{"id":"https://openalex.org/W2170568588","doi":"https://doi.org/10.1371/journal.pgen.1000303","title":"The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast","display_name":"The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast","publication_year":2008,"publication_date":"2008-12-11","ids":{"openalex":"https://openalex.org/W2170568588","doi":"https://doi.org/10.1371/journal.pgen.1000303","mag":"2170568588","pmid":"https://pubmed.ncbi.nlm.nih.gov/19079573","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2586090"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pgen.1000303","doi":"https://doi.org/10.1371/journal.pgen.1000303","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1000303","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000303&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000303&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004372835","display_name":"David Gresham","orcid":"https://orcid.org/0000-0002-4028-0364","observed_orcids":["https://orcid.org/0000-0002-4028-0364"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Gresham","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA","Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051640845","display_name":"Michael M. Desai","orcid":"https://orcid.org/0000-0002-9581-1150","observed_orcids":["https://orcid.org/0000-0002-9581-1150","https://orcid.org/0000-0002-5735-960X"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Desai","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033446152","display_name":"Cheryl M. Tucker","orcid":"https://orcid.org/0000-0003-2967-7448","observed_orcids":["https://orcid.org/0000-0003-2967-7448"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl M. Tucker","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051847085","display_name":"Harry T. Jenq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry T. Jenq","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031707688","display_name":"Dave A. Pai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dave A. Pai","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexandra Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Ward","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031798799","display_name":"Christopher G. DeSevo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher G. DeSevo","raw_affiliation_strings":["Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077542898","display_name":"David Botstein","orcid":"https://orcid.org/0000-0001-9499-4883","observed_orcids":["https://orcid.org/0000-0001-9499-4883"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David Botstein","raw_affiliation_strings":["Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038039561","display_name":"Maitreya J. Dunham","orcid":"https://orcid.org/0000-0001-9944-2666","observed_orcids":["https://orcid.org/0000-0001-9944-2666"]},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maitreya J. Dunham","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5038039561","https://openalex.org/A5077542898"],"corresponding_institution_ids":["https://openalex.org/I20089843","https://openalex.org/I201448701"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":9.3801,"has_fulltext":true,"cited_by_count":476,"citation_normalized_percentile":{"value":0.98680625,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"12","first_page":"e1000303","last_page":"e1000303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experimental-evolution","display_name":"experimental evolution","score":0.9750000238418579},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nutrient-limitation","display_name":"nutrient limitation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/glucose-limitation","display_name":"glucose limitation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/sulfate-limitation","display_name":"sulfate limitation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/phosphate-starvation","display_name":"phosphate limitation","score":1.0},{"id":"https://openalex.org/keywords/chemostat","display_name":"chemostat","score":0.765999972820282},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.7739999890327454},{"id":"https://openalex.org/keywords/retrotransposition","display_name":"retrotransposition","score":0.8119999766349792},{"id":"https://openalex.org/keywords/point-mutations","display_name":"point mutations","score":0.7540000081062317},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5989999771118164},{"id":"https://openalex.org/keywords/fitness","display_name":"fitness","score":0.574999988079071},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9202150702476501},{"id":"https://openalex.org/C125111812","wikidata":"https://www.wikidata.org/wiki/Q902311","display_name":"Chemostat","level":3,"score":0.8645812273025513},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.7716301679611206},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7154123187065125},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.6805017590522766},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.5383359789848328},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5003726482391357},{"id":"https://openalex.org/C2779040068","wikidata":"https://www.wikidata.org/wiki/Q7229807","display_name":"Population