{"id":"https://openalex.org/W2170820347","doi":"https://doi.org/10.1261/rna.5112704","title":"Regulation of splicing: The importance of being translatable: FIGURE 1.","display_name":"Regulation of splicing: The importance of being translatable: FIGURE 1.","publication_year":2003,"publication_date":"2003-12-17","ids":{"openalex":"https://openalex.org/W2170820347","doi":"https://doi.org/10.1261/rna.5112704","mag":"2170820347","pmid":"https://pubmed.ncbi.nlm.nih.gov/14681577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370510"},"language":"en","primary_location":{"id":"doi:10.1261/rna.5112704","doi":"https://doi.org/10.1261/rna.5112704","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.5112704","pdf_url":"http://rnajournal.cshlp.org/content/10/1/1.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://rnajournal.cshlp.org/content/10/1/1.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037653951","display_name":"Elana Miriami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"ELANA MIRIAMI","raw_affiliation_strings":["Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","Department of Genetics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]},{"raw_affiliation_string":"Department of Genetics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045761416","display_name":"Ruth Sperling","orcid":"https://orcid.org/0000-0002-8950-4584","observed_orcids":["https://orcid.org/0000-0002-8950-4584"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"RUTH SPERLING","raw_affiliation_strings":["Department of Genetics,","Department of Organic Chemis- try , The Weizmann Institute of Science , Rehovot 76100 , Israel;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics,","institution_ids":[]},{"raw_affiliation_string":"Department of Organic Chemis- try , The Weizmann Institute of Science , Rehovot 76100 , Israel;","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047459030","display_name":"Joseph M. Sperling","orcid":"https://orcid.org/0000-0003-1916-5633","observed_orcids":["https://orcid.org/0000-0003-1916-5633"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"JOSEPH SPERLING","raw_affiliation_strings":["Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065188908","display_name":"Uzi Motro","orcid":"https://orcid.org/0000-0002-4761-2229","observed_orcids":["https://orcid.org/0000-0002-4761-2229"]},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"UZI MOTRO","raw_affiliation_strings":["Department of Evolution, Systematics and Ecology, and","Department of Statistics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolution, Systematics and Ecology, and","institution_ids":[]},{"raw_affiliation_string":"Department of Statistics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047459030"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":null,"apc_paid":null,"fwci":1.1493,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.76063067,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"10","issue":"1","first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/splicing-regulation","display_name":"splicing regulation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/open-reading-frames","display_name":"open reading frames","score":0.8149999976158142},{"id":"https://openalex.org/keywords/pre-mrna","display_name":"pre-mRNA","score":0.7609999775886536},{"id":"https://openalex.org/keywords/introns","display_name":"introns","score":0.703000009059906},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.40700000524520874},{"id":"https://openalex.org/keywords/mrna-secondary-structure","display_name":"mRNA secondary structure","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8810393810272217},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.8671720623970032},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.7770430445671082},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.7570240497589111},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6552433967590332},{"id":"https://openalex.org/C2780989783","wikidata":"https://www.wikidata.org/wiki/Q7578557","display_name":"splice","level":3,"score":0.6225597262382507},{"id":"https://openalex.org/C62257209","wikidata":"https://www.wikidata.org/wiki/Q5487490","display_name":"Splice site mutation","level":5,"score":0.6122596263885498},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5028111338615417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5012576580047607},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4734843969345093},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4554642140865326},{"id":"https://openalex.org/C91779695","wikidata":"https://www.wikidata.org/wiki/Q3780824","display_name":"Coding region","level":3,"score":0.4476810097694397},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3876878619194031},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.12575918436050415}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007438","descriptor_name":"Introns","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012322","descriptor_name":"RNA Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012323","descriptor_name":"RNA Processing, Post-Transcriptional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1261/rna.5112704","doi":"https://doi.org/10.1261/rna.5112704","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.5112704","pdf_url":"http://rnajournal.cshlp.org/content/10/1/1.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:118319","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1370510","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1370510","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1370510","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"Text"},{"id":"pmid:14681577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14681577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:rna:10/1/1","doi":null,"is_oa":false,"landing_page_url":"http://rnajournal.cshlp.org/cgi/content/short/10/1/1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1261/rna.5112704","doi":"https://doi.org/10.1261/rna.5112704","is_oa":true,"landing_page_url":"https://doi.org/10.1261/rna.5112704","pdf_url":"http://rnajournal.cshlp.org/content/10/1/1.full.pdf","source":{"id":"https://openalex.org/S187657468","display_name":"RNA","issn_l":"1355-8382","issn":["1355-8382","1469-9001"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RNA","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170820347.pdf","grobid_xml":"https://content.openalex.org/works/W2170820347.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W1964648599","https://openalex.org/W1973722557","https://openalex.org/W1980743552","https://openalex.org/W2027011833","https://openalex.org/W2039537118","https://openalex.org/W2079862385","https://openalex.org/W2084212780","https://openalex.org/W2136314741","https://openalex.org/W2161839829"],"related_works":["https://openalex.org/W1980743552","https://openalex.org/W2027011833","https://openalex.org/W1971713434","https://openalex.org/W2014027189","https://openalex.org/W2086666876","https://openalex.org/W2136314741","https://openalex.org/W2125293116","https://openalex.org/W4249287523","https://openalex.org/W2166721157","https://openalex.org/W944452251"],"abstract_inverted_index":{"RNA":[0],"sequences":[1],"that":[2,28,54,69,94],"conform":[3],"to":[4,42],"the":[5,40,49,79,88,96,101],"consensus":[6],"sequence":[7],"of":[8,30,70,90,103],"5'":[9,62],"splice":[10,63],"sites":[11,35,64,74],"but":[12],"are":[13],"not":[14],"used":[15],"for":[16],"splicing":[17,31],"occur":[18],"frequently":[19],"in":[20,48,58,100],"protein":[21],"coding":[22],"genes.":[23],"Mutational":[24],"analyses":[25],"have":[26],"shown":[27],"suppression":[29],"at":[32],"such":[33,73],"latent":[34,61],"may":[36],"be":[37],"dictated":[38],"by":[39,82],"necessity":[41],"maintain":[43],"an":[44],"open":[45],"reading":[46,98],"frame":[47,99],"mRNA.":[50],"Here":[51],"we":[52],"show":[53],"stop":[55],"codon":[56],"frequency":[57],"introns":[59,71],"having":[60],"is":[65],"significantly":[66,76],"greater":[67,77],"than":[68,78],"lacking":[72],"and":[75],"expected":[80],"occurrence":[81,89],"chance":[83],"alone.":[84],"Both":[85],"observations":[86],"suggest":[87],"a":[91],"general":[92],"mechanism":[93],"recognizes":[95],"mRNA":[97],"context":[102],"pre-mRNA.":[104]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}