{"id":"https://openalex.org/W2170657202","doi":"https://doi.org/10.1158/0008-5472.can-04-0732","title":"Functional Correlation of Trophinin Expression with the Malignancy of Testicular Germ Cell Tumor","display_name":"Functional Correlation of Trophinin Expression with the Malignancy of Testicular Germ Cell Tumor","publication_year":2004,"publication_date":"2004-06-15","ids":{"openalex":"https://openalex.org/W2170657202","doi":"https://doi.org/10.1158/0008-5472.can-04-0732","mag":"2170657202","pmid":"https://pubmed.ncbi.nlm.nih.gov/15205339"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-04-0732","doi":"https://doi.org/10.1158/0008-5472.can-04-0732","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-04-0732","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011348912","display_name":"Shingo Hatakeyama","orcid":"https://orcid.org/0000-0002-0026-4079","observed_orcids":["https://orcid.org/0000-0002-0026-4079"]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Hatakeyama","raw_affiliation_strings":["1Department of Urology, Akita University School of Medicine, Akita, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Urology, Akita University School of Medicine, Akita, Japan;","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076273759","display_name":"Chikara \u039fhyama","orcid":"https://orcid.org/0000-0003-1550-8379","observed_orcids":["https://orcid.org/0000-0003-1550-8379"]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikara Ohyama","raw_affiliation_strings":["1Department of Urology, Akita University School of Medicine, Akita, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Urology, Akita University School of Medicine, Akita, Japan;","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003429544","display_name":"Shingo Minagawa","orcid":"https://orcid.org/0000-0003-2766-0933","observed_orcids":["https://orcid.org/0000-0003-2766-0933"]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Minagawa","raw_affiliation_strings":["1Department of Urology, Akita University School of Medicine, Akita, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Urology, Akita University School of Medicine, Akita, Japan;","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059104414","display_name":"Takamitsu Inoue","orcid":"https://orcid.org/0000-0002-1362-4344","observed_orcids":["https://orcid.org/0000-0002-1362-4344"]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takamitsu Inoue","raw_affiliation_strings":["1Department of Urology, Akita University School of Medicine, Akita, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Urology, Akita University School of Medicine, Akita, Japan;","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111671484","display_name":"Hideaki Kakinuma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Kakinuma","raw_affiliation_strings":["1Department of Urology, Akita University School of Medicine, Akita, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Urology, Akita University School of Medicine, Akita, Japan;","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060289225","display_name":"Atsushi Kyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Kyan","raw_affiliation_strings":["2Department of Urology, Tohoku University School of Medicine, Sendai, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Urology, Tohoku University School of Medicine, Sendai, Japan;","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080725230","display_name":"Yoichi Arai","orcid":"https://orcid.org/0009-0002-7352-0093","observed_orcids":["https://orcid.org/0009-0002-7352-0093"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichi Arai","raw_affiliation_strings":["2Department of Urology, Tohoku University School of Medicine, Sendai, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Urology, Tohoku University School of Medicine, Sendai, Japan;","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040618957","display_name":"Tomoaki Suga","orcid":"https://orcid.org/0000-0002-1143-5021","observed_orcids":["https://orcid.org/0000-0002-1143-5021"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoaki Suga","raw_affiliation_strings":["3Department of Internal Medicine, Shinshu University School of Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Internal Medicine, Shinshu University School of Medicine and","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105515724","display_name":"Jun Nakayama","orcid":"https://orcid.org/0000-0001-6773-2802","observed_orcids":["https://orcid.org/0000-0001-6773-2802"]},"institutions":[{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Nakayama","raw_affiliation_strings":["4Department of Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pathology, Shinshu University Graduate School of Medicine, Matsumoto, Japan; and","institution_ids":["https://openalex.org/I137975476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101017775","display_name":"Tetsuro