{"id":"https://openalex.org/W2170612253","doi":"https://doi.org/10.1002/syn.890180109","title":"Intracellularly recorded response of rat striatal neurons in vitro to fenoldopam and SKF 38393 following lesions of midbrain dopamine cells","display_name":"Intracellularly recorded response of rat striatal neurons in vitro to fenoldopam and SKF 38393 following lesions of midbrain dopamine cells","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W2170612253","doi":"https://doi.org/10.1002/syn.890180109","mag":"2170612253","pmid":"https://pubmed.ncbi.nlm.nih.gov/7825125"},"language":"en","primary_location":{"id":"doi:10.1002/syn.890180109","doi":"https://doi.org/10.1002/syn.890180109","is_oa":false,"landing_page_url":"https://doi.org/10.1002/syn.890180109","pdf_url":null,"source":{"id":"https://openalex.org/S158211696","display_name":"Synapse","issn_l":"0887-4476","issn":["0887-4476","1098-2396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082249228","display_name":"Michael J. Twery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. J. Twery","raw_affiliation_strings":["Cellular Physiology and Neurotransmission Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892","Cellular Physiology and Neurotransmission Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Physiology and Neurotransmission Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"raw_affiliation_string":"Cellular Physiology and Neurotransmission Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. A. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. A. Thompson","raw_affiliation_strings":["Neurophysiological Pharmacology Section, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurophysiological Pharmacology Section, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034511392","display_name":"Judith R. Walters","orcid":"https://orcid.org/0000-0002-9192-5222","observed_orcids":["https://orcid.org/0000-0002-9192-5222"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. R. Walters","raw_affiliation_strings":["Neurophysiological Pharmacology Section, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurophysiological Pharmacology Section, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5082249228"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210110767"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":0.6457,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.64130518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"1","first_page":"67","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.06239999830722809,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/striatal-neurons","display_name":"striatal neurons","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.7889999747276306},{"id":"https://openalex.org/keywords/dopamine-d2-3-receptors","display_name":"dopamine D2/D3 receptors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/fenoldopam","display_name":"fenoldopam","score":0.9309999942779541},{"id":"https://openalex.org/keywords/skf-38393","display_name":"SKF 38393","score":0.9789999723434448},{"id":"https://openalex.org/keywords/quinpirole","display_name":"quinpirole","score":0.906000018119812},{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.9290000200271606},{"id":"https://openalex.org/keywords/neuronal-excitability","display_name":"neuronal excitability","score":0.9819999933242798},{"id":"https://openalex.org/keywords/basal-ganglia","display_name":"basal ganglia","score":0.6549999713897705},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9589999914169312},{"id":"https://openalex.org/keywords/dopaminergic-modulation","display_name":"dopaminergic modulation","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C2779867896","wikidata":"https://www.wikidata.org/wiki/Q2357007","display_name":"Fenoldopam","level":4,"score":0.848239541053772},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.7779631018638611},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7515202760696411},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6324313879013062},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6107330322265625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4814676344394684},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.41248440742492676},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4063270092010498},{"id":"https://openalex.org/C120069818","wikidata":"https://www.wikidata.org/wiki/Q415496","display_name":"Dopamine receptor","level":3,"score":0.3555644452571869},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29620498418807983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.264523446559906},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1710691750049591},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07656753063201904}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004873","descriptor_name":"Ergolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015647","descriptor_name":"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017072","descriptor_name":"Neostriatum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018491","descriptor_name":"Dopamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018818","descriptor_name":"Fenoldopam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019257","descriptor_name":"Quinpirole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/syn.890180109","doi":"https://doi.org/10.1002/syn.890180109","is_oa":false,"landing_page_url":"https://doi.org/10.1002/syn.890180109","pdf_url":null,"source":{"id":"https://openalex.org/S158