{"id":"https://openalex.org/W2170777757","doi":"https://doi.org/10.1186/1471-2261-8-21","title":"Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways","display_name":"Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways","publication_year":2008,"publication_date":"2008-09-08","ids":{"openalex":"https://openalex.org/W2170777757","doi":"https://doi.org/10.1186/1471-2261-8-21","mag":"2170777757","pmid":"https://pubmed.ncbi.nlm.nih.gov/18778461","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2553399"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2261-8-21","doi":"https://doi.org/10.1186/1471-2261-8-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2261-8-21","pdf_url":"https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/1471-2261-8-21","source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/1471-2261-8-21","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104006769","display_name":"David Nilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"David Nilsson","raw_affiliation_strings":["Department of Medicine, Lund University Hospital, Sweden. david.nilsson@med.lu.se","Department of Medicine, Lund University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lund University Hospital, Sweden. david.nilsson@med.lu.se","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Medicine, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087997438","display_name":"Lotta Gustafsson","orcid":"https://orcid.org/0000-0002-9826-9133","observed_orcids":["https://orcid.org/0000-0002-9826-9133"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lotta Gustafsson","raw_affiliation_strings":["Department of Medicine, Lund University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080409948","display_name":"Angelica Wackenfors","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Angelica Wackenfors","raw_affiliation_strings":["Department of Medicine, Lund University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064100287","display_name":"Bodil Gesslein","orcid":"https://orcid.org/0000-0001-6698-8603","observed_orcids":["https://orcid.org/0000-0001-6698-8603"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bodil Gesslein","raw_affiliation_strings":["Department of Medicine, Lund University Hospital, Sweden","Department of Ophthalmology, Lund University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Ophthalmology, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084413123","display_name":"Lars IH Edvinsson","orcid":"https://orcid.org/0000-0002-1805-1346","observed_orcids":["https://orcid.org/0000-0002-1805-1346"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Lars Edvinsson","raw_affiliation_strings":["Department of Medicine, Lund University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015249929","display_name":"Per Paulsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Paulsson","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Lund University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075800539","display_name":"Richard Ingemansson","orcid":"https://orcid.org/0000-0001-7623-8953","observed_orcids":["https://orcid.org/0000-0001-7623-8953"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Richard Ingemansson","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Lund University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038241952","display_name":"Malin Malmsj\u00f6","orcid":"https://orcid.org/0000-0001-9849-9599","observed_orcids":["https://orcid.org/0000-0001-9849-9599"]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Malin Malmsj\u00f6","raw_affiliation_strings":["Department of Medicine, Lund University Hospital, Sweden","Department of Ophthalmology, Lund University Hospital, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Department of Ophthalmology, Lund University Hospital, Sweden","institution_ids":["https://openalex.org/I4210137844"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038241952"],"corresponding_institution_ids":["https://openalex.org/I4210137844"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":1.358,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.79628493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"1","first_page":"21","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelin-b-receptor","display_name":"endothelin B receptor","score":0.9509999752044678},{"id":"https://openalex.org/keywords/receptor-upregulation","display_name":"receptor up-regulation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8999999761581421},{"id":"https://openalex.org/keywords/internal-mammary-artery","display_name":"internal mammary artery","score":0.859000027179718},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.7870000004768372},{"id":"https://openalex.org/keywords/sarafotoxin-s6c","display_name":"sarafotoxin S6c","score":0.8980000019073486},{"id":"https://openalex.org/keywords/endothelin-a-receptor","display_name":"ETA