{"id":"https://openalex.org/W2170725201","doi":"https://doi.org/10.1093/molbev/msm019","title":"Proportion of Solvent-Exposed Amino Acids in a Protein and Rate of Protein Evolution","display_name":"Proportion of Solvent-Exposed Amino Acids in a Protein and Rate of Protein Evolution","publication_year":2007,"publication_date":"2007-01-30","ids":{"openalex":"https://openalex.org/W2170725201","doi":"https://doi.org/10.1093/molbev/msm019","mag":"2170725201","pmid":"https://pubmed.ncbi.nlm.nih.gov/17264066"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msm019","doi":"https://doi.org/10.1093/molbev/msm019","is_oa":false,"landing_page_url":"https://doi.org/10.1093/molbev/msm019","pdf_url":null,"source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001946174","display_name":"Yeong\u2010Shin Lin","orcid":"https://orcid.org/0000-0001-9229-0102","observed_orcids":["https://orcid.org/0000-0001-9229-0102"]},"institutions":[{"id":"https://openalex.org/I148366613","display_name":"National Yang Ming Chiao Tung University","ror":"https://ror.org/00se2k293","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Y.-S. Lin","raw_affiliation_strings":["Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan","institution_ids":["https://openalex.org/I148366613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002545282","display_name":"Wei-Lun Hsu","orcid":"https://orcid.org/0000-0002-3998-9181","observed_orcids":["https://orcid.org/0000-0002-3998-9181"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W.-L. Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110022757","display_name":"Jenn-Kang Hwang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.-K. Hwang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049358254","display_name":"Wen\u2010Hsiung Li","orcid":"https://orcid.org/0000-0003-2757-5026","observed_orcids":["https://orcid.org/0000-0003-2757-5026","https://orcid.org/0000-0003-1086-1456"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W.-H. Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":null,"fwci":3.5297,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.94402671,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"4","first_page":"1005","last_page":"1011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.026000000536441803,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-evolutionary-rate","display_name":"protein evolutionary rate","score":0.9679999947547913},{"id":"https://openalex.org/keywords/solvent-exposed-residues","display_name":"solvent-exposed residues","score":0.9380000233650208},{"id":"https://openalex.org/keywords/buried-residues","display_name":"buried residues","score":0.828000009059906},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.7820000052452087},{"id":"https://openalex.org/keywords/translational-selection","display_name":"translational selection","score":0.9710000157356262},{"id":"https://openalex.org/keywords/codon-usage-bias","display_name":"codon usage bias","score":0.9789999723434448},{"id":"https://openalex.org/keywords/protein-levels","display_name":"protein abundance","score":0.8510000109672546},{"id":"https://openalex.org/keywords/yeast-proteins","display_name":"yeast proteins","score":0.5320000052452087}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8426006436347961},{"id":"https://openalex.org/C87253356","wikidata":"https://www.wikidata.org/wiki/Q1106472","display_name":"Codon usage bias","level":4,"score":0.6643357276916504},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.55504310131073},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.49914073944091797},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.4776686131954193},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4440116882324219},{"id":"https://openalex.org/C2992240565","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Protein evolution","level":3,"score":0.42989981174468994},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39501041173934937},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3932819366455078},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.330752968788147},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2978730797767639},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/molbev/msm019","doi":"https://doi.org/10.1093/molbev/msm019","is_oa":false,"landing_page_url":"https://doi.org/10.1093/molbev/msm019","pdf_url":null,"source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmid:17264066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17264066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321040","display_name":"National Science Council","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320323443","display_name":"National Chiao Tung University","ror":"https://ror.org/00se2k293"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W78816759","https://openalex.org/W1617947194","https://openalex.org/W1918164078","https://openalex.org/W1969761972","https://openalex.org/W1975304761","https://openalex.org/W1987749411","https://openalex.org/W1997816460","https://openalex.org/W2001269124","https://openalex.org/W2007325254","https://openalex.org/W2008265915","https://openalex.org/W2008708467","https://openalex.org/W2009533642","https://openalex.org/W2012852001","https://openalex.org/W2013947447","https://openalex.org/W2018590530","https://openalex.org/W2023805311","https://openalex.org/W2029158589","https://openalex.org/W2036350498","https://openalex.org/W2040865917","https://openalex.org/W2054017637","https://openalex.org/W2061181383","https://openalex.org/W2073106255","https://openalex.org/W2077797834","https://openalex.org/W2086719212","https://openalex.org/W2094553873","https://openalex.org/W2096413602","https://openalex.org/W2109441358","https://openalex.org/W2115148114","https://openalex.org/W2123957843","https://openalex.org/W2125204768","https://openalex.org/W2130871092","https://openalex.org/W2135753651","https://openalex.org/W2136749660","https://openalex.org/W2144910983","https://openalex.org/W2153187042","https://openalex.org/W2158714788","https://openalex.org/W2163963584","https://openalex.org/W2169079604","https://openalex.org/W2169546600","https://openalex.org/W2170778160","https://openalex.org/W2463320856","https://openalex.org/W2916027804"],"related_works":["https://openalex.org/W2122376908","https://openalex.org/W2088702338","https://openalex.org/W1890232178","https://openalex.org/W2105000219","https://openalex.org/W2096413602","https://openalex.org/W2170511014","https://openalex.org/W2141404109","https://openalex.org/W2125204768","https://openalex.org/W2115148114","https://openalex.org/W2149067755"],"abstract_inverted_index":{"Translational":[0],"selection,":[1,97],"including":[2],"gene":[3],"expression,":[4],"protein":[5,20,29,43,107],"abundance,":[6],"and":[7],"codon":[8],"usage":[9],"bias,":[10],"has":[11],"been":[12],"suggested":[13],"as":[14],"the":[15,76,83,102,137],"single":[16],"dominant":[17],"determinant":[18,105],"of":[19,78,85,92,106],"evolutionary":[21,60,79,108],"rate":[22,80,109],"in":[23],"yeast.":[24],"Here,":[25],"we":[26],"show":[27],"that":[28,93,99,118],"structure":[30,44,128],"is":[31,101],"also":[32],"an":[33],"important":[34,104],"determinant.":[35],"Buried":[36],"residues,":[37],"which":[38],"are":[39,46,56,74],"responsible":[40],"for":[41],"maintaining":[42,127],"or":[45,129],"located":[47],"on":[48],"a":[49],"stable":[50],"interaction":[51],"surface":[52],"between":[53],"2":[54],"subunits,":[55],"usually":[57],"under":[58,123],"stronger":[59],"constraints":[61],"than":[62],"solvent-exposed":[63,86],"residues.":[64],"Our":[65,115],"partial":[66],"correlation":[67],"analysis":[68],"shows":[69],"that,":[70],"when":[71],"whole":[72],"proteins":[73,119],"included,":[75],"variance":[77],"explained":[81,94],"by":[82,95],"proportion":[84],"residues":[87,122],"(P(exposed))":[88],"can":[89],"reach":[90],"two-thirds":[91],"translational":[96,113],"indicating":[98],"P(exposed)":[100],"most":[103],"next":[110],"only":[111],"to":[112,133],"selection.":[114],"result":[116],"suggests":[117],"with":[120],"many":[121],"selective":[124],"constraint":[125],"(e.g.,":[126],"intermolecular":[130],"interaction)":[131],"tend":[132],"evolve":[134],"slowly,":[135],"supporting":[136],"\"fitness":[138],"(functional)":[139],"density\"":[140],"hypothesis.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}