{"id":"https://openalex.org/W2170872191","doi":"https://doi.org/10.3892/or.2013.2322","title":"The expression and function of Toll-like receptors 3 and 9 in human colon carcinoma","display_name":"The expression and function of Toll-like receptors 3 and 9 in human colon carcinoma","publication_year":2013,"publication_date":"2013-03-04","ids":{"openalex":"https://openalex.org/W2170872191","doi":"https://doi.org/10.3892/or.2013.2322","mag":"2170872191","pmid":"https://pubmed.ncbi.nlm.nih.gov/23467704"},"language":"en","primary_location":{"id":"doi:10.3892/or.2013.2322","doi":"https://doi.org/10.3892/or.2013.2322","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2013.2322","pdf_url":"http://www.spandidos-publications.com/or/29/5/1737/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/or/29/5/1737/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066533310","display_name":"Keiichiro Nojiri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KEIICHIRO NOJIRI","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109184777","display_name":"Kazushi Sugimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KAZUSHI SUGIMOTO","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061207039","display_name":"Katsuya Shiraki","orcid":"https://orcid.org/0000-0002-5164-1866","observed_orcids":["https://orcid.org/0000-0002-5164-1866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KATSUYA SHIRAKI","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065365769","display_name":"Masahiko Tameda","orcid":"https://orcid.org/0000-0003-4616-9939","observed_orcids":["https://orcid.org/0000-0003-4616-9939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MASAHIKO TAMEDA","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091067089","display_name":"YUUJI INAGAKI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YUUJI INAGAKI","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018139499","display_name":"Satoko Kusagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SATOKO KUSAGAWA","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068031569","display_name":"Suguru Ogura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SUGURU OGURA","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104109624","display_name":"Junichiro Tanaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JUNICHIRO TANAKA","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048880917","display_name":"Misao Yoneda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MISAO YONEDA","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100849967","display_name":"Norihiko Yamamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"NORIHIKO YAMAMOTO","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101710795","display_name":"Hiroshi Okano","orcid":"https://orcid.org/0000-0003-3612-7364","observed_orcids":["https://orcid.org/0000-0003-3612-7364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HIROSHI OKANO","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102401127","display_name":"Yoshiyuki Takei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YOSHIYUKI TAKEI","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101952689","display_name":"Masaaki Ito","orcid":"https://orcid.org/0000-0002-1661-9647","observed_orcids":["https://orcid.org/0000-0002-1661-9647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MASAAKI ITO","raw_affiliation_strings":["Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022959262","display_name":"Chika Kasai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CHIKA KASAI","raw_affiliation_strings":["Department of Molecular Diagnosis, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Diagnosis, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031250165","display_name":"Hidekazu Inoue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HIDEKAZU INOUE","raw_affiliation_strings":["Department of Molecular Diagnosis, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Diagnosis, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111732924","display_name":"Koujiro Takase","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KOUJIRO TAKASE","raw_affiliation_strings":["Department of Molecular Diagnosis, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Diagnosis, Mie Graduate University School of Medicine, Tsu, Mie 514-8507, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7847,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.67416314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"29","issue":"5","first_page":"1737","last_page":"1743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr3","display_name":"TLR3","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":1.0},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/double-stranded-rna","display_name":"double-stranded RNA","score":0.8090000152587891},{"id":"https://openalex.org/keywords/cpg-oligodeoxynucleotides","display_name":"CpG oligodeoxynucleotides","score":0.8809999823570251},{"id":"https://openalex.org/keywords/poly-i-c","display_name":"poly(I:C)","score":0.824999988079071},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.921999990940094},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/toll-like-receptor-agonists","display_name":"TLR agonists","score":0.7229999899864197},{"id":"https://openalex.org/keywords/pattern-recognition-receptors","display_name":"pattern recognition