{"id":"https://openalex.org/W2170794690","doi":null,"title":"Traumatic brain injury in humans and animal models","display_name":"Traumatic brain injury in humans and animal models","publication_year":2012,"publication_date":"2012-09-07","ids":{"openalex":"https://openalex.org/W2170794690","mag":"2170794690"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-212088","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212088","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212088","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045262598","display_name":"Elham Rostami","orcid":"https://orcid.org/0000-0003-1218-6247","observed_orcids":["https://orcid.org/0000-0003-1218-6247"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elham Rostami","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1218-6247","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045262598"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":1.0},{"id":"https://openalex.org/keywords/animal-models-of-tbi","display_name":"animal models of TBI","score":0.8069999814033508},{"id":"https://openalex.org/keywords/penetrating-trauma","display_name":"penetrating trauma","score":0.6779999732971191},{"id":"https://openalex.org/keywords/diffuse-axonal-injury","display_name":"diffuse axonal injury","score":0.9160000085830688},{"id":"https://openalex.org/keywords/axonal-injury","display_name":"axonal injury","score":0.8510000109672546},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.828000009059906},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.5450000166893005},{"id":"https://openalex.org/keywords/s100b","display_name":"S100B","score":0.9900000095367432},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.640999972820282},{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.6579999923706055},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7129999995231628},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.875},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5339999794960022},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.6140000224113464},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5070000290870667}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.7192742824554443},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.525221586227417},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.39123308658599854},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.3689091205596924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36351537704467773},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13982009887695312}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:DiVA.org:uu-212088","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212088","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:figshare.com:article/26907340","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Traumatic_brain_injury_in_humans_and_animal_models/26907340","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/41133","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/41133","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2170794690","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/41133","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-212088","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212088","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":376,"referenced_works":["https://openalex.org/W39805860","https://openalex.org/W45707290","https://openalex.org/W69395217","https://openalex.org/W85799227","https://openalex.org/W116844940","https://openalex.org/W133996984","https://openalex.org/W188973668","https://openalex.org/W1214095438","https://openalex.org/W1482799545","https://openalex.org/W1483477190","https://openalex.org/W1484497860","https://openalex.org/W1490397100","https://openalex.org/W1496877897","https://openalex.org/W1504679766","https://openalex.org/W1519358455","https://openalex.org/W1527035699","https://openalex.org/W1535546167","https://openalex.org/W1540484053","https://openalex.org/W1544685573","https://openalex.org/W1564756431","https://openalex.org/W1568806992","https://openalex.org/W1573139030","https://openalex.org/W1574637310","https://openalex.org/W1579454106","https://openalex.org/W1580988