{"id":"https://openalex.org/W2170913716","doi":null,"title":"Vectors and delivery systems in gene therapy.","display_name":"Vectors and delivery systems in gene therapy.","publication_year":2005,"publication_date":"2005-04-01","ids":{"openalex":"https://openalex.org/W2170913716","mag":"2170913716","pmid":"https://pubmed.ncbi.nlm.nih.gov/15795707"},"language":"en","primary_location":{"id":"pmid:15795707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15795707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081692602","display_name":"Roman Gardl\u00edk","orcid":"https://orcid.org/0000-0001-8211-907X","observed_orcids":["https://orcid.org/0000-0001-8211-907X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roman Gardl\u00edk","raw_affiliation_strings":["BiomeD Research and Publishing Group, Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BiomeD Research and Publishing Group, Bratislava, Slovakia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013899741","display_name":"Roland P\u00e1lffy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland P\u00e1lffy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023272919","display_name":"J\u00falius Hodosy","orcid":"https://orcid.org/0000-0002-6578-1886","observed_orcids":["https://orcid.org/0000-0002-6578-1886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00falius Hodosy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011737159","display_name":"J\u00e1n Luk\u00e1cs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00e1n Luk\u00e1cs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063713045","display_name":"J\u00e1n Tur\u0148a","orcid":"https://orcid.org/0000-0001-5813-566X","observed_orcids":["https://orcid.org/0000-0001-5813-566X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J\u00e1n Turna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055182886","display_name":"Peter Celec","orcid":"https://orcid.org/0000-0001-5883-3580","observed_orcids":["https://orcid.org/0000-0001-5883-3580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Celec","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.776,"has_fulltext":false,"cited_by_count":218,"citation_normalized_percentile":{"value":0.97971333,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"11","issue":"4","first_page":"RA110","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gene-delivery","display_name":"gene delivery","score":0.7260000109672546},{"id":"https://openalex.org/keywords/gene-delivery-vectors","display_name":"gene delivery vectors","score":0.7229999899864197},{"id":"https://openalex.org/keywords/viral-vectors","display_name":"viral vectors","score":0.953000009059906},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7799999713897705},{"id":"https://openalex.org/keywords/adeno-associated-virus-vectors","display_name":"adeno-associated virus vectors","score":0.9120000004768372},{"id":"https://openalex.org/keywords/lentivirus","display_name":"lentivirus","score":0.9020000100135803},{"id":"https://openalex.org/keywords/retroviruses","display_name":"retroviruses","score":1.0},{"id":"https://openalex.org/keywords/lipoplexes","display_name":"lipoplexes","score":0.9200000166893005},{"id":"https://openalex.org/keywords/naked-dna","display_name":"naked DNA","score":0.6290000081062317},{"id":"https://openalex.org/keywords/bacterial-vectors","display_name":"bacterial vectors","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gene-transfer-safety","display_name":"gene transfer safety","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.862820565700531},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6621667742729187},{"id":"https://openalex.org/C3018928802","wikidata":"https://www.wikidata.org/wiki/Q83185","display_name":"Gene transfer","level":3,"score":0.6450240612030029},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5692363381385803},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5660867094993591},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.49941205978393555},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49749258160591125},{"id":"https://openalex.org/C195856716","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"Naked DNA","level":4,"score":0.4648871123790741},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38089120388031006},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33681488037109375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33405035734176636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24191081523895264},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014780","descriptor_name":"Viruses","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014780","descriptor_name":"Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15795707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15795707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical science monitor : international medical journal of experimental and clinical research","raw_type":"Journal