{"id":"https://openalex.org/W2170791804","doi":"https://doi.org/10.1128/ec.00015-10","title":"Downregulation of an Entamoeba histolytica Rhomboid Protease Reveals Roles in Regulating Parasite Adhesion and Phagocytosis","display_name":"Downregulation of an Entamoeba histolytica Rhomboid Protease Reveals Roles in Regulating Parasite Adhesion and Phagocytosis","publication_year":2010,"publication_date":"2010-06-26","ids":{"openalex":"https://openalex.org/W2170791804","doi":"https://doi.org/10.1128/ec.00015-10","mag":"2170791804","pmid":"https://pubmed.ncbi.nlm.nih.gov/20581296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2918930"},"language":"en","primary_location":{"id":"doi:10.1128/ec.00015-10","doi":"https://doi.org/10.1128/ec.00015-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00015-10","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/ec.00015-10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067755139","display_name":"Leigh A. Baxt","orcid":"https://orcid.org/0000-0001-8286-3907","observed_orcids":["https://orcid.org/0000-0001-8286-3907"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leigh A. Baxt","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091536369","display_name":"Elena Rastew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elena Rastew","raw_affiliation_strings":["Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089410306","display_name":"Rivka Bracha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Rivka Bracha","raw_affiliation_strings":["Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073154471","display_name":"David Mirelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"David Mirelman","raw_affiliation_strings":["Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062822575","display_name":"Upinder Singh","orcid":"https://orcid.org/0000-0003-0630-0306","observed_orcids":["https://orcid.org/0000-0003-0630-0306"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Upinder Singh","raw_affiliation_strings":["Department of Internal Medicine, Division of Infectious Diseases, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305","Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Infectious Diseases, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062822575"],"corresponding_institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":3.6918,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.93072318,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"8","first_page":"1283","last_page":"1293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12463","display_name":"Amoebic Infections and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12463","display_name":"Amoebic Infections and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11879","display_name":"Protist diversity and phylogeny","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entamoeba-histolytica","display_name":"Entamoeba histolytica","score":1.0},{"id":"https://openalex.org/keywords/rhomboid-protease","display_name":"rhomboid protease","score":0.9020000100135803},{"id":"https://openalex.org/keywords/intramembrane-serine-proteases","display_name":"intramembrane serine proteases","score":0.8960000276565552},{"id":"https://openalex.org/keywords/host-cell-adhesion","display_name":"host cell adhesion","score":0.8650000095367432},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/erythrophagocytosis","display_name":"erythrophagocytosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8180000185966492},{"id":"https://openalex.org/keywords/complement-resistance","display_name":"complement resistance","score":0.8059999942779541},{"id":"https://openalex.org/keywords/gal-galnac-lectin","display_name":"Gal/GalNAc lectin","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7907905578613281},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.7611789107322693},{"id":"https://openalex.org/C2776867272","wikidata":"https://www.wikidata.org/wiki/Q131027","display_name":"Entamoeba histolytica","level":2,"score":0.7446236610412598},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5632100105285645},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.4226019084453583},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3366885781288147},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.321765273809433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20825394988059998},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15441671013832092},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06946215033531189}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004748","descriptor_name":"Entamoeba histolytica","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004748","descriptor_name":"Entamoeba histolytica","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004748","descriptor_name":"Entamoeba histolytica","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010271","descriptor_name":"Parasites","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D010271","descriptor_name":"Parasites","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010271","descriptor_name":"Parasites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016053","descriptor_name":"RNA, Protozoan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037161","descriptor_name":"Galectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/ec.00015-10","doi":"https://doi.org/10.1128/ec.00015-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00015-10","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2034202","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2918930","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2918930","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2918930","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryot Cell","raw_type":"Text"},{"id":"pmid:20581296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20581296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/ec.00015-10","doi":"https://doi.org/10.1128/ec.00015-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00015-10","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1085573040","display_name":null,"funder_award_id":"AI053724","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7178103278","display_name":"Investigating Entamoeba histolytica colonic pathogenesis","funder_award_id":"R01AI053724","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000908954","display_name":"Molecular Basis of Host Parasite Interaction","funder_award_id":"T32AI007328","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1562624833","https://openalex.org/W1579751065","https://openalex.org/W1862613154","https://openalex.org/W1875967330","https://openalex.org/W1897997059","https://openalex.org/W1924246988","https://openalex.org/W1982709114","https://openalex.org/W1985431081","https://openalex.org/W1985689820","https://openalex.org/W1998969910","https://openalex.org/W2000078078","https://openalex.org/W2000757976","https://openalex.org/W2008482750","https://openalex.org/W2019909856","https://openalex.org/W2020527847","https://openalex.org/W2022114463","https://openalex.org/W2023464111","https://openalex.org/W2023944731","https://openalex.org/W2027020827","https://openalex.org/W2027067333","https://openalex.org/W2029120984","https://openalex.org/W2029502542","https://openalex.org/W2030845606","https://openalex.org/W2032630270","https://openalex.org/W2033155615","https://openalex.org/W2033369789","https://openalex.org/W2036207377","https://openalex.org/W2036344614","https://openalex.org/W2042581118","https://openalex.org/W2048171163","https://openalex.org/W2053578620","https://openalex.org/W2057457553","https://openalex.org/W2057736065","https://openalex.org/W2064724700","https://openalex.org/W2072501163","https://openalex.org/W2076104235","https://openalex.org/W2081408903","https://openalex.org/W2082212717","https://openalex.org/W2087557242","https://openalex.org/W2091169541","https://openalex.org/W2091408467","https://openalex.org/W2098602123","https://openalex.org/W2099872182","https://openalex.org/W2116686601","https://openalex.org/W2123345044","https://openalex.org/W2129310049","https://openalex.org/W2134021782","https://openalex.org/W2135598891","https://openalex.org/W2140238241","https://openalex.org/W2140551159","https://openalex.org/W2147737500","https://openalex.org/W2152417786","https://openalex.org/W2152798475","https://openalex.org/W2164478123","https://openalex.org/W2169548492","https://openalex.org/W2170128395","https://openalex.org/W2170722556","https://openalex.org/W2171319547","https://openalex.org/W2241359850","https://openalex.org/W2415344616"],"related_works":["https://openalex.org/W7096819239","https://openalex.org/W2072728529","https://openalex.org/W2123345044","https://openalex.org/W3009997443","https://openalex.org/W2102687360","https://openalex.org/W2162351483","https://openalex.org/W2065583315","https://openalex.org/W2800787824","https://openalex.org/W2062305867","https://openalex.org/W2258824809"],"abstract_inverted_index":{"Entamoeba":[0],"histolytica":[1,32],"is":[2,46,190],"a":[3,34,132,142],"deep-branching":[4],"eukaryotic":[5],"pathogen.":[6],"Rhomboid":[7],"proteases":[8],"are":[9],"intramembrane":[10],"serine":[11,143],"proteases,":[12],"which":[13],"cleave":[14],"transmembrane":[15,24],"proteins":[16],"in,":[17],"or":[18,121,221],"in":[19,118,211,240,246],"close":[20],"proximity":[21],"to,":[22],"their":[23],"domain.":[25],"We":[26],"have":[27],"previously":[28],"shown":[29],"that":[30,100],"E.":[31],"contains":[33],"single":[35],"functional":[36],"rhomboid":[37,149],"protease":[38,144],"(EhROM1)":[39],"and":[40,52,59,164,184,249],"has":[41],"unique":[42],"substrate":[43],"specificity.":[44],"EhROM1":[45,79,82,101,110,239],"present":[47],"on":[48],"the":[49,61,64,75,88,93,98,104,194,224,228],"trophozoite":[50],"surface":[51,67,107,230],"relocalizes":[53],"to":[54,60,72,103],"internal":[55],"vesicles":[56],"during":[57,66,106],"erythrophagocytosis":[58],"base":[62],"of":[63,78,92,137,155,179,193,200,223,227,238],"cap":[65,105,119],"receptor":[68,108],"capping.":[69],"In":[70],"order":[71],"further":[73],"examine":[74],"biological":[76],"function":[77],"we":[80],"downregulated":[81],"expression":[83,220],"by":[84,86,135,218],">95%":[85],"utilizing":[87],"epigenetic":[89],"silencing":[90],"mechanism":[91],"G3":[94],"parasite":[95,247],"strain.":[96],"Despite":[97],"observation":[99],"relocalized":[102],"capping,":[109],"knockdown":[111],"[ROM(KD)]":[112],"parasites":[113,126,139,157,171],"had":[114,172],"no":[115,235],"gross":[116],"changes":[117],"formation":[120],"complement":[122,241],"resistance.":[123],"However,":[124],"ROM(KD)":[125,156,170],"demonstrated":[127],"decreased":[128,173],"host":[129,212],"cell":[130,213],"adhesion,":[131],"result":[133],"recapitulated":[134],"treatment":[136],"wild-type":[138],"with":[140,146,161,166,176],"DCI,":[141],"inhibitor":[145],"activity":[147],"against":[148],"proteases.":[150],"The":[151,209],"reduced":[152,177,195,204],"adhesion":[153,196,207,214,248],"phenotype":[154],"was":[158,203,215],"noted":[159],"exclusively":[160],"healthy":[162,180],"cells,":[163,181,183],"not":[165,216],"apoptotic":[167,182,201],"cells.":[168],"Additionally,":[169],"phagocytic":[174,188],"ability":[175,189],"ingestion":[178],"rice":[185],"starch.":[186],"Decreased":[187],"thus":[191],"independent":[192],"phenotype,":[197],"since":[198],"phagocytosis":[199],"cells":[202],"despite":[205],"normal":[206],"levels.":[208],"defect":[210],"explained":[217],"altered":[219],"localization":[222],"heavy":[225],"subunit":[226],"Gal/GalNAc":[229],"lectin.":[231],"These":[232],"results":[233],"suggest":[234],"significant":[236],"role":[237],"resistance":[242],"but":[243],"unexpected":[244],"roles":[245],"phagocytosis.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