107","https://openalex.org/W1584047372","https://openalex.org/W1585082252","https://openalex.org/W1603121691","https://openalex.org/W1603757083","https://openalex.org/W1672576559","https://openalex.org/W1712663563","https://openalex.org/W1807367985","https://openalex.org/W1847168837","https://openalex.org/W1880007786","https://openalex.org/W1892553999","https://openalex.org/W1898813276","https://openalex.org/W1906455986","https://openalex.org/W1919495767","https://openalex.org/W1926043920","https://openalex.org/W1940215351","https://openalex.org/W1963539721","https://openalex.org/W1964160578","https://openalex.org/W1964282366","https://openalex.org/W1965364787","https://openalex.org/W1965782875","https://openalex.org/W1965925370","https://openalex.org/W1966933652","https://openalex.org/W1966985715","https://openalex.org/W1967148805","https://openalex.org/W1967470495","https://openalex.org/W1968007289","https://openalex.org/W1968563974","https://openalex.org/W1968657909","https://openalex.org/W1969349734","https://openalex.org/W1969505025","https://openalex.org/W1970107990","https://openalex.org/W1970609605","https://openalex.org/W1971335269","https://openalex.org/W1971378711","https://openalex.org/W1971751449","https://openalex.org/W1971851666","https://openalex.org/W1973094858","https://openalex.org/W1974449064","https://openalex.org/W1975473823","https://openalex.org/W1975908033","https://openalex.org/W1976050094","https://openalex.org/W1977071806","https://openalex.org/W1977423783","https://openalex.org/W1977687604","https://openalex.org/W1977864670","https://openalex.org/W1978208103","https://openalex.org/W1979125012","https://openalex.org/W1980011499","https://openalex.org/W1980837729","https://openalex.org/W1980941036","https://openalex.org/W1981713291","https://openalex.org/W1982134982","https://openalex.org/W1982488885","https://openalex.org/W1982889157","https://openalex.org/W1982892406","https://openalex.org/W1983144557","https://openalex.org/W1983148583","https://openalex.org/W1983455034","https://openalex.org/W1984788006","https://openalex.org/W1984800913","https://openalex.org/W1985555928","https://openalex.org/W1986702986","https://openalex.org/W1987467195","https://openalex.org/W1987787017","https://openalex.org/W1988660081","https://openalex.org/W1988930568","https://openalex.org/W1989349306","https://openalex.org/W1989978179","https://openalex.org/W1990257603","https://openalex.org/W1990645648","https://openalex.org/W1991561787","https://openalex.org/W1991953639","https://openalex.org/W1992166336","https://openalex.org/W1992887367","https://openalex.org/W1994030229","https://openalex.org/W1995096028","https://openalex.org/W1995271063","https://openalex.org/W1995594765","https://openalex.org/W1995946234","https://openalex.org/W1996125369","https://openalex.org/W1996251887","https://openalex.org/W1996614758","https://openalex.org/W1997545658","https://openalex.org/W1999934730","https://openalex.org/W2000079550","https://openalex.org/W2000838270","https://openalex.org/W2002945532","https://openalex.org/W2003409520","https://openalex.org/W2003505305","https://openalex.org/W2003744669","https://openalex.org/W2003806363","https://openalex.org/W2004950446","https://openalex.org/W2005046755","https://openalex.org/W2005779853","https://openalex.org/W2006070589","https://openalex.org/W2006437073","https://openalex.org/W2006841841","https://openalex.org/W2007253175","https://openalex.org/W2007453010","https://openalex.org/W2007641444","https://openalex.org/W2007897070","https://openalex.org/W2008196796","https://openalex.org/W2009178440","https://openalex.org/W2009222090","https://openalex.org/W2009532273","https://openalex.org/W2009875407","https://openalex.org/W2010223365","https://openalex.org/W2012062176","https://openalex.org/W2012338377","https://openalex.org/W2012382378","https://openalex.org/W2012423618","https://openalex.org/W2012773722","https://openalex.org/W2013114350","https://openalex.org/W2013373204","https://openalex.org/W2013609330","https://openalex.org/W2014457069","https://openalex.org/W2015049091","https://openalex.org/W2015625647","https://openalex.org/W2015656291","https://openalex.org/W2016108891","https://openalex.org/W2018269249","