{"id":"https://openalex.org/W2170775439","doi":"https://doi.org/10.1002/jps.2600800907","title":"Synthesis, Antitumor Activity, and Nephrotoxicity of the Optical Isomers of 2-Aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)platinum(II)","display_name":"Synthesis, Antitumor Activity, and Nephrotoxicity of the Optical Isomers of 2-Aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)platinum(II)","publication_year":1991,"publication_date":"1991-09-01","ids":{"openalex":"https://openalex.org/W2170775439","doi":"https://doi.org/10.1002/jps.2600800907","mag":"2170775439","pmid":"https://pubmed.ncbi.nlm.nih.gov/1800705"},"language":"en","primary_location":{"id":"doi:10.1002/jps.2600800907","doi":"https://doi.org/10.1002/jps.2600800907","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600800907","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110286286","display_name":"Kazumi Morikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumi Morikawa","raw_affiliation_strings":["Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., Gotemba-shi, Japan","Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., Gotemba-shi, Japan","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109222795","display_name":"Masamitsu Honda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masamitsu Honda","raw_affiliation_strings":["Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079936614","display_name":"KO-ICHI ENDOH","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ko-Ich Endoh","raw_affiliation_strings":["Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103023712","display_name":"Tomoko Matsumoto","orcid":"https://orcid.org/0000-0003-0858-2474","observed_orcids":["https://orcid.org/0000-0003-0858-2474"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoko Matsumoto","raw_affiliation_strings":["Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002169362","display_name":"Ken\u2010ichi Akamatsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-Ichi Akamatsu","raw_affiliation_strings":["Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110023623","display_name":"Hiroki Mitsui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Mitsui","raw_affiliation_strings":["Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109867656","display_name":"Masuo Koizumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masuo Koizumi","raw_affiliation_strings":["Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Exploratory Research Laboratories, Chugai Pharmaceutical Company Ltd., 1-135, Komakado, Gotemba-shi 412, Japan","institution_ids":["https://openalex.org/I4405254473"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109867656"],"corresponding_institution_ids":["https://openalex.org/I4405254473"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":0.7185,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.76280728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"80","issue":"9","first_page":"837","last_page":"842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enantiomers","display_name":"enantiomers","score":0.9359999895095825},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/urine-protein","display_name":"urinary protein","score":0.6129999756813049},{"id":"https://openalex.org/keywords/urine-sugar","display_name":"urine sugar","score":0.8989999890327454},{"id":"https://openalex.org/keywords/platinum-ii-complexes","display_name":"platinum(II) complexes","score":0.7120000123977661},{"id":"https://openalex.org/keywords/stereoselectivity","display_name":"stereoselectivity","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C126189478","wikidata":"https://www.wikidata.org/wiki/Q1468324","display_name":"Nephrotoxicity","level":3,"score":0.8842277526855469},{"id":"https://openalex.org/C2780377690","wikidata":"https://www.wikidata.org/wiki/Q80232","display_name":"Cyclobutane","level":3,"score":0.7547628283500671},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7411437630653381},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.518508791923523},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48720425367355347},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.4567088484764099},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4426548480987549},{"id":"https://openalex.org/C518104683","wikidata":"https://www.wikidata.org/wiki/Q880","display_name":"Platinum","level":3,"score":0.4301655888557434},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3924614191055298},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3173099756240845},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2646902799606323},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16590705513954163},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.15825730562210083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14580869674682617},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.06479278206825256},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D016190","descriptor_name":"Carboplatin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.2600800907","doi":"https://doi.org/10.1002/jps.2600800907","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600800907","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:1800705","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1800705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2000673260","https://openalex.org/W2012108057","https://openalex.org/W2019008465","https://openalex.org/W2034081467","https://openalex.org/W2072557746","https://openalex.org/W2154384726","https://openalex.org/W2284825326","https://openalex.org/W2326678374","https://openalex.org/W3103140734","https://openalex.org/W3137040295","https://openalex.org/W4407023093"],"related_works":["https://openalex.org/W2020005203","https://openalex.org/W651668503","https://openalex.org/W2414598391","https://openalex.org/W2284825326","https://openalex.org/W7095556200","https://openalex.org/W2008834696","https://openalex.org/W3027069260","https://openalex.org/W2419354139","https://openalex.org/W2249997928","https://openalex.org/W2520302506"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}