{"id":"https://openalex.org/W2170621554","doi":null,"title":"Short-term pregnancy hormone treatment of N-methyl-N-nitrosourea-induced mammary carcinogenesis in relation to fatty acid composition of serum phospholipids in female Lewis rats.","display_name":"Short-term pregnancy hormone treatment of N-methyl-N-nitrosourea-induced mammary carcinogenesis in relation to fatty acid composition of serum phospholipids in female Lewis rats.","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W2170621554","mag":"2170621554","pmid":"https://pubmed.ncbi.nlm.nih.gov/20668323"},"language":"en","primary_location":{"id":"pmid:20668323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20668323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007118371","display_name":"Yen\u2010Chang Clark Lai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126884977","display_name":"Kansai Medical University","ror":"https://ror.org/001xjdh50","country_code":"JP","type":"education","lineage":["https://openalex.org/I126884977"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yen-Chang Lai","raw_affiliation_strings":["Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan","institution_ids":["https://openalex.org/I126884977"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011765223","display_name":"Kei Hamazaki","orcid":"https://orcid.org/0000-0003-0456-6805","observed_orcids":["https://orcid.org/0000-0003-0456-6805"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kei Hamazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057826873","display_name":"Katsuhiko Yoshizawa","orcid":"https://orcid.org/0000-0002-3996-032X","observed_orcids":["https://orcid.org/0000-0002-3996-032X","https://orcid.org/0000-0002-2551-6201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katsuhiko Yoshizawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018455001","display_name":"Ayako Kawanaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayako Kawanaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026933526","display_name":"Maki Kuwata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maki Kuwata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086222202","display_name":"Sayaka Kanematsu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sayaka Kanematsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014965523","display_name":"Tomohito Hamazaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomohito Hamazaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045696492","display_name":"Hideho Takada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideho Takada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018774495","display_name":"Airo Tsubura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Airo Tsubura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.735,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63667992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"24","issue":"4","first_page":"553","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9434000253677368,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12103","display_name":"Cancer Risks and Factors","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-methyl-n-nitrosourea","display_name":"N-methyl-N-nitrosourea","score":0.9290000200271606},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9359999895095825},{"id":"https://openalex.org/keywords/n-6-n-3-ratio","display_name":"n-6/n-3 ratio","score":0.9449999928474426},{"id":"https://openalex.org/keywords/age-at-treatment","display_name":"age at treatment","score":0.5130000114440918},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.8050000071525574},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.8830000162124634},{"id":"https://openalex.org/keywords/lewis-rats","display_name":"Lewis rats","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6138337254524231},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6090698838233948},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.5271546244621277},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.4891863167285919},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4802175462245941},{"id":"https://openalex.org/C2776659692","wikidata":"https://www.wikidata.org/wiki/Q719426","display_name":"Lactation","level":3,"score":0.4503426253795624},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.4475755989551544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4356231987476349},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.40137842297554016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37154048681259155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19489997625350952},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16136124730110168},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004281","descriptor_name":"Docosahexaenoic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008325","descriptor_name":"Mammary Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008770","descriptor_name":"Methylnitrosourea","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010743","descriptor_name":"Phospholipids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011374","descriptor_name":"Progesterone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20668323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20668323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vivo (Athens, Greece)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W10256500","https://openalex.org/W29873470","https://openalex.org/W187608920","https://openalex.org/W1487240281","https://openalex.org/W1518867262","https://openalex.org/W1909250455","https://openalex.org/W1977247177","https://openalex.org/W1980775229","https://openalex.org/W1981324020","https://openalex.org/W1986932828","https://openalex.org/W1993456041","https://openalex.org/W1996653282","https://openalex.org/W1999662564","https://openalex.org/W2006724508","https://openalex.org/W2009094206","https://openalex.org/W2014337671","https://openalex.org/W2015950242","https://openalex.org/W2027670865","https://openalex.org/W2027755936","https://openalex.org/W2029981991","https://openalex.org/W2031720531","https://openalex.org/W2043788392","https://openalex.org/W2045289959","https://openalex.org/W2046853960","https://openalex.org/W2047741256","https://openalex.org/W2064204128","https://openalex.org/W2076863949","https://openalex.org/W2095697394","https://openalex.org/W2104574123","https://openalex.org/W2111443842","https://openalex.org/W2113600934","https://openalex.org/W2138825852","https://openalex.org/W2139189933","https://openalex.org/W2144340361","https://openalex.org/W2151369312","https://openalex.org/W2152311269","https://openalex.org/W2167344317","https://openalex.org/W2205047025","https://openalex.org/W2411587890","https://openalex.org/W2424105007"],"related_works":["https://openalex.org/W4244917789","https://openalex.org/W2113600934","https://openalex.org/W2151468817","https://openalex.org/W2006724508","https://openalex.org/W2139189933","https://openalex.org/W2263344418","https://openalex.org/W1970341772","https://openalex.org/W2115485475","https://openalex.org/W2106963973","https://openalex.org/W2027755936"],"abstract_inverted_index":{"AIM:":[0],"Short-term":[1],"oestrogen":[2],"and":[3,41,61,82,92,117,176,178,186,241,278,308],"progesterone":[4,64],"treatment":[5],"(STEPT)":[6],"mimics":[7],"the":[8,15,112,162,165,212,254,267,271,287,309],"pregnancy":[9],"hormone":[10],"milieu.":[11],"This":[12],"study":[13],"compared":[14,204],"development":[16],"of":[17,48,114,137,164,201,222,244,256],"N-methyl-N-nitrosourea":[18],"(MNU)-induced":[19],"mammary":[20,154,202,298,319],"cancer":[21,189,203,213,320],"in":[22,29,38,69,71,79,102,104,125,158,215,229,250,303,318],"female":[23],"Lewis":[24],"rats":[25,70,103,124,148],"that":[26,221,286],"received":[27,43,84],"STEPT":[28,291],"early":[30],"or":[31,160],"later":[32],"life.":[33],"MATERIALS":[34],"AND":[35],"METHODS:":[36],"Rats":[37,78,228],"Groups":[39,80,174,184,276],"1":[40,73,175,195,231],"2":[42,177,207,252],"a":[44,197,315],"single":[45],"intraperitoneal":[46],"injection":[47],"50":[49,85],"mg/kg":[50,86],"MNU":[51,87],"at":[52,88,94,161,169,179,253,280,289],"4":[53,83,121,224,279],"weeks":[54,76,90,96,109,119,171,181,262],"old.":[55,77,97,110],"Pellets":[56],"containing":[57],"0.5":[58],"mg":[59,63],"17beta-estradiol":[60],"32.5":[62],"(EP)":[65],"were":[66,100,128,149],"subcutaneously":[67],"implanted":[68,101],"Group":[72,105,194,206,216,223,230,251],"during":[74,107],"6-9":[75],"3":[81,106,185,217,277],"22":[89],"old":[91,172,182],"again":[93],"23":[95],"EP":[98,115,257,264],"pellets":[99],"24-27":[108],"At":[111],"time":[113,255],"removal":[116,258],"8":[118,261],"afterward,":[120],"randomly":[122],"selected":[123],"each":[126],"group":[127],"sacrificed":[129,150],"for":[130,173,183],"blood":[131],"sampling.":[132],"The":[133,146],"fatty":[134,237],"acid":[135,238,246],"composition":[136],"serum":[138],"phospholipids":[139],"was":[140,168,190,218,301],"measured":[141],"by":[142,322],"capillary":[143],"gas":[144],"chromatography.":[145],"remaining":[147],"when":[151],"they":[152],"developed":[153],"tumours":[155],">or=1":[156],"cm":[157],"diameter":[159],"termination":[163],"experiment,":[166],"which":[167,290],"18":[170],"64":[180],"4.":[187],"Mammary":[188],"histologically":[191],"confirmed.":[192],"RESULTS:":[193],"had":[196,232],"significantly":[198,233],"suppressed":[199],"incidence":[200,214],"to":[205,220],"(7%":[208],"vs.":[209,226],"90%),":[210],"whereas":[211],"similar":[219],"(50%":[225],"56%).":[227],"smaller":[234],"n-6/n-3":[235,310],"polyunsaturated":[236],"(PUFA)":[239],"ratios":[240,269],"higher":[242],"levels":[243,273],"docosahexaenoic":[245],"(DHA)":[247],"than":[248],"those":[249],"but":[259],"not":[260],"after":[263],"removal.":[265],"Neither":[266],"PUFA":[268,311],"nor":[270],"DHA":[272,307],"differed":[274],"between":[275],"any":[281],"time.":[282],"These":[283],"data":[284],"suggest":[285],"age":[288],"is":[292,294],"administered":[293],"important,":[295],"since":[296],"its":[297],"cancer-suppressing":[299],"potential":[300],"lost":[302],"aged":[304],"animals.":[305],"CONCLUSION:":[306],"ratio":[312],"may":[313],"play":[314],"crucial":[316],"role":[317],"suppression":[321],"STEPT.":[323]},"counts_by_year":[{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}