https://openalex.org/W2019544787","https://openalex.org/W2020215900","https://openalex.org/W2020266918","https://openalex.org/W2020622209","https://openalex.org/W2021497853","https://openalex.org/W2021883241","https://openalex.org/W2022853909","https://openalex.org/W2023323938","https://openalex.org/W2023388136","https://openalex.org/W2023609873","https://openalex.org/W2023715580","https://openalex.org/W2025071036","https://openalex.org/W2025629499","https://openalex.org/W2025639202","https://openalex.org/W2025687868","https://openalex.org/W2026199497","https://openalex.org/W2027535421","https://openalex.org/W2028253537","https://openalex.org/W2028662192","https://openalex.org/W2028729448","https://openalex.org/W2029905908","https://openalex.org/W2029934068","https://openalex.org/W2030201417","https://openalex.org/W2030688762","https://openalex.org/W2031730172","https://openalex.org/W2032233246","https://openalex.org/W2033255320","https://openalex.org/W2033278909","https://openalex.org/W2033367566","https://openalex.org/W2035040528","https://openalex.org/W2035172439","https://openalex.org/W2036362108","https://openalex.org/W2039754720","https://openalex.org/W2040786733","https://openalex.org/W2041204070","https://openalex.org/W2042735193","https://openalex.org/W2042940424","https://openalex.org/W2043105135","https://openalex.org/W2043427017","https://openalex.org/W2044190163","https://openalex.org/W2045663952","https://openalex.org/W2045791737","https://openalex.org/W2045912241","https://openalex.org/W2046556661","https://openalex.org/W2046731614","https://openalex.org/W2047159816","https://openalex.org/W2047731623","https://openalex.org/W2049173294","https://openalex.org/W2049676706","https://openalex.org/W2050120071","https://openalex.org/W2050644696","https://openalex.org/W2050800676","https://openalex.org/W2051104594","https://openalex.org/W2051395367","https://openalex.org/W2051454336","https://openalex.org/W2051467418","https://openalex.org/W2051474774","https://openalex.org/W2051549180","https://openalex.org/W2051600991","https://openalex.org/W2051667606","https://openalex.org/W2051809205","https://openalex.org/W2053530117","https://openalex.org/W2054258745","https://openalex.org/W2054533649","https://openalex.org/W2055043789","https://openalex.org/W2056197197","https://openalex.org/W2057383858","https://openalex.org/W2057417429","https://openalex.org/W2057714861","https://openalex.org/W2058046532","https://openalex.org/W2059117412","https://openalex.org/W2059521678","https://openalex.org/W2059641640","https://openalex.org/W2059668400","https://openalex.org/W2059714521","https://openalex.org/W2059714868","https://openalex.org/W2060433627","https://openalex.org/W2060545591","https://openalex.org/W2060943628","https://openalex.org/W2061196406","https://openalex.org/W2061476401","https://openalex.org/W2061749458","https://openalex.org/W2061862943","https://openalex.org/W2062219794","https://openalex.org/W2063636071","https://openalex.org/W2064437704","https://openalex.org/W2065205627","https://openalex.org/W2065398567","https://openalex.org/W2066092834","https://openalex.org/W2066520613","https://openalex.org/W2066610668","https://openalex.org/W2067448822","https://openalex.org/W2067629356","https://openalex.org/W2067856703","https://openalex.org/W2068123273","https://openalex.org/W2068260202","https://openalex.org/W2068767931","https://openalex.org/W2068811322","https://openalex.org/W2068841408","https://openalex.org/W2069929706","https://openalex.org/W2070035561","https://openalex.org/W2071117688","https://openalex.org/W2072237144","https://openalex.org/W2072401555","https://openalex.org/W2073349153","https://openalex.org/W2074369656","https://openalex.org/W2076293933","https://openalex.org/W2076894554","https://openalex.org/W2076929445","https://openalex.org/W2077702812","https://openalex.org/W2077897416","https://openalex.org/W2078167209","https://openalex.org/W2078243391","https://openalex.org/W2078316783","https://openalex.org/W2079036536","https://openalex.org/W2079730704","https://openalex.org/W2080048398","https://openalex.org/W2080090356","https://openalex.org/W2080269340","https://openalex.org/W2080603276","https://openalex.org/W2082498537","https://