receptor","score":0.7170000076293945},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7770000100135803},{"id":"https://openalex.org/keywords/erk1-2","display_name":"ERK1/2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9850000143051147},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7089999914169312},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-contraction","display_name":"vascular smooth muscle contraction","score":0.703000009059906},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.6983045339584351},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.680435836315155},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5900940299034119},{"id":"https://openalex.org/C149601957","wikidata":"https://www.wikidata.org/wiki/Q390566","display_name":"Endothelin 1","level":3,"score":0.5748903751373291},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5742464661598206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5702420473098755},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5398999452590942},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4715839922428131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45143917202949524},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4513985514640808},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.42624953389167786},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3694130480289459},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33335381746292114}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008323","descriptor_name":"Mammary Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008323","descriptor_name":"Mammary Arteries","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044022","descriptor_name":"Receptor, Endothelin A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044023","descriptor_name":"Receptor, Endothelin B","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D044023","descriptor_name":"Receptor, Endothelin B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044023","descriptor_name":"Receptor, Endothelin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1471-2261-8-21","doi":"https://doi.org/10.1186/1471-2261-8-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2261-8-21","pdf_url":"https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/1471-2261-8-21","source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2553399","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2553399","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovasc Disord","raw_type":"Text"},{"id":"pmid:18778461","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18778461","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cardiovascular disorders","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/c04dc860-5aa9-4c1e-b2d8-e46ed91706c0","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/c04dc860-5aa9-4c1e-b2d8-e46ed91706c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nilsson, D, Gustafsson, L, Wackenfors, A, Gesslein, B, Edvinsson, L, Paulsson, P, Ingemansson, R & Malmsj\u00f6, M 2008, 'Up-regulation of endothelin type B receptors in the human internal mammary artery in culture is dependent on protein kinase C and mitogen-activated kinase signaling pathways', B M C Cardiovascular Disorders, vol. 8, 21. https://doi.org/10.1186/1471-2261-8-21","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.278.719","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.719","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c6/6d/BMC_Cardiovasc_Disord_2008_Sep_8_8_21.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:eea8998425f646e6ad99c1569171f85b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/eea8998425f646e6ad99c1569171f85b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cardiovascular Disorders, Vol 8, Iss 1, p 21 (2008)","raw_type":"article"},{"id":"pmh:oai:lup.lub.lu.se:e507b4d8-054f-4439-b4d4-6e9aadf5750b","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1243268","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1471-2261","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2261-8-21","doi":"https://doi.org/10.1186/1471-2261-8-21","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2261-8-21","pdf_url":"https://bmccardiovascdisord.biomedcentral.com/counter/pdf/10.1186/1471-2261-8-21","source":{"id":"https://openalex.org/S206686666","display_name":"BMC Cardiovascular Disorders","issn_l":"1471-2261","issn":["1471-2261"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cardiovascular Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309792","display_name":"\u00c5ke Wiberg Stiftelse","ror":"https://ror.org/03htnqd27"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320321761","display_name":"Crafoordska Stiftelsen","ror":"https://ror.org/02hwwbr17"},{"id":"https://openalex.org/F4320322169","display_name":"Hj\u00e4rt-Lungfonden","ror":"https://ror.org/052261q33"},{"id":"https://openalex.org/F4320323415","display_name":"Kungliga Fysiografiska S\u00e4llskapet i Lund","ror":"https://ror.org/05rnj0j91"},{"id":"https://openalex.org/F4320324308","display_name":"Sveriges L\u00e4karf\u00f6rbund","ror":"https://ror.org/04hdh0n29"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170777757.pdf","grobid_xml":"https://content.openalex.org/works/W2170777757.