{"id":"https://openalex.org/W2170912376","doi":"https://doi.org/10.1083/jcb.94.3.688","title":"Taxol binds to cellular microtubules.","display_name":"Taxol binds to cellular microtubules.","publication_year":1982,"publication_date":"1982-09-01","ids":{"openalex":"https://openalex.org/W2170912376","doi":"https://doi.org/10.1083/jcb.94.3.688","mag":"2170912376","pmid":"https://pubmed.ncbi.nlm.nih.gov/6127342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112233"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.94.3.688","doi":"https://doi.org/10.1083/jcb.94.3.688","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.94.3.688","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112233","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029300120","display_name":"James J. Manfredi","orcid":"https://orcid.org/0000-0003-2234-9097","observed_orcids":["https://orcid.org/0000-0003-2234-9097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Manfredi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054135091","display_name":"Jerome Parness","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Parness","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083740179","display_name":"Susan Band Horwitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S B Horwitz","raw_affiliation_strings":["Molecular Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7396,"has_fulltext":false,"cited_by_count":406,"citation_normalized_percentile":{"value":0.91366158,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"94","issue":"3","first_page":"688","last_page":"696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9829999804496765},{"id":"https://openalex.org/keywords/microtubule-binding","display_name":"microtubule binding","score":0.7799999713897705},{"id":"https://openalex.org/keywords/microtubule-bundles","display_name":"microtubule bundles","score":0.9010000228881836},{"id":"https://openalex.org/keywords/microtubule-polymerization","display_name":"microtubule assembly","score":0.9330000281333923},{"id":"https://openalex.org/keywords/drug-binding-sites","display_name":"drug binding sites","score":0.5709999799728394},{"id":"https://openalex.org/keywords/tubulin-depolymerization","display_name":"tubulin depolymerization","score":0.7850000262260437},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.8919531106948853},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.7784464359283447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6752952933311462},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.5715234875679016},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5419453382492065},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5130296945571899},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4890371263027191},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.46171972155570984},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4534379243850708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4356107711791992},{"id":"https://openalex.org/C94921385","wikidata":"https://www.wikidata.org/wiki/Q12134483","display_name":"Microtubule nucleation","level":5,"score":0.42255327105522156},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41574063897132874},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33831703662872314},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.14407038688659668},{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001386","descriptor_name":"Azides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008870","descriptor_name":"Microtubules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1083/jcb.94.3.688","doi":"https://doi.org/10.1083/jcb.94.3.688","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.94.3.688","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2112233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112233","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:6127342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6127342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.4262","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.4262","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/05/e2/J_Cell_Biol_1982_Sep_1_94(3)_688-696.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.8781","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.8781","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcb.rupress.org/content/94/3/688.