openalex.org/W2082824466","https://openalex.org/W2083200309","https://openalex.org/W2083623712","https://openalex.org/W2084175495","https://openalex.org/W2084380651","https://openalex.org/W2084877050","https://openalex.org/W2087154365","https://openalex.org/W2087217561","https://openalex.org/W2087232077","https://openalex.org/W2088615921","https://openalex.org/W2089631463","https://openalex.org/W2090095487","https://openalex.org/W2091161030","https://openalex.org/W2092324476","https://openalex.org/W2092380401","https://openalex.org/W2092935640","https://openalex.org/W2093567344","https://openalex.org/W2094432571","https://openalex.org/W2094544368","https://openalex.org/W2096327192","https://openalex.org/W2098489263","https://openalex.org/W2099150402","https://openalex.org/W2099233769","https://openalex.org/W2101821836","https://openalex.org/W2102147114","https://openalex.org/W2103044571","https://openalex.org/W2104090580","https://openalex.org/W2107464534","https://openalex.org/W2108591806","https://openalex.org/W2108676263","https://openalex.org/W2110755408","https://openalex.org/W2111040212","https://openalex.org/W2111279030","https://openalex.org/W2112514311","https://openalex.org/W2113094956","https://openalex.org/W2113570143","https://openalex.org/W2114057482","https://openalex.org/W2115040289","https://openalex.org/W2115084515","https://openalex.org/W2115766175","https://openalex.org/W2115823346","https://openalex.org/W2117516249","https://openalex.org/W2118546840","https://openalex.org/W2118855639","https://openalex.org/W2122045701","https://openalex.org/W2122606472","https://openalex.org/W2122683221","https://openalex.org/W2124755030","https://openalex.org/W2124793618","https://openalex.org/W2127282138","https://openalex.org/W2128468027","https://openalex.org/W2129000249","https://openalex.org/W2129029307","https://openalex.org/W2129079365","https://openalex.org/W2129436285","https://openalex.org/W2130004211","https://openalex.org/W2130417276","https://openalex.org/W2130844101","https://openalex.org/W2132468224","https://openalex.org/W2132569582","https://openalex.org/W2132918450","https://openalex.org/W2133188546","https://openalex.org/W2133214170","https://openalex.org/W2133776279","https://openalex.org/W2134844459","https://openalex.org/W2135380777","https://openalex.org/W2136750984","https://openalex.org/W2139403026","https://openalex.org/W2139469156","https://openalex.org/W2139565721","https://openalex.org/W2140409748","https://openalex.org/W2141533008","https://openalex.org/W2141568187","https://openalex.org/W2144564367","https://openalex.org/W2146493911","https://openalex.org/W2147783395","https://openalex.org/W2152554480","https://openalex.org/W2152664025","https://openalex.org/W2153279852","https://openalex.org/W2154104720","https://openalex.org/W2154562471","https://openalex.org/W2154727263","https://openalex.org/W2155634762","https://openalex.org/W2155683319","https://openalex.org/W2157001082","https://openalex.org/W2158217645","https://openalex.org/W2158752949","https://openalex.org/W2158935809","https://openalex.org/W2160956948","https://openalex.org/W2161127400","https://openalex.org/W2163305295","https://openalex.org/W2165804706","https://openalex.org/W2166801542","https://openalex.org/W2167864596","https://openalex.org/W2168334242","https://openalex.org/W2169200799","https://openalex.org/W2170424940","https://openalex.org/W2181576903","https://openalex.org/W2188166394","https://openalex.org/W2313447995","https://openalex.org/W2331808191","https://openalex.org/W2404639217","https://openalex.org/W2417082318","https://openalex.org/W2430615846","https://openalex.org/W2468565651","https://openalex.org/W2821438759","https://openalex.org/W4211255027","https://openalex.org/W4244977113","https://openalex.org/W4364863534"],"related_works":["https://openalex.org/W2316439872","https://openalex.org/W1566553376","https://openalex.org/W2513491912","https://openalex.org/W2040791904","https://openalex.org/W3196928522","https://openalex.org/W2354057807","https://openalex.org/W4407008461","https://openalex.org/W4410640694","https://openalex.org/W4401749800","https://openalex.org/W2335255222"],"abstract_inverted_index":{"Traumatic":[0,791],"brain":[1,44,166,442