{"id":"https://openalex.org/W2170880244","doi":null,"title":"The Pancreatic Macrophage Compartment in Health and autoimmune Diabetes: a study on Maturation, Mobility and Matrix interactions","display_name":"The Pancreatic Macrophage Compartment in Health and autoimmune Diabetes: a study on Maturation, Mobility and Matrix interactions","publication_year":2004,"publication_date":"2004-11-09","ids":{"openalex":"https://openalex.org/W2170880244","mag":"2170880244"},"language":"en","primary_location":{"id":"pmh:oai:repub.eur.nl:7183","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/7183","pdf_url":"http://repub.eur.nl/pub/7183","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repub.eur.nl/pub/7183","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023448596","display_name":"Sacha Brigitte Geutskens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sacha B. Geutskens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023448596"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9940000176429749},{"id":"https://openalex.org/keywords/autoimmune-diabetes","display_name":"autoimmune diabetes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/macrophage-maturation","display_name":"macrophage maturation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/extracellular-matrix-interactions","display_name":"extracellular matrix interactions","score":0.8740000128746033},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/beta-cell-destruction","display_name":"beta cell destruction","score":0.8270000219345093},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.7929999828338623},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8199999928474426},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7526868581771851},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.712203860282898},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.6501172184944153},{"id":"https://openalex.org/C2779511750","wikidata":"https://www.wikidata.org/wiki/Q922215","display_name":"Insulitis","level":4,"score":0.5859734416007996},{"id":"https://openalex.org/C2778013207","wikidata":"https://www.wikidata.org/wiki/Q1961243","display_name":"NOD mice","level":4,"score":0.5688876509666443},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.4897489547729492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4684484302997589},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46020644903182983},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4455064535140991},{"id":"https://openalex.org/C55851684","wikidata":"https://www.wikidata.org/wiki/Q518390","display_name":"Nod","level":3,"score":0.44271886348724365},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4390207529067993},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.4389505386352539},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.42334139347076416},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.404675155878067},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3809712529182434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36185792088508606},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15408077836036682},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repub.eur.nl:7183","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/7183","pdf_url":"http://repub.eur.nl/pub/7183","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:eur:oai:pure.eur.nl:publications/f9d098f3-7051-4934-9556-83268ad90d12","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/f9d098f3-7051-4934-9556-83268ad90d12","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"pmh:eur:oai:repub.eur.nl:7183","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/7183","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2170880244","doi":null,"is_oa":false,"landing_page_url":"https://repub.eur.nl/pub/7183/041109_Geutskens.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repub.eur.nl:7183","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/7183","pdf_url":"http://repub.eur.nl/pub/7183","source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3471726194","display_name":null,"funder_award_id":"96.606","funder_id":"https://openalex.org/F4320321708","funder_display_name":"Diabetes Fonds"}],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321708","display_name":"Diabetes