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1485526495","https://openalex.org/W1560650269","https://openalex.org/W1638665100","https://openalex.org/W1963861155","https://openalex.org/W1968007511","https://openalex.org/W1972817054","https://openalex.org/W1974073030","https://openalex.org/W1977416178","https://openalex.org/W1983358954","https://openalex.org/W1998937817","https://openalex.org/W2001470147","https://openalex.org/W2022353607","https://openalex.org/W2024110276","https://openalex.org/W2024242768","https://openalex.org/W2027137103","https://openalex.org/W2028273733","https://openalex.org/W2029796239","https://openalex.org/W2034831207","https://openalex.org/W2043893715","https://openalex.org/W2054177388","https://openalex.org/W2059369537","https://openalex.org/W2060154213","https://openalex.org/W2064509104","https://openalex.org/W2070042140","https://openalex.org/W2078318043","https://openalex.org/W2078592006","https://openalex.org/W2084016091","https://openalex.org/W2101919304","https://openalex.org/W2102037935","https://openalex.org/W2102202839","https://openalex.org/W2103900205","https://openalex.org/W2109283410","https://openalex.org/W2109721717","https://openalex.org/W2111848059","https://openalex.org/W2114791524","https://openalex.org/W2124251979","https://openalex.org/W2141536801","https://openalex.org/W2151869895","https://openalex.org/W2161849627","https://openalex.org/W2333322030","https://openalex.org/W2792659630"],"related_works":["https://openalex.org/W2028273733","https://openalex.org/W7098075694","https://openalex.org/W2022353607","https://openalex.org/W921173667","https://openalex.org/W2018946126","https://openalex.org/W1903815799","https://openalex.org/W2114791524","https://openalex.org/W2053699291","https://openalex.org/W1968007511","https://openalex.org/W2081382568"],"abstract_inverted_index":{"BACKGROUND:":[0],"Up-regulation":[1],"of":[2,14,18,44,47,66,96,128,144,204,246,272],"vascular":[3,273],"endothelin":[4,48,67,119,134,151,157,172,247,274],"type":[5],"B":[6],"(ETB)":[7],"receptors":[8,69],"is":[9],"implicated":[10],"in":[11,41,63,70,100,132,141,243,251,278],"the":[12,45,64,118,133,142,156,205,244,270],"pathogenesis":[13],"cardiovascular":[15,279],"disease.":[16,280],"Culture":[17],"intact":[19],"arteries":[20,79],"has":[21,30],"been":[22,32],"shown":[23],"to":[24,116,240],"induce":[25],"similar":[26],"receptor":[27,123,135,153,159,174,249,276],"alterations":[28],"and":[29,56,88,92,106,112,121,130,155,176,197,201,212,215,228,237],"therefore":[31],"suggested":[33],"as":[34],"a":[35,264],"suitable":[36],"method":[37],"for,":[38],"ex":[39],"vivo,":[40],"detail":[42],"delineation":[43],"regulation":[46,65,136],"receptors.":[49],"We":[50],"hypothesize":[51],"that":[52],"mitogen-activated":[53],"kinases":[54,210],"(MAPK)":[55],"protein":[57,175],"kinase":[58,218],"C":[59],"(PKC)":[60],"are":[61],"involved":[62,242],"ETB":[68,122,152,173,248,275],"human":[71,252],"internal":[72,77,253],"mammary":[73,78,254],"arteries.":[74,255],"METHODS:":[75],"Human":[76],"were":[80,89,114,163,180],"obtained":[81],"during":[82],"coronary":[83],"artery":[84],"bypass":[85],"graft":[86],"surgery":[87],"studied":[90],"before":[91],"after":[93,182],"24":[94],"hours":[95],"organ":[97,183],"culture,":[98],"using":[99],"vitro":[101],"pharmacology,":[102],"real":[103],"time":[104],"PCR":[105],"Western":[107],"blot":[108],"techniques.":[109],"Sarafotoxin":[110],"6c":[111,170],"endothelin-1":[113],"used":[115],"examine":[117],"ETA":[120,158],"effects,":[124],"respectively.":[125],"The":[126,147,168],"involvement":[127],"PKC":[129,191,236],"MAPK":[131,220,238],"was":[137,187],"examined":[138],"by":[139,166],"culture":[140],"presence":[143],"antagonists.":[145],"RESULTS:":[146],"endothelin-1-induced":[148],"contraction":[149],"(after":[150],"desensitization)":[154],"mRNA":[160,177],"expression":[161,178,250],"levels":[162,179],"not":[164],"altered":[165],"culture.":[167,184],"sarafotoxin":[169],"contraction,":[171],"increased":[181],"This":[185],"increase":[186],"antagonized":[188],"by;":[189],"(1)":[190],"inhibitors":[192,203],"(10":[193,222],"microM":[194,199,223,226,230],"bisindolylmaleimide":[195],"I":[196],"10":[198,225,229],"Ro-32-0432),":[200],"(2)":[202],"p38,":[206],"extracellular":[207],"signal":[208,259],"related":[209],"1":[211],"2":[213],"(ERK1/2)":[214],"C-jun":[216],"terminal":[217],"(JNK)":[219],"pathways":[221,261],"SB203580,":[224],"PD98059":[227],"SP600125,":[231],"respectively).":[232],"CONCLUSION:":[233],"In":[234],"conclusion,":[235],"seem":[239],"be":[241],"up-regulation":[245],"Inhibiting":[256],"these":[257],"intracellular":[258],"transduction":[260],"may":[262],"provide":[263],"future":[265],"therapeutic":[266],"target":[267],"for":[268],"hindering":[269],"development":[271],"changes":[277]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