,694,739,825,866],"injuries":[2,13,315,327,339,414],"(TBI)":[3],"are":[4,94,175,423],"receiving":[5],"increasing":[6,24],"attention":[7],"due":[8],"to":[9,15,22,97,107,177,190,195,205,251,279,316,370,429,437,517,605,614,625,648,655],"a":[10,67,89,98,114,179,187],"combination":[11],"of":[12,26,34,60,73,85,102,201,213,223,255,257,268,284,297,321,347,466,491,504,522,540,545,552,563,568,583,598,601,610,617,629,632,658,670,691,750],"related":[14,96,752],"war":[16],"and":[17,46,62,83,106,138,154,189,236,289,310,353,365,384,390,415,441,452,471,474,506,512,525,573,747,854,858,861],"sports,":[18],"as":[19,21,240,620,622,662,664],"well":[20,621,663],"an":[23,461],"number":[25],"traffic":[27],"accident":[28],"survivors.":[29],"Today":[30],"the":[31,48,53,71,76,79,109,158,183,193,196,244,253,266,322,344,351,359,374,393,407,420,448,453,464,467,488,502,530,538,542,550,558,581,587,590,596,607,615,640,649,656],"leading":[32],"cause":[33],"death":[35,54],"in":[36,39,47,70,75,164,210,226,231,299,302,308,329,336,341,350,358,381,406,419,477,514,529,557,580,698,783,788,852],"young":[37],"adults":[38],"industrialized":[40],"nations":[41],"is":[42,56,113,171,592,781],"traumatic":[43,738,824,865],"injury":[45,348,439,740],"population":[49],"under":[50],"35":[51],"years,":[52],"rate":[55],"3.5":[57],"times":[58],"that":[59,117,127,134,185,219,396,412,487,576,741],"cancer":[61],"heart":[63],"disease":[64],"combined.":[65],"Despite":[66,343],"major":[68,141,282],"improvement":[69],"outcome":[72,267,440,476],"TBI":[74,112,214,224,258,312,324,422,564,618,633],"acute":[77],"setting,":[78,589],"assessment,":[80],"therapeutic":[81],"interventions":[82],"prevention":[84],"long-term":[86],"complications":[87],"remain":[88],"challenge.":[90],"The":[91,140,199,305,319,376,520,627,777],"challenges":[92],"today":[93],"primarily":[95],"rapid":[99],"diagnosis,":[100],"identification":[101],"patient\u2019s":[103],"pathophysiological":[104],"heterogeneity":[105,256,433,616],"limit":[108],"secondary":[110,131,142,237,416],"injuries.":[111,602],"complex":[115,130],"condition":[116],"can":[118,434,644],"be":[119,317,435,578,646],"caused":[120],"by":[121,215,388,401,595],"focal":[122,784],"or":[123],"diffuse":[124,337,790],"primary":[125],"impacts":[126],"may":[128,577],"initiate":[129],"neurochemical":[132],"processes":[133,209,238],"proceeds":[135],"over":[136],"hours":[137],"days.":[139],"events":[143,184],"include":[144],"neuronal":[145],"death,":[146,399],"ischemia,":[147],"excitotoxicity,":[148],"mitochondrial":[149],"failure,":[150],"oxidative":[151],"stress,":[152],"oedema":[153],"inflammation.":[155],"In":[156,247,427,533,586,603],"addition,":[157],"brain\u2019s":[159],"restorative":[160],"capacity":[161],"involving":[162,243],"neurotrophins,":[163],"particular":[165],"derived":[167],"neurotrophic":[168],"factor":[169],"(BDNF),":[170],"triggered.":[172],"Animal":[173],"models":[174,218,278,554,634],"necessary":[176],"gain":[178],"deeper":[180],"insight":[181],"into":[182],"follow":[186],"TBI,":[188,269,386,445,546],"ultimately":[191],"apply":[192],"findings":[194,307,335],"clinical":[197,334,559,588,650],"setting.":[198,560,651],"aim":[200],"this":[202],"thesis":[203],"was":[204,325,379,403,460,527],"identify":[206],"distinct":[207,221,295,566,630],"pathological":[208],"different":[211,543,599],"types":[212,222,283,544,600,631],"using":[216],"animal":[217,277,553],"mimic":[220,280],"found":[225,294,328,418,486],"patients.":[227],"We":[228,275,293,456,485],"investigated":[229,457,501],"alterations":[230],"gene":[232,300,569],"expression,":[233,570],"serum":[234,360,584,753],"biomarkers":[235,361],"such":[239],"inflammatory":[241],"response":[242],"complement":[245,377,425,778],"cascade.":[246],"addition":[248,604],"we":[249,446,500],"aimed":[250],"assess":[252],"effects":[254],"patients,":[259],"based":[260],"on":[261,265,273],"their":[262,623],"genetic":[263,432,489,608],"background,":[264],"with":[270,333],"specific":[271],"focus":[272],"BDNF.":[274],"used":[276,436],"three":[281],"TBI;":[285],"blast":[286,309,692],"wave,":[287],"penetrating":[288,383,408,482,497,518,785,823,864],"rotational":[290,311,323,385,421],"acceleration":[291],"TBI.":[292,409,498,519],"profiles":[296],"alteration":[298],"expression":[301,503,521],"these":[303,314,535],"models.":[304],"histological":[306],"indicated":[313],"mild.":[318],"hallmark":[320],"axonal":[326,338,413],"anatomical":[330],"locations":[331],"comparable":[332],"(DAI)":[340],"humans.":[342],"mild":[345,737,789],"type":[346,562],"displayed":[349],"histology":[352],"behavioural":[354,571],"outcome,":[355,572],"significant":[356],"increases":[357],"Tau,":[362],"S100B,":[363],"NF-H":[364],"MBP":[366],"were":[367],"observed":[368],"up":[369],"2":[371],"weeks":[372],"following":[373,444,496,863],"injury.":[375,484,826,867],"cascade":[378],"initiated":[380],"both":[382],"detected":[387,400],"C1q":[389],"C3.":[391],"However,":[392],"terminal":[394,779],"pathway":[395,780],"generates":[397],"cell":[398],"C5b9,":[402],"only":[404,548],"activated":[405,782],"This":[410,652],"suggests":[411],"axotomy":[417],"not":[424,547,787],"mediated.":[426],"order":[428],"investigate":[430],"whether":[431,458],"predict":[438,493],"plasticity":[443],"targeted":[447],"ApoE":[449,468],"\u03b54":[450,469],"allele":[451,470],"BDNF":[454,472,492,505,817,853],"gene.":[455],"there":[459],"association":[462],"between":[463],"presence":[465],"polymorphisms":[473,490],"cognitive":[475],"veterans":[478],"who":[479],"had":[480],"suffered":[481],"head":[483],"general":[494,820],"intelligence":[495,821],"Subsequently":[499],"its":[507,855],"receptors":[508],"TrkB-full":[509],"length,":[510],"TrkB-truncated":[511],"p75NTR,":[513],"animals":[515],"exposed":[516],"TrkB":[523,860],"truncated":[524,859],"p75NTR":[526,862],"altered":[528],"chronic":[531],"phase.":[532],"summary,":[534],"results":[536],"show":[537],"importance":[539],"categorizing":[541],"through":[549],"use":[551,628],"but":[555,786],"also":[556],"Each":[561],"shows":[565],"patterns":[567],"morphological":[574],"changes":[575],"reflected":[579],"release":[582],"biomarkers.":[585,754],"situation":[591],"further":[593],"complicated":[594],"coexistence":[597],"this,":[606],"background":[609],"each":[611],"patient":[612],"contributes":[613],"pathology":[619],"ability":[624],"recover.":[626],"will":[635,653],"provide":[636],"essential":[637],"information":[638],"about":[639],"underlying":[641],"pathology,":[642],"which":[643],"then":[645],"applied":[647],"contribute":[654],"establishment":[657],"better":[659],"diagnostic":[660],"tools":[661],"more":[665],"individualized":[666],"treatment":[667],"approaches.":[668],"List":[669],"scientific":[671],"papers":[672],"I.":[673],"Risling":[674,732,773,813,849],"M,":[675,679,685,774,808,814],"Plantman":[676,726,841],"S,":[677,727,801,842],"Angeria":[678],"Rostami":[680,712,765,796,837],"E,":[681,713,766,797,838],"Bellander":[682,728,775],"BM,":[683,729],"Kirkegaard":[684],"Arborelius":[686],"U,":[687],"Davidsson":[688,714,767,843],"J.":[689,816],"Mechanisms":[690],"induced":[693],"injuries,":[695],"experimental":[696],"studies":[697],"rats.":[699],"Neuroimage.":[700],"2011":[701,832],"Jan;":[702],"54":[703],"Suppl":[704],"1:S89-97.":[705],"Epub":[706,759,831],"2010":[707],"May":[708],"21.":[709],"https://doi.org/10.1016/j.neuroimage.2010.05.031":[710],"II.":[711],"J,":[715,719,725,768,844,848],"Ng":[716],"KC,":[717],"Lu":[718],"Gyorgy":[720,771],"A,":[721,772],"Wingo":[722],"D,":[723,731,812],"Walker":[724],"Agoston":[730,769,845],"M.":[733,850],"A":[734],"model":[735],"for":[736],"induces":[742],"limited":[743],"transient":[744],"memory":[745],"impairment":[746],"increased":[748],"levels":[749],"axon":[751],"Front":[755],"Neurol.":[756],"2012;":[757],"3:115.":[758],"2012":[760],"Jul":[761],"23.":[762],"https://doi.org/10.3389/fneur.2012.00115":[763],"III.":[764],"DV,":[770,846],"BM.":[776],"Brain":[792],"Injury.":[793],"[Submitted]":[794,868],"IV.":[795],"Krueger":[798,839],"F,":[799,840],"Zoubak":[800],"Dal":[802],"Monte":[803],"O,":[804],"Raymont":[805],"V,":[806],"Pardini":[807],"Hodgkinson":[809],"CA,":[810],"Goldman":[811],"Grafman":[815,847],"polymorphism":[818],"predicts":[819],"after":[822],"PLoS":[827],"ONE.":[828],"2011;":[829],"6(11):e27389.":[830],"Nov":[833],"8.":[834],"https://doi.org/10.1371/journal.pone.0027389":[835],"V.":[836],"Alteration":[851],"receptors,":[856],"full-length":[857]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