Fonds","ror":"https://ror.org/04ch2g225"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320323917","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170880244.pdf","grobid_xml":"https://content.openalex.org/works/W2170880244.grobid-xml"},"referenced_works_count":345,"referenced_works":["https://openalex.org/W73231574","https://openalex.org/W170948591","https://openalex.org/W188699256","https://openalex.org/W195944211","https://openalex.org/W1480207260","https://openalex.org/W1481057445","https://openalex.org/W1481804181","https://openalex.org/W1487295185","https://openalex.org/W1488156534","https://openalex.org/W1499727701","https://openalex.org/W1514064771","https://openalex.org/W1519096730","https://openalex.org/W1519295067","https://openalex.org/W1530522871","https://openalex.org/W1534302749","https://openalex.org/W1546831560","https://openalex.org/W1562291393","https://openalex.org/W1562637495","https://openalex.org/W1572556724","https://openalex.org/W1576465077","https://openalex.org/W1585015128","https://openalex.org/W1590064498","https://openalex.org/W1590260400","https://openalex.org/W1590402535","https://openalex.org/W1591714343","https://openalex.org/W1593322963","https://openalex.org/W1594646606","https://openalex.org/W1595549379","https://openalex.org/W1598195946","https://openalex.org/W1599148944","https://openalex.org/W1601638672","https://openalex.org/W1608842679","https://openalex.org/W1622219374","https://openalex.org/W1658094738","https://openalex.org/W1743939398","https://openalex.org/W1795980252","https://openalex.org/W1823110768","https://openalex.org/W1823467089","https://openalex.org/W1853362881","https://openalex.org/W1857613114","https://openalex.org/W1866073711","https://openalex.org/W1905978178","https://openalex.org/W1912380699","https://openalex.org/W1927383279","https://openalex.org/W1929591819","https://openalex.org/W1934989380","https://openalex.org/W1935867447","https://openalex.org/W1939326986","https://openalex.org/W1956258286","https://openalex.org/W1958779837","https://openalex.org/W1959298931","https://openalex.org/W1965778848","https://openalex.org/W1965788272","https://openalex.org/W1965827039","https://openalex.org/W1965963643","https://openalex.org/W1966517387","https://openalex.org/W1966544076","https://openalex.org/W1969174394","https://openalex.org/W1969184940","https://openalex.org/W1969563910","https://openalex.org/W1969667746","https://openalex.org/W1969778924","https://openalex.org/W1971019443","https://openalex.org/W1972414463","https://openalex.org/W1972843541","https://openalex.org/W1975955687","https://openalex.org/W1976702022","https://openalex.org/W1976778352","https://openalex.org/W1978124436","https://openalex.org/W1978696183","https://openalex.org/W1980797966","https://openalex.org/W1981231681","https://openalex.org/W1982916524","https://openalex.org/W1983586579","https://openalex.org/W1984838539","https://openalex.org/W1986317985","https://openalex.org/W1986420505","https://openalex.org/W1986647322","https://openalex.org/W1988010265","https://openalex.org/W1989582506","https://openalex.org/W1990050623","https://openalex.org/W1990069832","https://openalex.org/W1990494705","https://openalex.org/W1990731798","https://openalex.org/W1991195369","https://openalex.org/W1991260416","https://openalex.org/W1991731944","https://openalex.org/W1991846489","https://openalex.org/W1992607364","https://openalex.org/W1992769276","https://openalex.org/W1993361953","https://openalex.org/W1993677761","https://openalex.org/W1994340136","https://openalex.org/W1995446704","https://openalex.org/W1995879433","https://openalex.org/W1998240361","https://openalex.org/W1998325878","https://openalex.org/W1999612815","https://openalex.org/W2001113147","https://openalex.org/W2001937023","https://openalex.org/W2002956679","https://openalex.org/W2003713557","https://openalex.org/W2005204898","https://openalex.org/W2006498696","https://openalex.org/W2007087804","https://openalex.org/W2007608304","https://openalex.org/W2009846829","https://openalex.org/W2012487047","https://openalex.org/W2014826699","https://openalex.org/W2015141911","https://openalex.org/W2015954946","https://openalex.org/W2016147208","https://openalex.org/W2016161821","https://openalex.org/W2016318369","https://openalex.org/W2017256134","https://openalex.org/W2017559831","https://openalex.org/W2018365688","https://openalex.org/W2018602356","https://openalex.org/W2018794044","https://openalex.org/W2019347038","https://openalex.org/W2021794852","https://openalex.org/W2021930587","https://openalex.org/W2022398608","https://openalex.org/W2022453973","https://openalex.org/W2022572601","https://openalex.org/W2023280347","https://openalex.org/W2023826518","https://openalex.org/W2024593057","https://openalex.org/W2024804515","https://openalex.org/W2025784989","https://openalex.org/W2026468137","https://openalex.org/W2026578487","https://openalex.org/W2027254518","https://openalex.org/W2027552805","https://openalex.org/W2028329969","https://openalex.org/W2028839680","https://openalex.org/W2029434044","https://openalex.org/W2032055419","https://openalex.org/W2032938030","https://openalex.org/W2033375159","https://openalex.org/W2034946836","https://openalex.org/W2036062239","https://openalex.org/W2036661461","https://openalex.org/W2037628646","https://openalex.org/W2038621681","https://openalex.org/W2038801248","https://openalex.org/W2039642400","https://openalex.org/W2039955018","https://openalex.org/W2041138285","https://openalex.org/W2041266914","https://openalex.org/W2041469322","https://openalex.org/W2041684915","https://openalex.org/W2042