{"id":"https://openalex.org/W2170711652","doi":"https://doi.org/10.1183/09031936.00063510","title":"Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial","display_name":"Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial","publication_year":2010,"publication_date":"2010-11-25","ids":{"openalex":"https://openalex.org/W2170711652","doi":"https://doi.org/10.1183/09031936.00063510","mag":"2170711652","pmid":"https://pubmed.ncbi.nlm.nih.gov/21109557"},"language":"en","primary_location":{"id":"doi:10.1183/09031936.00063510","doi":"https://doi.org/10.1183/09031936.00063510","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.00063510","pdf_url":"https://erj.ersjournals.com/content/erj/37/6/1352.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erj.ersjournals.com/content/erj/37/6/1352.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089020623","display_name":"Stephen T. Holgate","orcid":"https://orcid.org/0000-0003-2658-4617","observed_orcids":["https://orcid.org/0000-0003-2658-4617"]},"institutions":[{"id":"https://openalex.org/I2801388914","display_name":"Southampton General Hospital","ror":"https://ror.org/011cztj49","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801388914","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S.T. Holgate","raw_affiliation_strings":["School of Medicine, University of Southampton, III Division, Mail Point 810, Level F, South Block, Southampton General Hospital, Southampton, Hampshire, SO16 6YD, UK. sth@soton.ac.uk","School of Medicine, University of Southampton, III Division, Mail Point 810, Level F, South Block, Southampton General Hospital, Southampton, Hampshire SO16 6YD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Southampton, III Division, Mail Point 810, Level F, South Block, Southampton General Hospital, Southampton, Hampshire, SO16 6YD, UK. sth@soton.ac.uk","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]},{"raw_affiliation_string":"School of Medicine, University of Southampton, III Division, Mail Point 810, Level F, South Block, Southampton General Hospital, Southampton, Hampshire SO16 6YD, UK","institution_ids":["https://openalex.org/I2801388914","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067604175","display_name":"Michael James Noonan","orcid":"https://orcid.org/0000-0003-4512-0535","observed_orcids":["https://orcid.org/0000-0003-4512-0535"]},"institutions":[{"id":"https://openalex.org/I4210148703","display_name":"Allergy Associates Research Center","ror":"https://ror.org/04j485w94","country_code":"US","type":"other","lineage":["https://openalex.org/I4210148703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Noonan","raw_affiliation_strings":["Allergy Associates Res Ctr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy Associates Res Ctr","institution_ids":["https://openalex.org/I4210148703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073019940","display_name":"Pascal Chanez","orcid":"https://orcid.org/0000-0003-4059-0917","observed_orcids":["https://orcid.org/0000-0003-4059-0917"]},"institutions":[{"id":"https://openalex.org/I4405264361","display_name":"Universit\u00e9 de la M\u00e9diterran\u00e9e Aix-Marseille II","ror":"https://ror.org/01q1nds63","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767","https://openalex.org/I4405264361"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Chanez","raw_affiliation_strings":["AFFILIATIONS","Univ Aix Marseille 2, Universite de la Mediterranee - Aix-Marseille II, University of Aix-Marseille, Dept Malad Resp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFFILIATIONS","institution_ids":[]},{"raw_affiliation_string":"Univ Aix Marseille 2, Universite de la Mediterranee - Aix-Marseille II, University of Aix-Marseille, Dept Malad Resp","institution_ids":["https://openalex.org/I4405264361"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044980958","display_name":"William W. Busse","orcid":"https://orcid.org/0000-0003-2591-4696","observed_orcids":["https://orcid.org/0000-0003-2591-4696"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Busse","raw_affiliation_strings":["Dept of Medicine , University of Wisconsin , Madison , WI ,","Univ Wisconsin, University of Wisconsin Madison, University of Wisconsin System, Dept Med"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Medicine , University of Wisconsin , Madison , WI ,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Univ Wisconsin, University of Wisconsin Madison, University of Wisconsin System, Dept Med","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076531628","display_name":"Lieven Dupont","orcid":"https://orcid.org/0000-0003-3961-1522","observed_orcids":["https://orcid.org/0000-0003-3961-1522"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"L. Dupont","raw_affiliation_strings":["Dept of Respiratory Medicine , University Hospital Gasthuisberg , KU Leuven , Leuven , Belgium","University of Leuven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Respiratory Medicine , University Hospital Gasthuisberg , KU Leuven , Leuven , Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"University of Leuven","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078489750","display_name":"Ian Douglas Pavord","orcid":"https://orcid.org/0000-0002-4288-5973","observed_orcids":["https://orcid.org/0000-0002-4288-5973"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2802040150","display_name":"Glenfield Hospital","ror":"https://ror.org/048a96r61","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802040150","https://openalex.org/I2802445252"]},{"id":"https://openalex.org/I2802445252","display_name":"University Hospitals of Leicester