{"id":"https://openalex.org/W2170799985","doi":"https://doi.org/10.1017/s0033291710001431","title":"The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives","display_name":"The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives","publication_year":2010,"publication_date":"2010-07-29","ids":{"openalex":"https://openalex.org/W2170799985","doi":"https://doi.org/10.1017/s0033291710001431","mag":"2170799985","pmid":"https://pubmed.ncbi.nlm.nih.gov/20667170"},"language":"en","primary_location":{"id":"doi:10.1017/s0033291710001431","doi":"https://doi.org/10.1017/s0033291710001431","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0033291710001431","pdf_url":null,"source":{"id":"https://openalex.org/S71144982","display_name":"Psychological Medicine","issn_l":"0033-2917","issn":["0033-2917","1469-8978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychological Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://publications.aston.ac.uk/id/eprint/20428/1/Impact_of_the_Val158Met_catechol_O_methyltransferase_genotype_on_neural_correlates_of_sad_facial_affect_processing.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084311071","display_name":"G. Lelli-Chiesa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["GB","IT"],"is_corresponding":false,"raw_author_name":"G. Lelli-Chiesa","raw_affiliation_strings":["Section of Neurobiology of Psychosis, Institute of Psychiatry, King's College London, UK","Department of Psychiatry, Sant'Andrea Hospital, Second Medical School, La Sapienza University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology of Psychosis, Institute of Psychiatry, King's College London, UK","institution_ids":["https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Psychiatry, Sant'Andrea Hospital, Second Medical School, La Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011077117","display_name":"Matthew J. Kempton","orcid":"https://orcid.org/0000-0003-3541-9947","observed_orcids":["https://orcid.org/0000-0003-3541-9947"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. J. Kempton","raw_affiliation_strings":["Section of Neurobiology of Psychosis, Institute of Psychiatry, King's College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology of Psychosis, Institute of Psychiatry, King's College London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069453054","display_name":"Jigar Jogia","orcid":"https://orcid.org/0000-0003-1799-1245","observed_orcids":["https://orcid.org/0000-0003-1799-1245"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Jogia","raw_affiliation_strings":["Section of Neurobiology of Psychosis, Institute of Psychiatry, King's College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology of Psychosis, Institute of Psychiatry, King's College London, UK","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064580143","display_name":"Roberto Tatarelli","orcid":"https://orcid.org/0000-0003-4396-2632","observed_orcids":["https://orcid.org/0000-0003-4396-2632"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Tatarelli","raw_affiliation_strings":["Department of Psychiatry, Sant'Andrea Hospital, Second Medical School, La Sapienza University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Sant'Andrea Hospital, Second Medical School, La Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056789152","display_name":"Paolo Girardi","orcid":"https://orcid.org/0000-0001-8330-9414","observed_orcids":["https://orcid.org/0000-0001-8330-9414"]},"institutions":[{"id":"https://openalex.org/I4210125574","display_name":"Azienda Ospedaliera Sant'Andrea","ror":"https://ror.org/032298f51","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210125574"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. Girardi","raw_affiliation_strings":["Department of Psychiatry, Sant'Andrea Hospital, Second Medical School, La Sapienza University, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Sant'Andrea Hospital, Second Medical School, La Sapienza University, Rome, Italy","institution_ids":["https://openalex.org/I4210125574","https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011932191","display_name":"John F. Powell","orcid":"https://orcid.org/0000-0001-6124-439X","observed_orcids":["https://orcid.org/0000-0001-6124-439X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Powell","raw_affiliation_strings":["MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Neurodegeneration Research, Department of Neuroscience, Institute of Psychiatry, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008683089","display_name":"David Andrew Collier","orcid":"https://orcid.org/0000-0003-4087-1559","observed_orcids":["https://orcid.org/0000-0003-4087-1559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. A. Collier","raw_affiliation_strings":["Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, London, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015454510","display_name":"Sophia Frangou","orcid":"https://orcid.org/0000-0002-3210-6470","observed_orcids":["https://orcid.org/0000-0002-3210-6470"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"S. Frangou","raw_affiliation_strings":["Section of Neurobiology of Psychosis, Institute of Psychiatry, King's College London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Neurobiology of Psychosis, Institute of Psychiatry, King's College London, UK","institution_ids":["https://openalex.org/I183935753"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015454510"],"corresponding_institution_ids":["https://openalex.org/I183935753"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":5.1086,"has_fulltext":true,"cited_by_count":60,"citation_normalized_percentile":{"value":0.95480894,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"41","issue":"4","first_page":"779","last_page":"788"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.1509000062942505,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.08030000329017639,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comt-val158met-polymorphism","display_name":"COMT