{"id":"https://openalex.org/W2170674829","doi":"https://doi.org/10.1002/jcb.240370211","title":"Gene\u2010specific acquisition of hormonal responsiveness in rat liver during development","display_name":"Gene\u2010specific acquisition of hormonal responsiveness in rat liver during development","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W2170674829","doi":"https://doi.org/10.1002/jcb.240370211","mag":"2170674829","pmid":"https://pubmed.ncbi.nlm.nih.gov/2456297"},"language":"en","primary_location":{"id":"doi:10.1002/jcb.240370211","doi":"https://doi.org/10.1002/jcb.240370211","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.240370211","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102780098","display_name":"Alfred C. Johnson","orcid":"https://orcid.org/0000-0003-2285-4923","observed_orcids":["https://orcid.org/0000-0003-2285-4923"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred C. Johnson","raw_affiliation_strings":["University of Tennessee, Oak Ridge Graduate School of Biomedical Sciences","The University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, Tennessee 37831"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tennessee, Oak Ridge Graduate School of Biomedical Sciences","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"The University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge, Tennessee 37831","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045103683","display_name":"Kai\u2010Lin Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai\u2010Lin Lee","raw_affiliation_strings":["The Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040420379","display_name":"Kenneth R. Isham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth R. Isham","raw_affiliation_strings":["The Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831","institution_ids":["https://openalex.org/I1289243028"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052356363","display_name":"Francis T. Kenney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289243028","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289243028","https://openalex.org/I1330989302","https://openalex.org/I39565521","https://openalex.org/I4210159294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis T. Kenney","raw_affiliation_strings":["The Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831","institution_ids":["https://openalex.org/I1289243028"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":1.9214,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.87013673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"37","issue":"2","first_page":"243","last_page":"253"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.8198000192642212,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.06509999930858612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hormonal-responsiveness","display_name":"hormonal responsiveness","score":0.593999981880188},{"id":"https://openalex.org/keywords/gene-specific-regulation","display_name":"gene-specific regulation","score":0.6949999928474426},{"id":"https://openalex.org/keywords/liver-development","display_name":"liver development","score":0.7250000238418579},{"id":"https://openalex.org/keywords/fetal-liver","display_name":"fetal liver","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tyrosine-aminotransferase","display_name":"tyrosine aminotransferase","score":0.9409999847412109},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9359999895095825},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.9409999847412109},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.9210000038146973},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7549999952316284},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C2776491826","wikidata":"https://www.wikidata.org/wiki/Q7861685","display_name":"Tyrosine aminotransferase","level":4,"score":0.8826442956924438},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7254552841186523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6588786840438843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6574084758758545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6570370197296143},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6277152299880981},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6064249277114868},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5788490176200867},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.553718090057373},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.4610193967819214},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.18569886684417725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13759228587150574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10005083680152893},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.07584559917449951},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07380092144012451},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06310117244720459}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D011061","descriptor_name":"Poly A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014444","descriptor_name":"Tyrosine Transaminase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014444","descriptor_name":"Tyrosine Transaminase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014444","descriptor_name":"Tyrosine Transaminase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcb.240370211","doi":"https://doi.org/10.1002/jcb.240370211","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcb.240370211","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:2456297","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2456297","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2531534256","display_name":null,"funder_award_id":"R01 HD 14173","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5402015834","display_name":"PREDOCTORAL TRAINING PROGRAM IN GENETICS","funder_award_id":"T32GM007438","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W206773894","https://openalex.org/W570058961","https://openalex.org/W927388972","https://openalex.org/W1500057643","https://openalex.org/W1538151656","https://openalex.org/W1566077296","https://openalex.org/W1566548239","https://openalex.org/W1571670108","https://openalex.org/W1600512748","https://openalex.org/W1913034229","https://openalex.org/W1965674955","https://openalex.org/W1972479318","https://openalex.org/W1981048571","https://openalex.org/W1982905517","https://openalex.org/W2002854177","https://openalex.org/W2010434027","https://openalex.org/W2013812530","https://openalex.org/W2024628809","https://openalex.org/W2024911718","https://openalex.org/W2031687390","https://openalex.org/W2032067558","https://openalex.org/W2039372097","https://openalex.org/W2039439175","https://openalex.org/W2041785862","https://openalex.org/W2056072167","https://openalex.org/W2077077811","https://openalex.org/W2079439707","https://openalex.org/W2301083098","https://openalex.org/W4323913119"],"related_works":["https://openalex.org/W2010434027","https://openalex.org/W2024628809","https://openalex.org/W2032020317","https://openalex.org/W2036340836","https://openalex.org/W228235097","https://openalex.org/W1977487234","https://openalex.org/W2075440500","https://openalex.org/W1748043009","https://openalex.org/W2006597170","https://openalex.org/W2124106911"],"abstract_inverted_index":{"Cloned":[0],"cDNAs":[1],"were":[2],"used":[3],"in":[4,16,56,90,95,104,141],"hybridization":[5],"analyses":[6],"to":[7,71,80,115,126,128,151,153],"assess":[8],"hormonal":[9,51,88,154],"responsiveness":[10],"of":[11,18,23,29,47,61,75,86,92,98,123,145,148],"two":[12],"similarly":[13],"regulated":[14],"genes":[15,63,150],"livers":[17,91],"late-term":[19],"fetal":[20,105],"rats.":[21],"Transcription":[22],"the":[24,48,87,99,142,146],"tyrosine":[25],"aminotransferase":[26,102],"gene":[27,30,76,103,125],"and":[28,44,54,59],"33":[31,77],"(Lee":[32],"et":[33],"al.:":[34],"J":[35],"Biol":[36],"Chem":[37],"260:16433-16438,":[38],"1985)":[39],"is":[40,64],"enhanced":[41],"by":[42,45,84,110,117],"glucocorticoids":[43,119],"each":[46,85],"usually":[49],"antagonistic":[50],"agents,":[52],"insulin":[53,129],"cAMP,":[55],"adult":[57],"liver,":[58],"that":[60],"both":[62],"developmentally":[65],"activated":[66],"at":[67],"or":[68,120],"just":[69],"prior":[70],"birth.":[72],"The":[73,137],"mRNA":[74],"was":[78,107,113,130],"found":[79],"be":[81],"significantly":[82],"increased":[83,109],"regulators":[89],"fetuses":[93],"treated":[94],"utero.":[96],"Expression":[97],"nearly":[100],"silent":[101],"liver":[106],"appreciably":[108],"cAMP":[111],"but":[112],"refractory":[114],"control":[116],"either":[118],"insulin;":[121],"capacity":[122,147],"this":[124],"respond":[127,152],"not":[131],"realized":[132],"until":[133],"several":[134],"days":[135],"postpartum.":[136],"data":[138],"indicate":[139],"specificity":[140],"developmental":[143],"acquisition":[144],"individual":[149],"regulators.":[155]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
