{"id":"https://openalex.org/W2170659063","doi":null,"title":"Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.","display_name":"Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2170659063","mag":"2170659063","pmid":"https://pubmed.ncbi.nlm.nih.gov/23168708","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3516035"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3516035","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3516035/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3516035/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Med Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3516035/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075739031","display_name":"Ashish Saxena","orcid":"https://orcid.org/0000-0003-3353-129X","observed_orcids":["https://orcid.org/0000-0003-3353-129X"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashish Saxena","raw_affiliation_strings":["Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Texas, USA","Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Texas, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Texas, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102113281","display_name":"Sanket K. Shukla","orcid":"https://orcid.org/0000-0002-9260-2548","observed_orcids":["https://orcid.org/0000-0002-9260-2548"]},"institutions":[{"id":"https://openalex.org/I161370692","display_name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","ror":"https://ror.org/01rsgrz10","country_code":"IN","type":"facility","lineage":["https://openalex.org/I161370692"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sanket Kumar Shukla","raw_affiliation_strings":["Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India","institution_ids":["https://openalex.org/I161370692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051990347","display_name":"Kashi Nath Prasad","orcid":"https://orcid.org/0000-0002-8854-6459","observed_orcids":["https://orcid.org/0000-0002-8854-6459"]},"institutions":[{"id":"https://openalex.org/I161370692","display_name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","ror":"https://ror.org/01rsgrz10","country_code":"IN","type":"facility","lineage":["https://openalex.org/I161370692"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kashi Nath Prasad","raw_affiliation_strings":["Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India","institution_ids":["https://openalex.org/I161370692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027656448","display_name":"Uday C. Ghoshal","orcid":"https://orcid.org/0000-0003-0221-8495","observed_orcids":["https://orcid.org/0000-0003-0221-8495"]},"institutions":[{"id":"https://openalex.org/I161370692","display_name":"Sanjay Gandhi Post Graduate Institute of Medical Sciences","ror":"https://ror.org/01rsgrz10","country_code":"IN","type":"facility","lineage":["https://openalex.org/I161370692"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Uday Chand Ghoshal","raw_affiliation_strings":["Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, #N##TAB##TAB##TAB##TAB#India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, #N##TAB##TAB##TAB##TAB#India","institution_ids":["https://openalex.org/I161370692"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3705,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81345374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"136","issue":"4","first_page":"664","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/kras-codon-12-mutation","display_name":"K-ras codon 12 mutation","score":0.9760000109672546},{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":1.0},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":1.0},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":1.0},{"id":"https://openalex.org/keywords/functional-dyspepsia","display_name":"functional dyspepsia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gastric-carcinogenesis","display_name":"gastric carcinogenesis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/north-india","display_name":"North India","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7167342901229858},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.540241003036499},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5369346737861633},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.5042811632156372},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.486129492521286},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4408695697784424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4388713836669922},{"id":"https://openalex.org/C2780708398","wikidata":"https://www.wikidata.org/wiki/Q4101224","display_name":"Rapid urease test","level":4,"score":0.43596649169921875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4239524006843567},{"id":"https://openalex.org/C129219603","wikidata":"https://www.wikidata.org/wiki/Q1788683","display_name":"Single-strand conformation polymorphism","level":4,"score":0.42314213514328003},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4224313497543335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39338845014572144},{"id":"https://openalex.org/C2778677798","wikidata":"https://www.wikidata.org/wiki/Q183130","display_name":"Gastritis","level":3,"score":0.3541538119316101},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13553515076637268}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:3516035","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3516035/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3516035/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Med