Val158Met polymorphism","score":0.9589999914169312},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase","display_name":"catechol-O-methyltransferase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9509999752044678},{"id":"https://openalex.org/keywords/amygdala-activation","display_name":"amygdala activation","score":0.906000018119812},{"id":"https://openalex.org/keywords/ventrolateral-prefrontal-cortex","display_name":"ventrolateral prefrontal cortex","score":0.9390000104904175},{"id":"https://openalex.org/keywords/ventromedial-prefrontal-cortex","display_name":"ventromedial prefrontal cortex","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.5059999823570251},{"id":"https://openalex.org/keywords/emotion-regulation","display_name":"emotion regulation","score":0.5730000138282776},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.7910000085830688},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9929999709129333},{"id":"https://openalex.org/keywords/family-members","display_name":"family members","score":0.7039999961853027},{"id":"https://openalex.org/keywords/genetic-risk","display_name":"genetic risk","score":0.4620000123977661},{"id":"https://openalex.org/keywords/neural-correlates","display_name":"neural correlates","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6236643195152283},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.5989620089530945},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.566945493221283},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5542954206466675},{"id":"https://openalex.org/C185361966","wikidata":"https://www.wikidata.org/wiki/Q94291140","display_name":"Catechol-O-methyl transferase","level":4,"score":0.5374065041542053},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.5045210123062134},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.4304597079753876},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.41195985674858093},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.41064342856407166},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3798832893371582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3370494842529297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3127816915512085},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.29776281118392944},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24850216507911682},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.19486841559410095},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.17657062411308289},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1063784658908844},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000679","descriptor_name":"Amygdala","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D004292","descriptor_name":"Dominance, Cerebral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004292","descriptor_name":"Dominance, Cerebral","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004644","descriptor_name":"Emotions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005149","descriptor_name":"Facial Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010364","descriptor_name":"Pattern Recognition, Visual","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1017/s0033291710001431","doi":"https://doi.org/10.1017/s0033291710001431","is_oa":false,"landing_page_url":"https://doi.org/10.1017/s0033291710001431","pdf_url":null,"source":{"id":"https://openalex.org/S71144982","display_name":"Psychological Medicine","issn_l":"0033-2917","issn":["0033-2917","1469-8978"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychological Medicine","raw_type":"journal-article"},{"id":"pmid:20667170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20667170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychological medicine","raw_type":"Journal Article"},{"id":"pmh:oai:publications.aston.ac.uk:20428","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/id/eprint/20428/","pdf_url":"https://publications.aston.ac.uk/id/eprint/20428/1/Impact_of_the_Val158Met_catechol_O_methyltransferase_genotype_on_neural_correlates_of_sad_facial_affect_processing.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/754419","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/754419","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/62ffa2b7-49cc-4b24-b4f2-e8dd95c00fca","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/62ffa2b7-49cc-4b24-b4f2-e8dd95c00fca","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lelli-Chiesa, G, Kempton, M J, Jogia, J, Tatarelli, R, Girardi, P, Powell, J, Collier, D A & Frangou, S 2011, 'The impact of the Val(158)Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives', Psychological Medicine, vol. 41, no. 4, pp. 779 - 788. https://doi.org/10.1017/S0033291710001431","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:oai:publications.aston.ac.uk:20428","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/id/eprint/20428/","pdf_url":"https://publications.aston.ac.uk/id/eprint/20428/1/Impact_of_the_Val158Met_catechol_O_methyltransferase_genotype_on_neural_correlates_of_sad_facial_affect_processing.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311198","display_name":"South London and Maudsley NHS Foundation Trust","ror":"https://ror.org/015803449"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320285","display_name":"King's College London","ror":"https://ror.org/0220mzb33"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170799985.pdf","grobid_xml":"https://content.openalex.org/works/W2170799985.