{"id":"https://openalex.org/W2170682201","doi":"https://doi.org/10.1158/0008-5472.can-10-3320","title":"HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells","display_name":"HIF Induces Human Embryonic Stem Cell Markers in Cancer Cells","publication_year":2011,"publication_date":"2011-06-28","ids":{"openalex":"https://openalex.org/W2170682201","doi":"https://doi.org/10.1158/0008-5472.can-10-3320","mag":"2170682201","pmid":"https://pubmed.ncbi.nlm.nih.gov/21712410"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-10-3320","doi":"https://doi.org/10.1158/0008-5472.can-10-3320","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-10-3320","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3129496","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021769285","display_name":"Julie Mathieu","orcid":"https://orcid.org/0000-0002-3826-3549","observed_orcids":["https://orcid.org/0000-0002-3826-3549"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Mathieu","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393427","display_name":"Zhan Zhang","orcid":"https://orcid.org/0000-0002-9685-5753","observed_orcids":["https://orcid.org/0000-0002-9685-5753"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhan Zhang","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042032217","display_name":"Wenyu Zhou","orcid":"https://orcid.org/0000-0002-8447-8815","observed_orcids":["https://orcid.org/0000-0002-8447-8815"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenyu Zhou","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004250169","display_name":"Amy J. Wang","orcid":"https://orcid.org/0000-0002-8844-7223","observed_orcids":["https://orcid.org/0000-0002-8844-7223"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy J. Wang","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042915381","display_name":"John M. Heddleston","orcid":"https://orcid.org/0000-0002-9289-4114","observed_orcids":["https://orcid.org/0000-0002-9289-4114"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Heddleston","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036768601","display_name":"Claudia Maria Assunta Pinna","orcid":"https://orcid.org/0000-0002-5618-7842","observed_orcids":["https://orcid.org/0000-0002-5618-7842"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia M.A. Pinna","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075047444","display_name":"Alexis Hubaud","orcid":"https://orcid.org/0000-0003-1249-4282","observed_orcids":["https://orcid.org/0000-0003-1249-4282"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexis Hubaud","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074727708","display_name":"Bradford Stadler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradford Stadler","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113520771","display_name":"Michael Phillip Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Choi","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066212518","display_name":"Merav Bar","orcid":"https://orcid.org/0000-0001-5334-5158","observed_orcids":["https://orcid.org/0000-0001-5334-5158"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merav Bar","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079940700","display_name":"Muneesh Tewari","orcid":"https://orcid.org/0000-0002-7781-3152","observed_orcids":["https://orcid.org/0000-0002-7781-3152"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muneesh Tewari","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051104212","display_name":"Alvin Y.C. Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alvin Liu","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108554327","display_name":"Robert L. Vessella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Vessella","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075753686","display_name":"Robert Rostomily","orcid":"https://orcid.org/0000-0003-1431-162X","observed_orcids":["https://orcid.org/0000-0003-1431-162X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Rostomily","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011125577","display_name":"Donald E. Born","orcid":"https://orcid.org/0000-0001-6102-512X","observed_orcids":["https://orcid.org/0000-0001-6102-512X"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald Born","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028046331","display_name":"Marshall S. Horwitz","orcid":"https://orcid.org/0000-0002-1683-1680","observed_orcids":["https://orcid.org/0000-0002-1683-1680"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marshall Horwitz","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015601988","display_name":"Carol B. Ware","orcid":"https://orcid.org/0000-0002-7171-6685","observed_orcids":["https://orcid.org/0000-0002-7171-6685"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Ware","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044817889","display_name":"C. Anthony Blau","orcid":"https://orcid.org/0000-0001-8667-6068","observed_orcids":["https://orcid.org/0000-0001-8667-6068"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Anthony Blau","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110160385","display_name":"Michele A. Cleary","orcid":"https://orcid.org/0000-0001-9245-6707","observed_orcids":["https://orcid.org/0000-0001-9245-6707"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele A. Cleary","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021296578","display_name":"Jeremy N. Rich","orcid":"https://orcid.org/0000-0001-7845-5302","observed_orcids":["https://orcid.org/0000-0001-7845-5302"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy N. Rich","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021999547","display_name":"Hannele