{"id":"https://openalex.org/W2170899493","doi":"https://doi.org/10.1084/jem.175.1.91","title":"T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.","display_name":"T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2170899493","doi":"https://doi.org/10.1084/jem.175.1.91","mag":"2170899493","pmid":"https://pubmed.ncbi.nlm.nih.gov/1730929","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2119077"},"language":"en","primary_location":{"id":"doi:10.1084/jem.175.1.91","doi":"https://doi.org/10.1084/jem.175.1.91","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.175.1.91","pdf_url":"https://rupress.org/jem/article-pdf/175/1/91/1268184/91.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://rupress.org/jem/article-pdf/175/1/91/1268184/91.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015841302","display_name":"Thomas Miethke","orcid":"https://orcid.org/0000-0001-7451-5857","observed_orcids":["https://orcid.org/0000-0001-7451-5857"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T Miethke","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102379490","display_name":"Claudia Wahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C Wahl","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068349575","display_name":"Klaus M. Heeg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K Heeg","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084496232","display_name":"Bernd Echtenacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B Echtenacher","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047970569","display_name":"Peter\u2004H. Krammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P H Krammer","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109835366","display_name":"Hermann Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H Wagner","raw_affiliation_strings":["Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Microbiology and Hygiene, Technischen, Universit\u00e4t Munich, Germany","institution_ids":["https://openalex.org/I62916508","https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":17.7841,"has_fulltext":true,"cited_by_count":569,"citation_normalized_percentile":{"value":0.99493905,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"175","issue":"1","first_page":"91","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.774399995803833,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.10890000313520432,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcal-enterotoxin-b","display_name":"staphylococcal enterotoxin B","score":0.9710000157356262},{"id":"https://openalex.org/keywords/superantigens","display_name":"superantigens","score":0.7929999828338623},{"id":"https://openalex.org/keywords/toxic-shock-syndrome","display_name":"toxic shock syndrome","score":0.8629999756813049},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/d-galactosamine-sensitization","display_name":"D-galactosamine sensitization","score":0.9110000133514404},{"id":"https://openalex.org/keywords/lymphokines","display_name":"lymphokines","score":0.6309999823570251},{"id":"https://openalex.org/keywords/v-beta-8-t-cells","display_name":"V beta 8+ T cells","score":0.8220000267028809},{"id":"https://openalex.org/keywords/anti-tnf-monoclonal-antibody","display_name":"anti-TNF monoclonal antibody","score":0.7200000286102295},{"id":"https://openalex.org/keywords/scid-mice","display_name":"SCID mice","score":0.5199999809265137},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.382999986410141}],"concepts":[{"id":"https://openalex.org/C36333154","wikidata":"https://www.wikidata.org/wiki/Q772950","display_name":"Superantigen","level":4,"score":0.9107949733734131},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.6152750253677368},{"id":"https://openalex.org/C49382859","wikidata":"https://www.wikidata.org/wiki/Q286498","display_name":"Lymphokine","level":3,"score":0.5817570090293884},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5776775479316711},{"id":"https://openalex.org/C66999527","wikidata":"https://www.wikidata.org/wiki/Q421978","display_name":"Enterotoxin","level":4,"score":0.5689236521720886},{"id":"https://openalex.org/C2779821349","wikidata":"https://www.wikidata.org/wiki/Q1128440","display_name":"Toxic shock syndrome","level":4,"score":0.547967255115509},{"id":"https://openalex.org/C2778723905","wikidata":"https://www.wikidata.org/wiki/Q408649","display_name":"Exotoxin","level":3,"score":0.5470219850540161},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5294275879859924},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.48803749680519104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48038679361343384},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4583307206630707},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.33452850580215454},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3282555937767029},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.29064610600471497},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.17766621708869934},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1658777892589569},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.1239064633846283},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003643","descriptor_name":"Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005688","descriptor_name":"Galactosamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.175.1.91","doi":"https://doi.org/10.1084/jem.175.1.91","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.175.1.91","pdf_url":"https://rupress.org/jem/article-pdf/175/1/91/1268184/91.