{"id":"https://openalex.org/W2170934916","doi":null,"title":"The effect of paxilline on early alterations of electrophysiological properties of dentate gyrus granule cells in pilocarpine-treated rats.","display_name":"The effect of paxilline on early alterations of electrophysiological properties of dentate gyrus granule cells in pilocarpine-treated rats.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2170934916","mag":"2170934916","pmid":"https://pubmed.ncbi.nlm.nih.gov/24711838","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3977062"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3977062","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3977062/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3977062/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Pharm Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3977062/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006931297","display_name":"Nasrin Mehranfard","orcid":"https://orcid.org/0000-0002-7298-0189","observed_orcids":["https://orcid.org/0000-0002-7298-0189"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nasrin Mehranfard","raw_affiliation_strings":["Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041036148","display_name":"Hamid Gholami Pourbadie","orcid":"https://orcid.org/0000-0002-7634-7428","observed_orcids":["https://orcid.org/0000-0002-7634-7428"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hamid Gholamipour-Badie","raw_affiliation_strings":["Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090302298","display_name":"Fereshteh Motamedi","orcid":"https://orcid.org/0000-0003-4030-8627","observed_orcids":["https://orcid.org/0000-0003-4030-8627"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fereshteh Motamedi","raw_affiliation_strings":["Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007815716","display_name":"Mahyar Janahmadi","orcid":"https://orcid.org/0000-0002-7242-3964","observed_orcids":["https://orcid.org/0000-0002-7242-3964"]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahyar Janahmadi","raw_affiliation_strings":["Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Department of Physiology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032407549","display_name":"Nima Naderi","orcid":"https://orcid.org/0000-0003-4591-8918","observed_orcids":["https://orcid.org/0000-0003-4591-8918"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nima Naderi","raw_affiliation_strings":["Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8443,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.71599059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"13","issue":"Suppl","first_page":"125","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paxilline","display_name":"paxilline","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dentate-granule-cells","display_name":"dentate gyrus granule cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/temporal-lobe-epilepsy","display_name":"temporal lobe epilepsy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pilocarpine-induced-seizures","display_name":"pilocarpine-induced seizures","score":0.9409999847412109},{"id":"https://openalex.org/keywords/intrinsic-excitability","display_name":"intrinsic excitability","score":0.6579999923706055},{"id":"https://openalex.org/keywords/bapta","display_name":"BAPTA","score":0.7070000171661377},{"id":"https://openalex.org/keywords/bk-channels","display_name":"BK channels","score":0.890999972820282},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.656000018119812},{"id":"https://openalex.org/keywords/firing-rate","display_name":"firing rate","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.8959439992904663},{"id":"https://openalex.org/C93872552","wikidata":"https://www.wikidata.org/wiki/Q4690722","display_name":"Afterhyperpolarization","level":3,"score":0.661292552947998},{"id":"https://openalex.org/C2777204577","wikidata":"https://www.wikidata.org/wiki/Q411461","display_name":"Pilocarpine","level":3,"score":0.649759829044342},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.626426637172699},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.5217916965484619},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5026590824127197},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4919719398021698},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48041510581970215},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4728853106498718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45915451645851135},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4451773762702942},{"id":"https://openalex.org/C2778888523","wikidata":"https://www.wikidata.org/wiki/Q1777753","display_name":"Granule