{"id":"https://openalex.org/W2170719152","doi":"https://doi.org/10.1016/j.jalz.2012.05.923","title":"P2\u2010216: Pulsatile arterial spin labeling in differentiating Alzheimer's disease and cognitively normal elderly adults in a Chinese cohort","display_name":"P2\u2010216: Pulsatile arterial spin labeling in differentiating Alzheimer's disease and cognitively normal elderly adults in a Chinese cohort","publication_year":2012,"publication_date":"2012-07-01","ids":{"openalex":"https://openalex.org/W2170719152","doi":"https://doi.org/10.1016/j.jalz.2012.05.923","mag":"2170719152"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2012.05.923","doi":"https://doi.org/10.1016/j.jalz.2012.05.923","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.923","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077972068","display_name":"Henry Ka\u2010Fung Mak","orcid":"https://orcid.org/0000-0002-2007-0650","observed_orcids":["https://orcid.org/0000-0002-2007-0650"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Henry Ka Fung Mak","raw_affiliation_strings":["University of Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045637873","display_name":"Queenie Chan","orcid":"https://orcid.org/0000-0003-1270-995X","observed_orcids":["https://orcid.org/0000-0003-1270-995X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Queenie Chan","raw_affiliation_strings":["Philips Healthcare, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Philips Healthcare, Hong Kong, Hong Kong","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100410131","display_name":"Zhipeng Zhang","orcid":"https://orcid.org/0000-0003-0084-2833","observed_orcids":["https://orcid.org/0000-0003-0084-2833"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Zhipeng Zhang","raw_affiliation_strings":["The University of Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048100233","display_name":"Deqiang Qiu","orcid":"https://orcid.org/0000-0001-8375-1755","observed_orcids":["https://orcid.org/0000-0001-8375-1755"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Deqiang Qiu","raw_affiliation_strings":["The University of Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100650071","display_name":"Linda Zhang","orcid":"https://orcid.org/0000-0001-9486-419X","observed_orcids":["https://orcid.org/0000-0001-9486-419X"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Linda Zhang","raw_affiliation_strings":["The University of Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068544297","display_name":"Leung\u2010Wing Chu","orcid":"https://orcid.org/0000-0002-9066-2811","observed_orcids":["https://orcid.org/0000-0002-9066-2811"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Leung\u2010wing Chu","raw_affiliation_strings":["The University of Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18910305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":"4S_Part_9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.7588000297546387,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.23440000414848328,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-disease","display_name":"'s disease","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.7524938583374023},{"id":"https://openalex.org/C3018723549","wikidata":"https://www.wikidata.org/wiki/Q56284158","display_name":"Arterial spin labeling","level":3,"score":0.6043500900268555},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5696892142295837},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5322855114936829},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5223209261894226},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.46406492590904236},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.46167728304862976},{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.4604429006576538},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4353069067001343},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32596251368522644},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1879814863204956}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jalz.2012.05.923","doi":"https://doi.org/10.1016/j.jalz.2012.05.923","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2012.05.923