{"id":"https://openalex.org/W2170824969","doi":"https://doi.org/10.1042/bj20150358","title":"Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways","display_name":"Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways","publication_year":2015,"publication_date":"2015-08-20","ids":{"openalex":"https://openalex.org/W2170824969","doi":"https://doi.org/10.1042/bj20150358","mag":"2170824969","pmid":"https://pubmed.ncbi.nlm.nih.gov/26348905"},"language":"en","primary_location":{"id":"doi:10.1042/bj20150358","doi":"https://doi.org/10.1042/bj20150358","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20150358","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ying Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100397405","display_name":"Yang Yang","orcid":"https://orcid.org/0000-0001-6612-8865","observed_orcids":["https://orcid.org/0000-0001-6612-8865"]},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028069486","display_name":"Richard John Ward","orcid":"https://orcid.org/0000-0003-1136-5737","observed_orcids":["https://orcid.org/0000-0003-1136-5737"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Ward","raw_affiliation_strings":["Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069732713","display_name":"Su An","orcid":"https://orcid.org/0000-0001-8642-5322","observed_orcids":["https://orcid.org/0000-0001-8642-5322"]},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Su An","raw_affiliation_strings":["Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102282778","display_name":"Xiao\u2010Xi Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Xi Guo","raw_affiliation_strings":["Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China","institution_ids":["https://openalex.org/I10660446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318295","display_name":"Wei Li","orcid":"https://orcid.org/0000-0002-8449-3839","observed_orcids":["https://orcid.org/0000-0002-8449-3839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Urology, the People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, the People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082670286","display_name":"Tian\u2010Rui Xu","orcid":"https://orcid.org/0000-0002-2416-2149","observed_orcids":["https://orcid.org/0000-0002-2416-2149"]},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian-Rui Xu","raw_affiliation_strings":["Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China","institution_ids":["https://openalex.org/I10660446"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5069732713","https://openalex.org/A5100397405"],"corresponding_institution_ids":["https://openalex.org/I10660446"],"apc_list":null,"apc_paid":null,"fwci":0.4655,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.39801242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"470","issue":"2","first_page":"155","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biased-signalling","display_name":"biased signalling","score":0.9810000061988831},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/g-protein-subtypes","display_name":"G protein subtypes","score":0.8100000023841858},{"id":"https://openalex.org/keywords/beta-arrestin","display_name":"beta-arrestin","score":0.847000002861023},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.6389999985694885},{"id":"https://openalex.org/keywords/ligand-selectivity","display_name":"ligand selectivity","score":0.7250000238418579},{"id":"https://openalex.org/keywords/gs-protein","display_name":"Gs protein","score":0.6399999856948853},{"id":"https://openalex.org/keywords/galphaq-11","display_name":"G\u03b1q/11","score":0.9900000095367432},{"id":"https://openalex.org/keywords/galphai-o","display_name":"G\u03b1i/o","score":0.9750000238418579},{"id":"https://openalex.org/keywords/galpha12-13","display_name":"G\u03b112/13","score":0.9860000014305115},{"id":"https://openalex.org/keywords/receptor-effector-coupling","display_name":"receptor-effector coupling","score":0.5019999742507935},{"id":"https://openalex.org/keywords/therapeutic-drug-targets","display_name":"therapeutic drug targets","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.8924381136894226},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.8647319078445435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6444314122200012},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5826985836029053},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5594874620437622},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5069682598114014},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.4986286163330078},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49417927861213684},{"id":"https://openalex.org/C2777503648","wikidata":"https://www.wikidata.org/wiki/Q905671","display_name":"Arrestin","level":4,"score":0.491266667842865},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.44312217831611633},{"id":"https://openalex.org/C43587935","wikidata":"https://www.wikidata.org/wiki/Q1258877","display_name":"Functional