NHS Trust","ror":"https://ror.org/02fha3693","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. Pavord","raw_affiliation_strings":["Dept of Respiratory Medicine, Thoracic Surgery and Allergy , University Hospitals of Leicester NHS Trust , Glenfield Hospital , Leicester , UK","Glenfield Hosp, Glenfield Hospital, University of Leicester, Univ Hosp Leicester NHS Trust, Dept Resp Med Thorac Surg & Allergy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Respiratory Medicine, Thoracic Surgery and Allergy , University Hospitals of Leicester NHS Trust , Glenfield Hospital , Leicester , UK","institution_ids":["https://openalex.org/I2802040150","https://openalex.org/I2802445252"]},{"raw_affiliation_string":"Glenfield Hosp, Glenfield Hospital, University of Leicester, Univ Hosp Leicester NHS Trust, Dept Resp Med Thorac Surg & Allergy","institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2802040150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019809509","display_name":"A. Hakulinen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Hakulinen","raw_affiliation_strings":["AFFILIATIONS","Ihotautien, allergologian ja sukupuolitautien osasto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFFILIATIONS","institution_ids":[]},{"raw_affiliation_string":"Ihotautien, allergologian ja sukupuolitautien osasto","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044536787","display_name":"L Paolozzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Paolozzi","raw_affiliation_strings":["Pfizer, inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer, inc","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038128984","display_name":"Joseph S. Wajdula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4210148703","display_name":"Allergy Associates Research Center","ror":"https://ror.org/04j485w94","country_code":"US","type":"other","lineage":["https://openalex.org/I4210148703"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Wajdula","raw_affiliation_strings":["Allergy Associates Research Center , Portland , OR ,","Universite \u00b4de la Me \u00b4diterrane \u00b4e , Marseille , #","Pfizer, inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allergy Associates Research Center , Portland , OR ,","institution_ids":["https://openalex.org/I4210148703"]},{"raw_affiliation_string":"Universite \u00b4de la Me \u00b4diterrane \u00b4e , Marseille , #","institution_ids":[]},{"raw_affiliation_string":"Pfizer, inc","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060462523","display_name":"Chuanbo Zang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Zang","raw_affiliation_strings":["AFFILIATIONS","Pfizer, inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AFFILIATIONS","institution_ids":[]},{"raw_affiliation_string":"Pfizer, inc","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021609170","display_name":"Harold S. Nelson","orcid":"https://orcid.org/0000-0001-5545-3945","observed_orcids":["https://orcid.org/0000-0001-5545-3945"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Nelson","raw_affiliation_strings":["Dept of Medicine , University of Wisconsin , Madison , WI ,","Natl Jewish Hlth, National Jewish Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Medicine , University of Wisconsin , Madison , WI ,","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Natl Jewish Hlth, National Jewish Health","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085346097","display_name":"Donald G. Raible","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Raible","raw_affiliation_strings":["Pfizer, inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer, inc","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.9444,"has_fulltext":true,"cited_by_count":171,"citation_normalized_percentile":{"value":0.98292081,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"37","issue":"6","first_page":"1352","last_page":"1359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etanercept","display_name":"etanercept","score":1.0},{"id":"https://openalex.org/keywords/moderate-to-severe-asthma","display_name":"moderate-to-severe asthma","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.875},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.5989999771118164},{"id":"https://openalex.org/keywords/asthma-treatment-efficacy","display_name":"asthma treatment efficacy","score":0.5080000162124634},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6830000281333923},{"id":"https://openalex.org/keywords/fev1","display_name":"FEV1","score":0.7419999837875366},{"id":"https://openalex.org/keywords/asthma-control","display_name":"asthma control","score":0.5950000286102295},{"id":"https://openalex.org/keywords/methacholine-responsiveness","display_name":"methacholine responsiveness","score":0.7400000095367432},{"id":"https://openalex.org/keywords/asthma-exacerbations","display_name":"asthma exacerbations","score":0.7540000081062317},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9847617745399475},{"id":"https://openalex.org/C2777226972","wikidata":"https://www.wikidata.org/wiki/Q415343","display_name":"Etanercept","level":3,"score":0.8642768859863281},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.647174596786499},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4929084777832031},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.42494115233421326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38891059160232544},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.09661772847175598}],"mesh":[{"descriptor_ui":"D000068800","descriptor_name":"Etanercept","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005541","descriptor_name":"Forced Expiratory Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016210","descriptor_name":"Methacholine Chloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1183/09031936.00063510","doi":"https://doi.org/10.1183/09031936.00063510","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.00063510","pdf_url":"https://erj.ersjournals.com/content/erj/37/6/1352.