{"id":"https://openalex.org/W2170438544","doi":"https://doi.org/10.1136/gut.51.2.265","title":"Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis","display_name":"Hyperlipidaemic state and cardiovascular risk in primary biliary cirrhosis","publication_year":2002,"publication_date":"2002-07-28","ids":{"openalex":"https://openalex.org/W2170438544","doi":"https://doi.org/10.1136/gut.51.2.265","mag":"2170438544","pmid":"https://pubmed.ncbi.nlm.nih.gov/12117892","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1773333"},"language":"en","primary_location":{"id":"doi:10.1136/gut.51.2.265","doi":"https://doi.org/10.1136/gut.51.2.265","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.51.2.265","pdf_url":"https://gut.bmj.com/content/gutjnl/51/2/265.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://gut.bmj.com/content/gutjnl/51/2/265.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Longo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Longo","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018238625","display_name":"Andrea Crosignani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A Crosignani","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057244832","display_name":"Pier Maria Battezzati","orcid":"https://orcid.org/0000-0003-1344-3452","observed_orcids":["https://orcid.org/0000-0003-1344-3452"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P M Battezzati","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103949559","display_name":"Cristina Giussani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C Squarcia Giussani","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065511179","display_name":"Pietro Invernizzi","orcid":"https://orcid.org/0000-0003-3262-1998","observed_orcids":["https://orcid.org/0000-0003-3262-1998"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Invernizzi","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083246247","display_name":"Massimo Giovanni Zuin","orcid":"https://orcid.org/0000-0003-3906-4362","observed_orcids":["https://orcid.org/0000-0003-3906-4362"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M Zuin","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015159811","display_name":"Mauro Podda","orcid":"https://orcid.org/0000-0001-9941-0883","observed_orcids":["https://orcid.org/0000-0001-9941-0883"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"M Podda","raw_affiliation_strings":["Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy","Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, Via Di Rudin\u00ec 8, 20142 Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, University of Milan, Italy","institution_ids":["https://openalex.org/I189158943"]},{"raw_affiliation_string":"Division of Internal Medicine, Department of Medicine, Surgery, and Dentistry, San Paolo School of Medicine, Via Di Rudin\u00ec 8, 20142 Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5015159811"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":null,"apc_paid":null,"fwci":2.4435,"has_fulltext":true,"cited_by_count":192,"citation_normalized_percentile":{"value":0.88921589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"51","issue":"2","first_page":"265","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":1.0},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8930000066757202},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.6970000267028809},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.9089999794960022},{"id":"https://openalex.org/keywords/hyperbilirubinemia","display_name":"hyperbilirubinemia","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.7039999961853027},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.718999981880188},{"id":"https://openalex.org/keywords/cardiovascular-events","display_name":"cardiovascular events","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8328279256820679},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7703671455383301},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6488032341003418},{"id":"https://openalex.org/C2780366471","wikidata":"https://www.wikidata.org/wiki/Q1072420","display_name":"Primary biliary cirrhosis","level":2,"score":0.6386224627494812},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.554210364818573},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5281192064285278},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5152304768562317},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5097684264183044},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.49273207783699036},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.47528091073036194},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.4316043257713318},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4207383394241333},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.41915470361709595},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.41176119446754456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33887147903442383},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1136/gut.51.2.265","doi":"https://doi.org/10.1136/gut.51.2.265","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.51.2.265","pdf_url":"https://gut.bmj.com/content/gutjnl/51/2/265.