211696","display_name":"Synapse","issn_l":"0887-4476","issn":["0887-4476","1098-2396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse","raw_type":"journal-article"},{"id":"pmid:7825125","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7825125","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W593781028","https://openalex.org/W1517107662","https://openalex.org/W1550887894","https://openalex.org/W1590565925","https://openalex.org/W1622774380","https://openalex.org/W1677042430","https://openalex.org/W1831026099","https://openalex.org/W1854009736","https://openalex.org/W1917378969","https://openalex.org/W1964322678","https://openalex.org/W1966092598","https://openalex.org/W1966256648","https://openalex.org/W1970167407","https://openalex.org/W1970855023","https://openalex.org/W1972869078","https://openalex.org/W1976749972","https://openalex.org/W1977312832","https://openalex.org/W1978318953","https://openalex.org/W1979532884","https://openalex.org/W1982004851","https://openalex.org/W1987193373","https://openalex.org/W1988836643","https://openalex.org/W1991603311","https://openalex.org/W1995482433","https://openalex.org/W1997543830","https://openalex.org/W1998325459","https://openalex.org/W1999961963","https://openalex.org/W2001189426","https://openalex.org/W2002416605","https://openalex.org/W2005163824","https://openalex.org/W2008901888","https://openalex.org/W2009579516","https://openalex.org/W2010488335","https://openalex.org/W2012064273","https://openalex.org/W2012161211","https://openalex.org/W2021683549","https://openalex.org/W2031170958","https://openalex.org/W2035001553","https://openalex.org/W2039035354","https://openalex.org/W2039724227","https://openalex.org/W2039732315","https://openalex.org/W2041563380","https://openalex.org/W2041582460","https://openalex.org/W2042542014","https://openalex.org/W2044843706","https://openalex.org/W2057788173","https://openalex.org/W2062359923","https://openalex.org/W2062524799","https://openalex.org/W2062777901","https://openalex.org/W2064130609","https://openalex.org/W2065140545","https://openalex.org/W2066003859","https://openalex.org/W2067290431","https://openalex.org/W2068020919","https://openalex.org/W2068064905","https://openalex.org/W2072740414","https://openalex.org/W2084676667","https://openalex.org/W2088541353","https://openalex.org/W2089573753","https://openalex.org/W2090080311","https://openalex.org/W2121102366","https://openalex.org/W2128044824","https://openalex.org/W2151362131","https://openalex.org/W2155599139","https://openalex.org/W2159082363","https://openalex.org/W2164398262","https://openalex.org/W2206687388"],"related_works":["https://openalex.org/W2081132593","https://openalex.org/W2016337390","https://openalex.org/W2032881902","https://openalex.org/W2110293865","https://openalex.org/W2088445755","https://openalex.org/W2029290999","https://openalex.org/W1893239824","https://openalex.org/W2002988496","https://openalex.org/W2125347079","https://openalex.org/W2028183577"],"abstract_inverted_index":{"The":[0,136],"effect":[1],"of":[2,9,21,73,87,92,110,118,134,152,187,197,207,214,220],"long-term":[3],"(6-19":[4],"weeks)":[5],"6-hydroxydopamine-induced":[6],"(6-OHDA)":[7],"lesions":[8,72],"midbrain":[10,74],"dopamine":[11,14,75,175,192],"cells":[12],"on":[13,166],"D1-like":[15],"agonist-induced":[16],"changes":[17],"in":[18,27,43,84,102,131,155,190,200,223],"the":[19,85,93,106,114,156,160,185,191,212],"excitability":[20,42,86,103,186],"rat":[22],"striatal":[23,47,89,188,198],"neurons":[24,48,56,69,111,189,199],"was":[25],"investigated":[26],"vitro":[28],"using":[29],"tissue":[30],"slices":[31],"and":[32,37,55,120,177,211],"intracellular":[33],"recording":[34],"techniques.":[35],"Fenoldopam":[36,66],"(+/-)-SKF":[38,77,107,153],"38393":[39,154],"predominantly":[40,82],"decreased":[41],"control":[44],"preparations":[45],"including":[46],"located":[49],"contralateral":[50],"to":[51,71,113,128,142,159,182,204,217],"6-OHDA":[52],"injection":[53],"sites":[54],"obtained":[57],"from":[58],"rats":[59],"receiving":[60],"sham":[61],"injections":[62],"or":[63],"no":[64],"treatment.":[65],"also":[67,172],"inhibited":[68],"ipsilateral":[70,88,112,158],"cells.":[76],"38393,":[78],"unlike":[79],"fenoldopam,":[80],"produced":[81,126],"increases":[83],"neurons.":[90,135],"Superfusion":[91],"D1":[94,147,167,176],"receptor":[95,124,168],"antagonist,":[96],"SCH":[97],"23390,":[98],"blocked":[99],"fenoldopam-induced":[100],"decreases":[101],"but":[104],"not":[105,164],"38393-induced":[108],"excitation":[109],"lesion.":[115],"Sequential":[116],"application":[117],"fenoldopam":[119,143],"quinpirole,":[121],"a":[122,132],"D2/D3":[123,178],"agonist,":[125],"responses":[127,141],"both":[129],"drugs":[130],"majority":[133],"results":[137],"demonstrate":[138],"that":[139,174],"inhibitory":[140],"are":[144,162,180],"mediated":[145],"by":[146],"receptors,":[148],"while":[149],"excitatory":[150],"effects":[151],"striatum":[157],"lesion":[161],"apparently":[163],"dependent":[165],"activation.":[169],"These":[170],"findings":[171],"suggest":[173],"receptors":[179],"able":[181],"concurrently":[183],"influence":[184],"deafferentated":[193],"striatum.":[194],"Similar":[195],"regulation":[196,206],"vivo":[201],"may":[202],"contribute":[203],"dopaminergic":[205,221],"basal":[208],"ganglia":[209],"output":[210],"ability":[213],"dopaminomimetic":[215],"agents":[216],"ameliorate":[218],"symptoms":[219],"deficiency":[222],"Parkinson's":[224],"disease.":[225]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
