{"id":"https://openalex.org/W2170857776","doi":"https://doi.org/10.1002/bies.201400213","title":"Soma\u2010to\u2010germline feedback is implied by the extreme polymorphism at IGHV relative to MHC","display_name":"Soma\u2010to\u2010germline feedback is implied by the extreme polymorphism at IGHV relative to MHC","publication_year":2015,"publication_date":"2015-03-23","ids":{"openalex":"https://openalex.org/W2170857776","doi":"https://doi.org/10.1002/bies.201400213","mag":"2170857776","pmid":"https://pubmed.ncbi.nlm.nih.gov/25810320"},"language":"en","primary_location":{"id":"doi:10.1002/bies.201400213","doi":"https://doi.org/10.1002/bies.201400213","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.201400213","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075370774","display_name":"Edward J. Steele","orcid":"https://orcid.org/0000-0003-4700-3156","observed_orcids":["https://orcid.org/0000-0003-4700-3156"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Edward J. Steele","raw_affiliation_strings":["C.Y. O'Connor ERADE Village Foundation, Piara Waters, WA Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C.Y. O'Connor ERADE Village Foundation, Piara Waters, WA Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049693186","display_name":"Sally S. Lloyd","orcid":"https://orcid.org/0000-0002-0118-3094","observed_orcids":["https://orcid.org/0000-0002-0118-3094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sally S. Lloyd","raw_affiliation_strings":["C.Y. O'Connor ERADE Village Foundation, Piara Waters, WA Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C.Y. O'Connor ERADE Village Foundation, Piara Waters, WA Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075370774"],"corresponding_institution_ids":[],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":0.5991,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.53625378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"37","issue":"5","first_page":"557","last_page":"569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.007199999876320362,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mhc-polymorphism","display_name":"MHC polymorphism","score":0.8539999723434448},{"id":"https://openalex.org/keywords/immunoglobulin-variable-region-genes","display_name":"immunoglobulin variable region genes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.7239999771118164},{"id":"https://openalex.org/keywords/haplotype-data","display_name":"haplotype data","score":0.7850000262260437},{"id":"https://openalex.org/keywords/immunoglobulin-gene-evolution","display_name":"immunoglobulin gene evolution","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.7934554815292358},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6307255625724792},{"id":"https://openalex.org/C2779617337","wikidata":"https://www.wikidata.org/wiki/Q842429","display_name":"Soma","level":2,"score":0.6299915909767151},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5292607545852661},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.45061010122299194},{"id":"https://openalex.org/C2777609679","wikidata":"https://www.wikidata.org/wiki/Q5971015","display_name":"IGHV@","level":4,"score":0.44770103693008423},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4413795471191406},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2934626042842865},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14419427514076233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09565120935440063},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.0},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D005854","descriptor_name":"Germ Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007135","descriptor_name":"Immunoglobulin Variable Region","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/bies.201400213","doi":"https://doi.org/10.1002/bies.201400213","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bies.201400213","pdf_url":null,"source":{"id":"https://openalex.org/S27819959","display_name":"BioEssays","issn_l":"0265-9247","issn":["0265-9247","1521-1878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays","raw_type":"journal-article"},{"id":"pmid:25810320","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25810320","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BioEssays : news and reviews in molecular, cellular and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:alma.61MUN_INST:11136571840007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Soma-to-germline-feedback-is-implied-by-the/991005545119107891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:48762","doi":null,"is_oa":false,"landing_page_url":"https://researchrepository.murdoch.edu.au/id/eprint/48762/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Steele, E.J. &lt;https://researchrepository.murdoch.edu.au/view/author/Steele, Edward.html&gt; and Lloyd, S.S. &lt;https://researchrepository.murdoch.edu.au/view/author/Lloyd, Sally.html&gt;ORCID: 0000-0002-0118-3094 &lt;http://orcid.org/0000-0002-0118-3094&gt; (2015) Soma-to-germline feedback is implied by the extreme polymorphism at IGHV relative to MHC. BioEssays, 37 (5). pp. 