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},{"id":"pmid:21109557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21109557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European respiratory journal","raw_type":"Clinical Trial, Phase II"},{"id":"pmh:oai:eprints.soton.ac.uk:183177","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/183177/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1183/09031936.00063510","doi":"https://doi.org/10.1183/09031936.00063510","is_oa":true,"landing_page_url":"https://doi.org/10.1183/09031936.00063510","pdf_url":"https://erj.ersjournals.com/content/erj/37/6/1352.full.pdf","source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Respiratory Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320326518","display_name":"Tays","ror":"https://ror.org/02hvt5f17"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170711652.pdf","grobid_xml":"https://content.openalex.org/works/W2170711652.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1964215887","https://openalex.org/W1973155194","https://openalex.org/W1975847098","https://openalex.org/W1976434950","https://openalex.org/W1988758075","https://openalex.org/W1994585625","https://openalex.org/W2004611408","https://openalex.org/W2004646141","https://openalex.org/W2006174105","https://openalex.org/W2024585538","https://openalex.org/W2025111901","https://openalex.org/W2032064406","https://openalex.org/W2032080656","https://openalex.org/W2054870986","https://openalex.org/W2062918919","https://openalex.org/W2082908101","https://openalex.org/W2083078553","https://openalex.org/W2086721113","https://openalex.org/W2094714142","https://openalex.org/W2110579070","https://openalex.org/W2111609315","https://openalex.org/W2116888504","https://openalex.org/W2117596960","https://openalex.org/W2118704147","https://openalex.org/W2120270144","https://openalex.org/W2120745761","https://openalex.org/W2124657474","https://openalex.org/W2128690134","https://openalex.org/W2135790224","https://openalex.org/W2143371668","https://openalex.org/W2143417246","https://openalex.org/W2149793775","https://openalex.org/W2152194899","https://openalex.org/W2159813676","https://openalex.org/W2163779250","https://openalex.org/W2170599998","https://openalex.org/W2172037552","https://openalex.org/W2172283099","https://openalex.org/W2283801176","https://openalex.org/W2314052274","https://openalex.org/W2513416413","https://openalex.org/W2585717783","https://openalex.org/W4290142630"],"related_works":["https://openalex.org/W4321016640","https://openalex.org/W2172283099","https://openalex.org/W2089811542","https://openalex.org/W2153629315","https://openalex.org/W2170599998","https://openalex.org/W1909632427","https://openalex.org/W7065569896","https://openalex.org/W2133150773","https://openalex.org/W4237421779","https://openalex.org/W2025111901"],"abstract_inverted_index":{"Increased":[0],"tumour":[1],"necrosis":[2],"factor-\u03b1":[3],"levels":[4],"have":[5],"been":[6],"observed":[7,129,150],"in":[8,82,87,116,161,178,199],"bronchial":[9],"biopsies":[10],"and":[11,58,63,69,118,132],"induced":[12],"sputum":[13],"from":[14,77],"subjects":[15,41,162],"with":[16,43,145,163,183,185],"severe":[17],"asthma.":[18,31],"We":[19],"investigated":[20],"etanercept":[21],"(ETN)":[22],"as":[23],"a":[24,113,174],"therapeutic":[25],"option":[26],"for":[27,134],"treating":[28],"moderate-to-severe":[29,44,164],"persistent":[30,45,165],"In":[32],"this":[33,200],"12-week,":[34],"randomised,":[35],"double-blind,":[36],"placebo-controlled,":[37],"phase":[38],"2":[39],"trial,":[40],"(n=132)":[42],"asthma":[46,106,166,184],"received":[47],"subcutaneous":[48],"injections":[49],"of":[50,110,122,136,156,181,197],"25":[51],"mg":[52],"ETN":[53,131,140,157,171,198],"or":[54],"placebo":[55,133],"twice":[56],"weekly,":[57],"were":[59,128],"evaluated":[60],"at":[61,64],"baseline,":[62],"weeks":[65],"2,":[66],"4,":[67],"8":[68],"12.":[70],"The":[71],"primary":[72],"end-point":[73],"was":[74,142,158,173],"the":[75,119,137,152,194],"change":[76],"baseline":[78],"to":[79,191],"week":[80],"12":[81,168],"pre-bronchodilator":[83],"forced":[84],"expiratory":[85,97],"volume":[86],"1":[88],"s":[89],"(FEV1)%":[90],"predicted.":[91],"Secondary":[92],"end-points":[93],"included":[94],"morning":[95],"peak":[96],"flow,":[98],"FEV1%":[99],"pred,":[100],"Asthma":[101,120],"Control":[102],"Questionnaire":[103],"(5-item":[104],"version),":[105],"exacerbations,":[107],"provocative":[108],"concentration":[109],"methacholine":[111],"causing":[112],"20%":[114],"decrease":[115],"FEV1,":[117],"Quality":[121],"Life":[123],"Questionnaire.":[124],"No":[125],"significant":[126],"differences":[127],"between":[130],"any":[135],"efficacy":[138,155,196],"end-points.":[139],"treatment":[141,172],"well":[143],"tolerated,":[144],"no":[146],"unexpected":[147],"safety":[148],"findings":[149],"during":[151],"study.":[153],"Clinical":[154],"not":[159],"shown":[160],"over":[167],"weeks.":[169],"However,":[170],"well-tolerated":[175],"therapy.":[176],"Studies":[177],"specific":[179],"subsets":[180],"patients":[182],"longer-term":[186],"follow-up":[187],"may":[188],"be":[189],"needed":[190],"fully":[192],"evaluate":[193],"clinical":[195],"population.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}