https://openalex.org/W2146267270","https://openalex.org/W2148688106","https://openalex.org/W2157513658","https://openalex.org/W2157618233","https://openalex.org/W2159178453","https://openalex.org/W2161197775","https://openalex.org/W2165589182","https://openalex.org/W2166131777","https://openalex.org/W2168302341","https://openalex.org/W2249338989"],"related_works":["https://openalex.org/W2161197775","https://openalex.org/W2031352187","https://openalex.org/W2101065984","https://openalex.org/W1999596673","https://openalex.org/W2042608723","https://openalex.org/W2066079419","https://openalex.org/W1998476721","https://openalex.org/W1995183094","https://openalex.org/W2079196978","https://openalex.org/W2499515695"],"abstract_inverted_index":{"Kennedy's":[0],"disease":[1,5],"is":[2,14,168],"a":[3,17,42,56,115,153,162,212,245],"degenerative":[4],"of":[6,16,24,46,51,122,128,156,164,174,192,202,215],"motor":[7],"neurons":[8],"in":[9,67,99,189,199,222],"which":[10],"the":[11,21,25,62,65,73,81,105,129,138,148,175,190,195,200,219],"causative":[12],"mutation":[13],"expansion":[15,230],"CAG/polyglutamine":[18],"tract":[19],"near":[20],"5'":[22],"end":[23],"androgen":[26,68,83,232],"receptor":[27,69,84,107,150,180,197,221,233],"gene.":[28],"The":[29,178],"mutant":[30,106,130,149,179,220],"protein":[31,131],"misfolds,":[32],"aggregates,":[33],"and":[34,48,158,206,239],"interacts":[35],"abnormally":[36],"with":[37,85,108,125,211],"other":[38],"proteins,":[39],"leading":[40],"to":[41,60,90,133,160],"novel,":[43],"toxic":[44],"gain":[45,214],"function":[47,70,123,216,234],"an":[49],"alteration":[50],"normal":[52],"function.":[53],"We":[54],"used":[55],"cell":[57],"culture":[58],"model":[59],"explore":[61],"mechanisms":[63],"underlying":[64],"alterations":[66],"conferred":[71],"by":[72,92,137,171,218,235,240],"mutation.":[74],"Here":[75],"we":[76],"show":[77,114],"that":[78,147,194,228],"cells":[79,103],"expressing":[80,104],"wild-type":[82,176,196],"24":[86],"CAG":[87,110],"repeats":[88,111],"respond":[89],"ligand":[91,172,193],"showing":[93],"trophic":[94,117],"effects":[95],"including":[96,204],"prolonged":[97],"survival":[98],"low":[100],"serum,":[101],"whereas":[102],"65":[109],"do":[112],"not":[113],"robust":[116],"response.":[118],"This":[119],"partial":[120,154],"loss":[121,155],"correlates":[124],"decreased":[126],"levels":[127],"due":[132],"its":[134,237,242],"preferential":[135],"degradation":[136,238],"ubiquitin-proteasome":[139],"pathway.":[140],"Expression":[141],"analysis":[142],"using":[143],"oligonucleotide":[144],"arrays":[145],"confirms":[146],"has":[151,181],"undergone":[152,183],"function,":[157],"fails":[159],"regulate":[161],"subset":[163],"genes":[165],"whose":[166],"expression":[167,223],"normally":[169],"affected":[170],"activation":[173],"receptor.":[177],"also":[182],"several":[184],"functionally":[185],"important":[186],"post-translational":[187],"modifications":[188,209],"absence":[191],"undergoes":[198],"presence":[201],"ligand,":[203],"acetylation":[205],"phosphorylation.":[207],"These":[208],"correlate":[210],"ligand-independent":[213],"exhibited":[217],"analysis.":[224],"Our":[225],"findings":[226],"suggest":[227],"polyglutamine":[229],"alters":[231],"promoting":[236],"modifying":[241],"activity":[243],"as":[244],"transcription":[246],"factor.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}