{"id":"https://openalex.org/W2170680841","doi":"https://doi.org/10.1124/dmd.105.009100","title":"IMPORTANCE OF UDP-GLUCURONOSYLTRANSFERASE 1A10 (UGT1A10) IN THE DETOXIFICATION OF POLYCYCLIC AROMATIC HYDROCARBONS: DECREASED GLUCURONIDATIVE ACTIVITY OF THE UGT1A10139LYS ISOFORM","display_name":"IMPORTANCE OF UDP-GLUCURONOSYLTRANSFERASE 1A10 (UGT1A10) IN THE DETOXIFICATION OF POLYCYCLIC AROMATIC HYDROCARBONS: DECREASED GLUCURONIDATIVE ACTIVITY OF THE UGT1A10139LYS ISOFORM","publication_year":2006,"publication_date":"2006-03-02","ids":{"openalex":"https://openalex.org/W2170680841","doi":"https://doi.org/10.1124/dmd.105.009100","mag":"2170680841","pmid":"https://pubmed.ncbi.nlm.nih.gov/16510539"},"language":"en","primary_location":{"id":"doi:10.1124/dmd.105.009100","doi":"https://doi.org/10.1124/dmd.105.009100","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.105.009100","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029262061","display_name":"Ryan W. Dellinger","orcid":"https://orcid.org/0000-0003-2191-5878","observed_orcids":["https://orcid.org/0000-0003-2191-5878"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I4405268258","display_name":"Penn State Cancer Institute","ror":"https://ror.org/00bzx1854","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405268258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan W. Dellinger","raw_affiliation_strings":["Cancer Prevention and Control Program, Division of Population Sciences and Cancer Prevention, Penn State Cancer Institute, Penn State University College of Medicine, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Prevention and Control Program, Division of Population Sciences and Cancer Prevention, Penn State Cancer Institute, Penn State University College of Medicine, PA 17033, USA","institution_ids":["https://openalex.org/I130769515","https://openalex.org/I4405268258"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084291218","display_name":"Jia\u2010Long Fang","orcid":"https://orcid.org/0000-0002-4687-5043","observed_orcids":["https://orcid.org/0000-0002-4687-5043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jia-Long Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Gang Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gang Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136605158","display_name":"Rebecca Weinberg","orcid":"https://orcid.org/0000-0003-1398-0039","observed_orcids":["https://orcid.org/0000-0003-1398-0039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Weinberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082304021","display_name":"Philip J. Lazarus","orcid":"https://orcid.org/0000-0002-8686-0874","observed_orcids":["https://orcid.org/0000-0002-8686-0874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Lazarus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.862,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.94747494,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"6","first_page":"943","last_page":"949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ugt1a10","display_name":"UGT1A10","score":0.9020000100135803},{"id":"https://openalex.org/keywords/benzo-a-pyrene","display_name":"benzo[a]pyrene","score":0.6850000023841858},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.8970000147819519},{"id":"https://openalex.org/keywords/glucuronidation","display_name":"glucuronidation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/detoxification","display_name":"detoxification","score":0.765999972820282},{"id":"https://openalex.org/keywords/ugt1a3","display_name":"UGT1A3","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ugt1a4","display_name":"UGT1A4","score":0.621999979019165},{"id":"https://openalex.org/keywords/ugt1a6","display_name":"UGT1A6","score":0.671999990940094},{"id":"https://openalex.org/keywords/ugt1a7","display_name":"UGT1A7","score":0.7059999704360962},{"id":"https://openalex.org/keywords/ugt1a8","display_name":"UGT1A8","score":0.7990000247955322},{"id":"https://openalex.org/keywords/ugt1a9","display_name":"UGT1A9","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tobacco-related-cancer","display_name":"tobacco-related cancer","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2779907587","wikidata":"https://www.wikidata.org/wiki/Q14901439","display_name":"Glucuronidation","level":4,"score":0.9278239011764526},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8425654172897339},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7129532694816589},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.6857606172561646},{"id":"https://openalex.org/C2775959351","wikidata":"https://www.wikidata.org/wiki/Q415465","display_name":"Chrysene","level":3,"score":0.5655618906021118},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5518402457237244},{"id":"https://openalex.org/C2777538855","wikidata":"https://www.wikidata.org/wiki/Q306051","display_name":"Benzo(a)pyrene","level":3,"score":0.5459127426147461},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.486685574054718},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4166643023490906},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.27157628536224365},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07014229893684387}],"mesh":[{"descriptor_ui":"D001580","descriptor_name":"Benzopyrenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020719","descriptor_name":"Glucuronides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1124/dmd.105.009100","doi":"https://doi.org/10.1124/dmd.105.009100","is_oa":false,"landing_page_url":"https://doi.org/10.1124/dmd.105.009100","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmid:16510539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16510539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8500000238418579}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1997839388","display_name":null,"funder_award_id":"P01CA68384","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3267404543","display_name":"TOBACCO AND CANCER RISK--DOSE, METABOLISM AND GENETICS","funder_award_id":"P01CA068384","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G61816891","display_name":null,"funder_award_id":"R01 DE 13158","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G8921603095","display_name":"UDP-GLUCURONOSYLTRANSFERASE GENOTYPE AND CANCER RISK","funder_award_id":"R01DE013158","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W64056573","https://openalex.org/W283059944","https://openalex.org/W1547473277","https://openalex.org/W1973438638","https://openalex.org/W1977924630","https://openalex.org/W1986486620","https://openalex.org/W2009226355","https://openalex.org/W2012186981","https://openalex.org/W2016527473","https://openalex.org/W2020416620","https://openalex.org/W2028588941","https://openalex.org/W2030130765","https://openalex.org/W2047463986","https://openalex.org/W2048327703","https://openalex.org/W2052383391","https://openalex.org/W2053600295","https://openalex.org/W2061095913","https://openalex.org/W2066420900","https://openalex.org/W2073070205","https://openalex.org/W2073166174","https://openalex.org/W2098149591","https://openalex.org/W2099676423","https://openalex.org/W2104002575","https://openalex.org/W2105089690","https://openalex.org/W2132804094","https://openalex.org/W2151654781","https://openalex.org/W2169935883","https://openalex.org/W2214362811","https://openalex.org/W2272686432","https://openalex.org/W6602630057","https://openalex.org/W6682387700"],"related_works":["https://openalex.org/W182797402","https://openalex.org/W2105089690","https://openalex.org/W2053600295","https://openalex.org/W4389021276","https://openalex.org/W2139034558","https://openalex.org/W1964721034","https://openalex.org/W2522938127","https://openalex.org/W2159914374","https://openalex.org/W2584257800","https://openalex.org/W2614648784"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}