Res","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:2519360","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3516035","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23168708","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23168708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Indian journal of medical research","raw_type":"Journal Article"},{"id":"mag:2170659063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23168708","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3516035","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3516035/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3516035/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian J Med Res","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320325345","display_name":"Council of Science and Technology, U.P.","ror":"https://ror.org/01y25zv73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170659063.pdf","grobid_xml":"https://content.openalex.org/works/W2170659063.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W73509664","https://openalex.org/W140310733","https://openalex.org/W1933195498","https://openalex.org/W1966660119","https://openalex.org/W1973377881","https://openalex.org/W1986076152","https://openalex.org/W1987722451","https://openalex.org/W1994272410","https://openalex.org/W1999859802","https://openalex.org/W2001258296","https://openalex.org/W2019837696","https://openalex.org/W2022329296","https://openalex.org/W2027157544","https://openalex.org/W2031848000","https://openalex.org/W2053800122","https://openalex.org/W2055494293","https://openalex.org/W2060704131","https://openalex.org/W2067484068","https://openalex.org/W2069378448","https://openalex.org/W2072609051","https://openalex.org/W2081639721","https://openalex.org/W2083627679","https://openalex.org/W2108524147","https://openalex.org/W2132067762","https://openalex.org/W2140423708","https://openalex.org/W2149493693","https://openalex.org/W2416879511","https://openalex.org/W2469349276","https://openalex.org/W2948387191","https://openalex.org/W4297875023"],"related_works":["https://openalex.org/W2383585872","https://openalex.org/W2380156244","https://openalex.org/W2009325523","https://openalex.org/W1973377881","https://openalex.org/W2387980272","https://openalex.org/W2149493693","https://openalex.org/W2072709115","https://openalex.org/W2915186682","https://openalex.org/W2110782348","https://openalex.org/W1991774812"],"abstract_inverted_index":{"BACKGROUND":[0],"&":[1,192],"OBJECTIVES:":[2],"Mutations":[3],"in":[4,15,31,47,87,127,138,157,169,187,221,228],"the":[5,19,88,132,189,222],"oncogene":[6],"and":[7,23,27,37,60,84,102,135,141,146,164,179,212,226],"tumour":[8],"suppressor":[9],"genes":[10],"play":[11],"an":[12,67],"important":[13],"role":[14,220],"carcinogenesis.":[16],"We":[17],"investigated":[18],"association":[20],"of":[21,91,131,214,224],"p53":[22,92,122,151,170,198],"K-ras":[24,107,182,215],"gene":[25,93,108,123,152,171,183,199,216],"mutation":[26,111,124,153,172,184,200,217],"Helicobacter":[28],"pylori":[29,74,177,210],"infection":[30,75,211],"patients":[32,55,158],"with":[33,159,204],"gastric":[34,205],"cancer":[35],"(GC)":[36],"peptic":[38],"ulcer":[39],"disease":[40],"(PUD)":[41],"attending":[42],"a":[43],"tertiary":[44],"care":[45],"hospital":[46],"north":[48],"India.":[49],"METHODS:":[50],"In":[51],"total,":[52],"348":[53],"adult":[54],"[62":[56],"GC,":[57,139],"45":[58],"PUD":[59,140,162,227],"241":[61],"non-ulcer":[62],"dyspepsia":[63],"(NUD)]":[64],"who":[65],"underwent":[66],"upper":[68],"gastrointestinal":[69],"endoscopy":[70],"were":[71],"enrolled.":[72],"H.":[73,176,209],"was":[76,94,112,125,143,154,173,185],"diagnosed":[77],"by":[78,96,104,114],"rapid":[79],"urease":[80],"test,":[81],"culture,":[82],"histopathology":[83],"PCR.":[85],"Mutation":[86],"exon":[89],"5-8":[90],"analyzed":[95,113],"PCR-single":[97],"stranded":[98],"conformational":[99],"polymorphism":[100],"(SSCP)":[101],"confirmed":[103],"sequence":[105],"analysis.":[106],"codon":[109],"12":[110],"PCR-based":[115],"restriction":[116],"fragment":[117],"length":[118],"polymorphism.":[119],"RESULTS:":[120],"Overall":[121],"found":[126],"4.6":[128],"per":[129,148],"cent":[130],"study":[133],"population,":[134],"its":[136,219],"distribution":[137],"NUD":[142,165],"21,":[144],"4.4":[145],"0.4":[147],"cent,":[149],"respectively.":[150],"significantly":[155],"higher":[156],"GC":[160,225],"than":[161],"(P<0.05)":[163],"(P<0.001).":[166],"No":[167],"difference":[168],"observed":[174],"between":[175],"infected":[178],"non-infected":[180],"individuals.":[181],"absent":[186],"all":[188],"patients.":[190,230],"INTERPRETATION":[191],"CONCLUSIONS:":[193],"Our":[194],"results":[195],"show":[196],"that":[197],"may":[201],"be":[202],"associated":[203],"carcinogenesis":[206],"independent":[207],"to":[208],"absence":[213],"questions":[218],"pathogenesis":[223],"Indian":[229]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}