{"id":"https://openalex.org/W2170931378","doi":"https://doi.org/10.1177/107602969900500407","title":"Effects of Ticlopidine or Ticlopidine Plus Aspirin on Platelet Aggregation and ATP Release in Normal Volunteers: Why Aspirin Improves Ticlopidine Antiplatelet Activity","display_name":"Effects of Ticlopidine or Ticlopidine Plus Aspirin on Platelet Aggregation and ATP Release in Normal Volunteers: Why Aspirin Improves Ticlopidine Antiplatelet Activity","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2170931378","doi":"https://doi.org/10.1177/107602969900500407","mag":"2170931378","pmid":"https://pubmed.ncbi.nlm.nih.gov/10726021"},"language":"en","primary_location":{"id":"doi:10.1177/107602969900500407","doi":"https://doi.org/10.1177/107602969900500407","is_oa":false,"landing_page_url":"https://doi.org/10.1177/107602969900500407","pdf_url":null,"source":{"id":"https://openalex.org/S8942861","display_name":"Clinical and Applied Thrombosis/Hemostasis","issn_l":"1076-0296","issn":["1076-0296","1938-2723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Thrombosis/Hemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111882344","display_name":"Ra\u00fal Altman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raul Altman","raw_affiliation_strings":["Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111635976","display_name":"Alejandra Scazziota","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alejandra Scazziota","raw_affiliation_strings":["Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054933132","display_name":"Jorge Rouvier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Rouvier","raw_affiliation_strings":["Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058591494","display_name":"Claudio Daniel Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-3772-8850","observed_orcids":["https://orcid.org/0000-0002-3772-8850"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudio Gonzalez","raw_affiliation_strings":["Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Trombosis de Buenos Aires, Buenos Aires, Argentina","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.25775138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"5","issue":"4","first_page":"243","last_page":"246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ticlopidine","display_name":"ticlopidine","score":1.0},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/atp-release","display_name":"ATP release","score":0.921999990940094},{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.7099999785423279},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.5849999785423279},{"id":"https://openalex.org/keywords/sodium-arachidonate","display_name":"sodium arachidonate","score":0.7390000224113464},{"id":"https://openalex.org/keywords/adp-induced-platelet-aggregation","display_name":"ADP-induced aggregation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/platelet-rich-plasma","display_name":"platelet-rich plasma","score":0.8790000081062317},{"id":"https://openalex.org/keywords/arterial-thrombosis-prevention","display_name":"arterial thrombosis prevention","score":0.8889999985694885},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2778905298","wikidata":"https://www.wikidata.org/wiki/Q420571","display_name":"Ticlopidine","level":4,"score":0.9817746877670288},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.8374006152153015},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.6748953461647034},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.5898485779762268},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.561045229434967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.54749596118927},{"id":"https://openalex.org/C2777265216","wikidata":"https://www.wikidata.org/wiki/Q721432","display_name":"Antiplatelet drug","level":4,"score":0.5056724548339844},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29067462682724},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.21924281120300293}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013988","descriptor_name":"Ticlopidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1177/107602969900500407","doi":"https://doi.org/10.1177/107602969900500407","is_oa":false,"landing_page_url":"https://doi.org/10.1177/107602969900500407","pdf_url":null,"source":{"id":"https://openalex.org/S8942861","display_name":"Clinical and Applied Thrombosis/Hemostasis","issn_l":"1076-0296","issn":["1076-0296","1938-2723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Applied Thrombosis/Hemostasis","raw_type":"journal-article"},{"id":"pmid:10726021","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10726021","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W101025972","https://openalex.org/W163446288","https://openalex.org/W311320695","https://openalex.org/W1967020682","https://openalex.org/W1994275785","https://openalex.org/W1994345090","https://openalex.org/W2030568508","https://openalex.org/W2033843102","https://openalex.org/W2035545749","https://openalex.org/W2043614295","https://openalex.org/W2055005867","https://openalex.org/W2057441537","https://openalex.org/W2080649274","https://openalex.org/W2085652917","https://openalex.org/W2087910063","https://openalex.org/W2091709324","https://openalex.org/W2149799516","https://openalex.org/W2318352361","https://openalex.org/W2327850977","https://openalex.org/W2331216347","https://openalex.org/W2410758333","https://openalex.org/W2412532840"],"related_works":["https://openalex.org/W2355563412","https://openalex.org/W2427629123","https://openalex.org/W46220096","https://openalex.org/W2005425377","https://openalex.org/W1867144861","https://openalex.org/W2149799516","https://openalex.org/W2087910063","https://openalex.org/W2883687788","https://openalex.org/W2145613695","https://openalex.org/W2326682431"],"abstract_inverted_index":{"Aspirin":[0,141,158],"and":[1,32,42,94,121,142,183],"ticlopidine":[2,13,27,31,96,126,138,143,160,168,178],"are":[3],"used":[4],"to":[5,37,130,175],"prevent":[6,164],"arterial":[7,190],"thrombosis.":[8],"In":[9],"some":[10],"clinical":[11],"settings":[12],"is":[14],"administered":[15,23],"with":[16,67,177],"aspirin":[17,24,33,155,170,174],"for":[18,34],"improving":[19],"antithrombotic":[20],"effect.":[21],"We":[22],"(100":[25],"mg/day),":[26,29],"(500":[28],"or":[30,50,127,159],"7":[35],"days":[36],"healthy":[38],"volunteers.":[39],"Platelet":[40],"aggregation":[41,77,87],"ATP":[43],"release":[44,150],"induced":[45],"by":[46],"sodium":[47,107],"arachidonate,":[48],"ADP,":[49],"a":[51,74,84],"combination":[52],"of":[53,78,173],"both":[54],"were":[55],"measured.":[56],"Sodium":[57],"arachidonate":[58,108],"(0.25":[59],"mmol/L),":[60],"which":[61,72],"produces":[62],"no":[63],"platelet":[64,76,86,165],"aggregation,":[65],"combined":[66],"adenosine":[68,112,148],"diphosphate":[69,113],"(1":[70],"mumol/L),":[71],"produced":[73],"reversible":[75],"20%":[79],"after":[80,106,125,137],"ticlopidine,":[81],"resulted":[82],"in":[83,89,95,189],"synergistic":[85],"response":[88],"normal":[90],"(74.6":[91],"+/-":[92,100,119,123,132],"9.2%)":[93],"platelet-rich":[97],"plasma":[98],"(59.1%":[99],"14.9%,":[101],"p":[102],"<":[103,135],"0.0001).":[104],"Synergism":[105],"(0.75":[109],"mmol/L)":[110],"plus":[111,139,156,169],"(4":[114],"mumol/L)":[115],"fell":[116],"from":[117],"75.8%":[118],"11.0%":[120],"59.1%":[122],"15.6%":[124],"aspirin,":[128],"respectively,":[129],"14.8%":[131],"18.0%":[133],"(p":[134],"0.0001)":[136],"aspirin.":[140],"alone":[144],"did":[145,154],"not":[146,162],"inhibit":[147],"triphosphate":[149],"as":[151,153,167],"thoroughly":[152],"ticlopidine.":[157],"does":[161],"adequately":[163],"activity":[166,182],"do.":[171],"Addition":[172],"treatment":[176],"improves":[179],"their":[180],"antiplatelet":[181],"better":[184],"results":[185],"could":[186],"be":[187],"obtained":[188],"thrombotic":[191],"prevention":[192],"strategies.":[193]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