057376","https://openalex.org/W2042982622","https://openalex.org/W2043512289","https://openalex.org/W2044035130","https://openalex.org/W2044735069","https://openalex.org/W2044812837","https://openalex.org/W2045309329","https://openalex.org/W2045758494","https://openalex.org/W2047253193","https://openalex.org/W2047278218","https://openalex.org/W2048211245","https://openalex.org/W2048932111","https://openalex.org/W2049703421","https://openalex.org/W2049790627","https://openalex.org/W2051282357","https://openalex.org/W2052250748","https://openalex.org/W2052870879","https://openalex.org/W2053408583","https://openalex.org/W2053583666","https://openalex.org/W2054041390","https://openalex.org/W2054276465","https://openalex.org/W2055442982","https://openalex.org/W2057024358","https://openalex.org/W2057809738","https://openalex.org/W2057898581","https://openalex.org/W2058892008","https://openalex.org/W2059632969","https://openalex.org/W2059678568","https://openalex.org/W2059704957","https://openalex.org/W2063519247","https://openalex.org/W2064231933","https://openalex.org/W2065526169","https://openalex.org/W2065683540","https://openalex.org/W2065871536","https://openalex.org/W2066826893","https://openalex.org/W2068307038","https://openalex.org/W2070181989","https://openalex.org/W2070879288","https://openalex.org/W2071756824","https://openalex.org/W2071874046","https://openalex.org/W2072335802","https://openalex.org/W2072434175","https://openalex.org/W2072647934","https://openalex.org/W2073421421","https://openalex.org/W2075275435","https://openalex.org/W2075678923","https://openalex.org/W2076222554","https://openalex.org/W2077137690","https://openalex.org/W2078001237","https://openalex.org/W2078678936","https://openalex.org/W2079481583","https://openalex.org/W2081174864","https://openalex.org/W2081180734","https://openalex.org/W2081383446","https://openalex.org/W2081654176","https://openalex.org/W2081864087","https://openalex.org/W2082591904","https://openalex.org/W2082750322","https://openalex.org/W2083738937","https://openalex.org/W2084322883","https://openalex.org/W2084707443","https://openalex.org/W2084867808","https://openalex.org/W2084969813","https://openalex.org/W2085233986","https://openalex.org/W2087435915","https://openalex.org/W2088024377","https://openalex.org/W2089110736","https://openalex.org/W2089645383","https://openalex.org/W2089964497","https://openalex.org/W2090613865","https://openalex.org/W2090704440","https://openalex.org/W2091313620","https://openalex.org/W2091542696","https://openalex.org/W2091843594","https://openalex.org/W2094108596","https://openalex.org/W2094976787","https://openalex.org/W2095016279","https://openalex.org/W2095065860","https://openalex.org/W2096385412","https://openalex.org/W2096444181","https://openalex.org/W2096520512","https://openalex.org/W2100024388","https://openalex.org/W2101295479","https://openalex.org/W2101331467","https://openalex.org/W2101543719","https://openalex.org/W2102067914","https://openalex.org/W2103663550","https://openalex.org/W2104368621","https://openalex.org/W2105807629","https://openalex.org/W2106325503","https://openalex.org/W2106663224","https://openalex.org/W2107763843","https://openalex.org/W2107832675","https://openalex.org/W2108400189","https://openalex.org/W2108485405","https://openalex.org/W2108661128","https://openalex.org/W2109410335","https://openalex.org/W2110237261","https://openalex.org/W2110538738","https://openalex.org/W2112730454","https://openalex.org/W2115677315","https://openalex.org/W2116127788","https://openalex.org/W2116194397","https://openalex.org/W2118140893","https://openalex.org/W2118213304","https://openalex.org/W2118512041","https://openalex.org/W2118956711","https://openalex.org/W2121789150","https://openalex.org/W2122338989","https://openalex.org/W2122846793","https://openalex.org/W2124430683","https://openalex.org/W2125177388","https://openalex.org/W2125939378","https://openalex.org/W2126643398","https://openalex.org/W2126696395","https://openalex.org/W2127410502","https://openalex.org/W2127440907","https://openalex.org/W2128287467","https://openalex.org/W2128618196","https://openalex.org/W2130737345","https://openalex.org/W2131033270","https://openalex.org/W2132160710","https://openalex.org/W2132432595","https://openalex.org/W2133034713","https://openalex.org/W2133148589","https://openalex.org/W2133261439","https://openalex.org/W2133351125","https://openalex.org/W2133604102","https://openalex.org/W2133966414","https://openalex.org/W2135039348","https://openalex.org/W2135947561","https://openalex.org/W2135982188","https://openalex.org/W2138811906","https://openalex.org/W2138869419","https://openalex.org/W2141160128","https://openalex.org/W2141335997","https://openalex.org/W2142528008","https://openalex.org/W2143562677","https://openalex.org/W2144177716","https://openalex.org/W2145740221","https://openalex.org/W2146259054","https://openalex.org/W2146786154","https://openalex.org/W2147671004