Kato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuro Kato","raw_affiliation_strings":["1Department of Urology, Akita University School of Medicine, Akita, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Urology, Akita University School of Medicine, Akita, Japan;","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012066043","display_name":"Tomonori Habuchi","orcid":"https://orcid.org/0000-0003-0998-4432","observed_orcids":["https://orcid.org/0000-0003-0998-4432"]},"institutions":[{"id":"https://openalex.org/I203765153","display_name":"Akita University","ror":"https://ror.org/03hv1ad10","country_code":"JP","type":"education","lineage":["https://openalex.org/I203765153"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomonori Habuchi","raw_affiliation_strings":["1Department of Urology, Akita University School of Medicine, Akita, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Urology, Akita University School of Medicine, Akita, Japan;","institution_ids":["https://openalex.org/I203765153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006762365","display_name":"Michiko N. Fukuda","orcid":"https://orcid.org/0000-0003-4120-0490","observed_orcids":["https://orcid.org/0000-0003-4120-0490"]},"institutions":[{"id":"https://openalex.org/I188891513","display_name":"Sanford Burnham Prebys Medical Discovery Institute","ror":"https://ror.org/03m1g2s55","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I188891513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michiko N. Fukuda","raw_affiliation_strings":["5Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Glycobiology Program, Cancer Research Center, The Burnham Institute, La Jolla, California","institution_ids":["https://openalex.org/I188891513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6539,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.94594945,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"64","issue":"12","first_page":"4257","last_page":"4262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11069","display_name":"Testicular diseases and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/testicular-germ-cell-tumors","display_name":"testicular germ cell tumors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-malignancy","display_name":"tumor malignancy","score":0.6330000162124634},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6359999775886536},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6079999804496765},{"id":"https://openalex.org/keywords/trophoblast-like-cells","display_name":"trophoblast-like cells","score":0.7149999737739563},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.6399999856948853},{"id":"https://openalex.org/keywords/seminoma","display_name":"seminoma","score":0.5690000057220459},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.7870000004768372},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.49799999594688416},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.46399998664855957}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5656277537345886},{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.5311480760574341},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5306196212768555},{"id":"https://openalex.org/C32253518","wikidata":"https://www.wikidata.org/wiki/Q5158447","display_name":"Conceptus","level":4,"score":0.521384060382843},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5108627676963806},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.4858519732952118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46985068917274475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39068925380706787},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3222291171550751},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2582501769065857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.252552330493927},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23709294199943542},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.19715023040771484},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16627776622772217},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11107516288757324},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.09845021367073059},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0923212468624115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013736","descriptor_name":"Testicular Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018997","descriptor_name":"Chorionic Gonadotropin, beta Subunit, Human","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018997","descriptor_name":"Chorionic Gonadotropin, beta Subunit, Human","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-04-0732","doi":"https://doi.org/10.1158/0008-5472.can-04-0732","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-04-0732","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:15205339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15205339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1290887568","display_name":"EXPRESSION