{"id":"https://openalex.org/W2170774786","doi":"https://doi.org/10.1016/s0360-3016(98)00274-0","title":"Enhancement of fractionated-dose irradiation by retinoic acid plus interferon","display_name":"Enhancement of fractionated-dose irradiation by retinoic acid plus interferon","publication_year":1998,"publication_date":"1998-10-01","ids":{"openalex":"https://openalex.org/W2170774786","doi":"https://doi.org/10.1016/s0360-3016(98)00274-0","mag":"2170774786","pmid":"https://pubmed.ncbi.nlm.nih.gov/9806522"},"language":"en","primary_location":{"id":"doi:10.1016/s0360-3016(98)00274-0","doi":"https://doi.org/10.1016/s0360-3016(98)00274-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0360-3016(98)00274-0","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0360-3016(98)00274-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113516156","display_name":"Leo E. Gerweck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leo E Gerweck","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114-2617, USA","Department of Radiation Oncology, Massachustetts General Hospital, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114-2617, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Radiation Oncology, Massachustetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032804257","display_name":"S. Tanweer Zaidi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syed T Zaidi","raw_affiliation_strings":["Department of Radiation Oncology, Massachustetts General Hospital, Boston, MA 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachustetts General Hospital, Boston, MA 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019950679","display_name":"Thomas F. DeLaney","orcid":"https://orcid.org/0000-0002-0346-3487","observed_orcids":["https://orcid.org/0000-0002-0346-3487"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas F Delaney","raw_affiliation_strings":["Department of Radiation Oncology, Boston University Medical Center, Boston, MA 02118, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Boston University Medical Center, Boston, MA 02118, USA","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I1286490081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113516156"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":{"value":4130,"currency":"USD","value_usd":4130},"fwci":0.67,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.73719826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"42","issue":"3","first_page":"611","last_page":"615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.4065000116825104,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.4065000116825104,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.39480000734329224,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.09040000289678574,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fractionated-radiotherapy","display_name":"fractionated radiotherapy","score":0.8659999966621399},{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/interferon-alfa-2a","display_name":"interferon alfa-2a","score":0.8809999823570251},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.628000020980835},{"id":"https://openalex.org/keywords/tumor-repopulation","display_name":"tumor repopulation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/fadu-cells","display_name":"FaDu cells","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.778274655342102},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.6157072186470032},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5734591484069824},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5368431806564331},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.46638157963752747},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4622952342033386},{"id":"https://openalex.org/C11928243","wikidata":"https://www.wikidata.org/wiki/Q1360981","display_name":"Relative biological effectiveness","level":3,"score":0.4252012372016907},{"id":"https://openalex.org/C155806632","wikidata":"https://www.wikidata.org/wiki/Q5299253","display_name":"Dose fractionation","level":3,"score":0.41154640913009644},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3736305236816406},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2981971204280853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.285403847694397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1327286958694458},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1173880398273468},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011836","descriptor_name":"Radiation Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015474","descriptor_name":"Isotretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0360-3016(98)00274-0","doi":"https://doi.org/10.1016/s0360-3016(98)00274-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0360-3016(98)00274-0","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},{"id":"pmid:9806522","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9806522","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of