cell","level":4,"score":0.4307229816913605},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.4175381660461426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37595683336257935},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36730265617370605},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15484833717346191}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3977062","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3977062/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3977062/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Pharm Res","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2959893","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3977062","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24711838","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24711838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of pharmaceutical research : IJPR","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.785.7384","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.785.7384","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/82/64/ijpr-13-125.PMC3977062.pdf","raw_type":"text"},{"id":"mag:2170934916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24711838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3977062","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3977062/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3977062/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Pharm Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323457","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170934916.pdf","grobid_xml":"https://content.openalex.org/works/W2170934916.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W1983219116","https://openalex.org/W1991673195","https://openalex.org/W1993938009","https://openalex.org/W2001625371","https://openalex.org/W2007860569","https://openalex.org/W2068083065","https://openalex.org/W2088481798","https://openalex.org/W2119397841","https://openalex.org/W2162634566","https://openalex.org/W2167607970"],"related_works":["https://openalex.org/W7099326163","https://openalex.org/W2040961386","https://openalex.org/W2058464828","https://openalex.org/W2342280861","https://openalex.org/W2164929734","https://openalex.org/W1984255188","https://openalex.org/W7099857689","https://openalex.org/W1906116459","https://openalex.org/W1979339760","https://openalex.org/W7100127865"],"abstract_inverted_index":{"The":[0,111,231],"dentate":[1,31],"gyrus":[2,32],"of":[3,21,30,56,61,68,88,96,113,121,125,141,173,180,197,215,236,243,248,263,270,273],"hippocampus":[4],"has":[5,36],"long":[6],"been":[7,37],"considered":[8,38],"as":[9,39],"a":[10,82,117,201],"focal":[11],"point":[12],"for":[13,18],"studies":[14],"on":[15],"mechanisms":[16],"responsible":[17,43],"the":[19,53,86,171,260],"development":[20],"temporal":[22,45],"lobe":[23,46],"epilepsy":[24],"(TLE).":[25],"Change":[26],"in":[27,44,85,119,123,148,151,170,178,204,233,267],"intrinsic":[28,54,271],"properties":[29,55,115,235,272],"granule":[33],"cells":[34],"(GCs)":[35],"an":[40,168],"important":[41],"factor":[42],"seizures.":[47],"In":[48,166],"this":[49],"study,":[50],"we":[51],"evaluated":[52],"GCs,":[57],"during":[58],"acute":[59],"phase":[60],"seizure":[62,126,152,181,198],"(24":[63],"h":[64],"after":[65,92,240],"i.p.":[66],"injection":[67],"pilocarpine)":[69],"compared":[70,107,132,158,187,227],"to":[71,108,133,143,159,188,228],"sham":[72,109,134,160,189,229],"group":[73,127,135,153,161,182,190,199],"using":[74],"whole":[75],"cell":[76],"patch-clamp":[77],"recordings.":[78],"Our":[79,257],"results":[80,258],"showed":[81,200],"significant":[83,202],"increase":[84,169,203],"number":[87],"action":[89],"potentials":[90],"(APs)":[91],"applying":[93],"depolarizing":[94,213],"currents":[95,214],"200":[97,216],"pA":[98,217,223],"(p":[99,104],"<":[100,105,219,225],"0.01)":[101,220],"and":[102,208,221],"250pA":[103],"0.05)":[106,226],"group.":[110,230],"evaluation":[112],"AP":[114,122,149],"revealed":[116],"decrease":[118],"half-width":[120,150],"GCs":[124,179,196,237,274],"(1.27":[128],"\u00b1":[129,137,155,163,184,192],"0.03":[130],"ms)":[131,157],"(1.60":[136],"0.11).":[138],"Moreover,":[139],"addition":[140],"BAPTA":[142],"pipette":[144],"solution":[145],"prevented":[146],"changes":[147,232,269],"(1.71":[154],"0.11":[156],"(1.91":[162],"0.08":[164],"ms).":[165],"contrast,":[167],"amplitude":[172],"fast":[174],"afterhyperpolarization":[175],"was":[176],"observed":[177],"(-11.68":[183],"0.72":[185],"mV)":[186],"(-8.28":[191],"0.59":[193],"mV).":[194],"Also,":[195],"both":[205],"firing":[206,210],"rate":[207],"instantaneous":[209],"frequency":[211],"at":[212],"(P":[218,224],"250":[222],"electrophysiological":[234],"were":[238],"attenuated":[239],"bath":[241],"application":[242],"paxilline":[244],"suggesting":[245],"possible":[246,261],"involvement":[247,262],"large":[249],"conductance":[250],"Ca(2+)-":[251],"activated":[252],"K(+)":[253],"channel":[254],"(BK":[255],"channel).":[256],"suggested":[259],"certain":[264],"potassium":[265],"channels":[266],"early":[268],"which":[275],"eventually":[276],"facilitate":[277],"TLE":[278],"development.":[279]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}