selectivity","level":4,"score":0.43884554505348206},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34987759590148926},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3326183557510376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15944671630859375}],"mesh":[{"descriptor_ui":"D000071557","descriptor_name":"beta-Arrestins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018035","descriptor_name":"Receptors, Odorant","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018035","descriptor_name":"Receptors, Odorant","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019390","descriptor_name":"Arrestins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1042/bj20150358","doi":"https://doi.org/10.1042/bj20150358","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20150358","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:26348905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26348905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.gla.ac.uk:110958","doi":null,"is_oa":false,"landing_page_url":"http://eprints.gla.ac.uk/110958/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":186,"referenced_works":["https://openalex.org/W10418522","https://openalex.org/W42399513","https://openalex.org/W151368347","https://openalex.org/W309050847","https://openalex.org/W1480379639","https://openalex.org/W1491233801","https://openalex.org/W1511459507","https://openalex.org/W1519261066","https://openalex.org/W1539260265","https://openalex.org/W1550186761","https://openalex.org/W1612973312","https://openalex.org/W1737683501","https://openalex.org/W1851005922","https://openalex.org/W1906409273","https://openalex.org/W1925492557","https://openalex.org/W1927614137","https://openalex.org/W1967487729","https://openalex.org/W1969513496","https://openalex.org/W1970613671","https://openalex.org/W1970823335","https://openalex.org/W1972513389","https://openalex.org/W1972609403","https://openalex.org/W1973332235","https://openalex.org/W1974836258","https://openalex.org/W1976251092","https://openalex.org/W1977323674","https://openalex.org/W1978310995","https://openalex.org/W1978885306","https://openalex.org/W1979980861","https://openalex.org/W1980826665","https://openalex.org/W1980980884","https://openalex.org/W1981469606","https://openalex.org/W1983012384","https://openalex.org/W1984697870","https://openalex.org/W1985018554","https://openalex.org/W1986185847","https://openalex.org/W1988922279","https://openalex.org/W1989850958","https://openalex.org/W1990331613","https://openalex.org/W1990939074","https://openalex.org/W1991194592","https://openalex.org/W1991512318","https://openalex.org/W1992451257","https://openalex.org/W1992991774","https://openalex.org/W1993382663","https://openalex.org/W1994311169","https://openalex.org/W1996228057","https://openalex.org/W1997068355","https://openalex.org/W1998607602","https://openalex.org/W2000655486","https://openalex.org/W2001438720","https://openalex.org/W2001626986","https://openalex.org/W2003470142","https://openalex.org/W2004371220","https://openalex.org/W2005269842","https://openalex.org/W2006803138","https://openalex.org/W2007337947","https://openalex.org/W2009134620","https://openalex.org/W2011444549","https://openalex.org/W2012693347","https://openalex.org/W2013293486","https://openalex.org/W2013575813","https://openalex.org/W2014001501","https://openalex.org/W2018435841","https://openalex.org/W2018897042","https://openalex.org/W2020601776","https://openalex.org/W2021008077","https://openalex.org/W2022063352","https://openalex.org/W2022576341","https://openalex.org/W2023078781","https://openalex.org/W2023287752","https://openalex.org/W2025002146","https://openalex.org/W2027858920","https://openalex.org/W2031100869","https://openalex.org/W2031150814","https://openalex.org/W2032223992","https://openalex.org/W2034802340","https://openalex.org/W2036912738","https://openalex.org/W2038401950","https://openalex.org/W2039116306","https://openalex.org/W2040036814","https://openalex.org/W2041512150","https://openalex.org/W2042097750","https://openalex.org/W2042836920","https://openalex.org/W2047050449","https://openalex.org/W2047093986","https://openalex.org/W2047605827","https://openalex.org/W2053549636","https://openalex.org/W2054975957","https://openalex.org/W2055532484","https://openalex.org/W2055692319","https://openalex.org/W2056410410","https://openalex.org/W2058964766","https://openalex.org/W2059628641","https://openalex.org/W2059936336","https://openalex.org/W2060079790","https://openalex.org/W2060177143","https://openalex.org/W2060734518","https://openalex.org/W2060874643","https://openalex.org/W2062129106","https://openalex.org/W2064731163","https://openalex.org/W2066869240","https://openalex.org/W2071895813","https://openalex.org/W2072346080","https://openalex.org/W2074140379","https://openalex.org/W2074785708","https://openalex.org/W2076770170","https://openalex.org/W2078065935","https://openalex.org/W2078381037","https://openalex.org/W2080192851","https://openalex.org/W2081307324","https://openalex.org/W2082956345","https://openalex.org/W2083002981","https://openalex.org/W2084388540","https://openalex.org/W2085108731","https://openalex.org/W2085381168","https://openalex.org/W2086880198","https://openalex.org/W2087276894","https://openalex.org/W2089240977","https://openalex.org/W2089436854","https://openalex.org/W2090774157","https://openalex.org/W2090882011","https://openalex.org/W2093749333","https://openalex.org/W2094671820","https://