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:470947","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1773333","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1773333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1773333","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Text"},{"id":"pmid:12117892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12117892","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:gutjnl:51/2/265","doi":null,"is_oa":false,"landing_page_url":"http://gut.bmj.com/cgi/content/short/51/2/265","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/gut.51.2.265","doi":"https://doi.org/10.1136/gut.51.2.265","is_oa":true,"landing_page_url":"https://doi.org/10.1136/gut.51.2.265","pdf_url":"https://gut.bmj.com/content/gutjnl/51/2/265.full.pdf","source":{"id":"https://openalex.org/S3251770","display_name":"Gut","issn_l":"0017-5749","issn":["0017-5749","1468-3288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2170438544.pdf","grobid_xml":"https://content.openalex.org/works/W2170438544.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1975579398","https://openalex.org/W1996203016","https://openalex.org/W2009699811","https://openalex.org/W2020104402","https://openalex.org/W2021342304","https://openalex.org/W2022109882","https://openalex.org/W2032374289","https://openalex.org/W2034223692","https://openalex.org/W2040375465","https://openalex.org/W2057242782","https://openalex.org/W2061098926","https://openalex.org/W2068930396","https://openalex.org/W2075106817","https://openalex.org/W2079222390","https://openalex.org/W2084164125","https://openalex.org/W2112401496","https://openalex.org/W2118202495","https://openalex.org/W2118528060","https://openalex.org/W2132244235","https://openalex.org/W2141861294","https://openalex.org/W2159434940","https://openalex.org/W2165182105","https://openalex.org/W2312841542","https://openalex.org/W2329260516","https://openalex.org/W2411148069","https://openalex.org/W2418767787","https://openalex.org/W2520581567","https://openalex.org/W2607031541","https://openalex.org/W2797597138","https://openalex.org/W4238251256","https://openalex.org/W4249825849","https://openalex.org/W4285719527","https://openalex.org/W4300072036","https://openalex.org/W4300110167"],"related_works":["https://openalex.org/W2969400797","https://openalex.org/W2910536420","https://openalex.org/W2370564107","https://openalex.org/W2135782763","https://openalex.org/W2785969442","https://openalex.org/W1996203016","https://openalex.org/W4412199371","https://openalex.org/W2978260559","https://openalex.org/W3206542769","https://openalex.org/W4403721196"],"abstract_inverted_index":{"BACKGROUND:":[0],"Primary":[1],"biliary":[2,216],"cirrhosis":[3],"(PBC),":[4],"a":[5,50,124,212],"chronic":[6],"cholestatic":[7],"liver":[8],"disease,":[9],"is":[10,23,225],"frequently":[11],"associated":[12,122,161,186,227],"with":[13,123,162,172,187,200,228,239,255],"severe":[14,182,213,222,256],"hypercholesterolaemia":[15,174,183,241,257],"but":[16],"the":[17,38,143,207],"clinical":[18],"significance":[19,178],"of":[20,40,52,68,74,94,135,142,166,176,202,221,232],"this":[21],"finding":[22],"unclear.":[24],"AIMS:":[25],"To":[26],"characterise":[27],"changes":[28],"in":[29,43,80,126,206,215,252],"serum":[30,69,97,195],"lipid":[31,70],"profile":[32],"over":[33],"time":[34],"and":[35,72,108,129,204],"to":[36,62,140,244],"assess":[37],"risk":[39,165,189,231],"cardiovascular":[41,76,136,167,233,247],"disease":[42,119,209,234],"PBC.":[44],"SUBJECTS":[45],"AND":[46],"METHODS:":[47],"We":[48],"studied":[49],"cohort":[51],"400":[53],"PBC":[54,253],"patients":[55,95,103,238,254],"for":[56],"6.2":[57],"years":[58],"(range":[59],"4":[60],"months":[61],"24":[63],"years)":[64],"by":[65],"serial":[66],"determinations":[67],"levels":[71,99,115,197],"registration":[73],"all":[75],"events.":[77],"Subjects":[78],"included":[79],"an":[81,163,229,245],"Italian":[82],"prospective":[83],"population":[84,145],"based":[85],"study":[86],"served":[87],"as":[88],"controls.":[89],"RESULTS:":[90],"At":[91],"presentation,":[92],"76%":[93],"had":[96,104],"cholesterol":[98,107,114,196],">5.2":[100],"mmol/l.":[101],"Hyperbilirubinaemic":[102],"higher":[105],"total":[106,127],"lower":[109],"high":[110],"density":[111],"lipoprotein":[112],"(HDL)":[113],"(p<0.001).":[116],"With":[117],"time,":[118],"progression":[120],"was":[121,138,160,175,184],"reduction":[125,214],"(p<0.001)":[128],"HDL":[130],"(p<0.05)":[131],"cholesterol.":[132],"The":[133],"incidence":[134],"events":[137,168],"similar":[139],"that":[141],"general":[144],"(cerebrovascular":[146],"events:":[147,156],"standardised":[148],"ratio":[149],"1.4;":[150],"95%":[151],"confidence":[152],"interval":[153],"0.5-3.7;":[154],"coronary":[155],"2.2;":[157],"0.9-4.3).":[158],"Hypertension":[159],"increased":[164,188,246],"(3.8;":[169,179],"1.6-8.9).":[170],"Association":[171],"moderate":[173,240],"borderline":[177],"0.9-17)":[180],"whereas":[181],"not":[185,226],"(2.4,":[190],"0.5-11).":[191],"CONCLUSIONS:":[192],"In":[193],"PBC,":[194],"markedly":[198],"increase":[199],"worsening":[201],"cholestasis,":[203,224],"decrease":[205],"late":[208],"stages,":[210],"despite":[211],"secretion.":[217],"Marked":[218],"hypercholesterolaemia,":[219],"typical":[220],"longstanding":[223],"excess":[230],"while":[235],"less":[236],"advanced":[237],"are":[242],"exposed":[243],"risk.":[248],"Putative":[249],"protective":[250],"factors":[251],"should":[258],"be":[259],"assessed.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}