{"id":"https://openalex.org/W2170653100","doi":null,"title":"The role of insulin-like growth factor-I in neuroendocrine function and the consequent effects on sexual maturation: inferences from animal models.","display_name":"The role of insulin-like growth factor-I in neuroendocrine function and the consequent effects on sexual maturation: inferences from animal models.","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2170653100","mag":"2170653100","pmid":"https://pubmed.ncbi.nlm.nih.gov/14666141"},"language":"en","primary_location":{"id":"pmid:14666141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14666141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103417188","display_name":"Varadaraj Chandrashekar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110378019","display_name":"Southern Illinois University Carbondale","ror":"https://ror.org/049kefs16","country_code":"US","type":"education","lineage":["https://openalex.org/I110378019","https://openalex.org/I2801502357"]},{"id":"https://openalex.org/I196729704","display_name":"SIU Medicine","ror":"https://ror.org/0232r4451","country_code":"US","type":"education","lineage":["https://openalex.org/I196729704","https://openalex.org/I2801502357"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Varadaraj Chandrashekar","raw_affiliation_strings":["Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901-6512, USA. vchandrashekar@siumed.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 62901-6512, USA. vchandrashekar@siumed.edu","institution_ids":["https://openalex.org/I110378019","https://openalex.org/I196729704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018886262","display_name":"Andrzej Bartke","orcid":"https://orcid.org/0000-0002-2569-557X","observed_orcids":["https://orcid.org/0000-0002-2569-557X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrzej Bartke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1137,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.79904505,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"1","first_page":"7","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.12110000103712082,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9850000143051147},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.9769999980926514},{"id":"https://openalex.org/keywords/sexual-maturation","display_name":"sexual maturation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.6330000162124634},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/prolactin","display_name":"prolactin","score":0.6399999856948853},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.746999979019165},{"id":"https://openalex.org/keywords/ames-dwarf-mice","display_name":"Ames dwarf mice","score":0.7670000195503235},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.6320000290870667},{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":0.7419999837875366},{"id":"https://openalex.org/keywords/laron-syndrome","display_name":"Laron syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/gonadotropins","display_name":"gonadotropins","score":0.7979999780654907},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8621826171875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.849473237991333},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.7347801923751831},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6818674802780151},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.601134717464447},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5270191431045532},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5268065929412842},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5057642459869385},{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.4833054542541504},{"id":"https://openalex.org/C113675107","wikidata":"https://www.wikidata.org/wiki/Q2299608","display_name":"Growth hormone receptor","level":4,"score":0.4735114872455597},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.45094043016433716},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.43252211809158325},{"id":"https://openalex.org/C94984642","wikidata":"https://www.wikidata.org/wiki/Q3015605","display_name":"Somatotropic cell","level":4,"score":0.4238506257534027},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34046506881713867},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.2594769597053528},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.2550773620605469},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12634068727493286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09415924549102783}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012741","descriptor_name":"Sexual Maturation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:14666141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14666141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Reproductive biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.329.504","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.329.504","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.repbiol.pan.olsztyn.pl/docs/pdfs/repbiol_vol3_num1_page7.pdf","raw_type":"text"},{"id":"mag:2170653100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14666141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2352299542","display_name":"GROWTH HORMONE IN PITUITARY AND TESTICULAR FUNCTION","funder_award_id":"R15HD037950","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G564415784","display_name":"GH-DEPENDENT VS -INDEPENDENT EFFECTS OF IGF-I ON