Article"},{"id":"mag:2170913716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15795707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W80088001","https://openalex.org/W189956990","https://openalex.org/W1970111956","https://openalex.org/W1970862339","https://openalex.org/W1973957725","https://openalex.org/W1975745775","https://openalex.org/W1982770157","https://openalex.org/W1983770983","https://openalex.org/W1986327249","https://openalex.org/W1987024074","https://openalex.org/W1991755374","https://openalex.org/W2000739334","https://openalex.org/W2010228315","https://openalex.org/W2011767474","https://openalex.org/W2015125949","https://openalex.org/W2015231167","https://openalex.org/W2020297982","https://openalex.org/W2021576586","https://openalex.org/W2021989717","https://openalex.org/W2025532692","https://openalex.org/W2027822615","https://openalex.org/W2028322263","https://openalex.org/W2035910142","https://openalex.org/W2041208222","https://openalex.org/W2046079675","https://openalex.org/W2048291054","https://openalex.org/W2050249461","https://openalex.org/W2052835050","https://openalex.org/W2055444120","https://openalex.org/W2055475877","https://openalex.org/W2061678481","https://openalex.org/W2064330002","https://openalex.org/W2064767074","https://openalex.org/W2065547960","https://openalex.org/W2066389404","https://openalex.org/W2066724943","https://openalex.org/W2067096974","https://openalex.org/W2068525206","https://openalex.org/W2068733395","https://openalex.org/W2075300550","https://openalex.org/W2082792779","https://openalex.org/W2083646359","https://openalex.org/W2083858193","https://openalex.org/W2089866857","https://openalex.org/W2091131497","https://openalex.org/W2093437549","https://openalex.org/W2101041918","https://openalex.org/W2110574257","https://openalex.org/W2110921202","https://openalex.org/W2111389460","https://openalex.org/W2113937628","https://openalex.org/W2114458218","https://openalex.org/W2116030620","https://openalex.org/W2117353601","https://openalex.org/W2132141768","https://openalex.org/W2137440275","https://openalex.org/W2140031668","https://openalex.org/W2150996807","https://openalex.org/W2153955991","https://openalex.org/W2157758505","https://openalex.org/W2162161275","https://openalex.org/W2167769311","https://openalex.org/W2171847088","https://openalex.org/W2272498232","https://openalex.org/W2313291334","https://openalex.org/W2317719309","https://openalex.org/W2326348985","https://openalex.org/W2330163873","https://openalex.org/W2414990236","https://openalex.org/W2430121332","https://openalex.org/W2460059062"],"related_works":["https://openalex.org/W7073757347","https://openalex.org/W3144607323","https://openalex.org/W2233926480","https://openalex.org/W7203929666","https://openalex.org/W1585257520","https://openalex.org/W163680795","https://openalex.org/W2291573537","https://openalex.org/W4408436191","https://openalex.org/W2110921202","https://openalex.org/W2082157013"],"abstract_inverted_index":{"Gene":[0],"therapy":[1,41,141,169],"provides":[2],"modern":[3],"medicine":[4,21],"with":[5],"new":[6],"perspectives":[7],"that":[8],"were":[9],"unthinkable":[10],"two":[11],"decades":[12],"ago.":[13],"Progress":[14],"in":[15,59,114,138,145,172,185],"molecular":[16,20],"biology":[17],"and,":[18],"especially,":[19],"is":[22],"now":[23],"changing":[24],"the":[25,36,45,54,60,105,146,154],"basics":[26],"of":[27,31,35,47,65,74,90,131,148,156,175],"clinical":[28,51,100],"medicine.":[29],"Reports":[30],"long-term":[32],"side":[33],"effects":[34],"first":[37],"successful":[38],"human":[39],"gene":[40,86,111,115,140,168,179],"study":[42],"have":[43,81],"slowed":[44],"penetration":[46],"DNA":[48,158],"usage":[49],"into":[50,67],"routine.":[52],"However,":[53],"main":[55],"safety":[56,152],"problem":[57],"lies":[58],"secure":[61],"and":[62,70,76,92,99,108,126,133,150],"efficient":[63],"delivery":[64,106],"genes":[66],"target":[68],"cells":[69],"tissues.":[71],"A":[72,88],"number":[73],"older":[75],"more":[77],"recently":[78],"discovered":[79],"techniques":[80],"been":[82],"developed":[83],"for":[84,97,110,167],"therapeutic":[85,176],"transfer.":[87,159],"variety":[89],"viral":[91,121],"non-viral":[93],"possibilities":[94],"are":[95,120],"available":[96],"basic":[98],"research.":[101],"This":[102],"review":[103],"summarizes":[104],"routes":[107],"methods":[109],"transfer":[112],"used":[113],"therapy.":[116],"The":[117,160],"best":[118],"known":[119],"vectors":[122,166],"derived":[123],"from":[124],"adenoviruses":[125],"adeno-associated":[127],"viruses.":[128],"Specific":[129],"properties":[130],"lentiviruses":[132],"retroviruses":[134],"ensure":[135],"their":[136],"status":[137],"current":[139],"procedures.":[142],"Recent":[143],"advances":[144],"preparation":[147],"lipoplexes":[149],"greater":[151],"support":[153],"use":[155],"naked":[157],"latest":[161],"approach,":[162],"using":[163],"bacteria":[164],"as":[165,171],"or":[170],"situ":[173],"producers":[174],"proteins":[177],"(alternative":[178],"therapy),":[180],"must":[181],"undergo":[182],"critical":[183],"evaluation":[184],"further":[186],"experiments.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}