genomics","level":5,"score":0.49552834033966064},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.49008405208587646},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.41213545203208923},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4114255905151367},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.40360474586486816},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39361467957496643},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.38890695571899414},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.29785576462745667},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013431","descriptor_name":"Sulfates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020440","descriptor_name":"Gene Duplication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pgen.1000303","doi":"https://doi.org/10.1371/journal.pgen.1000303","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1000303","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000303&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2586090","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2586090","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genet","raw_type":"Text"},{"id":"pmid:19079573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19079573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.418.7438","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.418.7438","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.princeton.edu/genomics/botstein/research/2008_Gresham_Repertoire.pdf","raw_type":"text"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/161681","doi":null,"is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/161681","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Unpaywall 20191101","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:372bca7629554172aa29b1c024c48dea","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/372bca7629554172aa29b1c024c48dea","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Genetics, Vol 4, Iss 12, p e1000303 (2008)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/149070","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/The_Repertoire_and_Dynamics_of_Evolutionary_Adaptations_to_Controlled_Nutrient_Limited_Environments_in_Yeast/149070","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pgen.1000303","doi":"https://doi.org/10.1371/journal.pgen.1000303","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pgen.1000303","pdf_url":"https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000303&type=printable","source":{"id":"https://openalex.org/S103870658","display_name":"PLoS Genetics","issn_l":"1553-7390","issn":["1553-7390","1553-7404"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Genetics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4923349619","display_name":"GENETICS OF FUNCTIONAL INTERACTIONS IN YEAST","funder_award_id":"R37GM046406","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5037410752","display_name":"Genetics of Functional Interactions in Yeast","funder_award_id":"R01GM046406","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5822979879","display_name":null,"funder_award_id":"GM046406","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7118626832","display_name":"Defining and targeting the proteome to kill quiescent cells","funder_award_id":"R01GM107466","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7483086961","display_name":"Center for Quantitative Biology","funder_award_id":"P50GM071508","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000308907","display_name":null,"funder_award_id":"GM046406","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170568588.pdf","grobid_xml":"https://content.openalex.org/works/W2170568588.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1564573091","https://openalex.org/W1826309415","https://openalex.org/W1857653616","https://openalex.org/W1912468900","https://openalex.org/W1953861638","https://openalex.org/W1972029047","https://openalex.org/W1972703973","https://openalex.org/W1976940815","https://openalex.org/W1991624307","https://openalex.org/W1996490834","https://openalex.org/W1998971866","https://openalex.org/W2002852234","https://openalex.org/W2003867855","https://openalex.org/W2004368359","https://openalex.org/W2006141070","https://openalex.org/W2011836722","https://openalex.org/W2012766690","https://openalex.org/W2022910577","https://openalex.org/W2026681599","https://openalex.org/W2036073976","https://openalex.org/W2038462200","https://openalex.org/W2040557294","https://openalex.org/W2043168428","https://openalex.org/W2051116946","https://openalex.org/W2053731023","https://openalex.org/W2057017576","https://openalex.org/W2092265987","https://openalex.org/W2094248448","https://openalex.org/W2094961365","https://openalex.org/W2096160674","https://openalex.org/W2097455861","https://openalex.org/W2098066769","https://openalex.org/W2103238085","https://openalex.org/W2104669330","https://openalex.org/W2110027293","https://openalex.org/W2113862303","https://openalex.org/W2121553632","https://openalex.org/W2126582986","https://openalex.org/W2128898768","https://openalex.org/W2130757930","https://openalex.org/W2132617512","https://openalex.org/W2134957504","https://openalex.org/W2135257384","https://openalex.org/W2135962639","https://openalex.org/W2136223090","https://openalex.org/W2136947295","https://openalex.org/W2142504849","https://openalex.org/W2145406188","https://openalex.org/W2154279044","https://openalex.org/W2159010915","https://openalex.org/W2161942543","https://openalex.org/W2162251727","https://openalex.org/W2163949203","https://openalex.org/W2164832298","https://openalex.org/W2168475193","https://openalex.org/W2170343590","https://openalex.org/W2170549904","https://openalex.org/W2509656466","https://openalex.org/W4239648059","https://openalex.org/W4295837538"],"related_works":["https://openalex.org/W7099450121","https://openalex.org/W2092265987","https://openalex.org/W2064152536","https://openalex.org/W4376872524","https://openalex.org/W2900175013","https://openalex.org/W1805449453","https://openalex.org/W6892229075","https://openalex.org/W2148099207","https://openalex.org/W7100023526","https://openalex.org/W2531524037"],"abstract_inverted_index":{"The":[0],"experimental":[1,70,307],"evolution":[2,234,308],"of":[3,6,16,48,72,78,125,137,145,150,168,183,233,248,260,272,279,318],"laboratory":[4],"populations":[5,219],"microbes":[7],"provides":[8],"an":[9],"opportunity":[10],"to":[11,33,52,81,148,162,172,212,257,269,283,295],"observe":[12],"the":[13,69,123,134,142,151,155,181,193,231,241,245,252,261,273,280,289,314],"evolutionary":[14,208,301],"dynamics":[15,136,197],"adaptation":[17,71,138],"in":[18,37,83,114,154,174,186,199,210,224,244,251,293],"real":[19],"time.":[20],"Until":[21],"very":[22],"recently,":[23],"however,":[24],"such":[25],"studies":[26],"have":[27],"been":[28],"limited":[29],"by":[30,44,141,176],"our":[31,200,303],"inability":[32],"systematically":[34],"find":[35],"mutations":[36,132,185,264,281],"evolved":[38],"organisms.":[39],"We":[40,94,157,178,254],"overcome":[41],"this":[42],"limitation":[43],"using":[45],"a":[46],"variety":[47],"DNA":[49],"microarray-based":[50],"techniques":[51],"characterize":[53],"genetic":[54],"changes":[55,161],"--":[56,65],"including":[57],"point":[58,120],"mutations,":[59],"structural":[60],"changes,":[61],"and":[62,75,99,133,171,206,227,316],"insertion":[63],"variation":[64,112],"that":[66,130,180,306],"resulted":[67],"from":[68],"24":[73],"haploid":[74],"diploid":[76],"cultures":[77],"Saccharomyces":[79],"cerevisiae":[80],"growth":[82,146],"either":[84],"glucose,":[85],"sulfate,":[86],"or":[87,188],"phosphate-limited":[88,189],"chemostats":[89],"for":[90],"approximately":[91],"200":[92],"generations.":[93],"identified":[95,118],"frequent":[96],"genomic":[97],"amplifications":[98],"rearrangements":[100],"as":[101,103],"well":[102],"novel":[104],"retrotransposition":[105],"events":[106],"associated":[107,287],"with":[108,192,236,288],"adaptation.":[109],"Global":[110],"nucleotide":[111],"detection":[113],"ten":[115],"clonal":[116],"isolates":[117],"32":[119],"mutations.":[121],"On":[122],"basis":[124],"mutation":[126],"frequencies,":[127],"we":[128],"infer":[129],"these":[131,159,213],"subsequent":[135],"are":[139],"determined":[140],"batch":[143,194],"phase":[144,153,195],"prior":[147],"initiation":[149],"continuous":[152],"chemostat.":[156],"relate":[158,258],"genotypic":[160,205,226],"phenotypic":[163,207,228],"outcomes,":[164],"namely":[165],"global":[166],"patterns":[167],"gene":[169,267],"expression,":[170],"increases":[173],"fitness":[175],"5-50%.":[177],"found":[179],"spectrum":[182],"available":[184],"glucose-":[187],"environments":[190],"combined":[191],"population":[196],"early":[198],"experiments":[201],"allowed":[202],"several":[203],"distinct":[204],"pathways":[209],"response":[211],"nutrient":[214],"limitations.":[215],"By":[216],"contrast,":[217],"sulfate-limited":[218],"were":[220,255],"much":[221],"more":[222],"constrained":[223],"both":[225],"outcomes.":[229],"Thus,":[230,292],"reproducibility":[232],"varies":[235],"specific":[237],"selective":[238],"pressures,":[239],"reflecting":[240],"constraints":[242],"inherent":[243],"system-level":[246],"organization":[247],"metabolic":[249,275,320],"processes":[250],"cell.":[253],"able":[256],"some":[259],"observed":[262],"adaptive":[263],"(e.g.,":[265],"transporter":[266],"amplifications)":[268],"known":[270],"features":[271],"relevant":[274,290],"pathways,":[276],"but":[277],"many":[278],"pointed":[282],"genes":[284],"not":[285],"previously":[286],"physiology.":[291],"addition":[294],"answering":[296],"basic":[297],"mechanistic":[298],"questions":[299],"about":[300],"mechanisms,":[302],"work":[304],"suggests":[305],"can":[309],"also":[310],"shed":[311],"light":[312],"on":[313],"function":[315],"regulation":[317],"individual":[319],"pathways.":[321]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":33},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":44},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":47},{"year":2012,"cited_by_count":44}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