radiation oncology, biology, physics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0360-3016(98)00274-0","doi":"https://doi.org/10.1016/s0360-3016(98)00274-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0360-3016(98)00274-0","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1128695575","display_name":"CANCER THERAPY WITH RETINOIDS, INTERFERON, AND RADIATION","funder_award_id":"5r03ca068106-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7301173197","display_name":null,"funder_award_id":"R03 CA 68106","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1573490657","https://openalex.org/W1629970388","https://openalex.org/W1964686560","https://openalex.org/W1968713927","https://openalex.org/W1972741372","https://openalex.org/W2015059236","https://openalex.org/W2024149042","https://openalex.org/W2063178688","https://openalex.org/W2082232625","https://openalex.org/W2105150213","https://openalex.org/W2116097769","https://openalex.org/W2150930737","https://openalex.org/W2152715974","https://openalex.org/W2163610767","https://openalex.org/W2164726322","https://openalex.org/W2252336676","https://openalex.org/W6636310840","https://openalex.org/W6653984370"],"related_works":["https://openalex.org/W2025712256","https://openalex.org/W2015059236","https://openalex.org/W1964451610","https://openalex.org/W7066650024","https://openalex.org/W2004611735","https://openalex.org/W2082232625","https://openalex.org/W2034965567","https://openalex.org/W1998426632","https://openalex.org/W2030900439","https://openalex.org/W2252336676"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"evaluate":[2],"the":[3,10,35,98,109,114,119,129,137,176,197,224,253],"relative":[4],"cytotoxicity":[5],"of":[6,14,24,64,71,82,91,111,118,141,153,156,183,192,196,205,226,249,260,283],"fractionated-dose":[7],"radiation":[8,72,83,157,284],"in":[9,42,113,136,147,190,216,221,223],"presence":[11,115,140,225],"and":[12,57,108,116,271,285],"absence":[13,117,138],"13-cis-retinoic":[15],"acid":[16,266],"(RA)":[17],"plus":[18,267],"alpha-2a-interferon":[19],"(IFN),":[20],"as":[21],"a":[22,88,162,181,217],"function":[23],"overall":[25],"treatment":[26],"time.":[27],"METHODS":[28],"AND":[29],"MATERIALS:":[30],"Studies":[31],"were":[32,48,100],"performed":[33],"with":[34,50,87,102,161,201,207],"human":[36],"squamous":[37],"cell":[38,172,234,250,273,296],"carcinoma":[39],"line":[40],"FaDu,":[41],"vitro.":[43],"Attached":[44],"exponential":[45],"phase":[46],"cells":[47,99],"treated":[49],"RA":[51],"+":[52],"IFN":[53],"for":[54,171,293],"8-10":[55],"h":[56,93,211,241],"then":[58],"exposed":[59],"to":[60,68,79,237,246],"single":[61,126],"graded":[62],"doses":[63,70,81,155,204],"radiation,":[65],"or":[66,78,298],"1":[67],"6":[69,154,198],"at":[73,84,133,158],"2":[74,85,134,159],"Gy":[75,135],"per":[76],"dose,":[77],"5":[80,202],"Gy/dose":[86],"time":[89,164],"interval":[90,165],"4-24":[92],"between":[94,166,174,213,242,252],"treatments.":[95,256],"Following":[96,151],"irradiation,":[97,128],"incubated":[101],"drugs":[103,121,142,227],"present":[104],"throughout":[105],"colony":[106],"formation,":[107],"fraction":[110,131],"survivors":[112],"combined":[120],"was":[122,143,244],"calculated.":[123],"RESULTS:":[124],"For":[125],"graded-dose":[127],"surviving":[130,177],"ratio":[132],"vs.":[139,209,228,239],"1.27":[144],"+/-":[145],"0.19":[146],"3":[148],"repeat":[149],"experiments.":[150],"administration":[152],"Gy/fraction":[160],"5-h":[163],"treatments":[167,243],"and,":[168],"after":[169,194],"correcting":[170],"proliferation":[173,251,274,297],"treatments,":[175],"fractions":[178],"differed":[179],"by":[180],"factor":[182],"3.25,":[184],"again":[185],"indicating":[186],"an":[187],"average":[188],"difference":[189],"survival":[191,222],"1.26":[193],"each":[195],"2-Gy/fractions.":[199],"Treatment":[200],"2-Gy":[203],"irradiation":[206],"24":[208,238],"4":[210,240],"elapsing":[212],"doses,":[214],"resulted":[215],"3-fold":[218],"greater":[219,233],"decrease":[220],"no":[229],"drug.":[230],"The":[231,258],"relatively":[232],"kill":[235],"due":[236,245],"drug":[247],"inhibition":[248],"more":[254],"prolonged":[255],"CONCLUSIONS:":[257],"results":[259,278],"this":[261,281],"study":[262],"indicate":[263],"that":[264,280],"retinoic":[265],"interferon":[268],"both":[269],"sensitizes":[270],"inhibits":[272],"during":[275,301],"treatment.":[276],"These":[277],"suggest":[279],"combination":[282],"drugs,":[286],"when":[287],"used":[288],"concurrently,":[289],"may":[290],"be":[291],"effective":[292],"inhibiting":[294],"tumor":[295],"accelerated":[299],"repopulation":[300],"clinical":[302],"fractionated":[303],"radiotherapy.":[304]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