557-569.","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W27513676","https://openalex.org/W34051067","https://openalex.org/W48211979","https://openalex.org/W84988101","https://openalex.org/W171898253","https://openalex.org/W958324919","https://openalex.org/W1490325011","https://openalex.org/W1499793841","https://openalex.org/W1562707898","https://openalex.org/W1604521274","https://openalex.org/W1607133945","https://openalex.org/W1782113201","https://openalex.org/W1816276702","https://openalex.org/W1940341482","https://openalex.org/W1967505760","https://openalex.org/W1968496468","https://openalex.org/W1969073369","https://openalex.org/W1971328622","https://openalex.org/W1972226463","https://openalex.org/W1972564604","https://openalex.org/W1973107491","https://openalex.org/W1973649102","https://openalex.org/W1973879730","https://openalex.org/W1974496991","https://openalex.org/W1978817164","https://openalex.org/W1980404973","https://openalex.org/W1984491478","https://openalex.org/W1984732712","https://openalex.org/W1984744880","https://openalex.org/W1984971641","https://openalex.org/W1987825582","https://openalex.org/W1988324108","https://openalex.org/W1989735636","https://openalex.org/W1992406580","https://openalex.org/W1995570599","https://openalex.org/W1996220604","https://openalex.org/W1998349187","https://openalex.org/W1999622475","https://openalex.org/W2003903333","https://openalex.org/W2005062591","https://openalex.org/W2006765654","https://openalex.org/W2006973414","https://openalex.org/W2008546779","https://openalex.org/W2008868324","https://openalex.org/W2009416280","https://openalex.org/W2010295342","https://openalex.org/W2014569071","https://openalex.org/W2021550979","https://openalex.org/W2022316530","https://openalex.org/W2025520438","https://openalex.org/W2029627165","https://openalex.org/W2029992830","https://openalex.org/W2037919740","https://openalex.org/W2040073329","https://openalex.org/W2041121696","https://openalex.org/W2041309682","https://openalex.org/W2041467642","https://openalex.org/W2041632913","https://openalex.org/W2042042190","https://openalex.org/W2043854974","https://openalex.org/W2044767010","https://openalex.org/W2047554700","https://openalex.org/W2051710843","https://openalex.org/W2052042327","https://openalex.org/W2052428345","https://openalex.org/W2055519354","https://openalex.org/W2056182559","https://openalex.org/W2058544815","https://openalex.org/W2060876619","https://openalex.org/W2061880916","https://openalex.org/W2066158696","https://openalex.org/W2077352871","https://openalex.org/W2077556096","https://openalex.org/W2078927662","https://openalex.org/W2079206868","https://openalex.org/W2082400921","https://openalex.org/W2082480897","https://openalex.org/W2083643955","https://openalex.org/W2083972873","https://openalex.org/W2090806216","https://openalex.org/W2093644145","https://openalex.org/W2097745266","https://openalex.org/W2098309323","https://openalex.org/W2099391799","https://openalex.org/W2100522111","https://openalex.org/W2101868807","https://openalex.org/W2102733876","https://openalex.org/W2104483166","https://openalex.org/W2106929331","https://openalex.org/W2109086160","https://openalex.org/W2115291391","https://openalex.org/W2123286852","https://openalex.org/W2123787243","https://openalex.org/W2124341756","https://openalex.org/W2133086081","https://openalex.org/W2133641259","https://openalex.org/W2136892614","https://openalex.org/W2138067488","https://openalex.org/W2138071207","https://openalex.org/W2139660626","https://openalex.org/W2140383483","https://openalex.org/W2145378546","https://openalex.org/W2145870836","https://openalex.org/W2149962584","https://openalex.org/W2151760147","https://openalex.org/W2156465884","https://openalex.org/W2160807401","https://openalex.org/W2166593999","https://openalex.org/W2169079957","https://openalex.org/W2169410091","https://openalex.org/W2171115218","https://openalex.org/W2171690009","https://openalex.org/W2209157691","https://openalex.org/W2313665848","https://openalex.org/W2323854428","https://openalex.org/W2331349354","https://openalex.org/W2467126253","https://openalex.org/W3000376485","https://openalex.org/W4231539689","https://openalex.org/W4233546182","https://openalex.org/W4251633039"],"related_works":["https://openalex.org/W61551963","https://openalex.org/W7021103547","https://openalex.org/W999686974","https://openalex.org/W2081924139","https://openalex.org/W2025120059","https://openalex.org/W3022219237","https://openalex.org/W2055519354","https://openalex.org/W3161628871","https://openalex.org/W2313665848","https://openalex.org/W1984491478"],"abstract_inverted_index":{"Soma-to-germline":[0],"feedback":[1],"is":[2,10,25,62],"forbidden":[3],"under":[4],"the":[5,39,45,54,57,67,72,80,88,109,116,132],"neo-Darwinian":[6],"paradigm.":[7],"Nevertheless,":[8],"there":[9],"a":[11,26,32],"growing":[12],"realization":[13],"it":[14,119],"occurs":[15],"frequently":[16],"in":[17,36,71,115],"immunoglobulin":[18,92],"(Ig)":[19],"variable":[20],"(V)":[21],"region":[22,70],"genes.":[23],"This":[24,111],"surprising":[27],"development.":[28],"It":[29],"arises":[30],"from":[31],"most":[33,68],"unlikely":[34],"source":[35],"light":[37],"of":[38,41,48,56,82,104],"exposure":[40],"co-author":[42],"EJS":[43],"to":[44,65,130],"haplotype":[46],"data":[47],"RL":[49],"Dawkins":[50],"and":[51,123],"others":[52],"on":[53],"polymorphism":[55,84],"Major":[58],"Histocompatibility":[59],"Complex,":[60],"which":[61],"generally":[63],"assumed":[64],"be":[66,101],"polymorphic":[69,107],"genome":[73],"(spanning":[74,95],"\u223c4":[75],"Mb).":[76],"The":[77],"comparison":[78],"between":[79],"magnitude":[81,105],"MHC":[83],"with":[85],"estimates":[86],"for":[87],"human":[89],"heavy":[90],"chain":[91],"V":[93],"locus":[94],"\u223c1":[96],"Mb),":[97],"suggests":[98],"IGHV":[99,133],"could":[100],"many":[102],"orders":[103],"more":[106],"than":[108],"MHC.":[110],"conclusion":[112],"needs":[113],"airing":[114],"literature":[117],"as":[118],"implies":[120],"generational":[121],"churn":[122],"soma-to-germline":[124],"gene":[125],"feedback.":[126],"Pedigree-based":[127],"experimental":[128],"strategies":[129],"resolve":[131],"issue":[134],"are":[135],"outlined.":[136]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