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2112233","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2112233","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5600130715","display_name":"TRAINING PROGRAM IN PHARMACOLOGICAL SCIENCES","funder_award_id":"T32GM007260","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W581386893","https://openalex.org/W656256943","https://openalex.org/W1570441204","https://openalex.org/W1571155052","https://openalex.org/W1611640819","https://openalex.org/W1775749144","https://openalex.org/W1883854830","https://openalex.org/W1936480433","https://openalex.org/W1966433003","https://openalex.org/W1970266617","https://openalex.org/W1974174776","https://openalex.org/W1975324638","https://openalex.org/W1977374685","https://openalex.org/W1983649348","https://openalex.org/W1986680736","https://openalex.org/W1988085635","https://openalex.org/W1989743656","https://openalex.org/W1995473467","https://openalex.org/W1999020300","https://openalex.org/W1999159829","https://openalex.org/W2002073980","https://openalex.org/W2002140004","https://openalex.org/W2004961500","https://openalex.org/W2005818666","https://openalex.org/W2007067735","https://openalex.org/W2009896119","https://openalex.org/W2016603665","https://openalex.org/W2016965186","https://openalex.org/W2017365073","https://openalex.org/W2032342779","https://openalex.org/W2036291935","https://openalex.org/W2036319656","https://openalex.org/W2037490361","https://openalex.org/W2037668903","https://openalex.org/W2038853625","https://openalex.org/W2044723769","https://openalex.org/W2045134662","https://openalex.org/W2045541679","https://openalex.org/W2046171723","https://openalex.org/W2053914489","https://openalex.org/W2059453596","https://openalex.org/W2061876357","https://openalex.org/W2067299834","https://openalex.org/W2069200256","https://openalex.org/W2081406767","https://openalex.org/W2089043118","https://openalex.org/W2093063761","https://openalex.org/W2095387254","https://openalex.org/W2096873963","https://openalex.org/W2101038938","https://openalex.org/W2129935860","https://openalex.org/W2133782006","https://openalex.org/W2145555831","https://openalex.org/W2150382846","https://openalex.org/W2156327777","https://openalex.org/W2162546286","https://openalex.org/W2410530349","https://openalex.org/W2464465175"],"related_works":["https://openalex.org/W7097509212","https://openalex.org/W2145555831","https://openalex.org/W2132920804","https://openalex.org/W2138224881","https://openalex.org/W1983703945","https://openalex.org/W2056789797","https://openalex.org/W2091598442","https://openalex.org/W2074243605","https://openalex.org/W2159101935","https://openalex.org/W2413621975"],"abstract_inverted_index":{"Taxol":[0],"is":[1,167,180],"a":[2,38,79,92],"low":[3],"molecular":[4],"weight":[5],"plant":[6],"derivative":[7],"which":[8,106,112,192],"enhances":[9],"microtubule":[10,25,68],"assembly":[11],"in":[12,27,35,57,78,115,198],"vitro":[13,36],"and":[14,44,64,81,117],"has":[15],"the":[16,21,60,65,73,87,126,157,201],"unique":[17],"ability":[18],"to":[19,33,72,137,200,206],"promote":[20],"formation":[22,66],"of":[23,62,67,86,95,128,147,164,177,204],"discrete":[24],"bundles":[26],"cells.":[28],"Tritium-labeled":[29],"taxol":[30,134,205],"binds":[31,71,135],"directly":[32],"microtubules":[34,114],"with":[37,141,152],"stoichiometry":[39],"approaching":[40],"one":[41],"(Parness,":[42],"J.,":[43],"S.":[45],"B.":[46],"Horwitz,":[47],"1981,":[48],"J.":[49],"Cell":[50],"Biol.":[51],"91:479-487).":[52],"We":[53],"now":[54],"report":[55],"studies":[56],"cells":[58,119],"on":[59],"binding":[61,89,98,101,127,163,176,203],"[3H]taxol":[63],"bundles.":[69],"[3H]Taxol":[70],"macrophagelike":[74],"cell":[75],"line,":[76],"J774.2,":[77],"specific":[80,88,189],"saturable":[82],"manner.":[83],"Scatchard":[84],"analysis":[85],"data":[90],"demonstrates":[91],"single":[93],"set":[94],"high":[96],"affinity":[97],"sites.":[99],"Maximal":[100],"occurs":[102],"at":[103],"drug":[104],"concentrations":[105],"produce":[107],"maximal":[108],"growth":[109],"inhibition.":[110],"Conditions":[111],"depolymerize":[113],"intact":[116],"extracted":[118],"as":[120],"determined":[121],"by":[122,150],"tubulin":[123],"immunofluorescence":[124],"inhibit":[125],"[3H]taxol.":[129],"This":[130],"strongly":[131],"suggests":[132],"that":[133],"specifically":[136],"cellular":[138,148,190],"microtubules.":[139,208],"Extraction":[140],"0.1%":[142],"Nonidet":[143],"P-40":[144],"or":[145],"depletion":[146],"ATP":[149],"treatment":[151],"10":[153],"mM":[154],"NaN3":[155],"prevents":[156],"characteristic":[158],"taxol-induced":[159],"bundle":[160,196],"formation.":[161,174],"The":[162,175],"[3H]taxol,":[165,178],"however,":[166,179],"retained":[168,181],"under":[169,182],"these":[170,183],"conditions.":[171,184],"Thus,":[172,185],"there":[173,186],"must":[187],"be":[188],"mechanisms":[191],"are":[193],"required":[194],"for":[195],"formation,":[197],"addition":[199],"direct":[202],"cytoplasmic":[207]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
