{"id":"https://openalex.org/W2170927895","doi":"https://doi.org/10.1002/jso.21481","title":"Neoadjuvant treatment of soft\u2010tissue sarcoma: A multimodality approach","display_name":"Neoadjuvant treatment of soft\u2010tissue sarcoma: A multimodality approach","publication_year":2010,"publication_date":"2010-02-24","ids":{"openalex":"https://openalex.org/W2170927895","doi":"https://doi.org/10.1002/jso.21481","mag":"2170927895","pmid":"https://pubmed.ncbi.nlm.nih.gov/20187067"},"language":"en","primary_location":{"id":"doi:10.1002/jso.21481","doi":"https://doi.org/10.1002/jso.21481","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jso.21481","pdf_url":null,"source":{"id":"https://openalex.org/S13860802","display_name":"Journal of Surgical Oncology","issn_l":"0022-4790","issn":["0022-4790","1096-9098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031909010","display_name":"David Reynoso","orcid":"https://orcid.org/0000-0002-2639-4197","observed_orcids":["https://orcid.org/0000-0002-2639-4197"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Reynoso","raw_affiliation_strings":["Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas 77030, USA","Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043675371","display_name":"Vivek Subbiah","orcid":"https://orcid.org/0000-0002-6064-6837","observed_orcids":["https://orcid.org/0000-0002-6064-6837"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Subbiah","raw_affiliation_strings":["Department of Pediatric Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004418792","display_name":"Jonathan C. Trent","orcid":"https://orcid.org/0000-0001-6169-5238","observed_orcids":["https://orcid.org/0000-0001-6169-5238"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan C. Trent","raw_affiliation_strings":["Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053686676","display_name":"B. Ashleigh Guadagnolo","orcid":"https://orcid.org/0000-0002-4489-7070","observed_orcids":["https://orcid.org/0000-0002-4489-7070"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Ashleigh Guadagnolo","raw_affiliation_strings":["Department of Radiation Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050445982","display_name":"Alexander J. Lazar","orcid":"https://orcid.org/0000-0002-6395-4499","observed_orcids":["https://orcid.org/0000-0002-6395-4499"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander J. Lazar","raw_affiliation_strings":["Department of Pathology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046099119","display_name":"Robert S. Benjamin","orcid":"https://orcid.org/0000-0002-2589-5870","observed_orcids":["https://orcid.org/0000-0002-2589-5870"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Benjamin","raw_affiliation_strings":["Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066442021","display_name":"Raphael E. Pollock","orcid":"https://orcid.org/0000-0002-0443-1583","observed_orcids":["https://orcid.org/0000-0002-0443-1583"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raphael E. Pollock","raw_affiliation_strings":["Department of Surgical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065709859","display_name":"Joseph Aloysius Ludwig","orcid":"https://orcid.org/0000-0001-6631-8554","observed_orcids":["https://orcid.org/0000-0001-6631-8554"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph A. Ludwig","raw_affiliation_strings":["Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Sarcoma Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, Texas","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065709859"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":4570,"currency":"USD","value_usd":4570},"apc_paid":null,"fwci":0.4698,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.45165394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"4","first_page":"327","last_page":"333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/multimodal-treatment","display_name":"multimodal therapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/sarcoma-subtypes","display_name":"sarcoma subtypes","score":0.8650000095367432},{"id":"https://openalex.org/keywords/molecular-heterogeneity","display_name":"molecular heterogeneity","score":0.9079999923706055},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.8560000061988831},{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mesenchymal-tumors","display_name":"mesenchymal tumors","score":0.781000018119812},{"id":"https://openalex.org/keywords/randomized-controlled-trials","display_name":"randomized controlled