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W618310327","https://openalex.org/W1153329583","https://openalex.org/W1517011095","https://openalex.org/W1517585079","https://openalex.org/W1525298240","https://openalex.org/W1556541525","https://openalex.org/W1665095741","https://openalex.org/W1805858390","https://openalex.org/W1921971285","https://openalex.org/W1967996189","https://openalex.org/W1969032152","https://openalex.org/W1969227269","https://openalex.org/W1970806500","https://openalex.org/W1971228815","https://openalex.org/W1972851893","https://openalex.org/W1976031744","https://openalex.org/W1984166706","https://openalex.org/W1986171939","https://openalex.org/W1993773643","https://openalex.org/W1994041479","https://openalex.org/W1994843407","https://openalex.org/W1996330474","https://openalex.org/W1996395058","https://openalex.org/W1997343027","https://openalex.org/W1998939912","https://openalex.org/W2009140566","https://openalex.org/W2009348529","https://openalex.org/W2009973874","https://openalex.org/W2020615719","https://openalex.org/W2020844317","https://openalex.org/W2024565531","https://openalex.org/W2025292926","https://openalex.org/W2029582008","https://openalex.org/W2032866243","https://openalex.org/W2037004238","https://openalex.org/W2039148287","https://openalex.org/W2040263804","https://openalex.org/W2040533651","https://openalex.org/W2045159655","https://openalex.org/W2045728711","https://openalex.org/W2055807160","https://openalex.org/W2064540002","https://openalex.org/W2065650437","https://openalex.org/W2074356620","https://openalex.org/W2076220953","https://openalex.org/W2080019639","https://openalex.org/W2082071999","https://openalex.org/W2096127917","https://openalex.org/W2097434308","https://openalex.org/W2100040984","https://openalex.org/W2101520758","https://openalex.org/W2105837661","https://openalex.org/W2106188731","https://openalex.org/W2110247644","https://openalex.org/W2111464173","https://openalex.org/W2112650295","https://openalex.org/W2114613490","https://openalex.org/W2116628589","https://openalex.org/W2123636362","https://openalex.org/W2123734738","https://openalex.org/W2130259903","https://openalex.org/W2131721815","https://openalex.org/W2131871863","https://openalex.org/W2151786648","https://openalex.org/W2158553737","https://openalex.org/W2159011576","https://openalex.org/W2165696546","https://openalex.org/W2167659819","https://openalex.org/W2168931404","https://openalex.org/W2512799920"],"related_works":["https://openalex.org/W2016380577","https://openalex.org/W2541202807","https://openalex.org/W2127511653","https://openalex.org/W2059811111","https://openalex.org/W2583824229","https://openalex.org/W2055776898","https://openalex.org/W1967346633","https://openalex.org/W2045728711","https://openalex.org/W2065650437","https://openalex.org/W2093299549"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,51],"Met":[2],"allele":[3,147,157,187,233],"of":[4,31,34,142],"the":[5,29,72,106,145,155,163,170,182,185,215,224,231,239],"catechol-O-methyltransferase":[6],"(COMT)":[7],"valine-to-methionine":[8],"(Val158Met)":[9],"polymorphism":[10,60,218],"is":[11,24,55],"known":[12],"to":[13,27,69,77,102],"affect":[14,86,118],"dopamine-dependent":[15],"affective":[16,38,198,244],"regulation":[17],"within":[18,223],"amygdala-prefrontal":[19],"cortical":[20,236],"(PFC)":[21],"networks.":[22],"It":[23],"also":[25],"thought":[26],"increase":[28],"risk":[30,53],"a":[32,62,89,204,220],"number":[33],"disorders":[35,129],"characterized":[36],"by":[37],"morbidity":[39,199],"including":[40],"bipolar":[41],"disorder":[42,46],"(BD),":[43],"major":[44],"depressive":[45],"(MDD)":[47],"and":[48,111,127,136,154,165,172,207],"anxiety":[49,128],"disorders.":[50],"disease":[52,178],"conferred":[54],"small,":[56],"suggesting":[57],"that":[58,214],"this":[59],"represents":[61],"modifier":[63],"locus.":[64],"Therefore":[65],"our":[66],"aim":[67],"was":[68,148,188],"investigate":[70],"how":[71],"COMT":[73,216],"Val158Met":[74,217],"may":[75],"contribute":[76],"phenotypic":[78],"variation":[79],"in":[80,105,120,162,169,181,193,238,241],"clinical":[81,143],"diagnosis":[82,134,206],"using":[83],"sad":[84,116],"facial":[85,117],"processing":[87,119],"as":[88],"probe":[90],"for":[91],"its":[92],"neural":[93,225],"action.":[94],"METHOD:":[95],"We":[96],"employed":[97],"functional":[98],"magnetic":[99],"resonance":[100],"imaging":[101],"measure":[103],"activation":[104,153,192],"amygdala,":[107],"ventromedial":[108],"PFC":[109,113],"(vmPFC)":[110],"ventrolateral":[112],"(vlPFC)":[114],"during":[115],"family":[121,195],"members":[122,196],"with":[123,150,158,177,190,197,201,243],"BD":[124],"(n=40),":[125],"MDD":[126],"(n=22)":[130],"or":[131],"no":[132],"psychiatric":[133,205],"(n=25)":[135],"50":[137],"healthy":[138,208],"controls.":[139,209],"RESULTS:":[140],"Irrespective":[141],"phenotype,":[144],"Val158":[146],"associated":[149,176,189],"greater":[151,159,191],"amygdala":[152,171],"Met158":[156,186,232],"signal":[160],"change":[161],"vmPFC":[164,173],"vlPFC.":[166],"Signal":[167],"changes":[168],"were":[174],"not":[175],"expression.":[179],"However,":[180],"right":[183],"vlPFC":[184,240],"all":[194],"compared":[200],"relatives":[202],"without":[203],"CONCLUSIONS:":[210],"Our":[211],"results":[212],"suggest":[213],"has":[219],"pleiotropic":[221],"effect":[222],"networks":[226],"subserving":[227],"emotional":[228],"processing.":[229],"Furthermore":[230],"further":[234],"reduces":[235],"efficiency":[237],"individuals":[242],"morbidity.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}