PUBERTY","funder_award_id":"R03HD037672","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W78478196","https://openalex.org/W140667407","https://openalex.org/W1488424161","https://openalex.org/W1512089533","https://openalex.org/W1585240949","https://openalex.org/W1590530107","https://openalex.org/W1771833573","https://openalex.org/W1833131266","https://openalex.org/W1966978889","https://openalex.org/W1971161418","https://openalex.org/W1973018582","https://openalex.org/W1973531568","https://openalex.org/W1977825741","https://openalex.org/W1978166796","https://openalex.org/W1980640220","https://openalex.org/W1981450652","https://openalex.org/W1985071538","https://openalex.org/W1987919126","https://openalex.org/W1988509366","https://openalex.org/W1993531494","https://openalex.org/W1996199571","https://openalex.org/W2011927780","https://openalex.org/W2012347195","https://openalex.org/W2015852816","https://openalex.org/W2016364641","https://openalex.org/W2018249696","https://openalex.org/W2019061543","https://openalex.org/W2023144730","https://openalex.org/W2024497388","https://openalex.org/W2035545667","https://openalex.org/W2040124791","https://openalex.org/W2041802172","https://openalex.org/W2044918789","https://openalex.org/W2049286581","https://openalex.org/W2051195117","https://openalex.org/W2054286770","https://openalex.org/W2055243341","https://openalex.org/W2055709952","https://openalex.org/W2059223117","https://openalex.org/W2064903015","https://openalex.org/W2065185161","https://openalex.org/W2065752045","https://openalex.org/W2067185112","https://openalex.org/W2071316854","https://openalex.org/W2074093513","https://openalex.org/W2078197242","https://openalex.org/W2082691596","https://openalex.org/W2083638487","https://openalex.org/W2087196897","https://openalex.org/W2088127887","https://openalex.org/W2092224562","https://openalex.org/W2098729526","https://openalex.org/W2098829351","https://openalex.org/W2101045687","https://openalex.org/W2105393647","https://openalex.org/W2109373697","https://openalex.org/W2110570575","https://openalex.org/W2111031228","https://openalex.org/W2117645526","https://openalex.org/W2118600634","https://openalex.org/W2119860906","https://openalex.org/W2120198912","https://openalex.org/W2122893492","https://openalex.org/W2124483177","https://openalex.org/W2125297912","https://openalex.org/W2127246045","https://openalex.org/W2135159860","https://openalex.org/W2136461131","https://openalex.org/W2142619900","https://openalex.org/W2142848812","https://openalex.org/W2143828869","https://openalex.org/W2145440057","https://openalex.org/W2150759685","https://openalex.org/W2150786449","https://openalex.org/W2164259481","https://openalex.org/W2165101830","https://openalex.org/W2165736537","https://openalex.org/W2172100709","https://openalex.org/W2316033193","https://openalex.org/W2346394749","https://openalex.org/W2400261978","https://openalex.org/W2418546119","https://openalex.org/W3121462534"],"related_works":["https://openalex.org/W2350564693","https://openalex.org/W2064903015","https://openalex.org/W2066929307","https://openalex.org/W2398512658","https://openalex.org/W173190338","https://openalex.org/W2316033193","https://openalex.org/W7100911544","https://openalex.org/W4226420936","https://openalex.org/W2142848812","https://openalex.org/W2009020893"],"abstract_inverted_index":{"It":[0,269],"is":[1,90,200,270],"known":[2],"that":[3,18,27,118,168,215,274],"growth":[4,12,178],"hormone":[5],"(GH)":[6],"plays":[7],"an":[8],"important":[9,271],"role":[10,319],"in":[11,35,107,112,152,157,169,176,183,190,221,232,320],"and":[13,46,54,93,114,126,143,154,189,231,248,277,303,310],"development.Additionally,":[14],"emerging":[15],"evidence":[16],"suggest":[17],"it":[19,50,164],"also":[20],"influences":[21],"hypothalamic-pituitary-gonadal":[22],"function.":[23],"We":[24,212],"have":[25,116,213],"found":[26],"GH":[28,40,45,88,105,123,136,151,155,174,184,208,226,233,242],"from":[29,69,73],"different":[30,33],"species":[31],"has":[32,51,59,165],"effects":[34,82,96,121,243,251,323],"mice.":[36,237],"In":[37,146],"rodents,":[38],"human":[39],"(hGH)":[41],"binds":[42],"to":[43,135,255,262,272],"both":[44,52],"prolactin":[47],"(PRL)":[48],"receptors;":[49],"somatotrophic":[53],"lactotrophic":[55],"effects.":[56],"Since":[57],"PRL":[58],"a":[60,317],"profound":[61],"effect":[62],"on":[63,324],"neuroendocrine":[64],"function,":[65],"the":[66,77,95,100,103,127,132,139,194,216,225,241,249,256,263,275,297,304,313,325],"results":[67],"obtained":[68],"hGH":[70,78],"treatment":[71],"or":[72,204,260],"transgenic":[74,170,222],"animals":[75],"expressing":[76,172,224],"gene":[79,235],"reflect":[80],"PRL-like":[81],"of":[83,97,102,122,129,131,141,150,196,207,240,265,279,299,306],"this":[84,266],"hormone.":[85],"However,":[86],"bovine":[87],"(bGH)":[89],"purely":[91],"somatogenic":[92],"therefore":[94],"bGH":[98],"represent":[99],"function":[101],"natural":[104],"produced":[106],"rodents.":[108],"Furthermore,":[109,287],"our":[110],"studies":[111],"mice":[113,171,193,223,230],"rats":[115],"shown":[117,214],"not":[119],"all":[120],"are":[124,219,244,283],"stimulatory":[125],"duration":[128],"exposure":[130],"hypothalamo-hypophyseal-gonadal":[133],"system":[134],"might":[137,315],"influence":[138],"secretions":[140],"gonadotropins":[142],"gonadal":[144],"steroids.":[145],"humans,":[147],"excess":[148,203],"productions":[149],"acromegaly":[153],"resistance":[156],"Laron":[158],"syndrome":[159],"adversely":[160],"affect":[161,210],"reproduction.":[162,211],"Similarly,":[163],"been":[166],"demonstrated":[167],"various":[173],"genes,":[175,227],"insulin-like":[177],"factor-I":[179],"(IGF-I)":[180],"gene-knockout":[181],"mice,":[182,188],"receptor":[185,234],"gene-disrupted":[186],"(GHR-KO)":[187],"Ames":[191,228],"dwarf":[192,229],"onset":[195],"puberty":[197],"and/or":[198],"fertility":[199],"altered.":[201],"Therefore,":[202,296],"subnormal":[205],"secretion":[206,259],"can":[209,292],"hypothalamic-pituitary":[217],"functions":[218],"affected":[220],"knockout":[236],"The":[238],"majority":[239],"mediated":[245],"via":[246],"IGF-I":[247,258,294,311,322],"aforementioned":[250],"may":[252],"be":[253],"due":[254,261],"GH-induced":[257],"absence":[264],"peptide":[267],"production.":[268],"realize":[273],"syntheses":[276],"actions":[278],"IGF":[280,289,300],"binding":[281,290,301,308],"proteins":[282,291,302,309],"controlled":[284],"by":[285],"IGF-I.":[286],"some":[288],"inhibit":[293],"action.":[295],"concentrations":[298],"ratio":[305],"these":[307],"within":[312],"body":[314],"play":[316],"pivotal":[318],"modulating":[321],"neuroendocrine-gonadal":[326],"system.":[327]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}