openalex.org/W2096227949","https://openalex.org/W2098565708","https://openalex.org/W2098765385","https://openalex.org/W2100270680","https://openalex.org/W2102352522","https://openalex.org/W2102944287","https://openalex.org/W2106551540","https://openalex.org/W2108906644","https://openalex.org/W2111373319","https://openalex.org/W2111478093","https://openalex.org/W2113754496","https://openalex.org/W2113862155","https://openalex.org/W2114024266","https://openalex.org/W2117762969","https://openalex.org/W2119199305","https://openalex.org/W2119398013","https://openalex.org/W2120960339","https://openalex.org/W2121473111","https://openalex.org/W2126017948","https://openalex.org/W2126041445","https://openalex.org/W2126348225","https://openalex.org/W2127093973","https://openalex.org/W2129351604","https://openalex.org/W2129352725","https://openalex.org/W2132107001","https://openalex.org/W2133402952","https://openalex.org/W2135587043","https://openalex.org/W2137092708","https://openalex.org/W2137163300","https://openalex.org/W2138325877","https://openalex.org/W2140864873","https://openalex.org/W2141558659","https://openalex.org/W2142681298","https://openalex.org/W2145094745","https://openalex.org/W2145427538","https://openalex.org/W2147196684","https://openalex.org/W2149134174","https://openalex.org/W2150603117","https://openalex.org/W2151338791","https://openalex.org/W2153167479","https://openalex.org/W2153568634","https://openalex.org/W2154288976","https://openalex.org/W2157512279","https://openalex.org/W2157562973","https://openalex.org/W2158821099","https://openalex.org/W2159623504","https://openalex.org/W2159718916","https://openalex.org/W2161582173","https://openalex.org/W2164039705","https://openalex.org/W2165345221","https://openalex.org/W2165488941","https://openalex.org/W2165671231","https://openalex.org/W2167857702","https://openalex.org/W2183475472","https://openalex.org/W2187317746","https://openalex.org/W2244286335","https://openalex.org/W2395734972","https://openalex.org/W3149071432","https://openalex.org/W4211150788","https://openalex.org/W4230381786","https://openalex.org/W4230763112","https://openalex.org/W4406054873"],"related_works":["https://openalex.org/W2561886516","https://openalex.org/W2782408527","https://openalex.org/W4402635860","https://openalex.org/W7100887396","https://openalex.org/W2560943845","https://openalex.org/W4417046481","https://openalex.org/W4298120158","https://openalex.org/W2888638654","https://openalex.org/W4407424519","https://openalex.org/W2978232364"],"abstract_inverted_index":{"GPCRs":[0,24,124,147,154],"(G-protein-coupled":[1],"receptors)":[2],"are":[3,11,110,162],"members":[4],"of":[5,8,18,23,71,87,113,123,130,146,182,192,195,207,237],"a":[6,35,40,68,128,227],"family":[7],"proteins":[9],"which":[10,79],"generally":[12],"regarded":[13],"as":[14,82],"the":[15,60,121,131,143,189,193,199,204,235],"largest":[16],"group":[17],"therapeutic":[19],"drug":[20],"targets.":[21],"Ligands":[22],"do":[25],"not":[26],"usually":[27],"activate":[28,63,95,157],"all":[29],"cellular":[30,190],"signalling":[31,65,72,89,102,173,178,186,209,223,230],"pathways":[32,66,103,233],"linked":[33],"to":[34,62,98,105,125,127,167,216],"particular":[36,69,205],"seven-transmembrane":[37],"receptor":[38],"in":[39],"uniform":[41],"manner.":[42],"The":[43,85,180],"fundamental":[44],"idea":[45],"behind":[46],"this":[47,77],"concept":[48,78],"is":[49,76,80,90,224],"that":[50,91,221],"each":[51],"ligand":[52],"has":[53],"its":[54,212],"own":[55],"ability,":[56],"while":[57],"interacting":[58],"with":[59],"receptor,":[61],"different":[64,150],"(or":[67],"set":[70],"pathways)":[73],"and":[74,104,165,174,184,210,234],"it":[75,92],"known":[81],"biased":[83,88,114,153,208,222],"signalling.":[84,115],"importance":[86],"may":[93,155],"selectively":[94],"biological":[96,213],"responses":[97],"favour":[99],"therapeutically":[100],"beneficial":[101],"avoid":[106],"adverse":[107],"effects.":[108],"There":[109],"two":[111],"levels":[112],"First,":[116],"bias":[117],"can":[118],"arise":[119],"from":[120],"ability":[122],"couple":[126],"subset":[129],"available":[132],"G-protein":[133,172,183],"subtypes:":[134],"G\u03b1s,":[135],"G\u03b1q/11,":[136],"G\u03b1i/o":[137],"or":[138,159,169],"G\u03b112/13.":[139],"These":[140],"subtypes":[141],"produce":[142],"diverse":[144],"effects":[145,214],"by":[148],"targeting":[149],"effectors.":[151],"Secondly,":[152],"differentially":[156],"G-proteins":[158],"\u03b2-arrestins.":[160],"\u03b2-Arrestins":[161],"ubiquitously":[163],"expressed":[164],"function":[166],"terminate":[168],"inhibit":[170],"classic":[171],"initiate":[175],"distinct":[176],"\u03b2-arrestin-mediated":[177],"processes.":[179],"interplay":[181],"\u03b2-arrestin":[185],"largely":[187],"determines":[188],"consequences":[191],"administration":[194],"GPCR-targeted":[196],"drugs.":[197],"In":[198],"present":[200],"review,":[201],"we":[202],"highlight":[203],"functionalities":[206],"discuss":[211],"subsequent":[215],"GPCR":[217],"activation.":[218],"We":[219],"consider":[220],"potentially":[225],"allowing":[226],"choice":[228],"between":[229],"through":[231],"'beneficial'":[232],"avoidance":[236],"'harmful'":[238],"ones.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