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2119077","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2119077","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:1730929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1730929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.273.6699","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.6699","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/07/08/J_Exp_Med_1992_Jan_1_175(1)_91-98.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.334.1884","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.1884","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jem.rupress.org/content/175/1/91.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1084/jem.175.1.91","doi":"https://doi.org/10.1084/jem.175.1.91","is_oa":true,"landing_page_url":"https://doi.org/10.1084/jem.175.1.91","pdf_url":"https://rupress.org/jem/article-pdf/175/1/91/1268184/91.pdf","source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323015","display_name":"Bundesministerium f\u00fcr Forschung und Technologie","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170899493.pdf","grobid_xml":"https://content.openalex.org/works/W2170899493.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W349215864","https://openalex.org/W1486067478","https://openalex.org/W1524579337","https://openalex.org/W1889005813","https://openalex.org/W1953723383","https://openalex.org/W1962480635","https://openalex.org/W1986402170","https://openalex.org/W1997411530","https://openalex.org/W1999246265","https://openalex.org/W2004212058","https://openalex.org/W2006856765","https://openalex.org/W2019638781","https://openalex.org/W2027306447","https://openalex.org/W2038434279","https://openalex.org/W2041937940","https://openalex.org/W2050774038","https://openalex.org/W2058700616","https://openalex.org/W2067510436","https://openalex.org/W2068145342","https://openalex.org/W2084519264","https://openalex.org/W2086417745","https://openalex.org/W2092289140","https://openalex.org/W2101835477","https://openalex.org/W2107036768","https://openalex.org/W2108117103","https://openalex.org/W2126342903","https://openalex.org/W2132638987","https://openalex.org/W2137246864","https://openalex.org/W2142490832","https://openalex.org/W2142585662","https://openalex.org/W2144847280","https://openalex.org/W2168699998","https://openalex.org/W2174322658","https://openalex.org/W2332022311","https://openalex.org/W2405839966","https://openalex.org/W4211147310","https://openalex.org/W4247251063","https://openalex.org/W4285719527","https://openalex.org/W6808613070","https://openalex.org/W6808617187"],"related_works":["https://openalex.org/W7097622965","https://openalex.org/W7095802384","https://openalex.org/W2122477043","https://openalex.org/W2409941175","https://openalex.org/W2060288448","https://openalex.org/W2162677302","https://openalex.org/W2111438490","https://openalex.org/W2272152428","https://openalex.org/W2009186025","https://openalex.org/W2016335648"],"abstract_inverted_index":{"Because":[0],"mice":[1,19,96],"are":[2],"more":[3],"resistant":[4],"than":[5],"humans":[6],"to":[7,24,42,99,217],"the":[8,32,46,76,88,106,201,208,214,218],"pathogenic":[9],"effects":[10],"of":[11,94,108,143,145,155],"bacterial":[12],"toxins,":[13],"we":[14],"used":[15],"D-Galactosamine-":[16],"(D-Gal)":[17],"sensitized":[18],"as":[20,149],"a":[21,84,228],"model":[22],"system":[23],"evaluate":[25],"potential":[26],"toxic":[27,181],"shock":[28,51,73,115,182],"symptoms":[29],"triggered":[30,74],"by":[31,75,81,133,151,205,210],"superantigen":[33,77],"staphylococcal":[34],"enterotoxin":[35],"B":[36],"(SEB).":[37],"We":[38],"show":[39],"that":[40,90,172,200,225],"similar":[41,223],"endotoxin":[43,192],"(lipopolysaccharide)":[44],"[LPS],":[45],"exotoxin":[47,195],"SEB":[48,78,122],"causes":[49],"lethal":[50,72,114,197],"within":[52],"8":[53],"h":[54],"in":[55,112,141,199,224,231],"D-Gal-sensitized":[56],"mice,":[57],"inducing":[58,232],"100%":[59],"and":[60,66,194,207],"about":[61],"50%":[62],"lethality":[63],"with":[64,164],"20":[65],"2":[67],"micrograms":[68],"SEB,":[69],"respectively.":[70],"The":[71],"is":[79,174,177,203],"mediated":[80,204],"T":[82,91,109,146,160,211],"cells,":[83],"conclusion":[85],"based":[86],"on":[87],"observation":[89],"cell":[92,147],"repopulation":[93],"SCID":[95],"conferred":[97,104,169],"sensitivity":[98],"SEB.":[100],"Since":[101],"CSA":[102],"also":[103,168],"protection,":[105,170],"role":[107],"cell-derived":[110],"lymphokines":[111,137],"mediating":[113],"was":[116],"evaluated.":[117],"Within":[118],"30-60":[119],"min":[120],"after":[121],"injection,":[123],"serum":[124],"tumor":[125],"necrosis":[126],"factor":[127],"(TNF)":[128],"levels":[129],"peaked,":[130],"followed":[131],"immediately":[132],"interleukin-2":[134],"(IL-2).":[135],"Serum-borne":[136],"were":[138],"detected":[139],"well":[140],"advance":[142],"signs":[144],"activation,":[148],"assessed":[150],"IL-2":[152],"receptor":[153],"expression":[154],"SEB-reactive":[156],"V":[157],"beta":[158],"8+":[159],"cells.":[161,212],"Passive":[162],"immunization":[163],"anti-TNF-alpha/beta-neutralizing":[165],"monoclonal":[166],"antibody":[167],"indicating":[171],"it":[173],"TNF":[175,226],"which":[176],"critical":[178],"for":[179],"initiating":[180],"symptoms.":[183],"Taken":[184],"together,":[185],"this":[186],"study":[187],"defines":[188],"basic":[189],"differences":[190],"between":[191],"(LPS)-":[193],"(SEB)-mediated":[196],"shock,":[198],"former":[202],"macrophages":[206],"latter":[209],"Yet":[213],"pathogenesis":[215],"distal":[216],"lymphokine/cytokine-producing":[219],"cells":[220],"appears":[221],"surprisingly":[222],"represents":[227],"key":[229],"mediator":[230],"shock.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}