Ruohola\u2010Baker","orcid":"https://orcid.org/0000-0002-5588-4531","observed_orcids":["https://orcid.org/0000-0002-5588-4531","https://orcid.org/0000-0001-7896-6217"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannele Ruohola-Baker","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Biochemistry, 2Institute for Stem Cell and Regenerative Medicine, 3Departments of Medicine, 4Comparative Medicine, 5Biology, 6Urology, 7Neurological Surgery, and 8Pathology, University of Washington; 9Rosetta Inpharmatics LLC; 10Division of Human Biology, Fred Hutchinson Cancer Research Center (FHCRC), Seattle, Washington; 11Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750","https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":13.9126,"has_fulltext":false,"cited_by_count":508,"citation_normalized_percentile":{"value":0.99388811,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"71","issue":"13","first_page":"4640","last_page":"4652"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.17080000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.16779999434947968,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor","display_name":"hypoxia-inducible factor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.7039999961853027},{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":1.0},{"id":"https://openalex.org/keywords/sox2","display_name":"SOX2","score":0.9160000085830688},{"id":"https://openalex.org/keywords/klf4","display_name":"KLF4","score":0.9279999732971191},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.7799999713897705},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7400000095367432},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.7419999837875366},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6039999723434448},{"id":"https://openalex.org/keywords/neurospheres","display_name":"neurospheres","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C2777933648","wikidata":"https://www.wikidata.org/wiki/Q21114866","display_name":"SOX2","level":4,"score":0.9030791521072388},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.8562264442443848},{"id":"https://openalex.org/C2778265714","wikidata":"https://www.wikidata.org/wiki/Q18033993","display_name":"KLF4","level":5,"score":0.7559489011764526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6515025496482849},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6460941433906555},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.5915485620498657},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5793227553367615},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.546602725982666},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5169438719749451},{"id":"https://openalex.org/C49285185","wikidata":"https://www.wikidata.org/wiki/Q21121594","display_name":"LIN28","level":5,"score":0.5125362873077393},{"id":"https://openalex.org/C136302470","wikidata":"https://www.wikidata.org/wiki/Q7607299","display_name":"Stem cell marker","level":3,"score":0.48674583435058594},{"id":"https://openalex.org/C31194975","wikidata":"https://www.wikidata.org/wiki/Q20970095","display_name":"HIF1A","level":3,"score":0.4568330943584442},{"id":"https://openalex.org/C2908926650","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Nanog Homeobox Protein","level":5,"score":0.4370117485523224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2020188570022583},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08973124623298645},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.07742699980735779},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071317","descriptor_name":"Nanog Homeobox Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090062","descriptor_name":"Kruppel-Like Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090062","descriptor_name":"Kruppel-Like Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090062","descriptor_name":"Kruppel-Like Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090062","descriptor_name":"Kruppel-Like Factor 4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019073","descriptor_name":"HT29 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051793","descriptor_name":"Hypoxia-Inducible Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055748","descriptor_name":"SOXB1 Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-10-3320","doi":"https://doi.org/10.1158/0008-5472.can-10-3320","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-10-3320","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:21712410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21712410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3129496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3129496","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3129496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3129496","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.75}],"study_designs":[],"awards":[{"id":"https://openalex.org/G127680468","display_name":null,"funder_award_id":"CA 116659","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2291570324","display_name":null,"funder_award_id":"R01 CA116659","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2738939658","display_name":null,"funder_award_id":"CA112958","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3275234408","display_name":"The Roles of Osteonectin and Osteoactivin in Gliomas","funder_award_id":"K02NS047409","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3874151009","display_name":null,"funder_award_id":"R01 GM083867","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4509157925","display_name":null,"funder_award_id":"R01 