receptors","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2778420691","wikidata":"https://www.wikidata.org/wiki/Q14866230","display_name":"TLR3","level":5,"score":0.6079795956611633},{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.5395412445068359},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5170264840126038},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5007288455963135},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4735017418861389},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.44861191511154175},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4339957535266876},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.421619713306427},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.37509042024612427},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.3685559630393982},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36629197001457214},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3528045415878296},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.28757965564727783},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11928233504295349},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09438765048980713},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.08837065100669861},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009838","descriptor_name":"Oligodeoxyribonucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011070","descriptor_name":"Poly I-C","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.3892/or.2013.2322","doi":"https://doi.org/10.3892/or.2013.2322","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2013.2322","pdf_url":"http://www.spandidos-publications.com/or/29/5/1737/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},{"id":"pmid:23467704","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23467704","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology reports","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/or.2013.2322","doi":"https://doi.org/10.3892/or.2013.2322","is_oa":true,"landing_page_url":"https://doi.org/10.3892/or.2013.2322","pdf_url":"http://www.spandidos-publications.com/or/29/5/1737/download","source":{"id":"https://openalex.org/S124357017","display_name":"Oncology Reports","issn_l":"1021-335X","issn":["1021-335X","1791-2431"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5456095262","display_name":"Role of tumor-associated macrophages on response to chemotherapy in colon cancer","funder_award_id":"24591971","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170872191.pdf","grobid_xml":"https://content.openalex.org/works/W2170872191.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1503713311","https://openalex.org/W1965917728","https://openalex.org/W1969430178","https://openalex.org/W1970291282","https://openalex.org/W1976382352","https://openalex.org/W1995744610","https://openalex.org/W1998252979","https://openalex.org/W2007456673","https://openalex.org/W2009392385","https://openalex.org/W2023961167","https://openalex.org/W2054175331","https://openalex.org/W2061217549","https://openalex.org/W2065186557","https://openalex.org/W2069981713","https://openalex.org/W2075328959","https://openalex.org/W2076361525","https://openalex.org/W2101363646","https://openalex.org/W2117780508","https://openalex.org/W2129022624","https://openalex.org/W2130421043","https://openalex.org/W2134505828","https://openalex.org/W2157339124"],"related_works":["https://openalex.org/W2117780508","https://openalex.org/W2129022624","https://openalex.org/W3090991851","https://openalex.org/W2499455541","https://openalex.org/W2086602760","https://openalex.org/W2048941046","https://openalex.org/W2169721738","https://openalex.org/W2054670663","https://openalex.org/W2094606714","https://openalex.org/W2168522148"],"abstract_inverted_index":{"Toll-like":[0],"receptors":[1,5],"(TLRs)":[2],"are":[3,7,42],"pattern-recognition":[4],"that":[6],"important":[8,189],"in":[9,30,38,54,68,109,183,191],"immune":[10],"signaling.":[11],"TLR":[12,34],"recognition":[13],"of":[14,50,63,91,113,123,142,155,171,179,199,207],"various":[15],"viral":[16],"components":[17],"including":[18],"double-stranded":[19],"RNA":[20],"(TLR3)":[21],"and":[22,36,52,65,93,103,111,181],"unmethylated":[23],"CpG-DNA":[24],"(TLR9)":[25],"plays":[26,187],"a":[27,88],"crucial":[28],"role":[29,190],"cell":[31,70,76,81,95,131,160,192],"survival.":[32,193],"However,":[33],"expression":[35,49,178],"function":[37,62],"colon":[39,55,184,217],"carcinoma":[40,56,69,116,185,218],"cells":[41,57,186],"not":[43,129],"well":[44],"clarified.":[45],"We":[46],"investigated":[47],"the":[48,169,172,196,205],"TLR3":[51,64,102,124,180,202,209],"TLR9":[53,66,104,156,166,182],"using":[58,208],"immunohistochemical":[59,105],"methods.":[60],"The":[61],"signaling":[67],"lines":[71],"was":[72,107],"studied":[73],"by":[74,80,94],"direct":[75],"stimulation":[77,96,122,141,154],"with,":[78],"or":[79],"transfection":[82],"of,":[83],"polyinosinic-polycytidylic":[84],"acid":[85],"(Poly":[86],"I:C),":[87],"synthetic":[89],"form":[90],"dsRNA,":[92],"with":[97,125,145,157],"CpG-oligodeoxynucleotides":[98],"(ODNs),":[99],"respectively.":[100,119],"Positive":[101],"staining":[106],"observed":[108],"91":[110],"86%":[112],"human":[114],"hepatocellular":[115],"(HCC)":[117],"tissues,":[118],"Cell":[120,152,176],"surface":[121,153,177],"Poly":[126,147],"I:C":[127,148],"did":[128,135],"affect":[130],"viability":[132],"but":[133],"it":[134],"activate":[136],"NF-\u03baB":[137],"activity.":[138],"By":[139],"contrast,":[140],"intracellular":[143],"TLRs":[144],"transfected":[146],"significantly":[149],"induced":[150],"apoptosis.":[151],"CpG-ODNs":[158],"promoted":[159],"proliferation,":[161],"and,":[162],"furthermore,":[163],"these":[164],"CpG-ODN":[165],"agonists":[167,210],"reduced":[168],"cytotoxicity":[170],"anticancer":[173],"drug":[174],"adriamycin.":[175],"an":[188],"In":[194],"addition,":[195],"proapoptotic":[197],"activity":[198],"intracellularly":[200],"expressed":[201],"may":[203],"provide":[204],"possibility":[206],"as":[211],"novel":[212],"clinical":[213],"cytotoxic":[214],"agents":[215],"against":[216],"cells.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}