{"id":"https://openalex.org/W2170516396","doi":"https://doi.org/10.1007/s00259-004-1458-4","title":"Use of a standardized uptake value for parametric in vivo imaging of benzodiazepine receptor distribution on [ 11 C]flumazenil brain PET","display_name":"Use of a standardized uptake value for parametric in vivo imaging of benzodiazepine receptor distribution on [ 11 C]flumazenil brain PET","publication_year":2004,"publication_date":"2004-05-26","ids":{"openalex":"https://openalex.org/W2170516396","doi":"https://doi.org/10.1007/s00259-004-1458-4","mag":"2170516396","pmid":"https://pubmed.ncbi.nlm.nih.gov/14985864"},"language":"en","primary_location":{"id":"doi:10.1007/s00259-004-1458-4","doi":"https://doi.org/10.1007/s00259-004-1458-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00259-004-1458-4","pdf_url":null,"source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109999939","display_name":"Masahito Tsukamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahito Tsukamoto","raw_affiliation_strings":["Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. twosun@sh.rim.or.jp","Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. twosun@sh.rim.or.jp","institution_ids":["https://openalex.org/I205349734"]},{"raw_affiliation_string":"Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046674227","display_name":"Chietsugu Katoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chietsugu Katoh","raw_affiliation_strings":["Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102838938","display_name":"Tohru Shiga","orcid":"https://orcid.org/0000-0002-0140-9428","observed_orcids":["https://orcid.org/0000-0002-0140-9428","https://orcid.org/0000-0002-3238-3507"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Shiga","raw_affiliation_strings":["Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066559276","display_name":"Tomohito Kaji","orcid":"https://orcid.org/0000-0002-9973-6389","observed_orcids":["https://orcid.org/0000-0002-9973-6389"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohito Kaji","raw_affiliation_strings":["Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044131429","display_name":"Yuji Kuge","orcid":"https://orcid.org/0000-0002-0483-9706","observed_orcids":["https://orcid.org/0000-0002-0483-9706"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Kuge","raw_affiliation_strings":["Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027606087","display_name":"Kunihiro Nakada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiro Nakada","raw_affiliation_strings":["Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046528941","display_name":"Nagara Tamaki","orcid":"https://orcid.org/0000-0001-6193-8594","observed_orcids":["https://orcid.org/0000-0001-6193-8594"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nagara Tamaki","raw_affiliation_strings":["Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, Hokkaido University, Sapporo, Hokkaido, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109999939"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":null,"fwci":0.4693,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.65636063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"31","issue":"6","first_page":"846","last_page":"851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/11c-flumazenil","display_name":"[11C]flumazenil","score":0.9269999861717224},{"id":"https://openalex.org/keywords/benzodiazepine-receptor","display_name":"benzodiazepine receptor","score":0.8930000066757202},{"id":"https://openalex.org/keywords/standardized-uptake-value","display_name":"standardized uptake value","score":0.9309999942779541},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.8100000023841858},{"id":"https://openalex.org/keywords/parametric-imaging","display_name":"parametric imaging","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.8339999914169312},{"id":"https://openalex.org/keywords/acquisition-timing","display_name":"acquisition timing","score":0.5640000104904175},{"id":"https://openalex.org/keywords/brain-pet","display_name":"brain PET","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2778409475","wikidata":"https://www.wikidata.org/wiki/Q421920","display_name":"Flumazenil","level":4,"score":0.8363444209098816},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.8059020042419434},{"id":"https://openalex.org/C199374082","wikidata":"https://www.wikidata.org/wiki/Q907080","display_name":"Standardized uptake value","level":3,"score":0.6774162650108337},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5702229142189026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5512993931770325},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.32711851596832275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15901821851730347},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10367769002914429}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005442","descriptor_name":"Flumazenil","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007089","descriptor_name":"Image Enhancement","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00259-004-1458-4","doi":"https://doi.org/10.1007/s00259-004-1458-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00259-004-1458-4","pdf_url":null,"source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},{"id":"pmid:14985864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14985864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of nuclear medicine and molecular imaging","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1965579642","https://openalex.org/W1966242102","https://openalex.org/W1968437845","https://openalex.org/W1972249570","https://openalex.org/W1973636130","https://openalex.org/W1977459833","https://openalex.org/W1983356261","https://openalex.org/W1986903653","https://openalex.org/W1992781888","https://openalex.org/W2000981300","https://openalex.org/W2002838359","https://openalex.org/W2003090874","https://openalex.org/W2006879585","https://openalex.org/W2011251830","https://openalex.org/W2014661480","https://openalex.org/W2015155864","https://openalex.org/W2030301599","https://openalex.org/W2034548134","https://openalex.org/W2035010797","https://openalex.org/W2051340164","https://openalex.org/W2063745998","https://openalex.org/W2066886309","https://openalex.org/W2075446447","https://openalex.org/W2079438172","https://openalex.org/W2100391054","https://openalex.org/W2101067729","https://openalex.org/W2106588887","https://openalex.org/W2107751655","https://openalex.org/W2108254964","https://openalex.org/W2114634718","https://openalex.org/W2122591719","https://openalex.org/W2125070425","https://openalex.org/W2125961007","https://openalex.org/W2131777016","https://openalex.org/W2134479360","https://openalex.org/W2167205863","https://openalex.org/W2169838301","https://openalex.org/W2186897808"],"related_works":["https://openalex.org/W2621196953","https://openalex.org/W1992781888","https://openalex.org/W1985113224","https://openalex.org/W2001461281","https://openalex.org/W2109456560","https://openalex.org/W2475359951","https://openalex.org/W2124803105","https://openalex.org/W1985808875","https://openalex.org/W1988429974","https://openalex.org/W2050443585"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}