NS054276","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4844611706","display_name":null,"funder_award_id":"R01CA136808","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6150836687","display_name":null,"funder_award_id":"R01 GM097372","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G667665892","display_name":null,"funder_award_id":"NS054276","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G747264573","display_name":null,"funder_award_id":"R01GM083867-01","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G806034388","display_name":"Self Renewal and Differentiation of Human Embryonic Stem Cells","funder_award_id":"P01GM081619","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G92490311","display_name":null,"funder_award_id":"NS047409","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W195037975","https://openalex.org/W1223322285","https://openalex.org/W1877598057","https://openalex.org/W1964150693","https://openalex.org/W1970309962","https://openalex.org/W1973541913","https://openalex.org/W1977381537","https://openalex.org/W1979364059","https://openalex.org/W1979673666","https://openalex.org/W1979858258","https://openalex.org/W1990110626","https://openalex.org/W1998118468","https://openalex.org/W1998864452","https://openalex.org/W2000307839","https://openalex.org/W2001544973","https://openalex.org/W2009071437","https://openalex.org/W2009478313","https://openalex.org/W2027705428","https://openalex.org/W2030714059","https://openalex.org/W2032580087","https://openalex.org/W2039075677","https://openalex.org/W2043457504","https://openalex.org/W2056992430","https://openalex.org/W2062349562","https://openalex.org/W2068416436","https://openalex.org/W2073759231","https://openalex.org/W2082483448","https://openalex.org/W2084037323","https://openalex.org/W2086595831","https://openalex.org/W2090764096","https://openalex.org/W2092627144","https://openalex.org/W2097259163","https://openalex.org/W2102085111","https://openalex.org/W2104666893","https://openalex.org/W2105925116","https://openalex.org/W2106557940","https://openalex.org/W2108573150","https://openalex.org/W2109560454","https://openalex.org/W2116521322","https://openalex.org/W2119593356","https://openalex.org/W2119793842","https://openalex.org/W2138312235","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2143705566","https://openalex.org/W2151870437","https://openalex.org/W2161071327","https://openalex.org/W2169145911","https://openalex.org/W6607957899"],"related_works":["https://openalex.org/W3184233475","https://openalex.org/W2061968442","https://openalex.org/W3197184495","https://openalex.org/W2888516382","https://openalex.org/W2051290223","https://openalex.org/W2046013132","https://openalex.org/W2781498734","https://openalex.org/W2134030824","https://openalex.org/W4304816525","https://openalex.org/W2063961297"],"abstract_inverted_index":{"Low":[0],"oxygen":[1],"levels":[2],"have":[3,30,126],"been":[4,31],"shown":[5,32],"to":[6,33,181],"promote":[7],"self-renewal":[8],"in":[9,58,90,120,140,205],"many":[10,27],"stem":[11,42,79],"cells.":[12],"In":[13,172],"tumors,":[14,142],"hypoxia":[15,49,178],"is":[16],"associated":[17],"with":[18,112,166],"aggressive":[19,28,59],"disease":[20],"course":[21],"and":[22,88,103,137,148,156,161,184],"poor":[23],"clinical":[24],"outcomes.":[25],"Furthermore,":[26,106,159],"tumors":[29,147],"display":[34],"gene":[35],"expression":[36,139],"signatures":[37],"characteristic":[38],"of":[39,109,199,203],"human":[40],"embryonic":[41],"cells":[43],"(hESC).":[44],"We":[45,61],"now":[46],"tested":[47],"whether":[48],"might":[50],"be":[51],"responsible":[52],"for":[53],"the":[54,76,113],"hESC":[55,185],"signature":[56],"observed":[57],"tumors.":[60],"show":[62],"that":[63,125,191],"hypoxia,":[64],"through":[65],"hypoxia-inducible":[66],"factor":[67],"(HIF),":[68],"can":[69],"induce":[70,182],"an":[71],"hESC-like":[72],"transcriptional":[73],"program,":[74],"including":[75],"induced":[77],"pluripotent":[78],"cell":[80,93],"(iPSC)":[81],"inducers,":[82,116],"OCT4,":[83],"NANOG,":[84],"SOX2,":[85],"KLF4,":[86],"cMYC,":[87],"microRNA-302":[89],"11":[91],"cancer":[92],"lines":[94],"(from":[95],"prostate,":[96],"brain,":[97],"kidney,":[98],"cervix,":[99],"lung,":[100],"colon,":[101],"liver,":[102],"breast":[104],"tumors).":[105],"nondegradable":[107],"forms":[108],"HIF\u03b1,":[110],"combined":[111],"traditional":[114],"iPSC":[115,135],"are":[117],"highly":[118],"efficient":[119],"generating":[121],"A549":[122],"iPSC-like":[123],"colonies":[124],"high":[127],"tumorigenic":[128],"capacity.":[129],"To":[130],"test":[131],"potential":[132],"correlation":[133,152],"between":[134,153],"inducers":[136,198],"HIF":[138,192],"primary":[141,145,173],"we":[143],"analyzed":[144],"prostate":[146,168],"found":[149],"a":[150,200],"significant":[151],"NANOG-,":[154],"OCT4-,":[155],"HIF1\u03b1-positive":[157],"regions.":[158],"NANOG":[160],"OCT4":[162],"expressions":[163],"positively":[164],"correlated":[165],"increased":[167],"tumor":[169],"Gleason":[170],"score.":[171],"glioma-derived":[174],"CD133":[175],"negative":[176],"cells,":[177],"was":[179],"able":[180],"neurospheres":[183],"markers.":[186],"Together,":[187],"these":[188],"findings":[189],"suggest":[190],"targets":[193],"may":[194],"act":[195],"as":[196],"key":[197],"dynamic":[201],"state":[202],"stemness":[204],"pathologic":[206],"conditions.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":29},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":32},{"year":2019,"cited_by_count":38},{"year":2018,"cited_by_count":33},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":57},{"year":2015,"cited_by_count":49},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":54},{"year":2012,"cited_by_count":44}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