AND IN VIVO ROLE OF TROPHININ IN MICE","funder_award_id":"R01HD034108","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W57892688","https://openalex.org/W606948824","https://openalex.org/W1541170357","https://openalex.org/W1586519380","https://openalex.org/W1814660981","https://openalex.org/W1915178709","https://openalex.org/W1938617858","https://openalex.org/W1966981219","https://openalex.org/W1971419306","https://openalex.org/W1972649868","https://openalex.org/W1975751233","https://openalex.org/W1977762912","https://openalex.org/W1979265757","https://openalex.org/W1984132456","https://openalex.org/W1986437615","https://openalex.org/W2019842572","https://openalex.org/W2024488529","https://openalex.org/W2025258456","https://openalex.org/W2026511788","https://openalex.org/W2031192188","https://openalex.org/W2031829239","https://openalex.org/W2047283411","https://openalex.org/W2047672708","https://openalex.org/W2056671432","https://openalex.org/W2061354994","https://openalex.org/W2066794008","https://openalex.org/W2083452234","https://openalex.org/W2085562009","https://openalex.org/W2090564783","https://openalex.org/W2095443344","https://openalex.org/W2124733976","https://openalex.org/W2150811210","https://openalex.org/W2186929731","https://openalex.org/W2207003210","https://openalex.org/W2325674170","https://openalex.org/W2334576825","https://openalex.org/W2502134830","https://openalex.org/W4211232189","https://openalex.org/W4235518915","https://openalex.org/W4239180165"],"related_works":["https://openalex.org/W2567791008","https://openalex.org/W2793100635","https://openalex.org/W2075404463","https://openalex.org/W4253205822","https://openalex.org/W6903924942","https://openalex.org/W1993807192","https://openalex.org/W2154891352","https://openalex.org/W2248601737","https://openalex.org/W2062317559","https://openalex.org/W2063864637"],"abstract_inverted_index":{"Trophinin":[0,24],"is":[1,6],"a":[2,187],"membrane":[3],"protein":[4],"that":[5,35,48,59,62,198,253],"potentially":[7],"involved":[8],"in":[9,102,109,117,135,154,217,233],"human":[10,37,178],"embryo":[11,34,55],"implantation":[12],"by":[13,26,32,85],"mediating":[14],"homophillic":[15],"cell":[16,83,180,266],"adhesion":[17],"between":[18,213],"trophoblastic":[19],"cells":[20,28,201,229,259],"and":[21,52,112,215,260],"endometrial":[22],"cells.":[23,71],"expression":[25,125,189],"maternal":[27],"may":[29],"be":[30],"induced":[31],"the":[33,42,96,138,155,175,236,258],"secretes":[36],"chorionic":[38],"gonadotropin":[39],"(hCG).":[40],"Because":[41],"process":[43],"of":[44,49,77,99,106,114,137,141,148,174,235,257,263],"tumor":[45,84],"metastasis":[46,262],"resembles":[47],"trophoblast":[50],"invasion":[51],"proliferation":[53,219],"during":[54],"implantation,":[56],"we":[57],"hypothesized":[58],"testicular":[60,81,264],"cancers":[61],"synthesize":[63],"hCG":[64],"express":[65],"trophinin":[66,124,132,171,192,254],"thus":[67],"becoming":[68],"aggressive":[69],"trophoblast-like":[70],"We":[72],"screened":[73],"paraffin-embedded":[74],"orchiectomy":[75],"specimens":[76,94],"158":[78],"patients":[79,156],"with":[80,95,128,143,157,162,186],"germ":[82,265],"immunohistochemistry":[86],"using":[87],"antitrophinin":[88],"antibody.":[89],"This":[90],"screening":[91],"identified":[92],"trophinin-positive":[93,158],"frequencies":[97],"39":[98],"91":[100],"(43%)":[101],"stage":[103,110,118],"I,":[104],"14":[105],"24":[107],"(58%)":[108],"II,":[111],"41":[113],"43":[115],"(95%)":[116],"III":[119],"(P":[120,165],"<":[121],"0.001).":[122],"Thus,":[123],"positively":[126],"correlates":[127],"clinical":[129],"stage.":[130],"Remarkably,":[131],"was":[133,183],"found":[134],"all":[136,234],"cases":[139],"(33":[140],"33)":[142],"lung":[144],"metastasis.":[145],"The":[146],"levels":[147],"serum":[149],"hCG-beta":[150],"were":[151],"significantly":[152],"higher":[153],"tumors":[159,164],"than":[160,205],"those":[161],"trophinin-negative":[163,177],"=":[166,239,247],"0.004).":[167],"To":[168],"determine":[169],"whether":[170],"promotes":[172,261],"aggressiveness":[173],"cell,":[176],"seminona":[179],"line":[181],"JKT-1":[182],"stably":[184],"transfected":[185],"mammalian":[188],"vector":[190],"containing":[191],"cDNA.":[193],"In":[194],"vitro":[195],"assays":[196],"revealed":[197],"trophinin-expressing":[199],"JKT-1-Tro":[200,214,228],"are":[202,210],"more":[203],"invasive":[204],"JKT-1-mock":[206,216,242],"cells,":[207],"whereas":[208,241],"there":[209],"no":[211,244],"differences":[212],"their":[218],"activity.":[220],"Upon":[221],"orthotopic":[222],"inoculation":[223],"to":[224],"athymic":[225],"nude":[226],"mice,":[227],"exhibited":[230],"i.p.":[231],"metastases":[232,245],"mice":[237],"(n":[238,246],"5),":[240],"produced":[243],"5).":[248],"These":[249],"results":[250],"suggest":[251],"strongly":[252],"enhances":[255],"invasiveness":[256],"tumor.":[267]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}