","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},{"id":"pmh:oai:hub.hku.hk:10722/165155","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/165155","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference_Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2126587011","https://openalex.org/W2063622167","https://openalex.org/W2748429071","https://openalex.org/W4210605610","https://openalex.org/W2947829548","https://openalex.org/W4415855215","https://openalex.org/W2058745353","https://openalex.org/W2355116690","https://openalex.org/W2557712647","https://openalex.org/W4390200305"],"abstract_inverted_index":{"Cerebral":[0],"blood":[1,38,155],"flow":[2,156],"(CBF)":[3],"impairment":[4],"is":[5],"found":[6],"in":[7,26,41,202,217,224,226,242,267,275,289,297],"Alzheimer's":[8,69],"disease":[9],"(AD).":[10],"We":[11],"employ":[12],"pulsatile":[13],"arterial":[14,32,37],"spin":[15],"labeling":[16,111],"(ASL)":[17],"Magntice":[18],"resonance":[19],"imaging":[20],"(MRI)":[21],"to":[22,48,119,151,164,229,300],"detect":[23],"any":[24],"derangement":[25],"hemodynamic":[27],"parameters":[28],"such":[29],"as":[30],"CBF,":[31,170],"transit":[33],"time":[34,136,146],"(aTT)":[35],"and":[36,56,68,172,181,204,257,269,282,285,293,307],"volume":[39,233],"(aBV)":[40],"a":[42,91,115,129],"Chinese":[43],"cohort":[44],"of":[45,90,117,131,142,190,312],"AD":[46,54,227,298],"compared":[47,228,299],"cognitively":[49],"normal":[50],"elderly":[51],"adults.":[52],"13":[53,134],"patients":[55],"15":[57,236],"HC":[58,301],"subjects":[59],"underwent":[60],"3T":[61],"MRI":[62],"scanning.":[63],"Mini-Mental":[64],"State":[65],"Examination":[66],"(MMSE)":[67],"Disease":[70],"Assessment":[71],"Scale":[72],"cognitive":[73,79],"subscale":[74],"(ADAS-cog)":[75],"scores":[76,206],"for":[77,213,304],"global":[78],"ability":[80],"were":[81,138,158,175,184,195,199,240],"obtained":[82,159],"from":[83,149],"all":[84],"participants.":[85],"The":[86,123,169],"QUASAR":[87],"sequences":[88],"consisted":[89],"Look-Locker-based":[92],"EPI":[93],"sequence":[94],"(TR/TE":[95],"4000/22ms,":[96],"FOV":[97],"240mm,":[98],"matrix":[99],"64x64,":[100],"\u00b1":[101],"=":[102,220],"35\u00b0,":[103],"7":[104],"axial":[105],"6mm":[106],"slices":[107],"with":[108,114,160,310],"2mm":[109],"gap,":[110],"slab":[112],"150mm,":[113],"gap":[116],"15mm":[118],"the":[120,166,208],"closest":[121],"slice).":[122],"first":[124],"image":[125],"was":[126],"acquired":[127],"at":[128,140],"delay":[130],"40ms,":[132],"while":[133],"consecutive":[135],"points":[137,147],"measured":[139,314],"intervals":[141],"300ms,":[143],"yielding":[144],"ten":[145,191],"ranging":[148],"40":[150],"3640ms.":[152],"Two":[153],"separate":[154],"acquisitions":[157],"1":[161],"slice":[162],"overlap":[163],"cover":[165],"whole":[167],"brain.":[168],"aBV":[171,273],"aTT":[173,287,308],"maps":[174],"calculated":[176],"using":[177],"in-house":[178],"software.":[179],"Preprocessing":[180],"statistical":[182],"analyses":[183],"performed":[185],"on":[186],"SPM5.":[187],"ROI":[188,261],"studies":[189,262],"selected":[192],"cerebral":[193],"regions":[194],"also":[196],"conducted.":[197],"There":[198],"significant":[200,264,272,286],"differences":[201],"MMSE":[203],"ADAS-cog":[205],"between":[207],"2":[209],"groups":[210],"(P":[211,219,302],"<0.001":[212],"each)":[214],"but":[215],"none":[216],"age":[218],"0.068).":[221],"Significant":[222],"decreases":[223],"CBF":[225,265,306],"controls":[230],"(gray":[231],"matter":[232],"adjustment,":[234],"threshold":[235],"voxels,":[237],"P":[238],"<0.01)":[239],"present":[241],"right":[243,258,279],"middle":[244,268,294],"cingulate,":[245,271,284],"left":[246,248,254,276,290],"cuneus,":[247],"inferior":[249,255,280,291],"frontal,":[250,253],"bilateral":[251],"superior":[252,277],"parietal":[256,281],"supramarginal":[259],"gyri.":[260],"confirmed":[263],"reduction":[266,274],"posterior":[270,283],"temporal,":[278],"prolongation":[288],"frontal":[292],"cingulate":[295],"gyri":[296],"<0.05":[303],"all).":[305],"correlated":[309],"severity":[311],"disease,":[313],"through":[315],"neuropsychological":[316],"tests.":[317]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
