{"id":"https://openalex.org/W2170824337","doi":null,"title":"Fas and FasL expression in leukocytes from chronic granulomatous disease patients.","display_name":"Fas and FasL expression in leukocytes from chronic granulomatous disease patients.","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2170824337","mag":"2170824337","pmid":"https://pubmed.ncbi.nlm.nih.gov/22978048"},"language":"en","primary_location":{"id":"pmid:22978048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22978048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigacion clinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059577722","display_name":"Daniela Montes-Berrueta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203303854","display_name":"Universidad de Los Andes","ror":"https://ror.org/02h1b1x27","country_code":"VE","type":"education","lineage":["https://openalex.org/I203303854"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Daniela Montes-Berrueta","raw_affiliation_strings":["Institute of Clinical Immunology, University of Los Andes, M\u00e9rida, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Clinical Immunology, University of Los Andes, M\u00e9rida, Venezuela","institution_ids":["https://openalex.org/I203303854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lorena Ram\u00edrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203303854","display_name":"Universidad de Los Andes","ror":"https://ror.org/02h1b1x27","country_code":"VE","type":"education","lineage":["https://openalex.org/I203303854"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Lorena Ram\u00edrez","raw_affiliation_strings":["University of Los Andes, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Los Andes, Venezuela","institution_ids":["https://openalex.org/I203303854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080655887","display_name":"Siham Salmen","orcid":"https://orcid.org/0000-0002-7221-3510","observed_orcids":["https://orcid.org/0000-0002-7221-3510"]},"institutions":[{"id":"https://openalex.org/I203303854","display_name":"Universidad de Los Andes","ror":"https://ror.org/02h1b1x27","country_code":"VE","type":"education","lineage":["https://openalex.org/I203303854"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Siham Salmen","raw_affiliation_strings":["University of Los Andes, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Los Andes, Venezuela","institution_ids":["https://openalex.org/I203303854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066772476","display_name":"Lisbeth Berrueta","orcid":"https://orcid.org/0000-0002-5674-6448","observed_orcids":["https://orcid.org/0000-0002-5674-6448"]},"institutions":[{"id":"https://openalex.org/I203303854","display_name":"Universidad de Los Andes","ror":"https://ror.org/02h1b1x27","country_code":"VE","type":"education","lineage":["https://openalex.org/I203303854"]}],"countries":["VE"],"is_corresponding":false,"raw_author_name":"Lisbeth Berrueta","raw_affiliation_strings":["University of Los Andes, Venezuela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Los Andes, Venezuela","institution_ids":["https://openalex.org/I203303854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I203303854"],"apc_list":null,"apc_paid":null,"fwci":0.3895,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.56605364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"53","issue":"2","first_page":"157","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.030500000342726707,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-granulomatous-disease","display_name":"chronic granulomatous disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.9509999752044678},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6549999713897705},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.47999998927116394},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7609999775886536},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.902999997138977},{"id":"https://openalex.org/keywords/p47phox","display_name":"p47phox","score":0.8889999985694885},{"id":"https://openalex.org/keywords/p67phox","display_name":"p67phox","score":0.9990000128746033},{"id":"https://openalex.org/keywords/primary-immunodeficiency","display_name":"primary immunodeficiency","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2778175462","wikidata":"https://www.wikidata.org/wiki/Q2165663","display_name":"Chronic granulomatous disease","level":2,"score":0.908504068851471},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.901503324508667},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6118477582931519},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5820352435112},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5043576955795288},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4800197184085846},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.46074119210243225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4590929448604584},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4498231112957001},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.4492534101009369},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.34346258640289307},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2468334138393402},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15361449122428894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07945889234542847},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006105","descriptor_name":"Granulomatous