trials","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8553756475448608},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6061570048332214},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6005377769470215},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5948684811592102},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.5803164839744568},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5640738606452942},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.5567178130149841},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5487639307975769},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.4943273067474365},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.4614030718803406},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4303252696990967},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.4183095693588257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.413278728723526},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.3822556138038635},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3641745150089264},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018714","descriptor_name":"Radiotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jso.21481","doi":"https://doi.org/10.1002/jso.21481","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jso.21481","pdf_url":null,"source":{"id":"https://openalex.org/S13860802","display_name":"Journal of Surgical Oncology","issn_l":"0022-4790","issn":["0022-4790","1096-9098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:20187067","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20187067","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of surgical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W41001277","https://openalex.org/W48277571","https://openalex.org/W1503354330","https://openalex.org/W1907859928","https://openalex.org/W1912227677","https://openalex.org/W1930298597","https://openalex.org/W1964939572","https://openalex.org/W1975487499","https://openalex.org/W1981491302","https://openalex.org/W1984768061","https://openalex.org/W1985007265","https://openalex.org/W2002329690","https://openalex.org/W2008920989","https://openalex.org/W2013683232","https://openalex.org/W2021832379","https://openalex.org/W2024504178","https://openalex.org/W2049103239","https://openalex.org/W2051346698","https://openalex.org/W2059931397","https://openalex.org/W2061368365","https://openalex.org/W2064558107","https://openalex.org/W2067787818","https://openalex.org/W2074609728","https://openalex.org/W2075485315","https://openalex.org/W2080917909","https://openalex.org/W2082071039","https://openalex.org/W2086843197","https://openalex.org/W2089685470","https://openalex.org/W2100457375","https://openalex.org/W2117328978","https://openalex.org/W2119535651","https://openalex.org/W2119693954","https://openalex.org/W2126415088","https://openalex.org/W2129931005","https://openalex.org/W2135892076","https://openalex.org/W2137552823","https://openalex.org/W2152467488","https://openalex.org/W2153477869","https://openalex.org/W2165469184","https://openalex.org/W2169363650","https://openalex.org/W2275599683","https://openalex.org/W2314511842","https://openalex.org/W3198116466","https://openalex.org/W6601929251"],"related_works":["https://openalex.org/W4200085005","https://openalex.org/W2063288102","https://openalex.org/W2463983840","https://openalex.org/W2316646627","https://openalex.org/W2782469612","https://openalex.org/W2094600384","https://openalex.org/W2556082335","https://openalex.org/W2605483074","https://openalex.org/W1963813054","https://openalex.org/W2414578673"],"abstract_inverted_index":{"Unlike":[0],"epithelial":[1],"cancers":[2],"that":[3,97,140],"are":[4],"both":[5,124],"more":[6,36],"homogeneous":[7],"and":[8,31,76,82,129],"easily":[9],"categorized":[10],"by":[11],"their":[12],"respective":[13],"tissues":[14],"of":[15,27,35,48,66,93,105],"origin":[16],"(e.g.,":[17],"breast":[18],"or":[19],"lung":[20],"cancer),":[21],"sarcomas":[22,49],"represent":[23],"a":[24,51,94,114],"diverse":[25],"class":[26],"molecularly":[28],"distinct":[29],"bone":[30],"soft-tissue":[32],"mesenchymal":[33],"neoplasms":[34],"than":[37],"50":[38],"subtypes.":[39],"This":[40],"diversity,":[41],"as":[42,44,50],"well":[43],"the":[45,64,80,103,125,130],"relative":[46],"rarity":[47],"whole,":[52],"has":[53],"presented":[54],"challenges":[55],"in":[56,91],"conducting":[57],"prospective":[58],"randomized":[59],"clinical":[60,74],"trials":[61,75],"to":[62,116,137],"assess":[63],"value":[65],"neoadjuvant":[67,118],"chemotherapy":[68,119],"for":[69],"any":[70],"given":[71],"subtype.":[72,141],"Most":[73],"meta-analyses":[77],"have":[78],"neglected":[79],"phenotypic":[81],"molecular":[83],"heterogeneity":[84],"differentiating":[85],"one":[86],"sarcoma":[87],"subtype":[88,126],"from":[89],"another":[90],"favor":[92],"simplified":[95],"grouping":[96],"ensures":[98],"timely":[99],"trial":[100],"completion.":[101],"As":[102],"success":[104],"treating":[106],"gastrointestinal":[107],"stromal":[108],"tumors":[109],"(GISTs)":[110],"with":[111],"imatinib":[112],"demonstrates,":[113],"decision":[115],"provide":[117],"must":[120],"take":[121],"into":[122],"consideration":[123],"being":[127],"treated":[128],"effect":[131],"such":[132],"treatment":[133],"would":[134],"be":[135],"expected":[136],"exert":[138],"upon":[139]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