","https://openalex.org/W2148222156","https://openalex.org/W2148422620","https://openalex.org/W2148528048","https://openalex.org/W2149411814","https://openalex.org/W2149431167","https://openalex.org/W2150695445","https://openalex.org/W2151163209","https://openalex.org/W2153361366","https://openalex.org/W2154224978","https://openalex.org/W2155106725","https://openalex.org/W2156244085","https://openalex.org/W2156862610","https://openalex.org/W2158139956","https://openalex.org/W2159092116","https://openalex.org/W2159499933","https://openalex.org/W2160105055","https://openalex.org/W2163155417","https://openalex.org/W2164692566","https://openalex.org/W2165110544","https://openalex.org/W2165328587","https://openalex.org/W2165367810","https://openalex.org/W2166051507","https://openalex.org/W2166968370","https://openalex.org/W2167310349","https://openalex.org/W2167931587","https://openalex.org/W2168934662","https://openalex.org/W2169056709","https://openalex.org/W2169233545","https://openalex.org/W2169250125","https://openalex.org/W2169306631","https://openalex.org/W2169412075","https://openalex.org/W2169870204","https://openalex.org/W2172117915","https://openalex.org/W2183313062","https://openalex.org/W2183555496","https://openalex.org/W2185201488","https://openalex.org/W2188060873","https://openalex.org/W2188213271","https://openalex.org/W2196335236","https://openalex.org/W2405406971","https://openalex.org/W2410128514","https://openalex.org/W2410457253","https://openalex.org/W2411139466","https://openalex.org/W2413512267","https://openalex.org/W2419538297","https://openalex.org/W2423298231","https://openalex.org/W2467592953","https://openalex.org/W2606827166","https://openalex.org/W4313333698","https://openalex.org/W4313335068"],"related_works":["https://openalex.org/W4414273304","https://openalex.org/W4414780405","https://openalex.org/W2144305498","https://openalex.org/W2139707983","https://openalex.org/W2027830282","https://openalex.org/W4417363071","https://openalex.org/W267986998","https://openalex.org/W1974547058","https://openalex.org/W1990050623","https://openalex.org/W2142214572"],"abstract_inverted_index":{"Type":[0],"1":[1,36],"diabetes":[2,37],"is":[3,22,38,105,114,134,167],"a":[4,9,15,87],"disease":[5,85],"that":[6,52,125,166,189],"results":[7],"from":[8,223],"disturbed":[10],"glucose":[11],"metabolism":[12],"\\ndue":[13],"to":[14,28,86,98],"deficiency":[16,21],"in":[17,75,79,111,176,213,216,228],"insulin":[18],"production.":[19],"This":[20,129],"the":[23,29,49,54,57,71,84,95,100,112,117,145,159,163,180,184,217,220,229],"consequence":[24],"of":[25,34,48,59,103,121,139,152,162,179,203,219],"immune-\\nmediated":[26],"damage":[27],"insulin-producing":[30],"\u00df-cells.":[31],"The":[32,44,91,148],"cause":[33],"type":[35],"\\npresently":[39],"unknown":[40],"and":[41,46,78,123,141,200,232],"probably":[42],"multifactorial.":[43],"initiation":[45],"progression":[47],"\\ninflammatory":[50],"process":[51,110],"destroys":[53],"\u00df-cells":[55],"involves":[56],"interplay":[58],"environmental":[60],"\\nfactors":[61],"with":[62],"an":[63,137],"autoimmune-prone":[64],"genetic":[65],"background.":[66],"Abnormal":[67],"immune":[68,164],"regulation":[69],"\\nexplains":[70],"autoimmune":[72],"phenomena":[73],"observed":[74],"diabetic":[76,186],"patients":[77],"spontaneous":[80],"\\nanimal":[81],"models":[82],"for":[83,94],"limited":[88],"extent":[89],"only.":[90],"precise":[92],"reason":[93],"\\nimmune":[96],"system":[97,165],"target":[99],"pancreatic":[101],"islets":[102],"Langerhans":[104],"still":[106],"unclear.":[107],"\\n\\nThe":[108],"pathogenic":[109],"pancreas":[113,218],"characterized":[115],"by":[116,136],"pathology-\\nrelated":[118],"intra-islet":[119],"infiltration":[120,133],"T":[122,130],"B-lymphocytes":[124],"mediate":[126],"islet":[127,146,171],"destruction.":[128,172],"\\nand":[131],"B-cell":[132],"preceded":[135],"accumulation":[138,151],"macrophages":[140,210],"dendritic":[142],"cells":[143,156],"\\nat":[144],"periphery.":[147],"early":[149],"peri-islet":[150],"these":[153],"antigen":[154],"presenting":[155],"\\nprobably":[157],"reflects":[158],"first":[160],"response":[161],"progressively":[168],"heading":[169],"\\nfor":[170],"\\n\\nMacrophages":[173],"are":[174],"involved":[175],"every":[177],"step":[178],"diabetogenic":[181],"process.":[182],"In":[183],"non-\\nobese":[185],"(NOD)":[187],"mouse":[188,222],"spontaneously":[190],"develops":[191],"diabetes,":[192],"various":[193],"\\nmacrophage-abnormalities":[194],"like":[195],"defective":[196],"maturation,":[197],"reduced":[198],"phagocytosis":[199],"\\nincreased":[201],"production":[202],"IL-12,":[204],"have":[205],"been":[206],"described":[207],"previously.":[208],"Moreover,":[209],"\\nare":[211],"present":[212],"higher":[214],"numbers":[215],"NOD":[221],"birth":[224],"onwards,":[225],"\\nrandomly":[226],"distributed":[227],"connective":[230],"tissue":[231],"ex":[233]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