Disease, Chronic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:22978048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22978048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigacion clinica","raw_type":"Journal Article"},{"id":"pmh:oai:redalyc.org:372937688005","doi":null,"is_oa":false,"landing_page_url":"https://www.redalyc.org/articulo.oa?id=372937688005","pdf_url":null,"source":{"id":"https://openalex.org/S4377196100","display_name":"Redalyc (Universidad Aut\u00f3noma del Estado de M\u00e9xico)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I179647637","host_organization_name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","host_organization_lineage":["https://openalex.org/I179647637"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Investigaci\u00f3n Cl\u00ednica (Rep\u00fablica Bolivariana de Venezuela) Num.2 Vol.53","raw_type":"art\u00edculo cient\u00edfico"},{"id":"mag:2170824337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22978048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W116315320","https://openalex.org/W1032376300","https://openalex.org/W1583760582","https://openalex.org/W1593556005","https://openalex.org/W1642763135","https://openalex.org/W1951140057","https://openalex.org/W1976692354","https://openalex.org/W1987218634","https://openalex.org/W1988443097","https://openalex.org/W1992213437","https://openalex.org/W1995826417","https://openalex.org/W1996168515","https://openalex.org/W1997708855","https://openalex.org/W2002452021","https://openalex.org/W2005299533","https://openalex.org/W2007827117","https://openalex.org/W2020547407","https://openalex.org/W2041466047","https://openalex.org/W2042535720","https://openalex.org/W2046984814","https://openalex.org/W2047849952","https://openalex.org/W2053480920","https://openalex.org/W2064683290","https://openalex.org/W2084509745","https://openalex.org/W2102918221","https://openalex.org/W2102941331","https://openalex.org/W2107110723","https://openalex.org/W2108235369","https://openalex.org/W2110597235","https://openalex.org/W2110818336","https://openalex.org/W2113136739","https://openalex.org/W2116869192","https://openalex.org/W2119835397","https://openalex.org/W2127123481","https://openalex.org/W2130394140","https://openalex.org/W2155840031","https://openalex.org/W2157579772","https://openalex.org/W2157769836","https://openalex.org/W2159747058","https://openalex.org/W2169979796","https://openalex.org/W2997338506"],"related_works":["https://openalex.org/W7009829093","https://openalex.org/W1988443097","https://openalex.org/W2123360170","https://openalex.org/W2087213445","https://openalex.org/W4395115506","https://openalex.org/W1991063305","https://openalex.org/W2926696669","https://openalex.org/W2007887529","https://openalex.org/W2940615961","https://openalex.org/W2347100813"],"abstract_inverted_index":{"Abstract.":[0],"Chronic":[1],"Granulomatous":[2],"Disease":[3],"(CGD)":[4],"is":[5],"a":[6,51,78,151,160],"primary":[7],"immunodeficiency":[8],"characterized":[9],"by":[10],"defects":[11,165],"in":[12,20,81,87,100,112,173],"superoxide":[13],"(O2-)":[14],"production,":[15],"which":[16],"result":[17],"from":[18,43,117,140,159],"mutations":[19],"one":[21],"of":[22,68,90,98,130,146],"the":[23,35],"four":[24],"NADPH":[25],"oxidase":[26],"components,":[27],"predisposing":[28],"to":[29,48,57,62,76,123,168],"bacterial":[30],"and":[31,60,70,107,115,148],"fungal":[32],"infections.":[33],"Besides":[34],"O2-defect,":[36],"it":[37],"has":[38,54,84],"been":[39,55,85],"described":[40,86],"that":[41,53,137],"neutrophils":[42,116,158],"CGD":[44,119,141,161,174],"patients":[45,142],"are":[46],"resistant":[47],"cell":[49,82,171],"death,":[50,83],"phenomenon":[52],"connected":[56],"chronic":[58],"inflammation":[59],"predisposition":[61],"autoimmune":[63],"diseases.":[64],"A":[65],"diminished":[66,152],"expression":[67,154],"Fas":[69,106,147],"its":[71],"counterpart":[72],"FasL,":[73,149],"molecules":[74],"known":[75,122],"play":[77],"major":[79],"role":[80],"lymphocytes":[88,139],"depleted":[89],"O2-reactive":[91],"oxygen":[92],"species":[93],"(ROS),":[94],"suggesting":[95],"an":[96],"involvement":[97],"ROS":[99],"Fas/FasL":[101],"expression.":[102],"In":[103],"this":[104],"work,":[105],"FasL":[108,153],"expressions":[109],"were":[110],"analyzed":[111],"T":[113,138],"cells":[114],"two":[118,125],"families,":[120],"previously":[121],"harbor":[124],"different":[126],"molecular":[127],"defects:":[128],"absence":[129],"either":[131],"p47-phox":[132],"or":[133],"p67-phox.":[134],"We":[135],"found":[136],"express":[143],"low":[144],"levels":[145],"while":[150],"was":[155],"observed":[156],"on":[157],"A470":[162],"patient.":[163],"These":[164],"may":[166],"contribute":[167],"understand":[169],"altered":[170],"death":[172],"patients.":[175]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
